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The map label for this gene is fabF [H]

Identifier: 220904881

GI number: 220904881

Start: 1940026

End: 1941276

Strand: Direct

Name: fabF [H]

Synonym: Ddes_1616

Alternate gene names: 220904881

Gene position: 1940026-1941276 (Clockwise)

Preceding gene: 220904880

Following gene: 220904882

Centisome position: 67.52

GC content: 59.39

Gene sequence:

>1251_bases
ATGACCCGTCCCCGCGTAGTAATCACCGGCGTTGGCGGCGTTACGCCCCTCGCCAACGATATTGAGAGCACCTGGAAAAA
ACTGCTCGCAGGCGAGTCGGGCATCGCGCCCATCACGCTTTTTGACGCTTCCGCCTACGATTCGCGTATCGCGGGAGAAG
TGAAAAATTTTGTGCCCGAAGATTTCATGCCCGCCAAACAGGTGCGGCGCATGGACCGTTTTACCCAGTTTGCCGTGGCT
TCGGCCCAGATGCTGCTCAGGGACGCGGGCTATGAAGTGACGGACGCCAATGCCTATGACACCGCCGTTATTCTCGGCAT
CGGCCTTGGCGGCCTGCACACTATTGAAACGTACCACGCCAAGCTGCTGGAGGCCGGCCCCAACAGGATATCGCCCTTCA
TGATTCCCATGTTGATTTCAAACATGGGTCCGGGGCAGATTTCCATCTTTACAGGCGCCAAAGGCCCCAATATTGTCACC
ACCACGGCCTGCGCCTCGGCCATTCATGCCATGGGTACCGCGTTCAGCGAAATTCTGCTGGGCCGGGTCAAGGCTGTCAT
CACCGGTGGTGTGGAGGCCACGGTAACGCCCCTCGGCGTGGCCGGCTTTACGGCGCTCAAGGCGCTCTCCACCCAGTACA
ATGACGCCCCCACCAAGGCCTCGCGCCCGTTCGACGCCAAACGCGATGGCTTTGTCATCGGCGAAGGGGCCGGGCTGCTC
TTTGTTGAAACGCTGGAATCGGCTCAGGAACGCGGGGCCAGGATATATGCGGAGCTGGTCGGCTATGGCGCGTCGGGCGA
CGCCTACCACATGACCGCCCCCTGTGAAAATGGCGAAGGCATGGCCCGCGCCATGCAAAATGCCCTGCGCGAAGCCGGGA
TAGACCCGTCGGCCATCGGGCACATCAATGCCCACGCCACGTCCACCATGCTCAATGACAGCACGGAAACGAAGGCGATC
AAGCTGGTTTTCGGCGCCCACGCCAAGAAGGTCAAAATCTCTGCCACCAAATCCATGACCGGTCACCTGCTCGGCGCGGC
CGGCGGCATAGAATCTGTCTTCACCGCGCTGGCCCTGCATGATGAAAAGCTGCCGGGTACCATCAACCTTGAAAATCCCG
ATCCGGAATGCGATCTCGACTATATGGCTGACGGATCCCAAAATATCGCCTGTGAGTATGCCATGTGCAACTCTTTTGGC
TTTGGCGGCACCAATGCCAGCCTGATCCTGAAGAAGTGGGACGATAAATAG

Upstream 100 bases:

>100_bases
CCATTGCCTATATCGAAGAAAAGAAATAGCAAGGTTTGTTCGCCAGATATGCAGCGTGCGAGGGGGCGATAAAGCCCCCT
CCCGCACCAAAGGAGCATGC

Downstream 100 bases:

>100_bases
CATGCCGTCCGCCATGCCTGCCGGTACGGTTCGTATTTCCGGCAGGCATCCGGCGGCGCACGGTTAGCGTCTCCGCGCCG
CTACGGGACAACCCTGTTTT

Product: 3-oxoacyl-(acyl-carrier-protein) synthase 2

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTRPRVVITGVGGVTPLANDIESTWKKLLAGESGIAPITLFDASAYDSRIAGEVKNFVPEDFMPAKQVRRMDRFTQFAVA
SAQMLLRDAGYEVTDANAYDTAVILGIGLGGLHTIETYHAKLLEAGPNRISPFMIPMLISNMGPGQISIFTGAKGPNIVT
TTACASAIHAMGTAFSEILLGRVKAVITGGVEATVTPLGVAGFTALKALSTQYNDAPTKASRPFDAKRDGFVIGEGAGLL
FVETLESAQERGARIYAELVGYGASGDAYHMTAPCENGEGMARAMQNALREAGIDPSAIGHINAHATSTMLNDSTETKAI
KLVFGAHAKKVKISATKSMTGHLLGAAGGIESVFTALALHDEKLPGTINLENPDPECDLDYMADGSQNIACEYAMCNSFG
FGGTNASLILKKWDDK

Sequences:

>Translated_416_residues
MTRPRVVITGVGGVTPLANDIESTWKKLLAGESGIAPITLFDASAYDSRIAGEVKNFVPEDFMPAKQVRRMDRFTQFAVA
SAQMLLRDAGYEVTDANAYDTAVILGIGLGGLHTIETYHAKLLEAGPNRISPFMIPMLISNMGPGQISIFTGAKGPNIVT
TTACASAIHAMGTAFSEILLGRVKAVITGGVEATVTPLGVAGFTALKALSTQYNDAPTKASRPFDAKRDGFVIGEGAGLL
FVETLESAQERGARIYAELVGYGASGDAYHMTAPCENGEGMARAMQNALREAGIDPSAIGHINAHATSTMLNDSTETKAI
KLVFGAHAKKVKISATKSMTGHLLGAAGGIESVFTALALHDEKLPGTINLENPDPECDLDYMADGSQNIACEYAMCNSFG
FGGTNASLILKKWDDK
>Mature_415_residues
TRPRVVITGVGGVTPLANDIESTWKKLLAGESGIAPITLFDASAYDSRIAGEVKNFVPEDFMPAKQVRRMDRFTQFAVAS
AQMLLRDAGYEVTDANAYDTAVILGIGLGGLHTIETYHAKLLEAGPNRISPFMIPMLISNMGPGQISIFTGAKGPNIVTT
TACASAIHAMGTAFSEILLGRVKAVITGGVEATVTPLGVAGFTALKALSTQYNDAPTKASRPFDAKRDGFVIGEGAGLLF
VETLESAQERGARIYAELVGYGASGDAYHMTAPCENGEGMARAMQNALREAGIDPSAIGHINAHATSTMLNDSTETKAIK
LVFGAHAKKVKISATKSMTGHLLGAAGGIESVFTALALHDEKLPGTINLENPDPECDLDYMADGSQNIACEYAMCNSFGF
GGTNASLILKKWDDK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=42.7884615384615, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI223972627, Length=225, Percent_Identity=41.3333333333333, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI41872631, Length=423, Percent_Identity=24.5862884160757, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=52.0581113801453, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=36.9565217391304, Blast_Score=218, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI71983541, Length=418, Percent_Identity=37.5598086124402, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=44.2307692307692, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI212642053, Length=426, Percent_Identity=26.9953051643192, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17550940, Length=271, Percent_Identity=26.5682656826568, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=37.4164810690423, Blast_Score=274, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=41.9431279620853, Blast_Score=321, Evalue=5e-88,
Organism=Drosophila melanogaster, GI19920632, Length=429, Percent_Identity=24.9417249417249, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221330659, Length=429, Percent_Identity=24.9417249417249, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24581345, Length=430, Percent_Identity=23.4883720930233, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43799; Mature: 43668

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPRVVITGVGGVTPLANDIESTWKKLLAGESGIAPITLFDASAYDSRIAGEVKNFVPE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCC
DFMPAKQVRRMDRFTQFAVASAQMLLRDAGYEVTDANAYDTAVILGIGLGGLHTIETYHA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEEECCCCHHHHHHHHH
KLLEAGPNRISPFMIPMLISNMGPGQISIFTGAKGPNIVTTTACASAIHAMGTAFSEILL
HHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHH
GRVKAVITGGVEATVTPLGVAGFTALKALSTQYNDAPTKASRPFDAKRDGFVIGEGAGLL
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEE
FVETLESAQERGARIYAELVGYGASGDAYHMTAPCENGEGMARAMQNALREAGIDPSAIG
EHHHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHCC
HINAHATSTMLNDSTETKAIKLVFGAHAKKVKISATKSMTGHLLGAAGGIESVFTALALH
CEECCHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHEECCCCHHHHHHHHHHC
DEKLPGTINLENPDPECDLDYMADGSQNIACEYAMCNSFGFGGTNASLILKKWDDK
CCCCCCEEECCCCCCCCCCHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
TRPRVVITGVGGVTPLANDIESTWKKLLAGESGIAPITLFDASAYDSRIAGEVKNFVPE
CCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCC
DFMPAKQVRRMDRFTQFAVASAQMLLRDAGYEVTDANAYDTAVILGIGLGGLHTIETYHA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEEEEEECCCCHHHHHHHHH
KLLEAGPNRISPFMIPMLISNMGPGQISIFTGAKGPNIVTTTACASAIHAMGTAFSEILL
HHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHH
GRVKAVITGGVEATVTPLGVAGFTALKALSTQYNDAPTKASRPFDAKRDGFVIGEGAGLL
HHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEE
FVETLESAQERGARIYAELVGYGASGDAYHMTAPCENGEGMARAMQNALREAGIDPSAIG
EHHHHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHCC
HINAHATSTMLNDSTETKAIKLVFGAHAKKVKISATKSMTGHLLGAAGGIESVFTALALH
CEECCHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHEECCCCHHHHHHHHHHC
DEKLPGTINLENPDPECDLDYMADGSQNIACEYAMCNSFGFGGTNASLILKKWDDK
CCCCCCEEECCCCCCCCCCHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]