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The map label for this gene is nuoI [H]

Identifier: 220904925

GI number: 220904925

Start: 1997168

End: 1997872

Strand: Reverse

Name: nuoI [H]

Synonym: Ddes_1660

Alternate gene names: 220904925

Gene position: 1997872-1997168 (Counterclockwise)

Preceding gene: 220904926

Following gene: 220904924

Centisome position: 69.53

GC content: 60.71

Gene sequence:

>705_bases
ATGCAAGTACAGTACAAACCGCGCCGTAACTGGTTGCAAACATTGCTGCAAACCGAGATTGCCCAAGGCTTGGCGCTCAC
CCTGCGGCACATGTTCCGCAAACCGGTAACGCAGCAGTACCCGGATGAAAAGCCGGTGGTGGCGGCTGGTTTTCGCGGTC
GCCACGCCCTGGTGCGCGATGCGGAAAGCGGCGGCAGCCGCTGCGTGGCCTGTATGCGTTGCGCCCGGGTGTGCCCGTCG
CACTGCATCCGCATCCGCAGCCACAGGAGTGTGGACGGCAGCCGTAAGGTGGATGCTTACGTTATTGACGCCCTGCGGTG
CATCTACTGCGGGTATTGCGCAGAAGTCTGCCCGGTGAACGCCATCGTGCTGACAGAAATTTATGCCTATGCGGGCCGTA
CACGACAGGAATTTGTTTTTGATGAGGCCCATCTCTTGCGTAACTGGGATGAATTTGCCGCGGAAAAGGGCAGCCTGGAA
GGATATGTGAACCCGTTGAGCCGCCCCCGCAATGCTTTGCAGCGTTTTTTGCCGGCCCCCAAACGCAAGGAGCATGTGAG
TGCGGAGTGGAGCGGTGAGGAGCAGTGGGTAGGGCAACACTGGCAGGCGGGCAAGCTCCGCAATGAGACGGCGCACGGCA
TTGCCAACATGTGGGAAAGTGCCGCGCCGGGCCTGGCAAAGGCCCCTGCGGACACTGCGGAATAG

Upstream 100 bases:

>100_bases
CAACATCGTGCTGACGGCCATCGGCAGGGCCGTGTTCGGCTAGGGCGGACAGCCTTGTGCGCAACGGAATCCATGAAGGT
TTCTGCTTTGGAGGCCACTG

Downstream 100 bases:

>100_bases
GGCGAAGCGGCCCGGTCTTGCGGGCTGTTTTGCGTGATCAGGCAGCTTGAACAGGGCAGGATTGCCGGAAGAGCATGCAC
AAGTCCATTCCGGGAGGTGG

Product: NADH-quinone oxidoreductase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MQVQYKPRRNWLQTLLQTEIAQGLALTLRHMFRKPVTQQYPDEKPVVAAGFRGRHALVRDAESGGSRCVACMRCARVCPS
HCIRIRSHRSVDGSRKVDAYVIDALRCIYCGYCAEVCPVNAIVLTEIYAYAGRTRQEFVFDEAHLLRNWDEFAAEKGSLE
GYVNPLSRPRNALQRFLPAPKRKEHVSAEWSGEEQWVGQHWQAGKLRNETAHGIANMWESAAPGLAKAPADTAE

Sequences:

>Translated_234_residues
MQVQYKPRRNWLQTLLQTEIAQGLALTLRHMFRKPVTQQYPDEKPVVAAGFRGRHALVRDAESGGSRCVACMRCARVCPS
HCIRIRSHRSVDGSRKVDAYVIDALRCIYCGYCAEVCPVNAIVLTEIYAYAGRTRQEFVFDEAHLLRNWDEFAAEKGSLE
GYVNPLSRPRNALQRFLPAPKRKEHVSAEWSGEEQWVGQHWQAGKLRNETAHGIANMWESAAPGLAKAPADTAE
>Mature_234_residues
MQVQYKPRRNWLQTLLQTEIAQGLALTLRHMFRKPVTQQYPDEKPVVAAGFRGRHALVRDAESGGSRCVACMRCARVCPS
HCIRIRSHRSVDGSRKVDAYVIDALRCIYCGYCAEVCPVNAIVLTEIYAYAGRTRQEFVFDEAHLLRNWDEFAAEKGSLE
GYVNPLSRPRNALQRFLPAPKRKEHVSAEWSGEEQWVGQHWQAGKLRNETAHGIANMWESAAPGLAKAPADTAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=143, Percent_Identity=44.0559440559441, Blast_Score=131, Evalue=5e-31,
Organism=Escherichia coli, GI1788617, Length=117, Percent_Identity=39.3162393162393, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17555194, Length=147, Percent_Identity=40.8163265306122, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17864306, Length=145, Percent_Identity=41.3793103448276, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 26435; Mature: 26435

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVQYKPRRNWLQTLLQTEIAQGLALTLRHMFRKPVTQQYPDEKPVVAAGFRGRHALVRD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEECCCCCCHHHHHC
AESGGSRCVACMRCARVCPSHCIRIRSHRSVDGSRKVDAYVIDALRCIYCGYCAEVCPVN
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
AIVLTEIYAYAGRTRQEFVFDEAHLLRNWDEFAAEKGSLEGYVNPLSRPRNALQRFLPAP
HHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHCHHHHHHHHHHHHCCCC
KRKEHVSAEWSGEEQWVGQHWQAGKLRNETAHGIANMWESAAPGLAKAPADTAE
CCHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MQVQYKPRRNWLQTLLQTEIAQGLALTLRHMFRKPVTQQYPDEKPVVAAGFRGRHALVRD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEECCCCCCHHHHHC
AESGGSRCVACMRCARVCPSHCIRIRSHRSVDGSRKVDAYVIDALRCIYCGYCAEVCPVN
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
AIVLTEIYAYAGRTRQEFVFDEAHLLRNWDEFAAEKGSLEGYVNPLSRPRNALQRFLPAP
HHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHCHHHHHHHHHHHHCCCC
KRKEHVSAEWSGEEQWVGQHWQAGKLRNETAHGIANMWESAAPGLAKAPADTAE
CCHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA