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The map label for this gene is pyrC [H]

Identifier: 220905132

GI number: 220905132

Start: 2253559

End: 2254821

Strand: Reverse

Name: pyrC [H]

Synonym: Ddes_1870

Alternate gene names: 220905132

Gene position: 2254821-2253559 (Counterclockwise)

Preceding gene: 220905133

Following gene: 220905131

Centisome position: 78.47

GC content: 62.07

Gene sequence:

>1263_bases
ATGAGGCTTTGCATCAAAAATGCCCGCCACCTGGAAGCCCCGGTGGACCTTCTGGTGACCGGCGGAAAAATTACGACCAT
GACCCCTGCGGGGCATCACACGCCCCCCGAAGGCTGCGAGATTTTTGACGCGCGCGGCCTTGTGCTCATGCCGAGCCTTA
TCGACGCCCACGTACACCTGCGCGAACCCGGCTTTGAGTATAAGGAAGACGTGGCCTCGGGCCTTGAGGCTGCCGCGCGC
GGCGGTTTTGGCGGTGTCATGTGCATGGCCAATACAAAGCCCGTCAACGATACGGCAAGCGTTACCCGCCACATGCTGGA
CAAGGCCCGCCGGAGCCATCCGCACGGCCCGCGCCTGTTCCCTGTGGCCGCCGCCACCGTGGGTCTCAAGGGAGAAATGA
TGGCTCCCCTGGCCGAACTCAAGGAGGCCGGCTGCGTAGCTGTTTCCAATGACGGCCGCCCGCTGGAAAATGCCGAGCTT
GTGCGCCGTATCATGGAATATGGGGCGGATCTGGGGCTTGTACTCATTGACCATTGTGAAGACCCGCACCTGGCCCGTGG
CTGGATCATGCACGAAGGGCATACCAGCGGCCTGCTGGGCCTCAAGGGGCAGCCCGCCGCCGGTGAGGCCGTACAGGCCG
CCCGCGACATCATGCTTGCAGAGTATCTTGATATTCCGGTGCATATTGCGCATGTTTCGGCGGAACTGACGGTGGACATC
ATCCGCTGGGCCAAGGCGCGCGGCGTCAAGGTCAGCGCAGAAACCTGCCCGCATTACCTGCTGCTGGACGAGCACGCACT
TGAGAACTACAGTACCCAGGCCAAGGTCAGTCCGCCCCTGCGCACGGCGCGCGACCGCGATGCCCTGCGTGACGCTGTGA
AAACGGGTGTTGTGGATATTCTTGTTACCGACCATGCGCCCCATGCGGCCCATGAAAAGGACGGTACCCTGGACGAAGCA
CCCTGCGGTTTTACCGGCCTTGATCTGGCCCTGAGCCTTACCTGGGGGCTTGTGTGCGAAGGCGTGTTGGCCGAGGCCGA
TGCGCACCGCCTGTGGTGCCGCCGCCCGGGTGAAATTTTCGCTTTGCCGTGGAACGGGTTTATCCCCGGCGACCCGGCAG
ACTTCTTTTTGTTTGACCCGGACGAAACATGGGTTGCCTCACGGGAAACCATGTATTCCAAAAGCCTGAACACGCCCTTT
CTGGGGCAGACACTGCGCGGGCGCGTCAAGCATCACTGGATGGAGGGCAAACAGCTCTTCTGA

Upstream 100 bases:

>100_bases
ATGCCCCCGCAAGCCTGGTGCTTGATCAGGTGGCTGCGGGCGTGGCCACGCGCATGGCAGTGCTGTATCTTCTGGCCACG
CGCAATGATGGAGGACGCGC

Downstream 100 bases:

>100_bases
CCCCCGCCCGCGCCGCAACGGGGGTTTACATGCACCGGATATTGCAGGATAAAAGCCTCTTTCGTCCCCACTGCCTGATC
AACGGGCAGTGGTGCGATGC

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRLCIKNARHLEAPVDLLVTGGKITTMTPAGHHTPPEGCEIFDARGLVLMPSLIDAHVHLREPGFEYKEDVASGLEAAAR
GGFGGVMCMANTKPVNDTASVTRHMLDKARRSHPHGPRLFPVAAATVGLKGEMMAPLAELKEAGCVAVSNDGRPLENAEL
VRRIMEYGADLGLVLIDHCEDPHLARGWIMHEGHTSGLLGLKGQPAAGEAVQAARDIMLAEYLDIPVHIAHVSAELTVDI
IRWAKARGVKVSAETCPHYLLLDEHALENYSTQAKVSPPLRTARDRDALRDAVKTGVVDILVTDHAPHAAHEKDGTLDEA
PCGFTGLDLALSLTWGLVCEGVLAEADAHRLWCRRPGEIFALPWNGFIPGDPADFFLFDPDETWVASRETMYSKSLNTPF
LGQTLRGRVKHHWMEGKQLF

Sequences:

>Translated_420_residues
MRLCIKNARHLEAPVDLLVTGGKITTMTPAGHHTPPEGCEIFDARGLVLMPSLIDAHVHLREPGFEYKEDVASGLEAAAR
GGFGGVMCMANTKPVNDTASVTRHMLDKARRSHPHGPRLFPVAAATVGLKGEMMAPLAELKEAGCVAVSNDGRPLENAEL
VRRIMEYGADLGLVLIDHCEDPHLARGWIMHEGHTSGLLGLKGQPAAGEAVQAARDIMLAEYLDIPVHIAHVSAELTVDI
IRWAKARGVKVSAETCPHYLLLDEHALENYSTQAKVSPPLRTARDRDALRDAVKTGVVDILVTDHAPHAAHEKDGTLDEA
PCGFTGLDLALSLTWGLVCEGVLAEADAHRLWCRRPGEIFALPWNGFIPGDPADFFLFDPDETWVASRETMYSKSLNTPF
LGQTLRGRVKHHWMEGKQLF
>Mature_420_residues
MRLCIKNARHLEAPVDLLVTGGKITTMTPAGHHTPPEGCEIFDARGLVLMPSLIDAHVHLREPGFEYKEDVASGLEAAAR
GGFGGVMCMANTKPVNDTASVTRHMLDKARRSHPHGPRLFPVAAATVGLKGEMMAPLAELKEAGCVAVSNDGRPLENAEL
VRRIMEYGADLGLVLIDHCEDPHLARGWIMHEGHTSGLLGLKGQPAAGEAVQAARDIMLAEYLDIPVHIAHVSAELTVDI
IRWAKARGVKVSAETCPHYLLLDEHALENYSTQAKVSPPLRTARDRDALRDAVKTGVVDILVTDHAPHAAHEKDGTLDEA
PCGFTGLDLALSLTWGLVCEGVLAEADAHRLWCRRPGEIFALPWNGFIPGDPADFFLFDPDETWVASRETMYSKSLNTPF
LGQTLRGRVKHHWMEGKQLF

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=379, Percent_Identity=31.3984168865435, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1786722, Length=424, Percent_Identity=27.122641509434, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87082175, Length=448, Percent_Identity=25.6696428571429, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193204318, Length=376, Percent_Identity=27.6595744680851, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322218, Length=395, Percent_Identity=27.0886075949367, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642586, Length=385, Percent_Identity=32.987012987013, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI18859883, Length=208, Percent_Identity=27.4038461538462, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45789; Mature: 45789

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLCIKNARHLEAPVDLLVTGGKITTMTPAGHHTPPEGCEIFDARGLVLMPSLIDAHVHL
CCCCCCCCCCCCCCEEEEEECCEEEEECCCCCCCCCCCCEEECCCCEEEECHHHCCEEEE
REPGFEYKEDVASGLEAAARGGFGGVMCMANTKPVNDTASVTRHMLDKARRSHPHGPRLF
CCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
PVAAATVGLKGEMMAPLAELKEAGCVAVSNDGRPLENAELVRRIMEYGADLGLVLIDHCE
EHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCC
DPHLARGWIMHEGHTSGLLGLKGQPAAGEAVQAARDIMLAEYLDIPVHIAHVSAELTVDI
CCCCCCCEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH
IRWAKARGVKVSAETCPHYLLLDEHALENYSTQAKVSPPLRTARDRDALRDAVKTGVVDI
HHHHHHCCCEEEHHHCCCEEEECHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEE
LVTDHAPHAAHEKDGTLDEAPCGFTGLDLALSLTWGLVCEGVLAEADAHRLWCRRPGEIF
EEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEE
ALPWNGFIPGDPADFFLFDPDETWVASRETMYSKSLNTPFLGQTLRGRVKHHWMEGKQLF
EECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRLCIKNARHLEAPVDLLVTGGKITTMTPAGHHTPPEGCEIFDARGLVLMPSLIDAHVHL
CCCCCCCCCCCCCCEEEEEECCEEEEECCCCCCCCCCCCEEECCCCEEEECHHHCCEEEE
REPGFEYKEDVASGLEAAARGGFGGVMCMANTKPVNDTASVTRHMLDKARRSHPHGPRLF
CCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEE
PVAAATVGLKGEMMAPLAELKEAGCVAVSNDGRPLENAELVRRIMEYGADLGLVLIDHCE
EHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCC
DPHLARGWIMHEGHTSGLLGLKGQPAAGEAVQAARDIMLAEYLDIPVHIAHVSAELTVDI
CCCCCCCEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHH
IRWAKARGVKVSAETCPHYLLLDEHALENYSTQAKVSPPLRTARDRDALRDAVKTGVVDI
HHHHHHCCCEEEHHHCCCEEEECHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEE
LVTDHAPHAAHEKDGTLDEAPCGFTGLDLALSLTWGLVCEGVLAEADAHRLWCRRPGEIF
EEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEE
ALPWNGFIPGDPADFFLFDPDETWVASRETMYSKSLNTPFLGQTLRGRVKHHWMEGKQLF
EECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA