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The map label for this gene is atoC [H]

Identifier: 220904126

GI number: 220904126

Start: 998416

End: 999795

Strand: Direct

Name: atoC [H]

Synonym: Ddes_0853

Alternate gene names: 220904126

Gene position: 998416-999795 (Clockwise)

Preceding gene: 220904125

Following gene: 220904127

Centisome position: 34.75

GC content: 54.06

Gene sequence:

>1380_bases
ATGAGTGAAAAAGCGCATATTCTGATTATTGACGACGAAAAAAACTACCTTCTTGTTCTGCAGACCCTGCTGGAAGATGA
AGGGTACACCGTTACCGCCATCAGCGATCCAGAAACGGCACTGGCCTTTCTGGATGAAAGCGAAGTGGACGTGGTGGTCA
CGGACATGAAGATGCCCAAGGTAACAGGGCGCCAGGTGCTGGAACGGGTCAAGAAAAGCTGGCCGTATATTCCCGTGCTT
ATCATGACGGCATTCGGCTCCATTGAAAGCGCTGTGGAGCTTATGAAGTATGGCGCTTTCGACTACATTACCAAGCCGTT
TTCCAATGATGAACTGCTGCTTTCCATTCACAACGCGGTGGAACTTGCCCGCGCGCACCGGCAATACCGACTGTTGCAGG
AAGTGATGGAAGACCGCTACGGCGTCCACAAGATTGTGGGGCGCAGCCGCGCCATACGTGATGTGCTCATCATGGTCGAG
CGCGCCGCTCCCAGCCGGTCAACCGTGCTCATCACAGGTGAGTCGGGTACGGGCAAAGAACTGATTGCCCGCGCCATCCA
CTATACAAGCCCGCGTAAAGACAATCCTTTTGTTTCGGTCAACTGTATGGCGCTCAATCCCGGCGTGCTTGAAAGCGAGC
TTTTCGGGCATGAAAAAGGATCTTTTACCGGGGCAGTTGCCATGCGTCGGGGGCGTTTTGAGCAGGCCGACGGCGGCACG
CTTTTTCTTGATGAAATCGCCGAACTGACGCCGGACCTTCAGGTCAAGCTGCTGCGGGTGCTTCAGGAGCGGCGCTTTGA
GCGCGTTGGCGGAGGAGAGGAGATCGAGGTGGACATCCGCGTGGTGGCCGCCACCAATAAAGACCTTGCCGCCATGGTGG
AAAAGGGCACGTTTCGTGATGACCTCTATTACCGGCTCAATGTGGTGCAGATTCCCCTGCCGCCTCTGCGCGAACGCCGG
GAAGACATCCCGCTGCTTGTGGCTCACTTTGTAGATAAAGTCTGCACAGACAATACGATGCCTGCAAAAACCTTCAGCAC
CGAGGCTCTCAACTACCTAACGGGCTATGAGTGGCCTGGCAATATCCGTCAGCTTGAAAATGTGGTTGAAAGCTGTCTGG
TATTGGTACCCGGTACTGTCATCAATGTTGATAATCTGCCCGCAGAGATTCGCGATGAAGAGTCGCAGTTCAAAAGTGCT
GTGGACCTTCTGCCCGTACAGCTTGACCTGGCCGATACGCTGGAAAAAATTGAGGCCGCGCTTATCCGCCGTGCGCTGGT
ACGTGCTGACCTTGTTCAGGTTAAGGCGGCAGAATATTTGGGAATTTCAAAAAGCCTGCTGCAATACAAGTTGAAAAAAT
ACGCCATAACCGGGCACTAG

Upstream 100 bases:

>100_bases
AGCCACGGCGGCGTGATCCAACTGGAAAACGGCCCGGAAGGCGGCGCTCTTGTACGTGTGCTGCTGCCCGAAGCCCATGC
CGGGGTACAGGAATAGTCTC

Downstream 100 bases:

>100_bases
ACAGCTTGTTTTGGGGCATGCGTCCTCAGTCCTGATCAGGATGCATGCTGCGGCGGCAGCCGTGTAAACAGGCAATCTGC
TTGTTTTTATTGTTTTTCCA

Product: Fis family two component sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSEKAHILIIDDEKNYLLVLQTLLEDEGYTVTAISDPETALAFLDESEVDVVVTDMKMPKVTGRQVLERVKKSWPYIPVL
IMTAFGSIESAVELMKYGAFDYITKPFSNDELLLSIHNAVELARAHRQYRLLQEVMEDRYGVHKIVGRSRAIRDVLIMVE
RAAPSRSTVLITGESGTGKELIARAIHYTSPRKDNPFVSVNCMALNPGVLESELFGHEKGSFTGAVAMRRGRFEQADGGT
LFLDEIAELTPDLQVKLLRVLQERRFERVGGGEEIEVDIRVVAATNKDLAAMVEKGTFRDDLYYRLNVVQIPLPPLRERR
EDIPLLVAHFVDKVCTDNTMPAKTFSTEALNYLTGYEWPGNIRQLENVVESCLVLVPGTVINVDNLPAEIRDEESQFKSA
VDLLPVQLDLADTLEKIEAALIRRALVRADLVQVKAAEYLGISKSLLQYKLKKYAITGH

Sequences:

>Translated_459_residues
MSEKAHILIIDDEKNYLLVLQTLLEDEGYTVTAISDPETALAFLDESEVDVVVTDMKMPKVTGRQVLERVKKSWPYIPVL
IMTAFGSIESAVELMKYGAFDYITKPFSNDELLLSIHNAVELARAHRQYRLLQEVMEDRYGVHKIVGRSRAIRDVLIMVE
RAAPSRSTVLITGESGTGKELIARAIHYTSPRKDNPFVSVNCMALNPGVLESELFGHEKGSFTGAVAMRRGRFEQADGGT
LFLDEIAELTPDLQVKLLRVLQERRFERVGGGEEIEVDIRVVAATNKDLAAMVEKGTFRDDLYYRLNVVQIPLPPLRERR
EDIPLLVAHFVDKVCTDNTMPAKTFSTEALNYLTGYEWPGNIRQLENVVESCLVLVPGTVINVDNLPAEIRDEESQFKSA
VDLLPVQLDLADTLEKIEAALIRRALVRADLVQVKAAEYLGISKSLLQYKLKKYAITGH
>Mature_458_residues
SEKAHILIIDDEKNYLLVLQTLLEDEGYTVTAISDPETALAFLDESEVDVVVTDMKMPKVTGRQVLERVKKSWPYIPVLI
MTAFGSIESAVELMKYGAFDYITKPFSNDELLLSIHNAVELARAHRQYRLLQEVMEDRYGVHKIVGRSRAIRDVLIMVER
AAPSRSTVLITGESGTGKELIARAIHYTSPRKDNPFVSVNCMALNPGVLESELFGHEKGSFTGAVAMRRGRFEQADGGTL
FLDEIAELTPDLQVKLLRVLQERRFERVGGGEEIEVDIRVVAATNKDLAAMVEKGTFRDDLYYRLNVVQIPLPPLRERRE
DIPLLVAHFVDKVCTDNTMPAKTFSTEALNYLTGYEWPGNIRQLENVVESCLVLVPGTVINVDNLPAEIRDEESQFKSAV
DLLPVQLDLADTLEKIEAALIRRALVRADLVQVKAAEYLGISKSLLQYKLKKYAITGH

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=44.4201312910284, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1790437, Length=447, Percent_Identity=45.413870246085, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1790299, Length=471, Percent_Identity=38.8535031847134, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1788905, Length=383, Percent_Identity=43.0809399477807, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI87082117, Length=336, Percent_Identity=47.3214285714286, Blast_Score=284, Evalue=8e-78,
Organism=Escherichia coli, GI1789087, Length=356, Percent_Identity=44.6629213483146, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=41.7177914110429, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=43.8871473354232, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI87082152, Length=236, Percent_Identity=48.728813559322, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1787583, Length=357, Percent_Identity=35.8543417366947, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786524, Length=343, Percent_Identity=38.1924198250729, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI87081858, Length=310, Percent_Identity=34.5161290322581, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1789828, Length=271, Percent_Identity=34.3173431734317, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51531; Mature: 51400

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKAHILIIDDEKNYLLVLQTLLEDEGYTVTAISDPETALAFLDESEVDVVVTDMKMPK
CCCCEEEEEEECCCCEEEHHHHHHCCCCCEEEEECCCCHHEEEECCCCCEEEEECCCCCC
VTGRQVLERVKKSWPYIPVLIMTAFGSIESAVELMKYGAFDYITKPFSNDELLLSIHNAV
CHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCCCCEEEEHHHHH
ELARAHRQYRLLQEVMEDRYGVHKIVGRSRAIRDVLIMVERAAPSRSTVLITGESGTGKE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHH
LIARAIHYTSPRKDNPFVSVNCMALNPGVLESELFGHEKGSFTGAVAMRRGRFEQADGGT
HHHHHHHCCCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCE
LFLDEIAELTPDLQVKLLRVLQERRFERVGGGEEIEVDIRVVAATNKDLAAMVEKGTFRD
EEHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHHHHCCCCCC
DLYYRLNVVQIPLPPLRERREDIPLLVAHFVDKVCTDNTMPAKTFSTEALNYLTGYEWPG
CCEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
NIRQLENVVESCLVLVPGTVINVDNLPAEIRDEESQFKSAVDLLPVQLDLADTLEKIEAA
CHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCHHHHHHHHHHHHEEEECHHHHHHHHHHH
LIRRALVRADLVQVKAAEYLGISKSLLQYKLKKYAITGH
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
SEKAHILIIDDEKNYLLVLQTLLEDEGYTVTAISDPETALAFLDESEVDVVVTDMKMPK
CCCEEEEEEECCCCEEEHHHHHHCCCCCEEEEECCCCHHEEEECCCCCEEEEECCCCCC
VTGRQVLERVKKSWPYIPVLIMTAFGSIESAVELMKYGAFDYITKPFSNDELLLSIHNAV
CHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCCCCEEEEHHHHH
ELARAHRQYRLLQEVMEDRYGVHKIVGRSRAIRDVLIMVERAAPSRSTVLITGESGTGKE
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHH
LIARAIHYTSPRKDNPFVSVNCMALNPGVLESELFGHEKGSFTGAVAMRRGRFEQADGGT
HHHHHHHCCCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCE
LFLDEIAELTPDLQVKLLRVLQERRFERVGGGEEIEVDIRVVAATNKDLAAMVEKGTFRD
EEHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCHHHHHHHCCCCCC
DLYYRLNVVQIPLPPLRERREDIPLLVAHFVDKVCTDNTMPAKTFSTEALNYLTGYEWPG
CCEEEEEEEEECCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
NIRQLENVVESCLVLVPGTVINVDNLPAEIRDEESQFKSAVDLLPVQLDLADTLEKIEAA
CHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCHHHHHHHHHHHHEEEECHHHHHHHHHHH
LIRRALVRADLVQVKAAEYLGISKSLLQYKLKKYAITGH
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]