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The map label for this gene is nuoN

Identifier: 220904920

GI number: 220904920

Start: 1991142

End: 1992659

Strand: Reverse

Name: nuoN

Synonym: Ddes_1655

Alternate gene names: 220904920

Gene position: 1992659-1991142 (Counterclockwise)

Preceding gene: 220904921

Following gene: 220904919

Centisome position: 69.35

GC content: 59.03

Gene sequence:

>1518_bases
ATGACTGATACTGTTATTGCGCCTCTTTCTGCACTTCCCTTGCTGGCCGATCTGCCCGCCCTTGCGCCGGAGCTGGTTCT
GCTGGTCACGGCTGTCTGCCTCATGCTTGGCGATCTTTTTTATCCGCGCGAGCGGGTTTTCCAGCAGTGGCTTACCGCCG
CCGGGGCCGCCGTTGCTCTTGCCCTGACCCTGAGCATGAACTTCAGCGGCGGAGCCACCGCCTTTGGAGGCGTGTTTCGC
GCTGACGGTCTGGCCGCGGCCTTCAAGGTCGTCTGCCTGGCGGCCCTTGGTCTTACCGCCCTTATGAGCGAGGCCTTTTG
CCGCCATGCCTCCATGCGCCAGGGGGAGTATTACAGCCTCATGGCCTTTTCCACTCTCGGCATGTGCGTCATGGTTTCGG
CAGGCGATGCCATAGTGCTTTATCTTGGGCTTGAGTTGATGGCCCTGCCCATTTACGCCCTTGTGGCCCTGCGCACGGCT
GATCCGCGTAGCAGCGAGGCTGCCATCAAGTATTTTCTTATGGGCAGTTTTGCATCGGCCCTGCTGCTTTTTGGCCTGTC
CATTCTTTATGGTCTGACAGGGCAGACAGATATTGCAGAAATGGCGCACCGCCTTGCCGTAAGTCTGAGCGTATCGGACA
TGCACACCCTGCCTGCGGCAGTGGTGGCTCTGGGGCTGGTGCTGGCCGGGTTGGGCTTCAAGGTGGCGACGGTTCCCTTT
CATGTATGGGCGCCGGATGTTTACGAAGGCGCGCCTACCACCGTTACGGCTTTTATGTCTGTAGCGGCCAAAACGGCCAG
TTTTGCCGTGCTTGGGCGTGTGCTTTTGCAGGGGTTGCCGCAACTGAGCCCGTTATGGAGTGATGCCTTGGCCGGACTCG
CGGTGCTGACCATGCTTCTCGGCAACATTGCCGCCCTGGCCCAGACAAGCCTTAAACGCATGCTGGCCTATTCGGCCATT
GCGCATGCCGGGTACGCGCTCCTGGGCCTTGCCGCCTGTACTCCTGAAGGGCTGAGAGCTACGGCCGCCTACCTGACCAT
TTACCTGTGCATGAATATCGGCGCATTTGCCGTTATAATCTACCTTTCCGCCCGCTCCGGCAGAGGCCGTATGGGCGAAG
GCCCCGACGCCGGAGAGGATCTGGACGACTATCGCGGGCTTGCCGCGCGCAGCCCGCTTCTGGCGGCGGTTATGCTGGTT
TTTCTTTTCTCGCTGACGGGCATTCCGCCCACGGCCGGTTTTATGGGCAAGTTCATGCTGTTTCGTGCGGCCTTCGCGGC
CGGGTATCAGATTACTGTAGTGGTGGCTGTTGTGTGCAGCACCATATCGGCCTGGTATTATCTTGGTGTTGCAAAACGCA
TGTACATGCAGGATAGTCAAGATGATGCCCCCGCAACATCCTGCGCCATAACGGGCGAAACGGGCTTGCAAGCCGTGCTC
GCCGTCTGTCTTGCTGGAGCGGTGTTGTGGGGTATCTTCCCGCAATCATTGCTTTTCTGGATTAATGTGTATTTTTGA

Upstream 100 bases:

>100_bases
CTGGAATACACCCACGCTTCAGTAGAGCGGCTTGTCAGTGACACGCAGCAGGTTTTTGCGGCTTTTGCAGCCCGGTAGGG
CGGAGTAACAAGGAGCCACC

Downstream 100 bases:

>100_bases
CAAGGGCTGATCCTGTGCCGCTCTCTTCGGGGCGCACATAATTCAGGTGTTGACAAAGCAAATCTGGAGGAGATTGTTTA
TGAAAAACAGATGGATGCTC

Product: proton-translocating NADH-quinone oxidoreductase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTDTVIAPLSALPLLADLPALAPELVLLVTAVCLMLGDLFYPRERVFQQWLTAAGAAVALALTLSMNFSGGATAFGGVFR
ADGLAAAFKVVCLAALGLTALMSEAFCRHASMRQGEYYSLMAFSTLGMCVMVSAGDAIVLYLGLELMALPIYALVALRTA
DPRSSEAAIKYFLMGSFASALLLFGLSILYGLTGQTDIAEMAHRLAVSLSVSDMHTLPAAVVALGLVLAGLGFKVATVPF
HVWAPDVYEGAPTTVTAFMSVAAKTASFAVLGRVLLQGLPQLSPLWSDALAGLAVLTMLLGNIAALAQTSLKRMLAYSAI
AHAGYALLGLAACTPEGLRATAAYLTIYLCMNIGAFAVIIYLSARSGRGRMGEGPDAGEDLDDYRGLAARSPLLAAVMLV
FLFSLTGIPPTAGFMGKFMLFRAAFAAGYQITVVVAVVCSTISAWYYLGVAKRMYMQDSQDDAPATSCAITGETGLQAVL
AVCLAGAVLWGIFPQSLLFWINVYF

Sequences:

>Translated_505_residues
MTDTVIAPLSALPLLADLPALAPELVLLVTAVCLMLGDLFYPRERVFQQWLTAAGAAVALALTLSMNFSGGATAFGGVFR
ADGLAAAFKVVCLAALGLTALMSEAFCRHASMRQGEYYSLMAFSTLGMCVMVSAGDAIVLYLGLELMALPIYALVALRTA
DPRSSEAAIKYFLMGSFASALLLFGLSILYGLTGQTDIAEMAHRLAVSLSVSDMHTLPAAVVALGLVLAGLGFKVATVPF
HVWAPDVYEGAPTTVTAFMSVAAKTASFAVLGRVLLQGLPQLSPLWSDALAGLAVLTMLLGNIAALAQTSLKRMLAYSAI
AHAGYALLGLAACTPEGLRATAAYLTIYLCMNIGAFAVIIYLSARSGRGRMGEGPDAGEDLDDYRGLAARSPLLAAVMLV
FLFSLTGIPPTAGFMGKFMLFRAAFAAGYQITVVVAVVCSTISAWYYLGVAKRMYMQDSQDDAPATSCAITGETGLQAVL
AVCLAGAVLWGIFPQSLLFWINVYF
>Mature_504_residues
TDTVIAPLSALPLLADLPALAPELVLLVTAVCLMLGDLFYPRERVFQQWLTAAGAAVALALTLSMNFSGGATAFGGVFRA
DGLAAAFKVVCLAALGLTALMSEAFCRHASMRQGEYYSLMAFSTLGMCVMVSAGDAIVLYLGLELMALPIYALVALRTAD
PRSSEAAIKYFLMGSFASALLLFGLSILYGLTGQTDIAEMAHRLAVSLSVSDMHTLPAAVVALGLVLAGLGFKVATVPFH
VWAPDVYEGAPTTVTAFMSVAAKTASFAVLGRVLLQGLPQLSPLWSDALAGLAVLTMLLGNIAALAQTSLKRMLAYSAIA
HAGYALLGLAACTPEGLRATAAYLTIYLCMNIGAFAVIIYLSARSGRGRMGEGPDAGEDLDDYRGLAARSPLLAAVMLVF
LFSLTGIPPTAGFMGKFMLFRAAFAAGYQITVVVAVVCSTISAWYYLGVAKRMYMQDSQDDAPATSCAITGETGLQAVLA
VCLAGAVLWGIFPQSLLFWINVYF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=217, Percent_Identity=29.9539170506912, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI145693160, Length=489, Percent_Identity=34.7648261758691, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1788614, Length=362, Percent_Identity=28.1767955801105, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788827, Length=361, Percent_Identity=27.4238227146814, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788613, Length=390, Percent_Identity=23.3333333333333, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788831, Length=362, Percent_Identity=26.2430939226519, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367154, Length=403, Percent_Identity=24.5657568238213, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788829, Length=380, Percent_Identity=25.2631578947368, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_DESDA (B8J1C7)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480232.1
- GeneID:   7285358
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1655
- HOGENOM:   HBG747830
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 52961; Mature: 52830

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x27db2d6c)-; HASH(0x28716cc0)-; HASH(0x2890c46c)-; HASH(0x2854f984)-; HASH(0x289255b4)-; HASH(0x282354a0)-; HASH(0x27dffe9c)-; HASH(0x28918024)-; HASH(0x28759090)-; HASH(0x2725e148)-; HASH(0x2854f87c)-; HASH(0x289255f0)-; HASH(0x2890c304)-; HASH(0x27596f74)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTVIAPLSALPLLADLPALAPELVLLVTAVCLMLGDLFYPRERVFQQWLTAAGAAVAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ALTLSMNFSGGATAFGGVFRADGLAAAFKVVCLAALGLTALMSEAFCRHASMRQGEYYSL
HHHHEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
MAFSTLGMCVMVSAGDAIVLYLGLELMALPIYALVALRTADPRSSEAAIKYFLMGSFASA
HHHHHHCCEEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LLLFGLSILYGLTGQTDIAEMAHRLAVSLSVSDMHTLPAAVVALGLVLAGLGFKVATVPF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
HVWAPDVYEGAPTTVTAFMSVAAKTASFAVLGRVLLQGLPQLSPLWSDALAGLAVLTMLL
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GNIAALAQTSLKRMLAYSAIAHAGYALLGLAACTPEGLRATAAYLTIYLCMNIGAFAVII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YLSARSGRGRMGEGPDAGEDLDDYRGLAARSPLLAAVMLVFLFSLTGIPPTAGFMGKFML
HEECCCCCCCCCCCCCCCCCHHHHCCHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FRAAFAAGYQITVVVAVVCSTISAWYYLGVAKRMYMQDSQDDAPATSCAITGETGLQAVL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHH
AVCLAGAVLWGIFPQSLLFWINVYF
HHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
TDTVIAPLSALPLLADLPALAPELVLLVTAVCLMLGDLFYPRERVFQQWLTAAGAAVAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ALTLSMNFSGGATAFGGVFRADGLAAAFKVVCLAALGLTALMSEAFCRHASMRQGEYYSL
HHHHEECCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
MAFSTLGMCVMVSAGDAIVLYLGLELMALPIYALVALRTADPRSSEAAIKYFLMGSFASA
HHHHHHCCEEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LLLFGLSILYGLTGQTDIAEMAHRLAVSLSVSDMHTLPAAVVALGLVLAGLGFKVATVPF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
HVWAPDVYEGAPTTVTAFMSVAAKTASFAVLGRVLLQGLPQLSPLWSDALAGLAVLTMLL
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
GNIAALAQTSLKRMLAYSAIAHAGYALLGLAACTPEGLRATAAYLTIYLCMNIGAFAVII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YLSARSGRGRMGEGPDAGEDLDDYRGLAARSPLLAAVMLVFLFSLTGIPPTAGFMGKFML
HEECCCCCCCCCCCCCCCCCHHHHCCHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FRAAFAAGYQITVVVAVVCSTISAWYYLGVAKRMYMQDSQDDAPATSCAITGETGLQAVL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHH
AVCLAGAVLWGIFPQSLLFWINVYF
HHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA