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The map label for this gene is nuoH [H]

Identifier: 220905143

GI number: 220905143

Start: 2270883

End: 2271854

Strand: Direct

Name: nuoH [H]

Synonym: Ddes_1881

Alternate gene names: 220905143

Gene position: 2270883-2271854 (Clockwise)

Preceding gene: 220905142

Following gene: 220905144

Centisome position: 79.03

GC content: 58.54

Gene sequence:

>972_bases
ATGAGCGATACCCTGCTTGCCATACTGCATATGTGCGTCTTCCCCGGCGGGGCCTTTGCCCTCATGGTGGCCATGTTCTT
CAAAGGACTGGACCGCCGGGTAGAAGCCCGCCTGCAACGCCGCGTGGGGCCGCCCCTGGTGCAGCCCTGGCTGGACATTG
CAAAGCTGCTGACCAAGGAAACCATGATTCCCCGTACCGCCTGCCGCCCGGCATTTTTGCTGGCCCCGGTTTTCGGCTTC
ACGGGCATGGCCGTTTGTGCCGCCTTTATCCCCATCTCGGGCGTATATAACGGCCTGTTCAACATGGGTGACCTGCTGGT
GATCTTTTACCTGCTGCCCATTCCGGCCATGGCCATCATGCTTGGCGGCTCGGCCTCAAGCTCGCCCTTCGGCGCAGTGG
GCTTTTCACGCGAAATGACCCTTATGTTCGCCTATGAAACGCCTCTGCTCATGATTCTGCTGGCTGTAGCCATGCTGACA
GGCAAAACCCTTGCGGGCGGAGCCTGGGGCGCGGAATTCTCGCTTTACAAAATCGTGGCCCTGCAGCAGCAGGCCGGATC
TTTCGGCTTTAACCCGTCCATGATACCGGCGTTTCTGGCCTATCTGATCTTTCTGCCCGGCACTATGGGGGTTGTGCCCT
TTGACATCCCCGAGGCCGAAACAGAAATCATCGAAGGCCCGCTGCTGGAATACGGCGGCCCGCTGCTGGCGCTTTTTCAG
ATAACGTCGGCTCTCAAAACCTTCGTTGTTCTGGGGCTGGGGGTTGCGCTTTTCTTTCCCGGCACCATATCTGAATGGTG
GCCCATCAATCTCTTGTGGTTCCTGTTCAAGTGTTTCGCGCTCATGCTGGTTTCGCTCACCCTGGTCAAGTCGGCCACCG
GGCGTTTCCGCATTGACCAGGCGTTTCGCTTTTATGTGACTGTGCCCACAGCCCTTGCGCTGTGCAGCCTGATACTGGTC
TGGGTGATGTAA

Upstream 100 bases:

>100_bases
TGCCGCCCGAAACGGCCACCAGCCGCATGACGCCTTCCAGCATTTACGGCGGCCTCACGCGCCTTCTCGGCAGTGAGCGC
GCGCCCAAGGAGAACCGCTC

Downstream 100 bases:

>100_bases
GGAGGCCGCCGTGTCGCTTGACAATATGCTTAAAAAACTTTCCGTGCGTTCGCCGTGGCTGTTCCGCATCAATGCCGGTT
CCTGCAACGGCTGTGACGTG

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSDTLLAILHMCVFPGGAFALMVAMFFKGLDRRVEARLQRRVGPPLVQPWLDIAKLLTKETMIPRTACRPAFLLAPVFGF
TGMAVCAAFIPISGVYNGLFNMGDLLVIFYLLPIPAMAIMLGGSASSSPFGAVGFSREMTLMFAYETPLLMILLAVAMLT
GKTLAGGAWGAEFSLYKIVALQQQAGSFGFNPSMIPAFLAYLIFLPGTMGVVPFDIPEAETEIIEGPLLEYGGPLLALFQ
ITSALKTFVVLGLGVALFFPGTISEWWPINLLWFLFKCFALMLVSLTLVKSATGRFRIDQAFRFYVTVPTALALCSLILV
WVM

Sequences:

>Translated_323_residues
MSDTLLAILHMCVFPGGAFALMVAMFFKGLDRRVEARLQRRVGPPLVQPWLDIAKLLTKETMIPRTACRPAFLLAPVFGF
TGMAVCAAFIPISGVYNGLFNMGDLLVIFYLLPIPAMAIMLGGSASSSPFGAVGFSREMTLMFAYETPLLMILLAVAMLT
GKTLAGGAWGAEFSLYKIVALQQQAGSFGFNPSMIPAFLAYLIFLPGTMGVVPFDIPEAETEIIEGPLLEYGGPLLALFQ
ITSALKTFVVLGLGVALFFPGTISEWWPINLLWFLFKCFALMLVSLTLVKSATGRFRIDQAFRFYVTVPTALALCSLILV
WVM
>Mature_322_residues
SDTLLAILHMCVFPGGAFALMVAMFFKGLDRRVEARLQRRVGPPLVQPWLDIAKLLTKETMIPRTACRPAFLLAPVFGFT
GMAVCAAFIPISGVYNGLFNMGDLLVIFYLLPIPAMAIMLGGSASSSPFGAVGFSREMTLMFAYETPLLMILLAVAMLTG
KTLAGGAWGAEFSLYKIVALQQQAGSFGFNPSMIPAFLAYLIFLPGTMGVVPFDIPEAETEIIEGPLLEYGGPLLALFQI
TSALKTFVVLGLGVALFFPGTISEWWPINLLWFLFKCFALMLVSLTLVKSATGRFRIDQAFRFYVTVPTALALCSLILVW
VM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0650

COG function: function code C; Formate hydrogenlyase subunit 4

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=278, Percent_Identity=27.3381294964029, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI87082115, Length=242, Percent_Identity=33.8842975206612, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789077, Length=286, Percent_Identity=31.1188811188811, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788618, Length=301, Percent_Identity=27.5747508305648, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 35186; Mature: 35055

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTLLAILHMCVFPGGAFALMVAMFFKGLDRRVEARLQRRVGPPLVQPWLDIAKLLTKE
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TMIPRTACRPAFLLAPVFGFTGMAVCAAFIPISGVYNGLFNMGDLLVIFYLLPIPAMAIM
HCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGGSASSSPFGAVGFSREMTLMFAYETPLLMILLAVAMLTGKTLAGGAWGAEFSLYKIVA
CCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
LQQQAGSFGFNPSMIPAFLAYLIFLPGTMGVVPFDIPEAETEIIEGPLLEYGGPLLALFQ
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHHCCHHHHHHH
ITSALKTFVVLGLGVALFFPGTISEWWPINLLWFLFKCFALMLVSLTLVKSATGRFRIDQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
AFRFYVTVPTALALCSLILVWVM
HHEEEEEHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SDTLLAILHMCVFPGGAFALMVAMFFKGLDRRVEARLQRRVGPPLVQPWLDIAKLLTKE
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TMIPRTACRPAFLLAPVFGFTGMAVCAAFIPISGVYNGLFNMGDLLVIFYLLPIPAMAIM
HCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGGSASSSPFGAVGFSREMTLMFAYETPLLMILLAVAMLTGKTLAGGAWGAEFSLYKIVA
CCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
LQQQAGSFGFNPSMIPAFLAYLIFLPGTMGVVPFDIPEAETEIIEGPLLEYGGPLLALFQ
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHHHHCCHHHHHHH
ITSALKTFVVLGLGVALFFPGTISEWWPINLLWFLFKCFALMLVSLTLVKSATGRFRIDQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
AFRFYVTVPTALALCSLILVWVM
HHEEEEEHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA