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The map label for this gene is murC

Identifier: 220904385

GI number: 220904385

Start: 1308073

End: 1309446

Strand: Direct

Name: murC

Synonym: Ddes_1114

Alternate gene names: 220904385

Gene position: 1308073-1309446 (Clockwise)

Preceding gene: 220904384

Following gene: 220904386

Centisome position: 45.52

GC content: 56.11

Gene sequence:

>1374_bases
ATGAACAGCAAGATCCGGCACATCCACATGGTGGGCATTGGCGGCGCGGGTATGAGCGGCATTGCCGAGGTACTGCTCAA
TCTCAAATACGAAATTTCCGGTTCGGATATGAGCGATTCTGCCGTTGTCCGGCATCTGCGCAGCCTGGGTGCGCGTATTG
CGGTCGGGCATGCGGCAGAAAATGTAGGAGACGTGCAGGTGCTGGTCAAGTCCACAGCCATCAGCGATGATAATCCCGAG
CTTGTGGAGGCTCGCAAGCGCAATATCGCCATTATCCCCCGCGCTGAAATGCTGGCCGAGCTTATGCGTCTGCGCCAGGG
CATTGCCATTGCGGGTACGCACGGCAAAACCACGACCACATCGCTTACTGCCTCGATTTTTGATGAAGCCGGTCTTGATC
CCACTGTCATCATCGGCGGGCGTCTCAATGTTTACGGGGCCAATGCCCATCTTGGGCATGGGGAATACCTGATTGCCGAG
GCCGACGAATCTGACGGATCGTTTCTTTGCCTGTTGCCCATCATCAACGTGGTGACAAACGTGGACGAGGACCATCTGGA
CCATTACAAAACGCGGGAAGCCATAAACAGTGCCTTTGTGCAGTTCATGAACAATGTGCCGTTCTACGGCCTGAACATTG
TTTGTGGAGATGATCCCGGCGTGCTGGAACTTTTGCCGCAGGTAAAACGTCCGGTGCTTACCTATGGCTTTGCCGAGGAT
AACGCCCTGCGCGCTGTGCCACTGGAAAGCGGTCGGATCAGCCGCTTTCAGGTTTGGCTGCATGATGAAAAACTGGGCGA
AGTCAGTCTGCCGCAGCCGGGTCGCCACAATATCCTCAATGCACTTGCCTCTATCGGTGCAGCCATGGAGGTGGGTATCA
GCTTTGAAAAGTGTGCCGCGGGCCTGTGTGGATTCAAGGGTGTGGGGCGTCGCTTTGAATTCAAGGGCGAAAAACAGGGA
GTTACTGTGGTGGACGACTACGGCCATCATCCTGCTGAAATCGCCGCGACCCTTGCCACTGCCCGCCAGGTTTTCGAAGG
GCGGCGTATCGTGGCGGCGTTTCAGCCGCACCGCTTCAGCCGCACCGAAGCCCATTTTGGAGAGTTTTGCAAGGTTTTCA
ACAATGTTGACCAGTTGCTGCTGACGGAAATTTATGCAGCCTCTGAAAATCCCATCCCCGGTGTTTCGGGGCAAAGTCTT
GCGCAGGGGATTCGCCAGGTATCCTCAACGCCTGTGGAATATTTTCAGACGCTGGATGACCTTGCCCGGGCATTGCCGGA
TATTCTGCAGGAAGGGGATGTGTTGCTGACCCTGGGGGCGGGCAACATCACCCGTTTGGGGCCGACATGGCTGGAAGGGC
TTGATCATGCGTGA

Upstream 100 bases:

>100_bases
TTTTGGAAGAGATAGCCCGTCTGCGCTGAACGCGGTTGCGGGATATTTGGGTGGCAGACTGCCGCCTGTGGATTATCTAG
ACATTCTTTAAAGGTAACGC

Downstream 100 bases:

>100_bases
AATCGCTTCGCCGCAACTCGCCCAGCGTACAACGCTGCACCTTGGCGGGACAGCAATTGCAGAGCTGATTCTTGAAGGCC
CCGAGGATATAGTTCCATTA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MNSKIRHIHMVGIGGAGMSGIAEVLLNLKYEISGSDMSDSAVVRHLRSLGARIAVGHAAENVGDVQVLVKSTAISDDNPE
LVEARKRNIAIIPRAEMLAELMRLRQGIAIAGTHGKTTTTSLTASIFDEAGLDPTVIIGGRLNVYGANAHLGHGEYLIAE
ADESDGSFLCLLPIINVVTNVDEDHLDHYKTREAINSAFVQFMNNVPFYGLNIVCGDDPGVLELLPQVKRPVLTYGFAED
NALRAVPLESGRISRFQVWLHDEKLGEVSLPQPGRHNILNALASIGAAMEVGISFEKCAAGLCGFKGVGRRFEFKGEKQG
VTVVDDYGHHPAEIAATLATARQVFEGRRIVAAFQPHRFSRTEAHFGEFCKVFNNVDQLLLTEIYAASENPIPGVSGQSL
AQGIRQVSSTPVEYFQTLDDLARALPDILQEGDVLLTLGAGNITRLGPTWLEGLDHA

Sequences:

>Translated_457_residues
MNSKIRHIHMVGIGGAGMSGIAEVLLNLKYEISGSDMSDSAVVRHLRSLGARIAVGHAAENVGDVQVLVKSTAISDDNPE
LVEARKRNIAIIPRAEMLAELMRLRQGIAIAGTHGKTTTTSLTASIFDEAGLDPTVIIGGRLNVYGANAHLGHGEYLIAE
ADESDGSFLCLLPIINVVTNVDEDHLDHYKTREAINSAFVQFMNNVPFYGLNIVCGDDPGVLELLPQVKRPVLTYGFAED
NALRAVPLESGRISRFQVWLHDEKLGEVSLPQPGRHNILNALASIGAAMEVGISFEKCAAGLCGFKGVGRRFEFKGEKQG
VTVVDDYGHHPAEIAATLATARQVFEGRRIVAAFQPHRFSRTEAHFGEFCKVFNNVDQLLLTEIYAASENPIPGVSGQSL
AQGIRQVSSTPVEYFQTLDDLARALPDILQEGDVLLTLGAGNITRLGPTWLEGLDHA
>Mature_457_residues
MNSKIRHIHMVGIGGAGMSGIAEVLLNLKYEISGSDMSDSAVVRHLRSLGARIAVGHAAENVGDVQVLVKSTAISDDNPE
LVEARKRNIAIIPRAEMLAELMRLRQGIAIAGTHGKTTTTSLTASIFDEAGLDPTVIIGGRLNVYGANAHLGHGEYLIAE
ADESDGSFLCLLPIINVVTNVDEDHLDHYKTREAINSAFVQFMNNVPFYGLNIVCGDDPGVLELLPQVKRPVLTYGFAED
NALRAVPLESGRISRFQVWLHDEKLGEVSLPQPGRHNILNALASIGAAMEVGISFEKCAAGLCGFKGVGRRFEFKGEKQG
VTVVDDYGHHPAEIAATLATARQVFEGRRIVAAFQPHRFSRTEAHFGEFCKVFNNVDQLLLTEIYAASENPIPGVSGQSL
AQGIRQVSSTPVEYFQTLDDLARALPDILQEGDVLLTLGAGNITRLGPTWLEGLDHA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=460, Percent_Identity=48.0434782608696, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1790680, Length=463, Percent_Identity=28.7257019438445, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_DESDA (B8IZU2)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002479697.1
- ProteinModelPortal:   B8IZU2
- GeneID:   7284796
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1114
- HOGENOM:   HBG476594
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49344; Mature: 49344

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKIRHIHMVGIGGAGMSGIAEVLLNLKYEISGSDMSDSAVVRHLRSLGARIAVGHAAE
CCCCEEEEEEEEECCCCHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHCCCEEEECHHHC
NVGDVQVLVKSTAISDDNPELVEARKRNIAIIPRAEMLAELMRLRQGIAIAGTHGKTTTT
CCCCEEEEEEHHCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCEEEECCCCCCHH
SLTASIFDEAGLDPTVIIGGRLNVYGANAHLGHGEYLIAEADESDGSFLCLLPIINVVTN
HHHHHHHHHCCCCCEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
VDEDHLDHYKTREAINSAFVQFMNNVPFYGLNIVCGDDPGVLELLPQVKRPVLTYGFAED
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCC
NALRAVPLESGRISRFQVWLHDEKLGEVSLPQPGRHNILNALASIGAAMEVGISFEKCAA
CCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCHHHHHCCCHHHHHH
GLCGFKGVGRRFEFKGEKQGVTVVDDYGHHPAEIAATLATARQVFEGRRIVAAFQPHRFS
HHCCCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
RTEAHFGEFCKVFNNVDQLLLTEIYAASENPIPGVSGQSLAQGIRQVSSTPVEYFQTLDD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
LARALPDILQEGDVLLTLGAGNITRLGPTWLEGLDHA
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MNSKIRHIHMVGIGGAGMSGIAEVLLNLKYEISGSDMSDSAVVRHLRSLGARIAVGHAAE
CCCCEEEEEEEEECCCCHHHHHHHHHHCEEEECCCCCCHHHHHHHHHHCCCEEEECHHHC
NVGDVQVLVKSTAISDDNPELVEARKRNIAIIPRAEMLAELMRLRQGIAIAGTHGKTTTT
CCCCEEEEEEHHCCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCEEEECCCCCCHH
SLTASIFDEAGLDPTVIIGGRLNVYGANAHLGHGEYLIAEADESDGSFLCLLPIINVVTN
HHHHHHHHHCCCCCEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
VDEDHLDHYKTREAINSAFVQFMNNVPFYGLNIVCGDDPGVLELLPQVKRPVLTYGFAED
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCC
NALRAVPLESGRISRFQVWLHDEKLGEVSLPQPGRHNILNALASIGAAMEVGISFEKCAA
CCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCHHHHHCCCHHHHHH
GLCGFKGVGRRFEFKGEKQGVTVVDDYGHHPAEIAATLATARQVFEGRRIVAAFQPHRFS
HHCCCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
RTEAHFGEFCKVFNNVDQLLLTEIYAASENPIPGVSGQSLAQGIRQVSSTPVEYFQTLDD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHH
LARALPDILQEGDVLLTLGAGNITRLGPTWLEGLDHA
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA