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The map label for this gene is comEC [H]

Identifier: 220905061

GI number: 220905061

Start: 2170805

End: 2173618

Strand: Direct

Name: comEC [H]

Synonym: Ddes_1798

Alternate gene names: 220905061

Gene position: 2170805-2173618 (Clockwise)

Preceding gene: 220905060

Following gene: 220905062

Centisome position: 75.55

GC content: 64.11

Gene sequence:

>2814_bases
ATGCGCCATCCACCACTGCAAGCCCCGCTGTTATGGCAGCTCTGCCTTTGCTTCTGGATAGGAGGCATAGCTGCGGCCGT
ATGGCCCTGGCAGTCTTTGCTGTGCCTGCTGCTGCTTGTTCTCGCAGACCGCCGCCTGTGGAAAGCGGGGCGCATTGCCT
TCTGTACCCTGCTGGTCCTGGCCGGGCTGTTCACAGCTCGATGGCAACTTTACGGCAGCCCCTGGCACGGCGGTCTTCCT
CCAGCTTCTCCACCCTTCTGGCTGGCTGAAGCCCCCAAAGATATCCGCGTCTGCGGCACAGTGACCGACAGCCAGGGCCT
GCCGGACCAACGCCTGCGCCTGATTCTGTCTCACATGGCTCCTGACGCGACAGCTGCGGCAGACGATGCGTCGCGCCGCG
CAGACCTGCGAGCAGCCTTTGCCGCGCCCTTGCCCGGCCTTGTGGCCTTTACCTGGGAAAATCCCACACTGCGCCCGTTA
CCCGGCCAGACATTTTGCCTGGCACGCCGCCCCATGCCCATGCAGGGCTTCGCCAATGAGGGACAATCGGCCTGGGATCT
GTGGTGGGCCGCGCAGGACGTACGCTGGCGTCTATGGACGCAGGCGGAACGCGGCGAGCCGTTCGTCTCTGGCGAAGGGG
GGCGTTCCGCTCGCTGGCGAGAGTCCCTGCGCGAAAAATTCCTGGCAGCCCTGCAAGCTCCTGCGCAACCGGGCGATCTT
CTTCCTGCGGCCCGGAACGGCAGCCCCACGACGCATGGAGGGCATACAACAGCCTCGGGGCAGATAAAAGAACTCTCCGG
CGGGCATGCCGCATCCGGTGGCGAAATGCCGCCCGGCCAGAAAAGCCTGAGCCAGGGCAAAGCCATTGTACTGGCCCTGC
TTTTTGGCGACAGGCAATACCTCGCCCAGGCGACCCTGAACAATTTTGCCGCTGCCACCCTGGTGCACAGCCTGGCCCTT
TCGGGCCAGCACCTTGTGGTAGCAGGCATGATCGGGCTGTTCTGCGTACTGGCGGCATCACGCCTGCGGCCGGGAATCTA
TCTGCGCCGCCCCAAAGTCCTGTGGGTCATGCTCGCCTCTCTGCCGCCCGCCCTGGGGTATCTGTGGCTGGGCAACGCCC
CGGCATCCCTGTTGCGCGCCACAGTCATGATGCTTGTGGCGGCCCTGTGGATGGCTTCCGGCCGTCCGCGCACAACCCTG
GACGCACTGGGCGCGGCACTTCTTTGTATCACGGTATCCTTTCCCCTGAGCGTGCTGGATACCGGACTGCAGCTTTCAGC
CCTGTGTGTGGGGGCCATCGGCCTGAGCCTGCCCTGGTTGCGGCGCATCATTCCCCTGCCGGACCGTGGTGCGCCCGACT
CGCCTTCGCGCGTCACGGCGTGGCTGCGCGCTCTTATGCGCATTTTTCTTGTTTCACTGTTCATACAGATCGCCCTGCTA
CCGCTCAATATGCTGCTTTTCGGCAACGCGGGCTTCTGGTTTCCCCTTAATGTGGCATGGCTGCCCGTAGCCGACCTGAT
TGTACTGCCCGCAGCCGTACTGGGCCTGCTGTGCGCGGCCCTTGGCCTTGAATCACCGGCGCGCCTGATTCTGGATGTGG
CCGCCATGCCCTGCCAGTGGCTGGTGGACTCTCTGGCCTGGCTGGCCGAAAGTGGCCTGCTGGCTGCCCCGGCCATGCTG
CGCCCCCACTGGACGGCCCTGCCGGCCTTTGCTGCCTTGCTTACGGCTCTTGCTTTCATGGCCGGGCGAAAAACCATGCC
TGCGGGAGCAGCGCGACTGCTGCTGGCAGGGGGCGCGTTATTGCTGGCAGGGCCGCTGCTGCGCGTGGAACAGCGCCTTT
CACCGGAAATACGGCTGGAGGTGCTGGATGTGGGGCAAAGCCAGGCCGTGGCCCTGCGTTTGCCGGGACATGTGCGCCTG
CTGCTGGACGGCGGCGGCAGTGCCTCACCGCGCTTTGATCCCGGCCAGGCGCTGGTGGCTCCAGTCCTCCTCTATAATGA
TTCGCCCCGCCTTTCAGCCGTACTGAACAGCCATCCCGACCTTGACCATATGGGGGGACTGGTACATATTCTTGAGTATT
TCAAGGTAAACACCCTGTTTGACAACGGGCAGGACGGACGCAGCGACAGCGGCTGGGGCGCCCTGTGGACACAGGTCAGG
CAACAGCACAAGGCCCGCCCCCTTGCACAGGGCGATGTGCTGCAACTGGGCGACCCGATCCGCCAGCTCCAGCTGGAAAT
ACTGCACCCACCGCGCAGCGCCCGTGCTGAAGCACATTCGCCGTGGACCGGAAACAATGCTTCGCTGGTGGCCCGTCTGA
CCCACAAGGGCCGCGGCCTGGCCCTGATCCCCGGCGATGCCGAACGCCGTTCATTGCGGCACATGCTGGATCAGGGCATT
GACCTGCGTGCCGAGGTTCTGGTTTTGCCGCACCACGGATCAGACAGCAGCTATCTGGCTGATTTTTACAAGGCGGTGCA
GCCCCGTGTGGCGGTGGCTGCCTGCGGCTTTGAAAACCGCTATGGCTACCCCGGTAAAAAAGTGCGCGCATGGCTGGACA
AAGCAGGCATTCCCCTGCTGTTCACCGGGCGTGACGGGCAGGTGCAGCTGACCTGGCCTGGACGTGGCATGCAGTGGCCC
CCTACCGACGCTGAAGAACGCGCGGTGCTGCATCTACGGACACAAAGAGGCACTGCCGGGGTAAACAGTGCCGCGCCGGG
CGGCACCAGGCAGGACCATGAAAAAATGCCCGCCAAAGAGCATAAAGAGGAAGGCGAACTACGCGGCAAGGCTGATAGCG
GACAGACCGAATAG

Upstream 100 bases:

>100_bases
AAGCGCCCGGCGTCAATCGTGCGGGCGTTGCGACGCTTCGCATTGCAGAGCATCTCGTCCGGCAGATAGCGGAATGCTGC
ATGCTCCACAGAGCAAAAGC

Downstream 100 bases:

>100_bases
CGGCAGCCCGTCCTTTTTTCTGACCGTCGCGCCTGCACCTTCACAGCGAACGTTGCCCGCGCCGCCGCCAGAACATTCCC
AACGTGAAAATGCTCTGGAC

Product: ComEC/Rec2-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 937; Mature: 937

Protein sequence:

>937_residues
MRHPPLQAPLLWQLCLCFWIGGIAAAVWPWQSLLCLLLLVLADRRLWKAGRIAFCTLLVLAGLFTARWQLYGSPWHGGLP
PASPPFWLAEAPKDIRVCGTVTDSQGLPDQRLRLILSHMAPDATAAADDASRRADLRAAFAAPLPGLVAFTWENPTLRPL
PGQTFCLARRPMPMQGFANEGQSAWDLWWAAQDVRWRLWTQAERGEPFVSGEGGRSARWRESLREKFLAALQAPAQPGDL
LPAARNGSPTTHGGHTTASGQIKELSGGHAASGGEMPPGQKSLSQGKAIVLALLFGDRQYLAQATLNNFAAATLVHSLAL
SGQHLVVAGMIGLFCVLAASRLRPGIYLRRPKVLWVMLASLPPALGYLWLGNAPASLLRATVMMLVAALWMASGRPRTTL
DALGAALLCITVSFPLSVLDTGLQLSALCVGAIGLSLPWLRRIIPLPDRGAPDSPSRVTAWLRALMRIFLVSLFIQIALL
PLNMLLFGNAGFWFPLNVAWLPVADLIVLPAAVLGLLCAALGLESPARLILDVAAMPCQWLVDSLAWLAESGLLAAPAML
RPHWTALPAFAALLTALAFMAGRKTMPAGAARLLLAGGALLLAGPLLRVEQRLSPEIRLEVLDVGQSQAVALRLPGHVRL
LLDGGGSASPRFDPGQALVAPVLLYNDSPRLSAVLNSHPDLDHMGGLVHILEYFKVNTLFDNGQDGRSDSGWGALWTQVR
QQHKARPLAQGDVLQLGDPIRQLQLEILHPPRSARAEAHSPWTGNNASLVARLTHKGRGLALIPGDAERRSLRHMLDQGI
DLRAEVLVLPHHGSDSSYLADFYKAVQPRVAVAACGFENRYGYPGKKVRAWLDKAGIPLLFTGRDGQVQLTWPGRGMQWP
PTDAEERAVLHLRTQRGTAGVNSAAPGGTRQDHEKMPAKEHKEEGELRGKADSGQTE

Sequences:

>Translated_937_residues
MRHPPLQAPLLWQLCLCFWIGGIAAAVWPWQSLLCLLLLVLADRRLWKAGRIAFCTLLVLAGLFTARWQLYGSPWHGGLP
PASPPFWLAEAPKDIRVCGTVTDSQGLPDQRLRLILSHMAPDATAAADDASRRADLRAAFAAPLPGLVAFTWENPTLRPL
PGQTFCLARRPMPMQGFANEGQSAWDLWWAAQDVRWRLWTQAERGEPFVSGEGGRSARWRESLREKFLAALQAPAQPGDL
LPAARNGSPTTHGGHTTASGQIKELSGGHAASGGEMPPGQKSLSQGKAIVLALLFGDRQYLAQATLNNFAAATLVHSLAL
SGQHLVVAGMIGLFCVLAASRLRPGIYLRRPKVLWVMLASLPPALGYLWLGNAPASLLRATVMMLVAALWMASGRPRTTL
DALGAALLCITVSFPLSVLDTGLQLSALCVGAIGLSLPWLRRIIPLPDRGAPDSPSRVTAWLRALMRIFLVSLFIQIALL
PLNMLLFGNAGFWFPLNVAWLPVADLIVLPAAVLGLLCAALGLESPARLILDVAAMPCQWLVDSLAWLAESGLLAAPAML
RPHWTALPAFAALLTALAFMAGRKTMPAGAARLLLAGGALLLAGPLLRVEQRLSPEIRLEVLDVGQSQAVALRLPGHVRL
LLDGGGSASPRFDPGQALVAPVLLYNDSPRLSAVLNSHPDLDHMGGLVHILEYFKVNTLFDNGQDGRSDSGWGALWTQVR
QQHKARPLAQGDVLQLGDPIRQLQLEILHPPRSARAEAHSPWTGNNASLVARLTHKGRGLALIPGDAERRSLRHMLDQGI
DLRAEVLVLPHHGSDSSYLADFYKAVQPRVAVAACGFENRYGYPGKKVRAWLDKAGIPLLFTGRDGQVQLTWPGRGMQWP
PTDAEERAVLHLRTQRGTAGVNSAAPGGTRQDHEKMPAKEHKEEGELRGKADSGQTE
>Mature_937_residues
MRHPPLQAPLLWQLCLCFWIGGIAAAVWPWQSLLCLLLLVLADRRLWKAGRIAFCTLLVLAGLFTARWQLYGSPWHGGLP
PASPPFWLAEAPKDIRVCGTVTDSQGLPDQRLRLILSHMAPDATAAADDASRRADLRAAFAAPLPGLVAFTWENPTLRPL
PGQTFCLARRPMPMQGFANEGQSAWDLWWAAQDVRWRLWTQAERGEPFVSGEGGRSARWRESLREKFLAALQAPAQPGDL
LPAARNGSPTTHGGHTTASGQIKELSGGHAASGGEMPPGQKSLSQGKAIVLALLFGDRQYLAQATLNNFAAATLVHSLAL
SGQHLVVAGMIGLFCVLAASRLRPGIYLRRPKVLWVMLASLPPALGYLWLGNAPASLLRATVMMLVAALWMASGRPRTTL
DALGAALLCITVSFPLSVLDTGLQLSALCVGAIGLSLPWLRRIIPLPDRGAPDSPSRVTAWLRALMRIFLVSLFIQIALL
PLNMLLFGNAGFWFPLNVAWLPVADLIVLPAAVLGLLCAALGLESPARLILDVAAMPCQWLVDSLAWLAESGLLAAPAML
RPHWTALPAFAALLTALAFMAGRKTMPAGAARLLLAGGALLLAGPLLRVEQRLSPEIRLEVLDVGQSQAVALRLPGHVRL
LLDGGGSASPRFDPGQALVAPVLLYNDSPRLSAVLNSHPDLDHMGGLVHILEYFKVNTLFDNGQDGRSDSGWGALWTQVR
QQHKARPLAQGDVLQLGDPIRQLQLEILHPPRSARAEAHSPWTGNNASLVARLTHKGRGLALIPGDAERRSLRHMLDQGI
DLRAEVLVLPHHGSDSSYLADFYKAVQPRVAVAACGFENRYGYPGKKVRAWLDKAGIPLLFTGRDGQVQLTWPGRGMQWP
PTDAEERAVLHLRTQRGTAGVNSAAPGGTRQDHEKMPAKEHKEEGELRGKADSGQTE

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=604, Percent_Identity=25.8278145695364, Blast_Score=106, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 101228; Mature: 101228

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHPPLQAPLLWQLCLCFWIGGIAAAVWPWQSLLCLLLLVLADRRLWKAGRIAFCTLLVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHH
AGLFTARWQLYGSPWHGGLPPASPPFWLAEAPKDIRVCGTVTDSQGLPDQRLRLILSHMA
HHHHHHHHHEECCCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHC
PDATAAADDASRRADLRAAFAAPLPGLVAFTWENPTLRPLPGQTFCLARRPMPMQGFANE
CCCHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCC
GQSAWDLWWAAQDVRWRLWTQAERGEPFVSGEGGRSARWRESLREKFLAALQAPAQPGDL
CCCHHHHHEECCCHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
LPAARNGSPTTHGGHTTASGQIKELSGGHAASGGEMPPGQKSLSQGKAIVLALLFGDRQY
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCHHH
LAQATLNNFAAATLVHSLALSGQHLVVAGMIGLFCVLAASRLRPGIYLRRPKVLWVMLAS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
LPPALGYLWLGNAPASLLRATVMMLVAALWMASGRPRTTLDALGAALLCITVSFPLSVLD
CCCHHCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
TGLQLSALCVGAIGLSLPWLRRIIPLPDRGAPDSPSRVTAWLRALMRIFLVSLFIQIALL
CCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PLNMLLFGNAGFWFPLNVAWLPVADLIVLPAAVLGLLCAALGLESPARLILDVAAMPCQW
HHHHHEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
LVDSLAWLAESGLLAAPAMLRPHWTALPAFAALLTALAFMAGRKTMPAGAARLLLAGGAL
HHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHH
LLAGPLLRVEQRLSPEIRLEVLDVGQSQAVALRLPGHVRLLLDGGGSASPRFDPGQALVA
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCCCCHHHHE
PVLLYNDSPRLSAVLNSHPDLDHMGGLVHILEYFKVNTLFDNGQDGRSDSGWGALWTQVR
EEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
QQHKARPLAQGDVLQLGDPIRQLQLEILHPPRSARAEAHSPWTGNNASLVARLTHKGRGL
HHHHCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEE
ALIPGDAERRSLRHMLDQGIDLRAEVLVLPHHGSDSSYLADFYKAVQPRVAVAACGFENR
EEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCC
YGYPGKKVRAWLDKAGIPLLFTGRDGQVQLTWPGRGMQWPPTDAEERAVLHLRTQRGTAG
CCCCHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCC
VNSAAPGGTRQDHEKMPAKEHKEEGELRGKADSGQTE
CCCCCCCCCCCHHHCCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRHPPLQAPLLWQLCLCFWIGGIAAAVWPWQSLLCLLLLVLADRRLWKAGRIAFCTLLVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHH
AGLFTARWQLYGSPWHGGLPPASPPFWLAEAPKDIRVCGTVTDSQGLPDQRLRLILSHMA
HHHHHHHHHEECCCCCCCCCCCCCCCEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHC
PDATAAADDASRRADLRAAFAAPLPGLVAFTWENPTLRPLPGQTFCLARRPMPMQGFANE
CCCHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCC
GQSAWDLWWAAQDVRWRLWTQAERGEPFVSGEGGRSARWRESLREKFLAALQAPAQPGDL
CCCHHHHHEECCCHHEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
LPAARNGSPTTHGGHTTASGQIKELSGGHAASGGEMPPGQKSLSQGKAIVLALLFGDRQY
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCHHH
LAQATLNNFAAATLVHSLALSGQHLVVAGMIGLFCVLAASRLRPGIYLRRPKVLWVMLAS
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHH
LPPALGYLWLGNAPASLLRATVMMLVAALWMASGRPRTTLDALGAALLCITVSFPLSVLD
CCCHHCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
TGLQLSALCVGAIGLSLPWLRRIIPLPDRGAPDSPSRVTAWLRALMRIFLVSLFIQIALL
CCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PLNMLLFGNAGFWFPLNVAWLPVADLIVLPAAVLGLLCAALGLESPARLILDVAAMPCQW
HHHHHEECCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
LVDSLAWLAESGLLAAPAMLRPHWTALPAFAALLTALAFMAGRKTMPAGAARLLLAGGAL
HHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHH
LLAGPLLRVEQRLSPEIRLEVLDVGQSQAVALRLPGHVRLLLDGGGSASPRFDPGQALVA
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCEEEEEEECCCCCCCCCCCCHHHHE
PVLLYNDSPRLSAVLNSHPDLDHMGGLVHILEYFKVNTLFDNGQDGRSDSGWGALWTQVR
EEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
QQHKARPLAQGDVLQLGDPIRQLQLEILHPPRSARAEAHSPWTGNNASLVARLTHKGRGL
HHHHCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEE
ALIPGDAERRSLRHMLDQGIDLRAEVLVLPHHGSDSSYLADFYKAVQPRVAVAACGFENR
EEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCC
YGYPGKKVRAWLDKAGIPLLFTGRDGQVQLTWPGRGMQWPPTDAEERAVLHLRTQRGTAG
CCCCHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCC
VNSAAPGGTRQDHEKMPAKEHKEEGELRGKADSGQTE
CCCCCCCCCCCHHHCCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]