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The map label for this gene is pepA

Identifier: 220905468

GI number: 220905468

Start: 2660606

End: 2662111

Strand: Direct

Name: pepA

Synonym: Ddes_2206

Alternate gene names: 220905468

Gene position: 2660606-2662111 (Clockwise)

Preceding gene: 220905466

Following gene: 220905469

Centisome position: 92.59

GC content: 65.6

Gene sequence:

>1506_bases
ATGGACATACGCTTTCAAAATCTTGGCCCGGAACACTGGAAAGGCGAGATCATGCTGGCCCCCGTCTGCCAGGACGAGGT
CCTGACAGAAATTTGCCCCCAGATGGACAAGGCCGCCCCCTGGCTGGCCATAGCCCCCGCCCTGCGCGACTTCAAGGGCA
AAACCGGTGAACTGGCCCTCATGCACGGCCACCCCGAACTCGCCGTACCCCGTGTACTGGCCGTGGGCCTTGGCCCCCGT
GAAAAGGTGGACACCGCGGGCATTCGCAAGGCTGTTGCCGCCGCCGTGCAGTTGTGCCGCCAGAAGGGCTTTGGCTCCAT
CCTCCTGCCCGAACCGGCCCTGGCCCGCCTGCCCGGCGGCCGTGAGCGCCTGGTAGAAGAATGCGTGTGCGCCTCCCTGC
TGGCCCTTTACCGCTTTACGGCCCTGAAAAAGGCCGAAAAAGACGAGCCTGCCGAGCCGCAGTGGCTGGCCCTGGGCTTT
GACGGGCAGGAAGTGCCCGACGCCTCGCATGCCGCCGCCCGCAAGGGTGAAAACGCGGCCTGGGCCGTTATGCTTGCCCG
TGACCTGGCGAGCACGCCGCCCAACCTGCTGTACCCTGAAAAACTGGCCGAGCGCGCCCGGGAACTGGCCCGCGAAAAGG
GCTTTGCCTGCACCGTGCTTGACGAGCACGAGCTTGAAAAAGAAAGCATGGGCTGCCTGCTGGCCGTAGGCCAGGGTTCC
GGCCGTCCGCCCCGTCTTGTTATTCTTGAGCACGCCCCTGAAGGGCATGAACAGGAAAAACCCCTCATTCTTGTGGGCAA
GGGCATCACGTTTGATACGGGCGGTATCAGCCTCAAACCTGCCGCCAACATGCACCAGATGAAAGCCGACATGACCGGAG
CCGCCACAGTGCTGGCCACCCTGGCCGCGCTGGCCCAGGAAGATGCGCCCCGCCGCGTCATCGGCCTGCTGGCCTGCGCC
GAGAACATGCCCGGCGGCCGGGCCATGCGCCCCGGCGACGTGGTGCGCGCCGCCAACGGCGACAGCGTGGAAATACAGAA
TACCGATGCCGAAGGCCGCCTTGCCCTGTGCGATGCGCTGGCCTACGCCCAGAAAACGTGGACGCCGGCCGCCCTGGTCG
ATATAGCCACCCTTACCGGTGCGTGCGCCGTGGCTCTTGGCACACAGATCGCCGGGCTTTTCAGCGACGATGCAGACCTT
GCCGAGCGCATCCGTGCGGCCGGAGGCGCATGCGGCGAGGAATACTGGCCCCTGCCCCTGTGGAAGCCCTATGCGGAACA
GCTGAAAAGCGATGTGGCCGACATCTGCCACATGGGTCCGCGTGAAGGCGGAGCCATCAATGCCGCCCTGTTTTTGCAGC
ACTTCATTCAGGAGGGCGTGCGCTGGGCGCATCTGGACATTGCCGGGGTGGACTGGGTTTCCAAGCCCACGCCCCTGTGC
CCCGCCGGGCCTTCGGCCTTTGGCGCGCGCACGCTGCTTGAACTGGCCAGGGGAGGCGTTCTGTAA

Upstream 100 bases:

>100_bases
ATATTCCCCTACCCGGACAGGCCGCCGCATCAGGCAGGCCGTCAGCCGTCAGCCGCATCTTGCCGGCACACATACGGCAC
ATATGAGGAGAATGCAGCCC

Downstream 100 bases:

>100_bases
TGATGAAGGTGTATCTTATCGGCGCAGGCCCCGGCGATCCGGGCCTGCTGACCCTCAAGGGCCGCGATGCCTTGGCCGCT
GCGGATGTGGTGGTGTATGA

Product: Leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MDIRFQNLGPEHWKGEIMLAPVCQDEVLTEICPQMDKAAPWLAIAPALRDFKGKTGELALMHGHPELAVPRVLAVGLGPR
EKVDTAGIRKAVAAAVQLCRQKGFGSILLPEPALARLPGGRERLVEECVCASLLALYRFTALKKAEKDEPAEPQWLALGF
DGQEVPDASHAAARKGENAAWAVMLARDLASTPPNLLYPEKLAERARELAREKGFACTVLDEHELEKESMGCLLAVGQGS
GRPPRLVILEHAPEGHEQEKPLILVGKGITFDTGGISLKPAANMHQMKADMTGAATVLATLAALAQEDAPRRVIGLLACA
ENMPGGRAMRPGDVVRAANGDSVEIQNTDAEGRLALCDALAYAQKTWTPAALVDIATLTGACAVALGTQIAGLFSDDADL
AERIRAAGGACGEEYWPLPLWKPYAEQLKSDVADICHMGPREGGAINAALFLQHFIQEGVRWAHLDIAGVDWVSKPTPLC
PAGPSAFGARTLLELARGGVL

Sequences:

>Translated_501_residues
MDIRFQNLGPEHWKGEIMLAPVCQDEVLTEICPQMDKAAPWLAIAPALRDFKGKTGELALMHGHPELAVPRVLAVGLGPR
EKVDTAGIRKAVAAAVQLCRQKGFGSILLPEPALARLPGGRERLVEECVCASLLALYRFTALKKAEKDEPAEPQWLALGF
DGQEVPDASHAAARKGENAAWAVMLARDLASTPPNLLYPEKLAERARELAREKGFACTVLDEHELEKESMGCLLAVGQGS
GRPPRLVILEHAPEGHEQEKPLILVGKGITFDTGGISLKPAANMHQMKADMTGAATVLATLAALAQEDAPRRVIGLLACA
ENMPGGRAMRPGDVVRAANGDSVEIQNTDAEGRLALCDALAYAQKTWTPAALVDIATLTGACAVALGTQIAGLFSDDADL
AERIRAAGGACGEEYWPLPLWKPYAEQLKSDVADICHMGPREGGAINAALFLQHFIQEGVRWAHLDIAGVDWVSKPTPLC
PAGPSAFGARTLLELARGGVL
>Mature_501_residues
MDIRFQNLGPEHWKGEIMLAPVCQDEVLTEICPQMDKAAPWLAIAPALRDFKGKTGELALMHGHPELAVPRVLAVGLGPR
EKVDTAGIRKAVAAAVQLCRQKGFGSILLPEPALARLPGGRERLVEECVCASLLALYRFTALKKAEKDEPAEPQWLALGF
DGQEVPDASHAAARKGENAAWAVMLARDLASTPPNLLYPEKLAERARELAREKGFACTVLDEHELEKESMGCLLAVGQGS
GRPPRLVILEHAPEGHEQEKPLILVGKGITFDTGGISLKPAANMHQMKADMTGAATVLATLAALAQEDAPRRVIGLLACA
ENMPGGRAMRPGDVVRAANGDSVEIQNTDAEGRLALCDALAYAQKTWTPAALVDIATLTGACAVALGTQIAGLFSDDADL
AERIRAAGGACGEEYWPLPLWKPYAEQLKSDVADICHMGPREGGAINAALFLQHFIQEGVRWAHLDIAGVDWVSKPTPLC
PAGPSAFGARTLLELARGGVL

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=459, Percent_Identity=35.5119825708061, Blast_Score=235, Evalue=9e-62,
Organism=Homo sapiens, GI47155554, Length=366, Percent_Identity=33.0601092896175, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1790710, Length=505, Percent_Identity=36.6336633663366, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI87082123, Length=340, Percent_Identity=38.2352941176471, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=288, Percent_Identity=36.8055555555556, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=483, Percent_Identity=26.5010351966874, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355725, Length=300, Percent_Identity=37.3333333333333, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24661038, Length=300, Percent_Identity=37, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI20129969, Length=434, Percent_Identity=30.4147465437788, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI161077148, Length=346, Percent_Identity=30.9248554913295, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI20130057, Length=346, Percent_Identity=30.9248554913295, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24662227, Length=345, Percent_Identity=29.8550724637681, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20129963, Length=356, Percent_Identity=31.4606741573034, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21355645, Length=302, Percent_Identity=31.4569536423841, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24662223, Length=302, Percent_Identity=31.4569536423841, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19922386, Length=344, Percent_Identity=29.9418604651163, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221379063, Length=325, Percent_Identity=31.6923076923077, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI221379062, Length=325, Percent_Identity=31.6923076923077, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21357381, Length=325, Percent_Identity=31.6923076923077, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24646701, Length=347, Percent_Identity=27.6657060518732, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646703, Length=347, Percent_Identity=27.6657060518732, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21358201, Length=347, Percent_Identity=27.6657060518732, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_DESDA (B8J457)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480780.1
- MEROPS:   M17.003
- GeneID:   7285922
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_2206
- HOGENOM:   HBG742580
- ProtClustDB:   CLSK704608
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53370; Mature: 53370

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 279-279 ACT_SITE 353-353

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRFQNLGPEHWKGEIMLAPVCQDEVLTEICPQMDKAAPWLAIAPALRDFKGKTGELAL
CCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEE
MHGHPELAVPRVLAVGLGPREKVDTAGIRKAVAAAVQLCRQKGFGSILLPEPALARLPGG
EECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHCCCH
RERLVEECVCASLLALYRFTALKKAEKDEPAEPQWLALGFDGQEVPDASHAAARKGENAA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCH
WAVMLARDLASTPPNLLYPEKLAERARELAREKGFACTVLDEHELEKESMGCLLAVGQGS
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCEEEEECCCC
GRPPRLVILEHAPEGHEQEKPLILVGKGITFDTGGISLKPAANMHQMKADMTGAATVLAT
CCCCEEEEEECCCCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHHH
LAALAQEDAPRRVIGLLACAENMPGGRAMRPGDVVRAANGDSVEIQNTDAEGRLALCDAL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHH
AYAQKTWTPAALVDIATLTGACAVALGTQIAGLFSDDADLAERIRAAGGACGEEYWPLPL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
WKPYAEQLKSDVADICHMGPREGGAINAALFLQHFIQEGVRWAHLDIAGVDWVSKPTPLC
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCC
PAGPSAFGARTLLELARGGVL
CCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDIRFQNLGPEHWKGEIMLAPVCQDEVLTEICPQMDKAAPWLAIAPALRDFKGKTGELAL
CCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEE
MHGHPELAVPRVLAVGLGPREKVDTAGIRKAVAAAVQLCRQKGFGSILLPEPALARLPGG
EECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHCCCH
RERLVEECVCASLLALYRFTALKKAEKDEPAEPQWLALGFDGQEVPDASHAAARKGENAA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCH
WAVMLARDLASTPPNLLYPEKLAERARELAREKGFACTVLDEHELEKESMGCLLAVGQGS
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCEEEEECCCC
GRPPRLVILEHAPEGHEQEKPLILVGKGITFDTGGISLKPAANMHQMKADMTGAATVLAT
CCCCEEEEEECCCCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHHHHHHHHHH
LAALAQEDAPRRVIGLLACAENMPGGRAMRPGDVVRAANGDSVEIQNTDAEGRLALCDAL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHH
AYAQKTWTPAALVDIATLTGACAVALGTQIAGLFSDDADLAERIRAAGGACGEEYWPLPL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
WKPYAEQLKSDVADICHMGPREGGAINAALFLQHFIQEGVRWAHLDIAGVDWVSKPTPLC
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCC
PAGPSAFGARTLLELARGGVL
CCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA