Click here to switch to the map view.

The map label for this gene is mprA [H]

Identifier: 220904088

GI number: 220904088

Start: 954276

End: 954674

Strand: Direct

Name: mprA [H]

Synonym: Ddes_0814

Alternate gene names: 220904088

Gene position: 954276-954674 (Clockwise)

Preceding gene: 220904087

Following gene: 220904089

Centisome position: 33.21

GC content: 61.15

Gene sequence:

>399_bases
ATGGCTTTGCGCATACTGCTGGCTGATGACGAAAAGGATTTTGTGGAAACTCTGGCCGAAAGGCTTGAACTGCGCGGGCA
CAGCGTGCGCGTGGTTTACGACGGCCTGGCGGCCCTGCGCGCCGCTGTAGAAGATATGCCCGATGTGGTGGTGCTTGATC
TTCTCATGCCCGGTCTGCCCGGTGATGAAGTGCTGCACCGCCTCAAGAACGTGCAGCCCGATCTGCCCGTGCTGCTGCTT
ACCGGGCACGCGGCCGTGGACGACACGGGGCTTTCGCCCGTAAGCCAGGCCTATGCCTGCCTGACAAAGCCGTTAAGCTT
CAACACTTTTCTTGAAACGCTGGAGTCCGCATGCCGTGAAGGGCGCGAGGCAGCCTCCCGCGGGGGAGACATGTCATGA

Upstream 100 bases:

>100_bases
TCGGCGGCGATATCCGTGTGGACAGTGAAGAAGGGCGCGGCAGTACCGTGCGCGTGACCCTGCCTCTGGCTCCGCCTGAC
GGCTCTGTGGAGGTTTAGTA

Downstream 100 bases:

>100_bases
ATGTCAGTCAGTGTACGGCCCGCCTGCTGGCCTCGGCAGTGCACGATATGCGCAATGTTCTGGCCGTAATCCGTGAATCT
GCCGGGCTTGCGCAGGATCT

Product: response regulator receiver protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MALRILLADDEKDFVETLAERLELRGHSVRVVYDGLAALRAAVEDMPDVVVLDLLMPGLPGDEVLHRLKNVQPDLPVLLL
TGHAAVDDTGLSPVSQAYACLTKPLSFNTFLETLESACREGREAASRGGDMS

Sequences:

>Translated_132_residues
MALRILLADDEKDFVETLAERLELRGHSVRVVYDGLAALRAAVEDMPDVVVLDLLMPGLPGDEVLHRLKNVQPDLPVLLL
TGHAAVDDTGLSPVSQAYACLTKPLSFNTFLETLESACREGREAASRGGDMS
>Mature_131_residues
ALRILLADDEKDFVETLAERLELRGHSVRVVYDGLAALRAAVEDMPDVVVLDLLMPGLPGDEVLHRLKNVQPDLPVLLLT
GHAAVDDTGLSPVSQAYACLTKPLSFNTFLETLESACREGREAASRGGDMS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 14285; Mature: 14153

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALRILLADDEKDFVETLAERLELRGHSVRVVYDGLAALRAAVEDMPDVVVLDLLMPGLP
CEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
GDEVLHRLKNVQPDLPVLLLTGHAAVDDTGLSPVSQAYACLTKPLSFNTFLETLESACRE
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GREAASRGGDMS
HHHHHHCCCCCC
>Mature Secondary Structure 
ALRILLADDEKDFVETLAERLELRGHSVRVVYDGLAALRAAVEDMPDVVVLDLLMPGLP
EEEEEEECCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
GDEVLHRLKNVQPDLPVLLLTGHAAVDDTGLSPVSQAYACLTKPLSFNTFLETLESACRE
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GREAASRGGDMS
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA