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The map label for this gene is gcvPB [H]

Identifier: 220904063

GI number: 220904063

Start: 923620

End: 925068

Strand: Direct

Name: gcvPB [H]

Synonym: Ddes_0789

Alternate gene names: 220904063

Gene position: 923620-925068 (Clockwise)

Preceding gene: 220904062

Following gene: 220904067

Centisome position: 32.14

GC content: 60.25

Gene sequence:

>1449_bases
GTGAAAACCATCTTCGCCAAATCCGTTCCCGGGCGCGGCGCGTTCTGCATAGAGTCCGACGCCCCCAAGGCTGCGGACAT
GCTGCCCGCCGGCCTGCTGCGCAAGGAAGAACCGGGGCTGCCCCAATGCTCCGAGCTGGATGTGGTACGCCACTTTACCG
GCCTTTCAAAACTCAACTACAGTGTGGATGCCAATTTTTATCCGCTTGGCTCCTGCACAATGAAGTACAACCCCAAGTTT
ACTGAATACGTGGCCGCGCTGCCGGGGTTCGCGCGCCTGCACCCCATGCTTGCCCAACTGGGCGGCGCGGCGGGCTGCAC
CCAGGGCGCGTTACAGTGCATGTATGAAGCAGAAAACATGCTTTGCGAACTGACAGGCATGAAAGCCTTCACCCTGCAGC
CCATGGCCGGGGCCAATGGCGAGTTTGTGGGCGTCAAGCTTATTGCCGCCTACCACAAGGCCAAGGGGCGTGACCGCAAG
AAGATGCTCATCCCCGATGCTGCCCACGGCACCAACCCTGCCTCTGCCGCGCTGGCCGGATTCGAGACAATCAACCTTGA
ATCCCGCCACGGCATGGTAGACCCGGAAGCCATTATAGAAGCTATCCGCAAGCACGGAGAGGACGTGGCAGGGCTTATGA
TGACCTGCCCCAATACTCTGGGCCTTATGGAAGTGCATCTGCCCCGCATTGTGGCCGAGCTGCGCAAGATAGATGCGCTG
CTCTACTACGACGGAGCCAATATGAATGCCATCATGGGCAAGATGCGCGTGGGCGATGTGGGCTTTGACGTGGTGCACCT
CAATGTGCATAAAACCCTGTCCACCCCGCACGGTGGCGGTGGCCCCGGAGCGGGTCCCGTCGGCGTGAGCGAGTGCCTGC
TGCCTTTCCTGCCCGCGCCCCGTGTGCGCAAGCGTGAGGACGGCTCCTACTTCCTCGACTACGATGTGCCGCAGTCCATA
GGCTATATGGGGCCGTTTTATGGCAGCTTCGGCGTGATGGTCAAAGCGCTCGCCTACATGTTGCGCCTGGGAGGGGAGGG
CCTTACCCGGGCTTCGGAATACGCGGTGCTCAACGCCAACTATCTGAAAAAGAAGCTTGAAAACACGCTGGATATTCCCT
ATGCCGACAGGCTGTGCGCCCACGAGTTCGTGGCCTCGGCCCCGCAGGAAACCCGTGCTCTGGATATTGCCAAGGCTCTG
CTGGACCGCGGCTTCCATGCGCCGACCATCTACTTCCCGCTTATTGTGCATGAATGCATCATGGCCGAGCCGACGGAAAC
AGAAAGCAAGGAAACCCTGGATTCCTTTGTGCAGGCTCTTGAAGAGATCATGCTCCAGGCCAAGAGCGACCCGCAGGCCC
TGCTGGATGCTCCCGTAACCCTGCCCGCGCGCCGTATGGACGAGACCGGGGCCGCTCGCAACATGATCCTTACGGAAGAT
ATGGCCTAA

Upstream 100 bases:

>100_bases
GCTACTATCCCGGTATGGAAGACGTGCTGCTGCTGGCCTGCACCGAACGCAACAGCCGTCAGCAGATCGGCATGCTGGCC
GAAACCGTGGGAGGTCTGCT

Downstream 100 bases:

>100_bases
CGTCTTCGCGACAGCGGCAGTAATGCCCTAATCAGATATCAATAAACAGCAGCTCCCCCCCCGGCTTTCGGGGGAGCTGC
TGTTATTGCGAATGATGGAC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MKTIFAKSVPGRGAFCIESDAPKAADMLPAGLLRKEEPGLPQCSELDVVRHFTGLSKLNYSVDANFYPLGSCTMKYNPKF
TEYVAALPGFARLHPMLAQLGGAAGCTQGALQCMYEAENMLCELTGMKAFTLQPMAGANGEFVGVKLIAAYHKAKGRDRK
KMLIPDAAHGTNPASAALAGFETINLESRHGMVDPEAIIEAIRKHGEDVAGLMMTCPNTLGLMEVHLPRIVAELRKIDAL
LYYDGANMNAIMGKMRVGDVGFDVVHLNVHKTLSTPHGGGGPGAGPVGVSECLLPFLPAPRVRKREDGSYFLDYDVPQSI
GYMGPFYGSFGVMVKALAYMLRLGGEGLTRASEYAVLNANYLKKKLENTLDIPYADRLCAHEFVASAPQETRALDIAKAL
LDRGFHAPTIYFPLIVHECIMAEPTETESKETLDSFVQALEEIMLQAKSDPQALLDAPVTLPARRMDETGAARNMILTED
MA

Sequences:

>Translated_482_residues
MKTIFAKSVPGRGAFCIESDAPKAADMLPAGLLRKEEPGLPQCSELDVVRHFTGLSKLNYSVDANFYPLGSCTMKYNPKF
TEYVAALPGFARLHPMLAQLGGAAGCTQGALQCMYEAENMLCELTGMKAFTLQPMAGANGEFVGVKLIAAYHKAKGRDRK
KMLIPDAAHGTNPASAALAGFETINLESRHGMVDPEAIIEAIRKHGEDVAGLMMTCPNTLGLMEVHLPRIVAELRKIDAL
LYYDGANMNAIMGKMRVGDVGFDVVHLNVHKTLSTPHGGGGPGAGPVGVSECLLPFLPAPRVRKREDGSYFLDYDVPQSI
GYMGPFYGSFGVMVKALAYMLRLGGEGLTRASEYAVLNANYLKKKLENTLDIPYADRLCAHEFVASAPQETRALDIAKAL
LDRGFHAPTIYFPLIVHECIMAEPTETESKETLDSFVQALEEIMLQAKSDPQALLDAPVTLPARRMDETGAARNMILTED
MA
>Mature_482_residues
MKTIFAKSVPGRGAFCIESDAPKAADMLPAGLLRKEEPGLPQCSELDVVRHFTGLSKLNYSVDANFYPLGSCTMKYNPKF
TEYVAALPGFARLHPMLAQLGGAAGCTQGALQCMYEAENMLCELTGMKAFTLQPMAGANGEFVGVKLIAAYHKAKGRDRK
KMLIPDAAHGTNPASAALAGFETINLESRHGMVDPEAIIEAIRKHGEDVAGLMMTCPNTLGLMEVHLPRIVAELRKIDAL
LYYDGANMNAIMGKMRVGDVGFDVVHLNVHKTLSTPHGGGGPGAGPVGVSECLLPFLPAPRVRKREDGSYFLDYDVPQSI
GYMGPFYGSFGVMVKALAYMLRLGGEGLTRASEYAVLNANYLKKKLENTLDIPYADRLCAHEFVASAPQETRALDIAKAL
LDRGFHAPTIYFPLIVHECIMAEPTETESKETLDSFVQALEEIMLQAKSDPQALLDAPVTLPARRMDETGAARNMILTED
MA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=451, Percent_Identity=37.6940133037694, Blast_Score=231, Evalue=1e-60,
Organism=Escherichia coli, GI1789269, Length=433, Percent_Identity=36.2586605080831, Blast_Score=213, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17535605, Length=425, Percent_Identity=38.5882352941176, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI32564013, Length=410, Percent_Identity=37.5609756097561, Blast_Score=215, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6323843, Length=436, Percent_Identity=36.2385321100917, Blast_Score=230, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24645648, Length=414, Percent_Identity=38.4057971014493, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 52235; Mature: 52235

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIFAKSVPGRGAFCIESDAPKAADMLPAGLLRKEEPGLPQCSELDVVRHFTGLSKLNY
CCCEECCCCCCCCEEEECCCCCCHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCE
SVDANFYPLGSCTMKYNPKFTEYVAALPGFARLHPMLAQLGGAAGCTQGALQCMYEAENM
EECCCEEECCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LCELTGMKAFTLQPMAGANGEFVGVKLIAAYHKAKGRDRKKMLIPDAAHGTNPASAALAG
HHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHC
FETINLESRHGMVDPEAIIEAIRKHGEDVAGLMMTCPNTLGLMEVHLPRIVAELRKIDAL
CEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEE
LYYDGANMNAIMGKMRVGDVGFDVVHLNVHKTLSTPHGGGGPGAGPVGVSECLLPFLPAP
EEECCCCCHHHHHCCEECCCCEEEEEEEEEHEECCCCCCCCCCCCCCCHHHHHHHCCCCC
RVRKREDGSYFLDYDVPQSIGYMGPFYGSFGVMVKALAYMLRLGGEGLTRASEYAVLNAN
CCCCCCCCCEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEECHH
YLKKKLENTLDIPYADRLCAHEFVASAPQETRALDIAKALLDRGFHAPTIYFPLIVHECI
HHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MAEPTETESKETLDSFVQALEEIMLQAKSDPQALLDAPVTLPARRMDETGAARNMILTED
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHCCCCCCCCEEEECC
MA
CC
>Mature Secondary Structure
MKTIFAKSVPGRGAFCIESDAPKAADMLPAGLLRKEEPGLPQCSELDVVRHFTGLSKLNY
CCCEECCCCCCCCEEEECCCCCCHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCE
SVDANFYPLGSCTMKYNPKFTEYVAALPGFARLHPMLAQLGGAAGCTQGALQCMYEAENM
EECCCEEECCCEEEEECCCHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LCELTGMKAFTLQPMAGANGEFVGVKLIAAYHKAKGRDRKKMLIPDAAHGTNPASAALAG
HHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHC
FETINLESRHGMVDPEAIIEAIRKHGEDVAGLMMTCPNTLGLMEVHLPRIVAELRKIDAL
CEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEE
LYYDGANMNAIMGKMRVGDVGFDVVHLNVHKTLSTPHGGGGPGAGPVGVSECLLPFLPAP
EEECCCCCHHHHHCCEECCCCEEEEEEEEEHEECCCCCCCCCCCCCCCHHHHHHHCCCCC
RVRKREDGSYFLDYDVPQSIGYMGPFYGSFGVMVKALAYMLRLGGEGLTRASEYAVLNAN
CCCCCCCCCEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEECHH
YLKKKLENTLDIPYADRLCAHEFVASAPQETRALDIAKALLDRGFHAPTIYFPLIVHECI
HHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MAEPTETESKETLDSFVQALEEIMLQAKSDPQALLDAPVTLPARRMDETGAARNMILTED
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHCCCCCCCCEEEECC
MA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA