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The map label for this gene is nuoH1 [H]

Identifier: 220904926

GI number: 220904926

Start: 1997930

End: 1998898

Strand: Reverse

Name: nuoH1 [H]

Synonym: Ddes_1661

Alternate gene names: 220904926

Gene position: 1998898-1997930 (Counterclockwise)

Preceding gene: 220904927

Following gene: 220904925

Centisome position: 69.56

GC content: 56.04

Gene sequence:

>969_bases
ATGGACATACTGCTTATTCTGCTGCAACTCATCGTGCTCTTCGTGCTTGTGATGCTGCATGTGGCCTACGCCACGTACTG
CGAGCGCAAGGTGATCGGGCACATCCAGATGCGCCTCGGCCCCATGCGCGTAGGCTGGCACGGCCTTTTGCAGCCCATTG
CCGACGGCATAAAAAGTTTCTTCAAAGAAGATATCGTCCCCGTCGCCGCAGACAGGCCCATTTTTCTGGCGGCTCCCATC
ATCTGCCTAGTTCCGGCTTTCGCTTCTCTTGCCATACTGCCCTGGGCCGAGGGCTGGGCCGTTACCGATGTGAACATCGG
CCTGCTTTTCGTCTTTGCCATGAGTTCCATCGGTGCTTATGGCGTGGTGCTGGCGGGCTGGGCTTCCAACTCCAAGTACA
GCTTTCTTGGCGGATTGCGCGCTTCGGCGCAGGTGATCAGCTACGAGATAGCCATGGGGCTGAGCCTTGTGGGCGTCATG
CTGCTTTCCGGCTCGCTCAACCTTGGCGACATTGTTCAGGCGCAGGGCGACAGTTTTTTCGGCATGTTCATTTTCCGGCA
GATTATCGGCTTTTTTGTATTCTGCGTGGCCATGCTGGCCGAAACGAACAGGGTTCCTTTTGACCTGCCCGAGGCGGAAA
CTGAGCTTGTTTCAGGCTATTCCACCGAATACAGCGGCATGCGCTACGCGCTTTTTTTCATGGCCGAGTATACATCCATG
TTCGTTATGGCCACCGTGGGTACCATATGCTTTCTCGGCGGCTGGAACGGGCCGGTAGACCTGCCATTTTTTCCGCCGTT
CTGGCTGCTTATCAAAGTATATTTTATCATGTTCGTTTTTTTCTGGCTACGCGCCACCCTGCCACGTTACCGCTACGACC
AGTTGATGTCTCTTGGCTGGAAGGTGCTCATTCCCCTGGCGCTGCTCAACATCGTGCTGACGGCCATCGGCAGGGCCGTG
TTCGGCTAG

Upstream 100 bases:

>100_bases
GGGCGAATCGGACCGCTGAAGCCCGACGCGGCATGCCCGCGTACGCCCGGCGGCTTGTAGGCGCAACATGACAAAACGGG
TCTGAAACAGGACAAGCCAT

Downstream 100 bases:

>100_bases
GGCGGACAGCCTTGTGCGCAACGGAATCCATGAAGGTTTCTGCTTTGGAGGCCACTGATGCAAGTACAGTACAAACCGCG
CCGTAACTGGTTGCAAACAT

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 1; NDH-1 subunit H 1 [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MDILLILLQLIVLFVLVMLHVAYATYCERKVIGHIQMRLGPMRVGWHGLLQPIADGIKSFFKEDIVPVAADRPIFLAAPI
ICLVPAFASLAILPWAEGWAVTDVNIGLLFVFAMSSIGAYGVVLAGWASNSKYSFLGGLRASAQVISYEIAMGLSLVGVM
LLSGSLNLGDIVQAQGDSFFGMFIFRQIIGFFVFCVAMLAETNRVPFDLPEAETELVSGYSTEYSGMRYALFFMAEYTSM
FVMATVGTICFLGGWNGPVDLPFFPPFWLLIKVYFIMFVFFWLRATLPRYRYDQLMSLGWKVLIPLALLNIVLTAIGRAV
FG

Sequences:

>Translated_322_residues
MDILLILLQLIVLFVLVMLHVAYATYCERKVIGHIQMRLGPMRVGWHGLLQPIADGIKSFFKEDIVPVAADRPIFLAAPI
ICLVPAFASLAILPWAEGWAVTDVNIGLLFVFAMSSIGAYGVVLAGWASNSKYSFLGGLRASAQVISYEIAMGLSLVGVM
LLSGSLNLGDIVQAQGDSFFGMFIFRQIIGFFVFCVAMLAETNRVPFDLPEAETELVSGYSTEYSGMRYALFFMAEYTSM
FVMATVGTICFLGGWNGPVDLPFFPPFWLLIKVYFIMFVFFWLRATLPRYRYDQLMSLGWKVLIPLALLNIVLTAIGRAV
FG
>Mature_322_residues
MDILLILLQLIVLFVLVMLHVAYATYCERKVIGHIQMRLGPMRVGWHGLLQPIADGIKSFFKEDIVPVAADRPIFLAAPI
ICLVPAFASLAILPWAEGWAVTDVNIGLLFVFAMSSIGAYGVVLAGWASNSKYSFLGGLRASAQVISYEIAMGLSLVGVM
LLSGSLNLGDIVQAQGDSFFGMFIFRQIIGFFVFCVAMLAETNRVPFDLPEAETELVSGYSTEYSGMRYALFFMAEYTSM
FVMATVGTICFLGGWNGPVDLPFFPPFWLLIKVYFIMFVFFWLRATLPRYRYDQLMSLGWKVLIPLALLNIVLTAIGRAV
FG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=288, Percent_Identity=40.2777777777778, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI1788618, Length=316, Percent_Identity=46.2025316455696, Blast_Score=289, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 35721; Mature: 35721

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDILLILLQLIVLFVLVMLHVAYATYCERKVIGHIQMRLGPMRVGWHGLLQPIADGIKSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FKEDIVPVAADRPIFLAAPIICLVPAFASLAILPWAEGWAVTDVNIGLLFVFAMSSIGAY
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCHH
GVVLAGWASNSKYSFLGGLRASAQVISYEIAMGLSLVGVMLLSGSLNLGDIVQAQGDSFF
HHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHH
GMFIFRQIIGFFVFCVAMLAETNRVPFDLPEAETELVSGYSTEYSGMRYALFFMAEYTSM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
FVMATVGTICFLGGWNGPVDLPFFPPFWLLIKVYFIMFVFFWLRATLPRYRYDQLMSLGW
HHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
KVLIPLALLNIVLTAIGRAVFG
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDILLILLQLIVLFVLVMLHVAYATYCERKVIGHIQMRLGPMRVGWHGLLQPIADGIKSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FKEDIVPVAADRPIFLAAPIICLVPAFASLAILPWAEGWAVTDVNIGLLFVFAMSSIGAY
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCHH
GVVLAGWASNSKYSFLGGLRASAQVISYEIAMGLSLVGVMLLSGSLNLGDIVQAQGDSFF
HHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHH
GMFIFRQIIGFFVFCVAMLAETNRVPFDLPEAETELVSGYSTEYSGMRYALFFMAEYTSM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
FVMATVGTICFLGGWNGPVDLPFFPPFWLLIKVYFIMFVFFWLRATLPRYRYDQLMSLGW
HHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
KVLIPLALLNIVLTAIGRAVFG
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA