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The map label for this gene is dnaA [H]

Identifier: 220904107

GI number: 220904107

Start: 978500

End: 979948

Strand: Direct

Name: dnaA [H]

Synonym: Ddes_0833

Alternate gene names: 220904107

Gene position: 978500-979948 (Clockwise)

Preceding gene: 220904106

Following gene: 220904116

Centisome position: 34.05

GC content: 55.56

Gene sequence:

>1449_bases
ATGCGAGATAAATGGGCTGAAATTTCTGAAAATCTCAAAAAAATGCTTAAATCCGGACTTTTCAAGGTCTGGATTGCTCC
TCTGCACGCCAGTGTTCATGAAGGCGGGCTGCACCTTGTGGCGCCCAATGCCTACGTGGCCGGTAGGCTGGAAAGCATGA
TGCTTGCCTCACTGCGTGAGGCTGCCGCGCCTGTTCTTGGCCTTGAGCCGGAGCAGGTCGATGTACGTATCGAGGCAGCA
GAGCAAAGTGCAGACGCAGAGATTGTTGAAGAAAAACAAAGTAGTATGCAAAAAAAACCTGCCGATAGAGCTGATGTTTC
AGCTTCCGCGCCTTCTGCCGTTGCGTCTTTTATGGCGCCGGCCCGGGCGCCGCGTCAGGCATCGCTGCCGCTTCCGTCTG
TGGCCGTGTACCGTGATACGCAGAATTGGCGATATTCCTTTGCCGATTTTGTGGTAGGACCCACCAACAATATGGCTGTT
GCCGCCGCGCAGGATGTGAGTCGCAGTTGTGGCTGTGTGCGCACCCTTTTTGTCAATTCCAGCTCGGGGCTGGGCAAAAC
ACATCTGGCCCAGGCCGTGGGGCGCGCCATCAGCGAAGAAGGCACCAATGCCCGCGTGGGCTATCTTACGGCCGAAGAAT
TTGCCTCGCGTTTCGTCACGGCCTTGCGGGCGCAGGACATTGAAGGCTTTAAGGCCCGCTTTCGCGAACTTGATGTGCTC
CTGATGGAAGACGTGCACTTTTTCCAGGGTAAGGAAAAAATGCAGGATATGGCCCTGGCTGTTGTTAAAAGCCTTCAGGC
CAAAGGCGGGCGCGCCATTTTTACCTCTTCGTTTTCACCGCGCGAACTGCAGAAAGTGGACAGCCAGCTTGTGTCGCATT
TCTGTTCCGGCATTCTGACCGACATGGGCCGACCCACCAAGGATATGCGCTGTGACATTCTTGGGCGCAAGGCCAGAACA
TTTCAGGTGCTTTTGCCCGAATCGGTCTGTGACCTGCTCGCCAGCCGCCTGACGGGCGACGTGCGTCAGATGGAGTCCTG
CCTTAACAGCCTTATCTTCAAGGCCCGCCTGCTGAACTGCGGCCTGAATGTCGATCTGGCCATGGAAGTTCTGAGCCAGT
ACGCTGACGTGGCCTGCGGTCCTGATTTTTCCACGATCCTGCGCCTTGTTTGTGAAAGTTACGGTCTTAACGAGCGCCAG
CTGTCTTCGCGCTCACGCCGCAAGGAATGCGTGGTCGGGCGCAACACGGCATTTTATCTGGCTCGCAAGCATACGGAAAT
GACCCTGGAAGAAATCGGCGAAAAATTCAACCGCCGTCATTCTACCGTCATTAAGGGCATTACTTCGCTTGAGCGTGAAC
TTTCCAGAGAATCCACTGAGGGCCGTCGTATCGCCCGCGCCGTATCACTTATTGAGCGTAATGCAGGGCTGGCTGAACGC
CCCATGTAG

Upstream 100 bases:

>100_bases
TTAACAGGAATGGCAATTGGGGAAAGCAAAAGCCGCCTCCGCCCCAAACAGCCTTTATTCATCAATTGCCCGCCGCCCGG
ATTTTGGGCTACAAGGCGTC

Downstream 100 bases:

>100_bases
AGCTGTATTGCCCATACGGCAAATAAGCGGCCCGGTTTTTAAAAACCGGGCCGCTTTTGCATGATTGCGTTTGAGTGCTG
CTGTGAGATTTTGGTTCTTG

Product: Chromosomal replication initiator DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MRDKWAEISENLKKMLKSGLFKVWIAPLHASVHEGGLHLVAPNAYVAGRLESMMLASLREAAAPVLGLEPEQVDVRIEAA
EQSADAEIVEEKQSSMQKKPADRADVSASAPSAVASFMAPARAPRQASLPLPSVAVYRDTQNWRYSFADFVVGPTNNMAV
AAAQDVSRSCGCVRTLFVNSSSGLGKTHLAQAVGRAISEEGTNARVGYLTAEEFASRFVTALRAQDIEGFKARFRELDVL
LMEDVHFFQGKEKMQDMALAVVKSLQAKGGRAIFTSSFSPRELQKVDSQLVSHFCSGILTDMGRPTKDMRCDILGRKART
FQVLLPESVCDLLASRLTGDVRQMESCLNSLIFKARLLNCGLNVDLAMEVLSQYADVACGPDFSTILRLVCESYGLNERQ
LSSRSRRKECVVGRNTAFYLARKHTEMTLEEIGEKFNRRHSTVIKGITSLERELSRESTEGRRIARAVSLIERNAGLAER
PM

Sequences:

>Translated_482_residues
MRDKWAEISENLKKMLKSGLFKVWIAPLHASVHEGGLHLVAPNAYVAGRLESMMLASLREAAAPVLGLEPEQVDVRIEAA
EQSADAEIVEEKQSSMQKKPADRADVSASAPSAVASFMAPARAPRQASLPLPSVAVYRDTQNWRYSFADFVVGPTNNMAV
AAAQDVSRSCGCVRTLFVNSSSGLGKTHLAQAVGRAISEEGTNARVGYLTAEEFASRFVTALRAQDIEGFKARFRELDVL
LMEDVHFFQGKEKMQDMALAVVKSLQAKGGRAIFTSSFSPRELQKVDSQLVSHFCSGILTDMGRPTKDMRCDILGRKART
FQVLLPESVCDLLASRLTGDVRQMESCLNSLIFKARLLNCGLNVDLAMEVLSQYADVACGPDFSTILRLVCESYGLNERQ
LSSRSRRKECVVGRNTAFYLARKHTEMTLEEIGEKFNRRHSTVIKGITSLERELSRESTEGRRIARAVSLIERNAGLAER
PM
>Mature_482_residues
MRDKWAEISENLKKMLKSGLFKVWIAPLHASVHEGGLHLVAPNAYVAGRLESMMLASLREAAAPVLGLEPEQVDVRIEAA
EQSADAEIVEEKQSSMQKKPADRADVSASAPSAVASFMAPARAPRQASLPLPSVAVYRDTQNWRYSFADFVVGPTNNMAV
AAAQDVSRSCGCVRTLFVNSSSGLGKTHLAQAVGRAISEEGTNARVGYLTAEEFASRFVTALRAQDIEGFKARFRELDVL
LMEDVHFFQGKEKMQDMALAVVKSLQAKGGRAIFTSSFSPRELQKVDSQLVSHFCSGILTDMGRPTKDMRCDILGRKART
FQVLLPESVCDLLASRLTGDVRQMESCLNSLIFKARLLNCGLNVDLAMEVLSQYADVACGPDFSTILRLVCESYGLNERQ
LSSRSRRKECVVGRNTAFYLARKHTEMTLEEIGEKFNRRHSTVIKGITSLERELSRESTEGRRIARAVSLIERNAGLAER
PM

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=461, Percent_Identity=30.1518438177874, Blast_Score=195, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 53157; Mature: 53157

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDKWAEISENLKKMLKSGLFKVWIAPLHASVHEGGLHLVAPNAYVAGRLESMMLASLRE
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHH
AAAPVLGLEPEQVDVRIEAAEQSADAEIVEEKQSSMQKKPADRADVSASAPSAVASFMAP
HHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
ARAPRQASLPLPSVAVYRDTQNWRYSFADFVVGPTNNMAVAAAQDVSRSCGCVRTLFVNS
CCCCCCCCCCCCCEEEEECCCCCCEEHHHEEECCCCCEEEEEHHHHHHHCCHHHHEEEEC
SSGLGKTHLAQAVGRAISEEGTNARVGYLTAEEFASRFVTALRAQDIEGFKARFRELDVL
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LMEDVHFFQGKEKMQDMALAVVKSLQAKGGRAIFTSSFSPRELQKVDSQLVSHFCSGILT
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
DMGRPTKDMRCDILGRKARTFQVLLPESVCDLLASRLTGDVRQMESCLNSLIFKARLLNC
HCCCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHC
GLNVDLAMEVLSQYADVACGPDFSTILRLVCESYGLNERQLSSRSRRKECVVGRNTAFYL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEE
ARKHTEMTLEEIGEKFNRRHSTVIKGITSLERELSRESTEGRRIARAVSLIERNAGLAER
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
PM
CC
>Mature Secondary Structure
MRDKWAEISENLKKMLKSGLFKVWIAPLHASVHEGGLHLVAPNAYVAGRLESMMLASLRE
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHH
AAAPVLGLEPEQVDVRIEAAEQSADAEIVEEKQSSMQKKPADRADVSASAPSAVASFMAP
HHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
ARAPRQASLPLPSVAVYRDTQNWRYSFADFVVGPTNNMAVAAAQDVSRSCGCVRTLFVNS
CCCCCCCCCCCCCEEEEECCCCCCEEHHHEEECCCCCEEEEEHHHHHHHCCHHHHEEEEC
SSGLGKTHLAQAVGRAISEEGTNARVGYLTAEEFASRFVTALRAQDIEGFKARFRELDVL
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LMEDVHFFQGKEKMQDMALAVVKSLQAKGGRAIFTSSFSPRELQKVDSQLVSHFCSGILT
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
DMGRPTKDMRCDILGRKARTFQVLLPESVCDLLASRLTGDVRQMESCLNSLIFKARLLNC
HCCCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHC
GLNVDLAMEVLSQYADVACGPDFSTILRLVCESYGLNERQLSSRSRRKECVVGRNTAFYL
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEE
ARKHTEMTLEEIGEKFNRRHSTVIKGITSLERELSRESTEGRRIARAVSLIERNAGLAER
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
PM
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA