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The map label for this gene is panC

Identifier: 220905547

GI number: 220905547

Start: 2753037

End: 2753885

Strand: Direct

Name: panC

Synonym: Ddes_2286

Alternate gene names: 220905547

Gene position: 2753037-2753885 (Clockwise)

Preceding gene: 220905545

Following gene: 220905548

Centisome position: 95.81

GC content: 62.66

Gene sequence:

>849_bases
ATGCAGATATTTACTACGCCTCAGCAACTTGCGGCCCAATGCCGCGCCTGGCATGCGGCCGGGGACGATATCGCCCTTGT
GCCCACCATGGGCTACTACCACGCCGGCCATGAAGACCTCATGGCCCATGGCCGCACCTTGGCCAAACGCCTGGTGGTAA
GCCTTTTCGTCAACCCTGCCCAGTTCGGCCCCGGTGAAGATCTGGCCGCTTACCCGCGCGACGCCGAGCGCGATACGGCC
ATTGCCGCAAGCCACGGCGCTGACGCCATTTTCATGCCTGAACCGGGGAGCATGTACGAAGCCGACCATGCCACCTGGGT
TGAAGTGCCGGACCTTGCCAGGGGCCTGTGCGGGCAAAGCCGCCCCACGCACTTTCGCGGAGTCTGCACGGTGGTGCTCA
AGCTCTTTATGCTGAGCGCGGCAGACGTGGCTGTTTTCGGCCAGAAAGACTGGCAGCAGCAGGCCATCATCAAACGTATG
GTCCGCGATCTGAACCTGCCCGTGCGCATTGAAACCCGGCCCACCGTACGCGAAGCCGACGGTCTGGCCCTGTCTTCGCG
CAACGTCTACCTTTCGCCGGAAGAACGCGCACAGGCGCCGCAAATCCGCCAGGCCCTGCTCCACGCCCAGAAGCTGGCGC
AAGAAGGGGCAGGCAGCGCAACACTGCTGCGCGAGGCCGTATTGCGCCGCTGGGCAGAACTTCTGCCCCTTGGCCGTCTG
GACTACCTCACCATAGTGCATCCGGAATCACTGGAGCCGCTTGACGAGGTAGTAGGCCCGGCCCTTATGGCCTGTGCCGT
GCGTATGGGCAAGGCACGCCTTATCGACAACATTCTTTTACATTCGTAA

Upstream 100 bases:

>100_bases
CGCGCTGCGGCGCGCTTTCCGCAAGGCCGAGTTTTCCTTTACAACCATGCCCTGTACGTGTATAAGAAGTCATTCATAAA
CTATATCACAATACCTTGAT

Downstream 100 bases:

>100_bases
ACCACCGCGCCTGCCGCGCGTCCCTTCAAGGAGAACAGCATGCAGACCAAGGGCAAATATTTTTTCACCTCTGAATCCGT
TACCGAAGGCCACCCCGACA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MQIFTTPQQLAAQCRAWHAAGDDIALVPTMGYYHAGHEDLMAHGRTLAKRLVVSLFVNPAQFGPGEDLAAYPRDAERDTA
IAASHGADAIFMPEPGSMYEADHATWVEVPDLARGLCGQSRPTHFRGVCTVVLKLFMLSAADVAVFGQKDWQQQAIIKRM
VRDLNLPVRIETRPTVREADGLALSSRNVYLSPEERAQAPQIRQALLHAQKLAQEGAGSATLLREAVLRRWAELLPLGRL
DYLTIVHPESLEPLDEVVGPALMACAVRMGKARLIDNILLHS

Sequences:

>Translated_282_residues
MQIFTTPQQLAAQCRAWHAAGDDIALVPTMGYYHAGHEDLMAHGRTLAKRLVVSLFVNPAQFGPGEDLAAYPRDAERDTA
IAASHGADAIFMPEPGSMYEADHATWVEVPDLARGLCGQSRPTHFRGVCTVVLKLFMLSAADVAVFGQKDWQQQAIIKRM
VRDLNLPVRIETRPTVREADGLALSSRNVYLSPEERAQAPQIRQALLHAQKLAQEGAGSATLLREAVLRRWAELLPLGRL
DYLTIVHPESLEPLDEVVGPALMACAVRMGKARLIDNILLHS
>Mature_282_residues
MQIFTTPQQLAAQCRAWHAAGDDIALVPTMGYYHAGHEDLMAHGRTLAKRLVVSLFVNPAQFGPGEDLAAYPRDAERDTA
IAASHGADAIFMPEPGSMYEADHATWVEVPDLARGLCGQSRPTHFRGVCTVVLKLFMLSAADVAVFGQKDWQQQAIIKRM
VRDLNLPVRIETRPTVREADGLALSSRNVYLSPEERAQAPQIRQALLHAQKLAQEGAGSATLLREAVLRRWAELLPLGRL
DYLTIVHPESLEPLDEVVGPALMACAVRMGKARLIDNILLHS

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=284, Percent_Identity=40.1408450704225, Blast_Score=181, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6322046, Length=285, Percent_Identity=36.8421052631579, Blast_Score=169, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_DESDA (B8J4Q1)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480859.1
- GeneID:   7286004
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_2286
- HOGENOM:   HBG428839
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30995; Mature: 30995

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIFTTPQQLAAQCRAWHAAGDDIALVPTMGYYHAGHEDLMAHGRTLAKRLVVSLFVNPA
CCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
QFGPGEDLAAYPRDAERDTAIAASHGADAIFMPEPGSMYEADHATWVEVPDLARGLCGQS
CCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCEEECHHHHHHHCCCC
RPTHFRGVCTVVLKLFMLSAADVAVFGQKDWQQQAIIKRMVRDLNLPVRIETRPTVREAD
CCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHCC
GLALSSRNVYLSPEERAQAPQIRQALLHAQKLAQEGAGSATLLREAVLRRWAELLPLGRL
CCEEECCCEEECCHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
DYLTIVHPESLEPLDEVVGPALMACAVRMGKARLIDNILLHS
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQIFTTPQQLAAQCRAWHAAGDDIALVPTMGYYHAGHEDLMAHGRTLAKRLVVSLFVNPA
CCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
QFGPGEDLAAYPRDAERDTAIAASHGADAIFMPEPGSMYEADHATWVEVPDLARGLCGQS
CCCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCEEECHHHHHHHCCCC
RPTHFRGVCTVVLKLFMLSAADVAVFGQKDWQQQAIIKRMVRDLNLPVRIETRPTVREAD
CCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHCC
GLALSSRNVYLSPEERAQAPQIRQALLHAQKLAQEGAGSATLLREAVLRRWAELLPLGRL
CCEEECCCEEECCHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
DYLTIVHPESLEPLDEVVGPALMACAVRMGKARLIDNILLHS
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA