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The map label for this gene is hypA2 [H]

Identifier: 220905148

GI number: 220905148

Start: 2274681

End: 2275064

Strand: Direct

Name: hypA2 [H]

Synonym: Ddes_1886

Alternate gene names: 220905148

Gene position: 2274681-2275064 (Clockwise)

Preceding gene: 220905147

Following gene: 220905149

Centisome position: 79.16

GC content: 57.29

Gene sequence:

>384_bases
ATGCATGAAGCGAGTCTGGTTCAGGGCCTTCTGGACATCTGCCTGAAGTCTCTGAAAGATCACAACGAGGCGCACCCTGA
AAACCAGGTAGAGCGCATACACAAGGTGGAATGCCAGCTTGGCCTTATCGCCTGCGTGGAGGCGCAAACCCTTACCGCCT
GCTTTGAGCTTTTTGCGGAAGGAACCCCGGCCGAAGGAGCGCAATTGCTTTTGCATACAGCGCCCCTGCCCTGCCGCTGT
ACTGATTGCAGCCATGAATTCAGCCTGACGCAACGGCATTTCGTCTGTCCCAGTTGCGGCGGCGAGAACATCCACTTCAA
CGGGGGCCACGGACTTACCCTGATGGCCCTGCACGTTGCATCCGAGGAAACGGACCATGACTGA

Upstream 100 bases:

>100_bases
TGCGCGGAACGCCCCTGCGGCGTTCCGCCGGATAAAAACCGGCCCGGCGCACGGCAACAGCCGCCCCATGCCACAAACGT
CGAAGCGGCGGACAAAGCCC

Downstream 100 bases:

>100_bases
ACATATCCAGGTCGTACCCGACAAATGCCGCGCCTGTCGCCGCTGTGAAGTGGCCTGTATTGCCGCCCACCACGGCATGA
GTTTCAAAGAGGCCATGAAG

Product: hydrogenase expression/synthesis HypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 127; Mature: 127

Protein sequence:

>127_residues
MHEASLVQGLLDICLKSLKDHNEAHPENQVERIHKVECQLGLIACVEAQTLTACFELFAEGTPAEGAQLLLHTAPLPCRC
TDCSHEFSLTQRHFVCPSCGGENIHFNGGHGLTLMALHVASEETDHD

Sequences:

>Translated_127_residues
MHEASLVQGLLDICLKSLKDHNEAHPENQVERIHKVECQLGLIACVEAQTLTACFELFAEGTPAEGAQLLLHTAPLPCRC
TDCSHEFSLTQRHFVCPSCGGENIHFNGGHGLTLMALHVASEETDHD
>Mature_127_residues
MHEASLVQGLLDICLKSLKDHNEAHPENQVERIHKVECQLGLIACVEAQTLTACFELFAEGTPAEGAQLLLHTAPLPCRC
TDCSHEFSLTQRHFVCPSCGGENIHFNGGHGLTLMALHVASEETDHD

Specific function: Probably plays a role in an hydrogenase nickel cofactor insertion step [H]

COG id: COG0375

COG function: function code R; Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hypA/hybF family [H]

Homologues:

Organism=Escherichia coli, GI1789365, Length=119, Percent_Identity=30.2521008403361, Blast_Score=63, Evalue=6e-12,
Organism=Escherichia coli, GI1789081, Length=123, Percent_Identity=30.0813008130081, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000688
- InterPro:   IPR020538 [H]

Pfam domain/function: PF01155 HypA [H]

EC number: NA

Molecular weight: Translated: 13869; Mature: 13869

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01249 HYPA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

7.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
7.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
8.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEASLVQGLLDICLKSLKDHNEAHPENQVERIHKVECQLGLIACVEAQTLTACFELFAE
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTPAEGAQLLLHTAPLPCRCTDCSHEFSLTQRHFVCPSCGGENIHFNGGHGLTLMALHVA
CCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEECCCCCCCEEEEECCCCEEEEEEEHH
SEETDHD
CCCCCCC
>Mature Secondary Structure
MHEASLVQGLLDICLKSLKDHNEAHPENQVERIHKVECQLGLIACVEAQTLTACFELFAE
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTPAEGAQLLLHTAPLPCRCTDCSHEFSLTQRHFVCPSCGGENIHFNGGHGLTLMALHVA
CCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEECCCCCCCEEEEECCCCEEEEEEEHH
SEETDHD
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA