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The map label for this gene is gcvPA

Identifier: 220904062

GI number: 220904062

Start: 922292

End: 923623

Strand: Direct

Name: gcvPA

Synonym: Ddes_0788

Alternate gene names: 220904062

Gene position: 922292-923623 (Clockwise)

Preceding gene: 220904061

Following gene: 220904063

Centisome position: 32.1

GC content: 61.64

Gene sequence:

>1332_bases
ATGCCATACATCCCCCACACGCCGGAAGAGTTGCAGGAAATGCTCTCTGTGGTTGGCGTGCGCGATCTGGACGGCCTTTT
TGCCGATATCCCCCCAGAAATGCGCCCCAAACAGTTCAATCTGCCCAAAGGCCAGTCCGAAGCCGCGGTTTGCGCCTATT
TTGAAGGCCTGGCCGCCAAAAACTGCCCGGATCTCGTGTCGTTTCTGGGCGCGGGCTATTATGCTCACGACATCCCCAAA
GCTGTGGATGCTCTTGCTGGCCGCAGTGAATTCTATACCTCCTACACGCCTTATCAGCCCGAATGCTCGCAGGGAACCCT
TCAGGCCATCTTCGAGTTTCAGACGGCCATAAGCCGCCTCCTGGGCATGGATTGCGCCAACGCCTCCGTGTATGACGGCG
GCACGGCCATTTTCGAGGCCGCCATGATGGCAGTGCGCTCCACCCGCCGCCGTGTGCTGGTGGTGGACGAGGCCGTCAAT
CCCATCTGGCGGGTCATGCTGGCTTCATACATCTCCAGCCTTGATCTTGAACTCAAGACCGTGCAGCAGGAAAAGGGCGT
GAGCCGCCTTGACGCGCTCATGGCCGCCATTGACGACACCACCGCTGCCGTGATTGTGCAGAACCCCAACTTCTTCGGGG
CCGTGGCGGACTACACCCAGGTATTCGCCAAAGCCCGCGCGCACAAGGCGTTCGGCGTCATTTCCGTGTATCCTGTCATG
CAGTCCGTGCTGAAAACCCCCGGTGAAATGGGGGCGGACGTGGCGGTGGCCGAAGGCCAGAGCATAGGCATGCCCCTTTC
TTTCGGCGGTCCCTATCTGGGGCTGATGACCTGCCGCAAGGAGCATATCCGCCAGTTCCCCGGCCGTATTGTGGGCCGTA
CCACAGATGTGGACGGCAAAACAGGCTACGTGCTTACCCTGCAGGCGCGGGAGCAGCACATTCGCCGGGCCAAGGCCACA
TCCAATATCTGCTCCAACCAGGCCCTGTGCGCCCTGCGGGCGCTCATCCACCTGTCCCTGCTGGGTCCCTGCGGGCTTAC
ACGACTGGCGGAAAACAACATGGCCCTTACCCGTTACGCCGTGGAGCGCCTCACCTCCATCAAGGGCATTGAGCTTCTCA
ACGATGCGCCTTACGGCAATGAGGTGGCCCTGCGCCTGCCCATGCCCGCCCAGATGCTGGTGGATGCCCTGTCCGCGCAC
GGCTGCGTGCCCGGCTATCCTCTTGGCCGCTACTATCCCGGTATGGAAGACGTGCTGCTGCTGGCCTGCACCGAACGCAA
CAGCCGTCAGCAGATCGGCATGCTGGCCGAAACCGTGGGAGGTCTGCTGTGA

Upstream 100 bases:

>100_bases
CCGATTTGCCGCGCAAGCGAAAGCCACCCGCCGTTCCGTATCTGCGTCATCATGCTTTTTTCAGGCACACGTTCACGCGT
AACATGCTCAAGGAGCGGAT

Downstream 100 bases:

>100_bases
AAACCATCTTCGCCAAATCCGTTCCCGGGCGCGGCGCGTTCTGCATAGAGTCCGACGCCCCCAAGGCTGCGGACATGCTG
CCCGCCGGCCTGCTGCGCAA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MPYIPHTPEELQEMLSVVGVRDLDGLFADIPPEMRPKQFNLPKGQSEAAVCAYFEGLAAKNCPDLVSFLGAGYYAHDIPK
AVDALAGRSEFYTSYTPYQPECSQGTLQAIFEFQTAISRLLGMDCANASVYDGGTAIFEAAMMAVRSTRRRVLVVDEAVN
PIWRVMLASYISSLDLELKTVQQEKGVSRLDALMAAIDDTTAAVIVQNPNFFGAVADYTQVFAKARAHKAFGVISVYPVM
QSVLKTPGEMGADVAVAEGQSIGMPLSFGGPYLGLMTCRKEHIRQFPGRIVGRTTDVDGKTGYVLTLQAREQHIRRAKAT
SNICSNQALCALRALIHLSLLGPCGLTRLAENNMALTRYAVERLTSIKGIELLNDAPYGNEVALRLPMPAQMLVDALSAH
GCVPGYPLGRYYPGMEDVLLLACTERNSRQQIGMLAETVGGLL

Sequences:

>Translated_443_residues
MPYIPHTPEELQEMLSVVGVRDLDGLFADIPPEMRPKQFNLPKGQSEAAVCAYFEGLAAKNCPDLVSFLGAGYYAHDIPK
AVDALAGRSEFYTSYTPYQPECSQGTLQAIFEFQTAISRLLGMDCANASVYDGGTAIFEAAMMAVRSTRRRVLVVDEAVN
PIWRVMLASYISSLDLELKTVQQEKGVSRLDALMAAIDDTTAAVIVQNPNFFGAVADYTQVFAKARAHKAFGVISVYPVM
QSVLKTPGEMGADVAVAEGQSIGMPLSFGGPYLGLMTCRKEHIRQFPGRIVGRTTDVDGKTGYVLTLQAREQHIRRAKAT
SNICSNQALCALRALIHLSLLGPCGLTRLAENNMALTRYAVERLTSIKGIELLNDAPYGNEVALRLPMPAQMLVDALSAH
GCVPGYPLGRYYPGMEDVLLLACTERNSRQQIGMLAETVGGLL
>Mature_442_residues
PYIPHTPEELQEMLSVVGVRDLDGLFADIPPEMRPKQFNLPKGQSEAAVCAYFEGLAAKNCPDLVSFLGAGYYAHDIPKA
VDALAGRSEFYTSYTPYQPECSQGTLQAIFEFQTAISRLLGMDCANASVYDGGTAIFEAAMMAVRSTRRRVLVVDEAVNP
IWRVMLASYISSLDLELKTVQQEKGVSRLDALMAAIDDTTAAVIVQNPNFFGAVADYTQVFAKARAHKAFGVISVYPVMQ
SVLKTPGEMGADVAVAEGQSIGMPLSFGGPYLGLMTCRKEHIRQFPGRIVGRTTDVDGKTGYVLTLQAREQHIRRAKATS
NICSNQALCALRALIHLSLLGPCGLTRLAENNMALTRYAVERLTSIKGIELLNDAPYGNEVALRLPMPAQMLVDALSAHG
CVPGYPLGRYYPGMEDVLLLACTERNSRQQIGMLAETVGGLL

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=347, Percent_Identity=34.5821325648415, Blast_Score=192, Evalue=5e-49,
Organism=Escherichia coli, GI1789269, Length=365, Percent_Identity=32.3287671232877, Blast_Score=171, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17535605, Length=385, Percent_Identity=34.2857142857143, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323843, Length=362, Percent_Identity=33.9779005524862, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24645648, Length=342, Percent_Identity=33.9181286549708, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_DESDA (B8IYW9)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002479374.1
- GeneID:   7284462
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_0788
- HOGENOM:   HBG288345
- ProtClustDB:   PRK00451
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 48098; Mature: 47967

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYIPHTPEELQEMLSVVGVRDLDGLFADIPPEMRPKQFNLPKGQSEAAVCAYFEGLAAK
CCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
NCPDLVSFLGAGYYAHDIPKAVDALAGRSEFYTSYTPYQPECSQGTLQAIFEFQTAISRL
CCHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LGMDCANASVYDGGTAIFEAAMMAVRSTRRRVLVVDEAVNPIWRVMLASYISSLDLELKT
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHH
VQQEKGVSRLDALMAAIDDTTAAVIVQNPNFFGAVADYTQVFAKARAHKAFGVISVYPVM
HHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSVLKTPGEMGADVAVAEGQSIGMPLSFGGPYLGLMTCRKEHIRQFPGRIVGRTTDVDGK
HHHHCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCC
TGYVLTLQAREQHIRRAKATSNICSNQALCALRALIHLSLLGPCGLTRLAENNMALTRYA
CCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHH
VERLTSIKGIELLNDAPYGNEVALRLPMPAQMLVDALSAHGCVPGYPLGRYYPGMEDVLL
HHHHHHHCCHHHCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEE
LACTERNSRQQIGMLAETVGGLL
EEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PYIPHTPEELQEMLSVVGVRDLDGLFADIPPEMRPKQFNLPKGQSEAAVCAYFEGLAAK
CCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
NCPDLVSFLGAGYYAHDIPKAVDALAGRSEFYTSYTPYQPECSQGTLQAIFEFQTAISRL
CCHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LGMDCANASVYDGGTAIFEAAMMAVRSTRRRVLVVDEAVNPIWRVMLASYISSLDLELKT
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHH
VQQEKGVSRLDALMAAIDDTTAAVIVQNPNFFGAVADYTQVFAKARAHKAFGVISVYPVM
HHHHCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSVLKTPGEMGADVAVAEGQSIGMPLSFGGPYLGLMTCRKEHIRQFPGRIVGRTTDVDGK
HHHHCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCC
TGYVLTLQAREQHIRRAKATSNICSNQALCALRALIHLSLLGPCGLTRLAENNMALTRYA
CCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHH
VERLTSIKGIELLNDAPYGNEVALRLPMPAQMLVDALSAHGCVPGYPLGRYYPGMEDVLL
HHHHHHHCCHHHCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEE
LACTERNSRQQIGMLAETVGGLL
EEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA