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The map label for this gene is cobC [H]

Identifier: 220905078

GI number: 220905078

Start: 2188126

End: 2188707

Strand: Reverse

Name: cobC [H]

Synonym: Ddes_1815

Alternate gene names: 220905078

Gene position: 2188707-2188126 (Counterclockwise)

Preceding gene: 220905079

Following gene: 220905067

Centisome position: 76.17

GC content: 64.95

Gene sequence:

>582_bases
ATGAACGGCATGTGGCTCGTGCGGCACGGCGCTTTGCCGCCCAATCCCGAGCGGCGGATTGTGGGCAACCGCGATATCCC
GCTCAGCGATGCCGGGCGAAATCAGATCCGCCGTCTGGCCCGCGACTTCATGCCTGCCCTGGCGGGAAGACTGGCGGCAG
TGGTGAGTTCGGACCTGGGGCGTTGCCGTGAAACCACGTCCATTCTTCTGACCGGAAATGAATGGGCCGCCAGCCCGCCC
CCTGTACATGCCGAGCCGGGCCTGCGGGAAATAGACATGGGGCAGTGGCAGGGCCTGACCCGGAACGAGATCGAACAGCG
CTTTCCCGGTCAGTACGCTGTGCGGGGCAAGGATTTTGCCCGCTTCAGGCCCGAGGGCGGCGAGAGCTTCGCCTGCCTTC
AGGAGCGGGCCCTTGAGGCCGTGCAGCGCTGGCGACGGCAGTATCCTGACGGGCTTGTGCTTGTGGTGGCGCATGCGGGC
GTCATACGCTGTTTGCTGGCCCACTATATGGCGCTGCCGCTTGAAGAGGCGCTGAACATCCCGCAGGAATACGGCTGCCG
GACGTTTGTGCCGGAATGGTAA

Upstream 100 bases:

>100_bases
GTTTTTCATGGCGGCTGCGCGAGCGTATGCCCGTAACCGCCAGCACAGTTCCAGAATAAAGTTGTTTCCCCGCGCTGCAG
GGAGCAAAGGAGATATCTCA

Downstream 100 bases:

>100_bases
TGATGCCTTGGGCGGCTGCATTTTTGCGGCCATATGGTTTGCAGGGCTTGCGGGGCATTGGCCGGACGCATCCGCTCAGC
GCAGTTGCAGGTTGACGCCT

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MNGMWLVRHGALPPNPERRIVGNRDIPLSDAGRNQIRRLARDFMPALAGRLAAVVSSDLGRCRETTSILLTGNEWAASPP
PVHAEPGLREIDMGQWQGLTRNEIEQRFPGQYAVRGKDFARFRPEGGESFACLQERALEAVQRWRRQYPDGLVLVVAHAG
VIRCLLAHYMALPLEEALNIPQEYGCRTFVPEW

Sequences:

>Translated_193_residues
MNGMWLVRHGALPPNPERRIVGNRDIPLSDAGRNQIRRLARDFMPALAGRLAAVVSSDLGRCRETTSILLTGNEWAASPP
PVHAEPGLREIDMGQWQGLTRNEIEQRFPGQYAVRGKDFARFRPEGGESFACLQERALEAVQRWRRQYPDGLVLVVAHAG
VIRCLLAHYMALPLEEALNIPQEYGCRTFVPEW
>Mature_193_residues
MNGMWLVRHGALPPNPERRIVGNRDIPLSDAGRNQIRRLARDFMPALAGRLAAVVSSDLGRCRETTSILLTGNEWAASPP
PVHAEPGLREIDMGQWQGLTRNEIEQRFPGQYAVRGKDFARFRPEGGESFACLQERALEAVQRWRRQYPDGLVLVVAHAG
VIRCLLAHYMALPLEEALNIPQEYGCRTFVPEW

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Homo sapiens, GI118582286, Length=198, Percent_Identity=30.8080808080808, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4758902, Length=198, Percent_Identity=30.8080808080808, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI224282149, Length=197, Percent_Identity=31.9796954314721, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI4758900, Length=197, Percent_Identity=31.9796954314721, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI64762445, Length=197, Percent_Identity=30.9644670050761, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI64762406, Length=197, Percent_Identity=30.9644670050761, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1786857, Length=184, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71993390, Length=199, Percent_Identity=32.6633165829146, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17510917, Length=198, Percent_Identity=32.3232323232323, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25145314, Length=183, Percent_Identity=32.2404371584699, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322306, Length=182, Percent_Identity=31.3186813186813, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 21751; Mature: 21751

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGMWLVRHGALPPNPERRIVGNRDIPLSDAGRNQIRRLARDFMPALAGRLAAVVSSDLG
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RCRETTSILLTGNEWAASPPPVHAEPGLREIDMGQWQGLTRNEIEQRFPGQYAVRGKDFA
HHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHCCCCEEECCCCHH
RFRPEGGESFACLQERALEAVQRWRRQYPDGLVLVVAHAGVIRCLLAHYMALPLEEALNI
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHCC
PQEYGCRTFVPEW
CHHCCCCCCCCCC
>Mature Secondary Structure
MNGMWLVRHGALPPNPERRIVGNRDIPLSDAGRNQIRRLARDFMPALAGRLAAVVSSDLG
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RCRETTSILLTGNEWAASPPPVHAEPGLREIDMGQWQGLTRNEIEQRFPGQYAVRGKDFA
HHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHCCCCEEECCCCHH
RFRPEGGESFACLQERALEAVQRWRRQYPDGLVLVVAHAGVIRCLLAHYMALPLEEALNI
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHCC
PQEYGCRTFVPEW
CHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]