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The map label for this gene is yciC [H]

Identifier: 220904987

GI number: 220904987

Start: 2083915

End: 2085762

Strand: Direct

Name: yciC [H]

Synonym: Ddes_1723

Alternate gene names: 220904987

Gene position: 2083915-2085762 (Clockwise)

Preceding gene: 220904986

Following gene: 220904989

Centisome position: 72.52

GC content: 61.85

Gene sequence:

>1848_bases
ATGCATCTGCACAGCCTGCTGCCGCGCCCATTGAATCCCCAGGCCGGGGCGGAAAGCCCTTCCATACTGACGGCCCTGCT
GTCGGGTATTCACCTGAATCGCAAACAGGCCCGCGCCCTGGGCTGGCGGGGTGTGCGCCCATCGGCCCTGAAAGGACCGG
CATGGACCTGCAGGGTTGCTCCGCTGCCGCATGTTTTCGGCCTGGTTTTTCTTGATGAATATGTGGAAAAGAATGCCCTG
CACGGCACGTTTGCCGCCTGTGTCTTCCCGGAAGCGCAAGACTCCCTGCTGGACAGTTTTCCGCTGCAGGCCCTGGCAAT
CGCTCTGGGGCCGGACTATGCACATGCCGTGCGCGAACTTTCGGCCCATGCCGAAGCCCTGTCTCCGTTCTGCCTGGGAC
ACATCAGCATTACAGCAGCCCTGGACGGATCGTGGCTTTCCCTCAGCCTTTCCGCTCCGGCACGGCAACGCATTGTATCG
CTGGAAGGCATCGCCGTTCCCGGTCATACCGGCAAAGCAGGCGCTGCCCATACCGCACATGAGCGGCAATGGATTGTGCC
GCCCGGTGGCCTTGAGTGTGATATACCCGCCTTCCGCCTGCTGCTGCGTTTTTTTTCCGCTCTGGCCGGTACGGCATGCA
GCCTGCTGGGCGAAACGCCGACCGTACACCTGCGCAGGATGCCGCTGGCACTTCAGGGCTGGTCCCAATCCGCCGATGCC
AGCCCCGCAGGCGGACCATGCTGGCAGATGCGCCTGACAGTCGGCCTTGGCGGCGCGCCCTACTGTGCTGCAAGGGAGGA
CAAAAAACTTTCCCGGCTGCCGGGGCGCTACTCTCCCCGGCCGGATGAGCTTTCGTCCCTGCCTGTCATGCACATCCTTA
CCGGCTTTCTCGGCTCAGGCAAAACAACCTTTCTGCGCCGCTGGCTGGACTTTCTTAACGGACGGGAGCAGTACGCGGCG
GTGATCCAGAACGAATTCGGCAAGATAGGCCTGGATGCGGCCCTGACCCGAAGTGAAACACATGTGGAGGCACTGGACGA
AGGCTGCGTATGCTGCTCGCTGGCGGACACCTTGCGCCCGGGGCTGCAGCGCCTGCTGGACACGGCTCCGGCGGAGCAGG
TCATTCTGGAAACCACAGGGCTGGCCAACCCTGCCAATGTGCTGCGAACCCTGACAGAACTGGCGGATCTTGTGCAGCCG
GGGCTGGTTATTACCGTGACGGACGCTCTGGAATGGAGCACCGGCATTACCCCTGCCCGGAACTTTGACGGAGTGCGGCT
GGTGCAGATCGAACAGGCCGACGTCATCATCGCAAACAAGGCTGATGCCGTGACGGAAAAATGCTTTCAGGAGTTTCTGC
ACGCCCTGCGCGCCGCCAACGGCAAAGCATGCATTTTACCCGCTGTACAGGGTAACATTGCCTTTGCGCGGCTGGATGCT
TTTTTGACAGGCTGGCAGGACAGGCACAGCCCCGCGCCGTCACGCCGTCCGCGCCTTTATGACATGCCCCGGCTGCAGGA
ACGTTCCGGCACACATGCGGATGAAGGGTTTTCCTCACGTACCGTTCCCATGCCCGCCCCGGTGGATGAGCACAGCCTGG
GGCAAATGCTGAAAGCCGCCGGAACAGGGCTGTGCCGGGCCAAAGGTATCGTGAACCTGCGGCACGAAGGGCGTGTTTTT
CCCGTGGTGATACAATACGCGGCAGGCCGTCTGGCATTTGAAGATGCCCCTGGAGACGAAGCCGAACGATATATGGTTTT
TATAGGTATTGACTTGCCGGACAACATGGAAAACGCCCTTCTGGCTCCCGGGCCGGTTCAGGGACCGCCTCACGCATGCC
CGGCCTGA

Upstream 100 bases:

>100_bases
TCCCCTCCTGACTCTGAACACCCCTGCGGGACCAGGCATGCCGTCCAGGTCCCGCAGAGCCATCCGGCGCGCCACCACGC
GCCACAACCAGGGAGCCGCC

Downstream 100 bases:

>100_bases
CCGCAGAAACGGAAAATCCATCAGGTTTTTATCATTTCTGCGCACAGATACAGCGGCCCGGCACAACAGCAATTGCACCG
CATGCGGCAGGCACTGCGGA

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MHLHSLLPRPLNPQAGAESPSILTALLSGIHLNRKQARALGWRGVRPSALKGPAWTCRVAPLPHVFGLVFLDEYVEKNAL
HGTFAACVFPEAQDSLLDSFPLQALAIALGPDYAHAVRELSAHAEALSPFCLGHISITAALDGSWLSLSLSAPARQRIVS
LEGIAVPGHTGKAGAAHTAHERQWIVPPGGLECDIPAFRLLLRFFSALAGTACSLLGETPTVHLRRMPLALQGWSQSADA
SPAGGPCWQMRLTVGLGGAPYCAAREDKKLSRLPGRYSPRPDELSSLPVMHILTGFLGSGKTTFLRRWLDFLNGREQYAA
VIQNEFGKIGLDAALTRSETHVEALDEGCVCCSLADTLRPGLQRLLDTAPAEQVILETTGLANPANVLRTLTELADLVQP
GLVITVTDALEWSTGITPARNFDGVRLVQIEQADVIIANKADAVTEKCFQEFLHALRAANGKACILPAVQGNIAFARLDA
FLTGWQDRHSPAPSRRPRLYDMPRLQERSGTHADEGFSSRTVPMPAPVDEHSLGQMLKAAGTGLCRAKGIVNLRHEGRVF
PVVIQYAAGRLAFEDAPGDEAERYMVFIGIDLPDNMENALLAPGPVQGPPHACPA

Sequences:

>Translated_615_residues
MHLHSLLPRPLNPQAGAESPSILTALLSGIHLNRKQARALGWRGVRPSALKGPAWTCRVAPLPHVFGLVFLDEYVEKNAL
HGTFAACVFPEAQDSLLDSFPLQALAIALGPDYAHAVRELSAHAEALSPFCLGHISITAALDGSWLSLSLSAPARQRIVS
LEGIAVPGHTGKAGAAHTAHERQWIVPPGGLECDIPAFRLLLRFFSALAGTACSLLGETPTVHLRRMPLALQGWSQSADA
SPAGGPCWQMRLTVGLGGAPYCAAREDKKLSRLPGRYSPRPDELSSLPVMHILTGFLGSGKTTFLRRWLDFLNGREQYAA
VIQNEFGKIGLDAALTRSETHVEALDEGCVCCSLADTLRPGLQRLLDTAPAEQVILETTGLANPANVLRTLTELADLVQP
GLVITVTDALEWSTGITPARNFDGVRLVQIEQADVIIANKADAVTEKCFQEFLHALRAANGKACILPAVQGNIAFARLDA
FLTGWQDRHSPAPSRRPRLYDMPRLQERSGTHADEGFSSRTVPMPAPVDEHSLGQMLKAAGTGLCRAKGIVNLRHEGRVF
PVVIQYAAGRLAFEDAPGDEAERYMVFIGIDLPDNMENALLAPGPVQGPPHACPA
>Mature_615_residues
MHLHSLLPRPLNPQAGAESPSILTALLSGIHLNRKQARALGWRGVRPSALKGPAWTCRVAPLPHVFGLVFLDEYVEKNAL
HGTFAACVFPEAQDSLLDSFPLQALAIALGPDYAHAVRELSAHAEALSPFCLGHISITAALDGSWLSLSLSAPARQRIVS
LEGIAVPGHTGKAGAAHTAHERQWIVPPGGLECDIPAFRLLLRFFSALAGTACSLLGETPTVHLRRMPLALQGWSQSADA
SPAGGPCWQMRLTVGLGGAPYCAAREDKKLSRLPGRYSPRPDELSSLPVMHILTGFLGSGKTTFLRRWLDFLNGREQYAA
VIQNEFGKIGLDAALTRSETHVEALDEGCVCCSLADTLRPGLQRLLDTAPAEQVILETTGLANPANVLRTLTELADLVQP
GLVITVTDALEWSTGITPARNFDGVRLVQIEQADVIIANKADAVTEKCFQEFLHALRAANGKACILPAVQGNIAFARLDA
FLTGWQDRHSPAPSRRPRLYDMPRLQERSGTHADEGFSSRTVPMPAPVDEHSLGQMLKAAGTGLCRAKGIVNLRHEGRVF
PVVIQYAAGRLAFEDAPGDEAERYMVFIGIDLPDNMENALLAPGPVQGPPHACPA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=347, Percent_Identity=27.6657060518732, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI146231952, Length=349, Percent_Identity=27.5071633237822, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI148727351, Length=349, Percent_Identity=27.2206303724928, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI33469141, Length=347, Percent_Identity=27.3775216138329, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI223941779, Length=342, Percent_Identity=25.4385964912281, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87082430, Length=325, Percent_Identity=31.3846153846154, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788499, Length=195, Percent_Identity=29.7435897435897, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324356, Length=186, Percent_Identity=31.7204301075269, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 66081; Mature: 66081

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLHSLLPRPLNPQAGAESPSILTALLSGIHLNRKQARALGWRGVRPSALKGPAWTCRVA
CCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEECC
PLPHVFGLVFLDEYVEKNALHGTFAACVFPEAQDSLLDSFPLQALAIALGPDYAHAVREL
CCHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCHHHHHHHCCCHHHHHHHHH
SAHAEALSPFCLGHISITAALDGSWLSLSLSAPARQRIVSLEGIAVPGHTGKAGAAHTAH
HHHHHHHCHHHEEEEEEEEEECCCEEEEEECCCHHHHEEEECCEEECCCCCCCCCCCCCC
ERQWIVPPGGLECDIPAFRLLLRFFSALAGTACSLLGETPTVHLRRMPLALQGWSQSADA
CCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCC
SPAGGPCWQMRLTVGLGGAPYCAAREDKKLSRLPGRYSPRPDELSSLPVMHILTGFLGSG
CCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCHHHCCCHHHHHHHHHCCC
KTTFLRRWLDFLNGREQYAAVIQNEFGKIGLDAALTRSETHVEALDEGCVCCSLADTLRP
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCEEEHHHHHHHH
GLQRLLDTAPAEQVILETTGLANPANVLRTLTELADLVQPGLVITVTDALEWSTGITPAR
HHHHHHHCCCHHHEEEHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
NFDGVRLVQIEQADVIIANKADAVTEKCFQEFLHALRAANGKACILPAVQGNIAFARLDA
CCCCEEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
FLTGWQDRHSPAPSRRPRLYDMPRLQERSGTHADEGFSSRTVPMPAPVDEHSLGQMLKAA
HHHCCHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GTGLCRAKGIVNLRHEGRVFPVVIQYAAGRLAFEDAPGDEAERYMVFIGIDLPDNMENAL
CCCCCHHCCCEEECCCCCEEEEEEEECCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCE
LAPGPVQGPPHACPA
ECCCCCCCCCCCCCC
>Mature Secondary Structure
MHLHSLLPRPLNPQAGAESPSILTALLSGIHLNRKQARALGWRGVRPSALKGPAWTCRVA
CCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEECC
PLPHVFGLVFLDEYVEKNALHGTFAACVFPEAQDSLLDSFPLQALAIALGPDYAHAVREL
CCHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCHHHHHHHCCCHHHHHHHHH
SAHAEALSPFCLGHISITAALDGSWLSLSLSAPARQRIVSLEGIAVPGHTGKAGAAHTAH
HHHHHHHCHHHEEEEEEEEEECCCEEEEEECCCHHHHEEEECCEEECCCCCCCCCCCCCC
ERQWIVPPGGLECDIPAFRLLLRFFSALAGTACSLLGETPTVHLRRMPLALQGWSQSADA
CCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCCC
SPAGGPCWQMRLTVGLGGAPYCAAREDKKLSRLPGRYSPRPDELSSLPVMHILTGFLGSG
CCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCHHHCCCHHHHHHHHHCCC
KTTFLRRWLDFLNGREQYAAVIQNEFGKIGLDAALTRSETHVEALDEGCVCCSLADTLRP
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCEEEHHHHHHHH
GLQRLLDTAPAEQVILETTGLANPANVLRTLTELADLVQPGLVITVTDALEWSTGITPAR
HHHHHHHCCCHHHEEEHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
NFDGVRLVQIEQADVIIANKADAVTEKCFQEFLHALRAANGKACILPAVQGNIAFARLDA
CCCCEEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
FLTGWQDRHSPAPSRRPRLYDMPRLQERSGTHADEGFSSRTVPMPAPVDEHSLGQMLKAA
HHHCCHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
GTGLCRAKGIVNLRHEGRVFPVVIQYAAGRLAFEDAPGDEAERYMVFIGIDLPDNMENAL
CCCCCHHCCCEEECCCCCEEEEEEEECCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCE
LAPGPVQGPPHACPA
ECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]