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The map label for this gene is purM [H]

Identifier: 220905102

GI number: 220905102

Start: 2219335

End: 2220402

Strand: Reverse

Name: purM [H]

Synonym: Ddes_1839

Alternate gene names: 220905102

Gene position: 2220402-2219335 (Counterclockwise)

Preceding gene: 220905107

Following gene: 220905101

Centisome position: 77.27

GC content: 58.99

Gene sequence:

>1068_bases
ATGTCCAGCGATCGCGCGAAAGCCTATACTCAGGCAGGCGTTGACATTGAGGCGGGAAACACCCTTGTGTCGCGCATCAA
GTCTATGGTGCAGAGCACCCAGACCAGGGGTGTCATTTCAGACATAGGCGGCTTCGGCGGCCTTTTCCGTCCCGATCTCA
GCGGCATGAGCGAGCCTGTGCTGGTTTCTTCCACCGATGGTGTGGGCACCAAGCTCAAACTGGCTTTCGCTTTTGACAAG
CACGACACCGTGGGCATCGACCTGGTGGCCATGAGTGTGAACGATATTCTTGTTCAGGGGGCCACGCCCCTGTTCTTTCT
TGACTATTTTGCCACTGGCAAGCTGGACGTAGACACGGCCCAGACCGTCATCGGCGGCGTGGCCGAAGGCTGCCGCCAGT
CCGATTGCGCCCTGTTGGGCGGCGAAACAGCGGAAATGCCCGACATGTACGCCCCCGGCGAGTATGATCTGGCCGGTTTC
TGCGTAGGCATTGTGGACAATGCCAGACTTATTGACGGCTCAAGCATTCAGGTGGGCGACCACATCGTGGGCATTGCCTC
GTCGGGCCTGCATTCAAACGGTTATTCCCTGGCCCGCAAGGTGCTGGAAAAGAGCGGCCTTGCCCCCGACGATGTTTTTC
CTGGCGCGGACGGCGCCACAGTGCGCGACGTAATGCTTGCCCCCACCATCATTTATGTGGAGGCCGTGCGTTCCCTCCTG
CGCGACCTTAACGTCAAGGGCATGGCCCATATTACGGGCGGCGGCTTTTATGACAATATCCCCCGCGTCCTGCCTGCGCA
GGTGGAGGCCCGCATCAATTTCGGCAGCTGGCAGATGGCTCCGGTTTTCAGGTGGCTCAAGGAAACGGGCGACCTTTCCT
GGCCTGAAATCCTGCAGATATTCAACGGCGGCATCGGCTACGTACTGGTGCTGCCCCCTGACCAGAGCGAAGAAGCCATC
AGCCGTATTCAGGCGTTCAACCTGCGCGCCTGGCATATCGGCAATGTGGCCCGCCGTGGCAAGAATGATGCGGGCGGCGA
AAATGAACAGGTTATTGTAAACTTCTGA

Upstream 100 bases:

>100_bases
CGACGCGCCATGCGCGGGGTACTGCTTCGGCCATGCAAAAAAGTCGCTTGGGCTTTGCGGCAAAATCTGCTAAAGAACCG
CAATCCAAAGGAGGCTACGG

Downstream 100 bases:

>100_bases
TTTCCGGCGCATCAGTTTACAGCCGCCCCGGGCGGCCAAAGCCCGTCTGCGCCGGTTTCGCGGGCGGGCTGTTTTCATGT
CGTATGGCCGGGACACGCCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSSDRAKAYTQAGVDIEAGNTLVSRIKSMVQSTQTRGVISDIGGFGGLFRPDLSGMSEPVLVSSTDGVGTKLKLAFAFDK
HDTVGIDLVAMSVNDILVQGATPLFFLDYFATGKLDVDTAQTVIGGVAEGCRQSDCALLGGETAEMPDMYAPGEYDLAGF
CVGIVDNARLIDGSSIQVGDHIVGIASSGLHSNGYSLARKVLEKSGLAPDDVFPGADGATVRDVMLAPTIIYVEAVRSLL
RDLNVKGMAHITGGGFYDNIPRVLPAQVEARINFGSWQMAPVFRWLKETGDLSWPEILQIFNGGIGYVLVLPPDQSEEAI
SRIQAFNLRAWHIGNVARRGKNDAGGENEQVIVNF

Sequences:

>Translated_355_residues
MSSDRAKAYTQAGVDIEAGNTLVSRIKSMVQSTQTRGVISDIGGFGGLFRPDLSGMSEPVLVSSTDGVGTKLKLAFAFDK
HDTVGIDLVAMSVNDILVQGATPLFFLDYFATGKLDVDTAQTVIGGVAEGCRQSDCALLGGETAEMPDMYAPGEYDLAGF
CVGIVDNARLIDGSSIQVGDHIVGIASSGLHSNGYSLARKVLEKSGLAPDDVFPGADGATVRDVMLAPTIIYVEAVRSLL
RDLNVKGMAHITGGGFYDNIPRVLPAQVEARINFGSWQMAPVFRWLKETGDLSWPEILQIFNGGIGYVLVLPPDQSEEAI
SRIQAFNLRAWHIGNVARRGKNDAGGENEQVIVNF
>Mature_354_residues
SSDRAKAYTQAGVDIEAGNTLVSRIKSMVQSTQTRGVISDIGGFGGLFRPDLSGMSEPVLVSSTDGVGTKLKLAFAFDKH
DTVGIDLVAMSVNDILVQGATPLFFLDYFATGKLDVDTAQTVIGGVAEGCRQSDCALLGGETAEMPDMYAPGEYDLAGFC
VGIVDNARLIDGSSIQVGDHIVGIASSGLHSNGYSLARKVLEKSGLAPDDVFPGADGATVRDVMLAPTIIYVEAVRSLLR
DLNVKGMAHITGGGFYDNIPRVLPAQVEARINFGSWQMAPVFRWLKETGDLSWPEILQIFNGGIGYVLVLPPDQSEEAIS
RIQAFNLRAWHIGNVARRGKNDAGGENEQVIVNF

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=343, Percent_Identity=49.8542274052478, Blast_Score=340, Evalue=8e-94,
Organism=Homo sapiens, GI209869995, Length=343, Percent_Identity=49.8542274052478, Blast_Score=340, Evalue=8e-94,
Organism=Homo sapiens, GI209869993, Length=343, Percent_Identity=49.8542274052478, Blast_Score=340, Evalue=8e-94,
Organism=Escherichia coli, GI1788845, Length=334, Percent_Identity=52.6946107784431, Blast_Score=351, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=39.1304347826087, Blast_Score=232, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321203, Length=348, Percent_Identity=44.8275862068966, Blast_Score=295, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24582400, Length=310, Percent_Identity=43.5483870967742, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37830; Mature: 37699

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00359 RIBOSOMAL_L11

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDRAKAYTQAGVDIEAGNTLVSRIKSMVQSTQTRGVISDIGGFGGLFRPDLSGMSEPV
CCCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCE
LVSSTDGVGTKLKLAFAFDKHDTVGIDLVAMSVNDILVQGATPLFFLDYFATGKLDVDTA
EEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHEECCCCCEEEEEHHCCCCCCCHHH
QTVIGGVAEGCRQSDCALLGGETAEMPDMYAPGEYDLAGFCVGIVDNARLIDGSSIQVGD
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCHHEEEEEEECCCEEECCCCEEECC
HIVGIASSGLHSNGYSLARKVLEKSGLAPDDVFPGADGATVRDVMLAPTIIYVEAVRSLL
EEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RDLNVKGMAHITGGGFYDNIPRVLPAQVEARINFGSWQMAPVFRWLKETGDLSWPEILQI
HHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHCCCCHHHHHHH
FNGGIGYVLVLPPDQSEEAISRIQAFNLRAWHIGNVARRGKNDAGGENEQVIVNF
HCCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCHHHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SSDRAKAYTQAGVDIEAGNTLVSRIKSMVQSTQTRGVISDIGGFGGLFRPDLSGMSEPV
CCCHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCE
LVSSTDGVGTKLKLAFAFDKHDTVGIDLVAMSVNDILVQGATPLFFLDYFATGKLDVDTA
EEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHEECCCCCEEEEEHHCCCCCCCHHH
QTVIGGVAEGCRQSDCALLGGETAEMPDMYAPGEYDLAGFCVGIVDNARLIDGSSIQVGD
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCHHEEEEEEECCCEEECCCCEEECC
HIVGIASSGLHSNGYSLARKVLEKSGLAPDDVFPGADGATVRDVMLAPTIIYVEAVRSLL
EEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RDLNVKGMAHITGGGFYDNIPRVLPAQVEARINFGSWQMAPVFRWLKETGDLSWPEILQI
HHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHCCCCHHHHHHH
FNGGIGYVLVLPPDQSEEAISRIQAFNLRAWHIGNVARRGKNDAGGENEQVIVNF
HCCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCHHHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA