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The map label for this gene is ffh [H]

Identifier: 220905067

GI number: 220905067

Start: 2177229

End: 2178767

Strand: Reverse

Name: ffh [H]

Synonym: Ddes_1804

Alternate gene names: 220905067

Gene position: 2178767-2177229 (Counterclockwise)

Preceding gene: 220905078

Following gene: 220905066

Centisome position: 75.82

GC content: 60.69

Gene sequence:

>1539_bases
ATGTTCGAAAGCCTTTCAGACAGACTTTCCGGCGTATTCCGTTCTTTCGGCGGACGCGGCCAGCTTACCGAAGAAAACGT
GCAGGCCGGCCTGCGCGAAGTGCGGCTGGCCCTGCTGGAAGCGGACGTTAACTTCAAGGTCGTTAAAGACTTTGTTGAAA
ACGTGCGCGAGAAGTGTCTCGGCCAGGAAGTGCTCAAAGGGGTAAGTCCGGCACAGCAGGTGGTCAAGATCGTTCATGAT
GAGCTGGTCGGCCTGCTTGGCGGTGAAACCGCCGCGCTTGACCTTCAGGGGCGTGAGCCGGCTGTCATCATGCTTGTGGG
CCTGCAAGGCTCGGGTAAAACCACCTCTGCGGGCAAGATAGCAAATATTTTGCGCAAGCAAAAGATGCGCCCCTACCTTG
TGCCGGCCGACGTATACCGCCCTGCGGCCATTGACCAGCTGACGGTGCTTGCCAAGCAGTTGGACATGCCCTGCTATCCT
TCCACCGTGGACATGGACCCCGTGGACATAGCAAAGGCCGCGCTTGAAGAGGCTCGGCGAGAGCAGGCCACGGTGCTGCT
GCTTGACACGGCGGGCCGCCTGCATGTTGACGAACCGCTCATGCAGGAGCTTGAGGCCATCAAGGCTGCTGTGCAGCCGC
AGGAAATTCTGTTCGTGGCTGATGCCATGACCGGTCAGGATGCCGTGACCGTGGCCGAAAGCTTTAACGAGCGGCTGGGC
GTCACCGGCGTGGTACTGACCAAGATGGACGGCGATGCGCGCGGCGGTGCGGCCCTTTCCATCCGCGCGGTGACGGGCGC
GCCAGTAAAATTTGTGGGTATGGGCGAAAAGCTGTCGGAGATGGAGGTCTTCCACCCCGACCGTATCGCCGGGCGTATTC
TGGGCATGGGCGACGTGCTTACTCTGGTGGAGAAAGCACAGGGCGCCATCAACGCCGAAGAAGCCGAAGAGCTGGCCCGC
AAGATGAAAAAAGCCAGCTTTGACCTTGAAGATTTTCGTACCCAGATGCGCCGCATCAAAAAGCTTGGTTCGCTGGAAAG
CATCCTCAAGATGATTCCCGGCCTGGGCGGTCTGCGCGACAAGCTGGCCGAAGCCAGCGGCGCCATGCCAGAAAAGGAAA
TGGCACGCACCGAGGCCATAATCAATTCGATGACTATGGCCGAACGGCGCAATCCCGACCTTCTGAACGGCAGCCGCCGG
GCGCGTATTGCCAAGGGCGCGGGCGTAACCGTAGCCCAGGTGAACCAGCTTGTGCGCCAGTTTGAGCAGATGCGCCAGAT
GATGAAGGGCATGATGGGCGGCAAGGGCGCAAAAATGCCCTCAATGCCGCGCATGCGCGGCATGCCCCCCGGCATGATGC
CCCCCGGCGGCATGGGTGGCATGCCCGGCATGGGCGGCCTGCCTGGTATGGGCGGTCTGCCCGGAATGGGGGGATTGCCC
GGTATGGAAGGCATGCCCGGCGGGCGTTCCGGTTCCGGAAAGTCGGCTGCGGCTAAAAAGCGCAAGAAAAAAGAGCGCCA
GAAGCGCAAGAAAAAATAA

Upstream 100 bases:

>100_bases
TGGGGCGTATGCGCCGTGCGGCGGCCGCGTGCAGGCATGTCTGCGCGGGGCAGGCGACAGCACTGCTTTTTTGCCGCTTG
GCGGCCCCTGTGGAGACTGC

Downstream 100 bases:

>100_bases
GGCATTTCGCGGCAAGGAGCGCCGTCGTAGCGGCAACACCTCTTTGCGCCAGGGCTTTTCCGCCCTTGCCCTTTCCCGGG
CGCAACGATAACATAACACC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MFESLSDRLSGVFRSFGGRGQLTEENVQAGLREVRLALLEADVNFKVVKDFVENVREKCLGQEVLKGVSPAQQVVKIVHD
ELVGLLGGETAALDLQGREPAVIMLVGLQGSGKTTSAGKIANILRKQKMRPYLVPADVYRPAAIDQLTVLAKQLDMPCYP
STVDMDPVDIAKAALEEARREQATVLLLDTAGRLHVDEPLMQELEAIKAAVQPQEILFVADAMTGQDAVTVAESFNERLG
VTGVVLTKMDGDARGGAALSIRAVTGAPVKFVGMGEKLSEMEVFHPDRIAGRILGMGDVLTLVEKAQGAINAEEAEELAR
KMKKASFDLEDFRTQMRRIKKLGSLESILKMIPGLGGLRDKLAEASGAMPEKEMARTEAIINSMTMAERRNPDLLNGSRR
ARIAKGAGVTVAQVNQLVRQFEQMRQMMKGMMGGKGAKMPSMPRMRGMPPGMMPPGGMGGMPGMGGLPGMGGLPGMGGLP
GMEGMPGGRSGSGKSAAAKKRKKKERQKRKKK

Sequences:

>Translated_512_residues
MFESLSDRLSGVFRSFGGRGQLTEENVQAGLREVRLALLEADVNFKVVKDFVENVREKCLGQEVLKGVSPAQQVVKIVHD
ELVGLLGGETAALDLQGREPAVIMLVGLQGSGKTTSAGKIANILRKQKMRPYLVPADVYRPAAIDQLTVLAKQLDMPCYP
STVDMDPVDIAKAALEEARREQATVLLLDTAGRLHVDEPLMQELEAIKAAVQPQEILFVADAMTGQDAVTVAESFNERLG
VTGVVLTKMDGDARGGAALSIRAVTGAPVKFVGMGEKLSEMEVFHPDRIAGRILGMGDVLTLVEKAQGAINAEEAEELAR
KMKKASFDLEDFRTQMRRIKKLGSLESILKMIPGLGGLRDKLAEASGAMPEKEMARTEAIINSMTMAERRNPDLLNGSRR
ARIAKGAGVTVAQVNQLVRQFEQMRQMMKGMMGGKGAKMPSMPRMRGMPPGMMPPGGMGGMPGMGGLPGMGGLPGMGGLP
GMEGMPGGRSGSGKSAAAKKRKKKERQKRKKK
>Mature_512_residues
MFESLSDRLSGVFRSFGGRGQLTEENVQAGLREVRLALLEADVNFKVVKDFVENVREKCLGQEVLKGVSPAQQVVKIVHD
ELVGLLGGETAALDLQGREPAVIMLVGLQGSGKTTSAGKIANILRKQKMRPYLVPADVYRPAAIDQLTVLAKQLDMPCYP
STVDMDPVDIAKAALEEARREQATVLLLDTAGRLHVDEPLMQELEAIKAAVQPQEILFVADAMTGQDAVTVAESFNERLG
VTGVVLTKMDGDARGGAALSIRAVTGAPVKFVGMGEKLSEMEVFHPDRIAGRILGMGDVLTLVEKAQGAINAEEAEELAR
KMKKASFDLEDFRTQMRRIKKLGSLESILKMIPGLGGLRDKLAEASGAMPEKEMARTEAIINSMTMAERRNPDLLNGSRR
ARIAKGAGVTVAQVNQLVRQFEQMRQMMKGMMGGKGAKMPSMPRMRGMPPGMMPPGGMGGMPGMGGLPGMGGLPGMGGLP
GMEGMPGGRSGSGKSAAAKKRKKKERQKRKKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=502, Percent_Identity=33.6653386454183, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI226371618, Length=445, Percent_Identity=32.8089887640449, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI89061728, Length=163, Percent_Identity=35.5828220858896, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI295424842, Length=303, Percent_Identity=27.3927392739274, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI23308697, Length=303, Percent_Identity=27.3927392739274, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1788963, Length=458, Percent_Identity=53.056768558952, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=31.8181818181818, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=459, Percent_Identity=32.6797385620915, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI193206261, Length=291, Percent_Identity=31.6151202749141, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=467, Percent_Identity=34.6895074946467, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6320498, Length=260, Percent_Identity=26.5384615384615, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17647949, Length=485, Percent_Identity=31.5463917525773, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24641198, Length=319, Percent_Identity=26.0188087774295, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 54973; Mature: 54973

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
7.0 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLSDRLSGVFRSFGGRGQLTEENVQAGLREVRLALLEADVNFKVVKDFVENVREKCL
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GQEVLKGVSPAQQVVKIVHDELVGLLGGETAALDLQGREPAVIMLVGLQGSGKTTSAGKI
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCCCCCCHHHH
ANILRKQKMRPYLVPADVYRPAAIDQLTVLAKQLDMPCYPSTVDMDPVDIAKAALEEARR
HHHHHHHCCCCEECCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
EQATVLLLDTAGRLHVDEPLMQELEAIKAAVQPQEILFVADAMTGQDAVTVAESFNERLG
HCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHHHHHCC
VTGVVLTKMDGDARGGAALSIRAVTGAPVKFVGMGEKLSEMEVFHPDRIAGRILGMGDVL
CCEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHCCCCHHHHHHHHCHHHHH
TLVEKAQGAINAEEAEELARKMKKASFDLEDFRTQMRRIKKLGSLESILKMIPGLGGLRD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHH
KLAEASGAMPEKEMARTEAIINSMTMAERRNPDLLNGSRRARIAKGAGVTVAQVNQLVRQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHH
FEQMRQMMKGMMGGKGAKMPSMPRMRGMPPGMMPPGGMGGMPGMGGLPGMGGLPGMGGLP
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GMEGMPGGRSGSGKSAAAKKRKKKERQKRKKK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFESLSDRLSGVFRSFGGRGQLTEENVQAGLREVRLALLEADVNFKVVKDFVENVREKCL
CCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GQEVLKGVSPAQQVVKIVHDELVGLLGGETAALDLQGREPAVIMLVGLQGSGKTTSAGKI
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCCCCCCHHHH
ANILRKQKMRPYLVPADVYRPAAIDQLTVLAKQLDMPCYPSTVDMDPVDIAKAALEEARR
HHHHHHHCCCCEECCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
EQATVLLLDTAGRLHVDEPLMQELEAIKAAVQPQEILFVADAMTGQDAVTVAESFNERLG
HCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHHHHHCC
VTGVVLTKMDGDARGGAALSIRAVTGAPVKFVGMGEKLSEMEVFHPDRIAGRILGMGDVL
CCEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHCCCCHHHHHHHHCHHHHH
TLVEKAQGAINAEEAEELARKMKKASFDLEDFRTQMRRIKKLGSLESILKMIPGLGGLRD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHH
KLAEASGAMPEKEMARTEAIINSMTMAERRNPDLLNGSRRARIAKGAGVTVAQVNQLVRQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHH
FEQMRQMMKGMMGGKGAKMPSMPRMRGMPPGMMPPGGMGGMPGMGGLPGMGGLPGMGGLP
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GMEGMPGGRSGSGKSAAAKKRKKKERQKRKKK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]