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The map label for this gene is ppa [H]

Identifier: 220905117

GI number: 220905117

Start: 2235741

End: 2236496

Strand: Direct

Name: ppa [H]

Synonym: Ddes_1854

Alternate gene names: 220905117

Gene position: 2235741-2236496 (Clockwise)

Preceding gene: 220905116

Following gene: 220905119

Centisome position: 77.81

GC content: 57.54

Gene sequence:

>756_bases
ATGAAAAGATTCATATTCCTCCTTGCCATATGCCTTCTTGCCATGCCCGCAGCGTCTTTTGGCGAAACCGCGACAGCGCG
CGCCCAGCAGGCTGTGCTCAAAGGAGAAAAAAACTATCTTACCGGCTATCCGGCGCACAATGCTGACGGAACCGTCAATG
TGATCATTGAAATACCCGCCGGAACCACGGCCAAATACGAAGTGGATCATGCCACCGGCCTTATGGTTCTTGAGCAGAAA
AACGGTCAGCCCTGCTACGTGCAGTACCTCCCCTATCCCGGCAACTACGGTTTTGTGCCACGCACCGTTCTCGCCAGAGA
ACTGGGCGGCGATGGAGATCCGCTTGACGTCATAGTTCTTGGCGATGCCGTACCCAGAGGCAGCATCCTGAAGGCCCGCC
CCCTGGGCGTACTGACCCTCAACGACAGCGGCGAGGAAGACAGCAAGATCGTCATGGCCGCCGTGGGTTCGCCCTTTGAA
AAAGTACGCGGCGTCAAGCAGCTCGACGAGCAGTTTCCCGGCGTGACAGACATACTTCAGACCTGGTTCACCTCATACAA
GGGCAAGGACAAGAGCGGAAAACCCTATCTGAGCAGCAACGGCATGCTGGACCGCACCGAAGCCATCCGCATTATCGGCG
ATGCGCCCCTGCAGTTTGAGCGCTCCGTCATTACCGAGGCCGACAAACCCGCCCTTGACCCCGACGGCAATCCCCGCGTG
TATTTTTCTCCGCAGGCTCGCAACATCAGCGACTAG

Upstream 100 bases:

>100_bases
AAAAATAAAATTGCTCCAGAACATATGACTTCTGCAACCATTTAACCTGCCTATTAAGATGTCATGGTTCACCGCTATTA
CCATTCAGGAGCGTGATACA

Downstream 100 bases:

>100_bases
GCCAAGTAACTCTTGAAAACGTCCTTGGCCTATGCCCGAGACGGCTAGAGCCGTTTACGAATGAAATGAGTTACCTGCTC
TGCAAGGATTTTCAGGAAAA

Product: Inorganic pyrophosphatase

Products: NA

Alternate protein names: Pyrophosphate phospho-hydrolase; PPase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MKRFIFLLAICLLAMPAASFGETATARAQQAVLKGEKNYLTGYPAHNADGTVNVIIEIPAGTTAKYEVDHATGLMVLEQK
NGQPCYVQYLPYPGNYGFVPRTVLARELGGDGDPLDVIVLGDAVPRGSILKARPLGVLTLNDSGEEDSKIVMAAVGSPFE
KVRGVKQLDEQFPGVTDILQTWFTSYKGKDKSGKPYLSSNGMLDRTEAIRIIGDAPLQFERSVITEADKPALDPDGNPRV
YFSPQARNISD

Sequences:

>Translated_251_residues
MKRFIFLLAICLLAMPAASFGETATARAQQAVLKGEKNYLTGYPAHNADGTVNVIIEIPAGTTAKYEVDHATGLMVLEQK
NGQPCYVQYLPYPGNYGFVPRTVLARELGGDGDPLDVIVLGDAVPRGSILKARPLGVLTLNDSGEEDSKIVMAAVGSPFE
KVRGVKQLDEQFPGVTDILQTWFTSYKGKDKSGKPYLSSNGMLDRTEAIRIIGDAPLQFERSVITEADKPALDPDGNPRV
YFSPQARNISD
>Mature_251_residues
MKRFIFLLAICLLAMPAASFGETATARAQQAVLKGEKNYLTGYPAHNADGTVNVIIEIPAGTTAKYEVDHATGLMVLEQK
NGQPCYVQYLPYPGNYGFVPRTVLARELGGDGDPLDVIVLGDAVPRGSILKARPLGVLTLNDSGEEDSKIVMAAVGSPFE
KVRGVKQLDEQFPGVTDILQTWFTSYKGKDKSGKPYLSSNGMLDRTEAIRIIGDAPLQFERSVITEADKPALDPDGNPRV
YFSPQARNISD

Specific function: Unknown

COG id: COG0221

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPase family [H]

Homologues:

Organism=Homo sapiens, GI11056044, Length=208, Percent_Identity=31.7307692307692, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI29171702, Length=165, Percent_Identity=32.1212121212121, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1790673, Length=145, Percent_Identity=30.3448275862069, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71984889, Length=205, Percent_Identity=32.1951219512195, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71984880, Length=205, Percent_Identity=32.1951219512195, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71984883, Length=205, Percent_Identity=32.1951219512195, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71984895, Length=205, Percent_Identity=32.1951219512195, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323923, Length=158, Percent_Identity=36.7088607594937, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319483, Length=166, Percent_Identity=29.5180722891566, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45549187, Length=165, Percent_Identity=35.7575757575758, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221468704, Length=165, Percent_Identity=35.7575757575758, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 5480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008162 [H]

Pfam domain/function: PF00719 Pyrophosphatase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 27192; Mature: 27192

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRFIFLLAICLLAMPAASFGETATARAQQAVLKGEKNYLTGYPAHNADGTVNVIIEIPA
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEEECCC
GTTAKYEVDHATGLMVLEQKNGQPCYVQYLPYPGNYGFVPRTVLARELGGDGDPLDVIVL
CCCEEEEECCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEE
GDAVPRGSILKARPLGVLTLNDSGEEDSKIVMAAVGSPFEKVRGVKQLDEQFPGVTDILQ
ECCCCCCCEEEECCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHH
TWFTSYKGKDKSGKPYLSSNGMLDRTEAIRIIGDAPLQFERSVITEADKPALDPDGNPRV
HHHHHCCCCCCCCCCEECCCCCEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCEE
YFSPQARNISD
EECCCCCCCCC
>Mature Secondary Structure
MKRFIFLLAICLLAMPAASFGETATARAQQAVLKGEKNYLTGYPAHNADGTVNVIIEIPA
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEEECCC
GTTAKYEVDHATGLMVLEQKNGQPCYVQYLPYPGNYGFVPRTVLARELGGDGDPLDVIVL
CCCEEEEECCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEE
GDAVPRGSILKARPLGVLTLNDSGEEDSKIVMAAVGSPFEKVRGVKQLDEQFPGVTDILQ
ECCCCCCCEEEECCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHH
TWFTSYKGKDKSGKPYLSSNGMLDRTEAIRIIGDAPLQFERSVITEADKPALDPDGNPRV
HHHHHCCCCCCCCCCEECCCCCEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCEE
YFSPQARNISD
EECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9055427 [H]