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The map label for this gene is cymR [H]

Identifier: 220904116

GI number: 220904116

Start: 989490

End: 990035

Strand: Direct

Name: cymR [H]

Synonym: Ddes_0843

Alternate gene names: 220904116

Gene position: 989490-990035 (Clockwise)

Preceding gene: 220904107

Following gene: 220904117

Centisome position: 34.44

GC content: 55.13

Gene sequence:

>546_bases
ATGCGTATTTCCACCATGGCTTGTCATGCGCTGCACCTGCTATTGTGCCTTTCTGAACAAGATCGGGCTATTCCTGCTTC
TGCTTCCGAATTGGCGGCCTGTACGGGCATTTCTGAAAAGTTTGTGCAAAAAATCATGCGCTTGCTGCAGGCTGAGGGAA
TTATCAAAAGCGTACGGGGCATCGCCGGGGGCCATATGCTTGCCCGCAACCCCGAAGCCATAACTCTGGCGGACATCATC
TGCGCAGTGGAAGGGGGCATTACCCTGCCCGGCGTCAACAGCGAAGCTCCGGCGGGCAAAGCCGCTCTGGATGTTTGGGA
TAAAGCCGCCACGGCTTTGCGCAACTCCCTTGATGCGGTTACCCTTTGCTCCGTCCGCCAGAACGCGGGGCTTTCGCAAC
GGCATGGCACGCGCCGTAAGGCTGAATATCCTGTTCACAGAAGATCAGAATCCGAACTCGGAGGCCCCAATGCAAAAGCA
TATTCTCTTGGTAGACAGCGATGCCGAAAATCTAAGCAGGATGTCGCAAGCTCTACGTCAATCTGA

Upstream 100 bases:

>100_bases
GCGCAAAGTGGCTTGAGCTAAGAATCATGAGTAAAGCAGTCTAAATTAGACGTATCAAGTATGGTAAATTTTATCGTCTC
CAGCAAAATAAGGAATAAAT

Downstream 100 bases:

>100_bases
TTATCAGGTGAGCGTAGCCGGTAATTGTGATGAAAGTCTGAACATGGTCCGCAGCCTCAAGCCTGACTGCATCATTTTTG
ATGTGGAACTGGAGGGCACG

Product: BadM/Rrf2 family transcriptional regulator

Products: NA

Alternate protein names: Cysteine metabolism repressor [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MRISTMACHALHLLLCLSEQDRAIPASASELAACTGISEKFVQKIMRLLQAEGIIKSVRGIAGGHMLARNPEAITLADII
CAVEGGITLPGVNSEAPAGKAALDVWDKAATALRNSLDAVTLCSVRQNAGLSQRHGTRRKAEYPVHRRSESELGGPNAKA
YSLGRQRCRKSKQDVASSTSI

Sequences:

>Translated_181_residues
MRISTMACHALHLLLCLSEQDRAIPASASELAACTGISEKFVQKIMRLLQAEGIIKSVRGIAGGHMLARNPEAITLADII
CAVEGGITLPGVNSEAPAGKAALDVWDKAATALRNSLDAVTLCSVRQNAGLSQRHGTRRKAEYPVHRRSESELGGPNAKA
YSLGRQRCRKSKQDVASSTSI
>Mature_181_residues
MRISTMACHALHLLLCLSEQDRAIPASASELAACTGISEKFVQKIMRLLQAEGIIKSVRGIAGGHMLARNPEAITLADII
CAVEGGITLPGVNSEAPAGKAALDVWDKAATALRNSLDAVTLCSVRQNAGLSQRHGTRRKAEYPVHRRSESELGGPNAKA
YSLGRQRCRKSKQDVASSTSI

Specific function: Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulate

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000944 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 19258; Mature: 19258

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISTMACHALHLLLCLSEQDRAIPASASELAACTGISEKFVQKIMRLLQAEGIIKSVRG
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IAGGHMLARNPEAITLADIICAVEGGITLPGVNSEAPAGKAALDVWDKAATALRNSLDAV
HHCCCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
TLCSVRQNAGLSQRHGTRRKAEYPVHRRSESELGGPNAKAYSLGRQRCRKSKQDVASSTS
HHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
I
C
>Mature Secondary Structure
MRISTMACHALHLLLCLSEQDRAIPASASELAACTGISEKFVQKIMRLLQAEGIIKSVRG
CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IAGGHMLARNPEAITLADIICAVEGGITLPGVNSEAPAGKAALDVWDKAATALRNSLDAV
HHCCCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
TLCSVRQNAGLSQRHGTRRKAEYPVHRRSESELGGPNAKAYSLGRQRCRKSKQDVASSTS
HHHHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]