Click here to switch to the map view.

The map label for this gene is mdtA [H]

Identifier: 220904006

GI number: 220904006

Start: 857899

End: 859221

Strand: Direct

Name: mdtA [H]

Synonym: Ddes_0732

Alternate gene names: 220904006

Gene position: 857899-859221 (Clockwise)

Preceding gene: 220904005

Following gene: 220904007

Centisome position: 29.86

GC content: 63.42

Gene sequence:

>1323_bases
ATGCCCGTTATTCAACATAGGCCTGTTTCCGGCCTGCTTTCAGGACGCCGCAAGGCAGTGGTCCTGATACTGGCCCTTCT
GGCTCTTGCCGCGGGCTGGAAACTGTTGGGCAGGGGAGCGGGCCGCCCGGACATGAGCATGGATGCGCCGCCGGTGCGTG
TGGCCGCCGCCCTGGCCCAGAATGTACCTCATTTTCTCAATGGTCTCGGTACGGTGCTGCCTTCCGGTGATGTGCTTGTG
ACCAGCCGGGTGGACGGGCAGTTGCTGCGCCTGCACTTTGCCGAGGGCCAGCGCGTGAAGGCCGGAGACCTGTTGGCCGA
GATTGACCCGCGTCCTTTTCAGGCCAGCCTTGACCAGGCCCTGGGCAACCTTGCCAGAGACAAGGCCCAGCTTGAAAACG
CGCGCAAAGACCTTTCCCGCTACGCCAAACTTGTTCAGGGCAGTTTTATCGCCGCCCAGCAGTATGAAACGCAACGCGCG
CTGGTGCGTCAGTACGAAGGCACGGTTGAAGCTGACCAGGCCGCCGTGGATTCTGCGCGCCTGCAACTGGAATACAGCCG
GATTACCGCACCCATCAGCGGCCGTCTCGGCCTGCGTAATGTGGACGAGGGCAATATGATCAAAAGCTCGGACTCCGGCG
GGCTTGTGCGCATTACTGAAATCAGCCCATGTGACGTCATTTTTACCCTGCCCGAAAGTCAGGTGCCGCTGGTTGTGCAG
GCCCTGCGCCGTGCTGAAGCGCAGCCTGCCCCGCACCGTCTGGCGGTTCAGGCCTGGGACAGGGAGCAGAAGTACCTGCT
GGGCACAGGCCGCCTGATTTCTCTTGATAACCAGATAGACAGCGCCACGGGCACAGTGCGCCTCAAGGCAGTTTTTCCCA
ACAAGGACGAAGCGCTGTATCCCAACCAGTTTGTCAACGCCAGGCTTTTGGTGCGCGTGCTGCATGACGCGGTTACGGTT
CCCGCCGCTGCGGTGCAGCTTGGCAGGCGCGGCGCGTATGTCTATGTGGTGCGCCAGGGTGAAAAGGGTGGGGATGAGGC
GGAACTGCGCCTGGTCACGCCGGGCATCAGTGCCGGCGGCCTGACGGTCATTGAAAAAGGACTTGAACCTGGAGAAAAAG
TGGTGGTCGACGGTCTGGACCGCCTGCGCGAGGGCATTGCCGTGCGCGTTGCGGCCACCACGGAAACGCCCAGGGCCGAA
AGCGCCGATACCGCGCCCGAAAACGGCCCGGACGCCGTTTCGGCGTTCGCTCCCGGCACTCCGCCATCCGCTGGCGCATC
GTCTCCGGCCGGGCCAGCTCCCGGCACGGGCGGGGCACCGTAA

Upstream 100 bases:

>100_bases
TGGGCTGGCGGCTCGAGCTTGCGTCACTTCCCGCAGGCGTGGATGGAGTGACCGTTTTCAGCCTTATTTTCCCCCCGGCA
GCCCAAGGAGAAGACGTATA

Downstream 100 bases:

>100_bases
GCTTTTTTTCGTGCCGCCCGGCTCACAGGATATATGCCGCCATGAATCTTTCCCGCATTTTTATTCTCCGGCCCATAGCC
ACGTCTCTGCTCATGGTGGC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MPVIQHRPVSGLLSGRRKAVVLILALLALAAGWKLLGRGAGRPDMSMDAPPVRVAAALAQNVPHFLNGLGTVLPSGDVLV
TSRVDGQLLRLHFAEGQRVKAGDLLAEIDPRPFQASLDQALGNLARDKAQLENARKDLSRYAKLVQGSFIAAQQYETQRA
LVRQYEGTVEADQAAVDSARLQLEYSRITAPISGRLGLRNVDEGNMIKSSDSGGLVRITEISPCDVIFTLPESQVPLVVQ
ALRRAEAQPAPHRLAVQAWDREQKYLLGTGRLISLDNQIDSATGTVRLKAVFPNKDEALYPNQFVNARLLVRVLHDAVTV
PAAAVQLGRRGAYVYVVRQGEKGGDEAELRLVTPGISAGGLTVIEKGLEPGEKVVVDGLDRLREGIAVRVAATTETPRAE
SADTAPENGPDAVSAFAPGTPPSAGASSPAGPAPGTGGAP

Sequences:

>Translated_440_residues
MPVIQHRPVSGLLSGRRKAVVLILALLALAAGWKLLGRGAGRPDMSMDAPPVRVAAALAQNVPHFLNGLGTVLPSGDVLV
TSRVDGQLLRLHFAEGQRVKAGDLLAEIDPRPFQASLDQALGNLARDKAQLENARKDLSRYAKLVQGSFIAAQQYETQRA
LVRQYEGTVEADQAAVDSARLQLEYSRITAPISGRLGLRNVDEGNMIKSSDSGGLVRITEISPCDVIFTLPESQVPLVVQ
ALRRAEAQPAPHRLAVQAWDREQKYLLGTGRLISLDNQIDSATGTVRLKAVFPNKDEALYPNQFVNARLLVRVLHDAVTV
PAAAVQLGRRGAYVYVVRQGEKGGDEAELRLVTPGISAGGLTVIEKGLEPGEKVVVDGLDRLREGIAVRVAATTETPRAE
SADTAPENGPDAVSAFAPGTPPSAGASSPAGPAPGTGGAP
>Mature_439_residues
PVIQHRPVSGLLSGRRKAVVLILALLALAAGWKLLGRGAGRPDMSMDAPPVRVAAALAQNVPHFLNGLGTVLPSGDVLVT
SRVDGQLLRLHFAEGQRVKAGDLLAEIDPRPFQASLDQALGNLARDKAQLENARKDLSRYAKLVQGSFIAAQQYETQRAL
VRQYEGTVEADQAAVDSARLQLEYSRITAPISGRLGLRNVDEGNMIKSSDSGGLVRITEISPCDVIFTLPESQVPLVVQA
LRRAEAQPAPHRLAVQAWDREQKYLLGTGRLISLDNQIDSATGTVRLKAVFPNKDEALYPNQFVNARLLVRVLHDAVTVP
AAAVQLGRRGAYVYVVRQGEKGGDEAELRLVTPGISAGGLTVIEKGLEPGEKVVVDGLDRLREGIAVRVAATTETPRAES
ADTAPENGPDAVSAFAPGTPPSAGASSPAGPAPGTGGAP

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=361, Percent_Identity=50.9695290858726, Blast_Score=354, Evalue=6e-99,
Organism=Escherichia coli, GI1789665, Length=325, Percent_Identity=34.7692307692308, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1786668, Length=327, Percent_Identity=32.1100917431193, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789929, Length=320, Percent_Identity=29.375, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI87081951, Length=173, Percent_Identity=30.635838150289, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081796, Length=330, Percent_Identity=24.8484848484848, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 46557; Mature: 46425

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVIQHRPVSGLLSGRRKAVVLILALLALAAGWKLLGRGAGRPDMSMDAPPVRVAAALAQ
CCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCHHHHHHHHHH
NVPHFLNGLGTVLPSGDVLVTSRVDGQLLRLHFAEGQRVKAGDLLAEIDPRPFQASLDQA
CCHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCEEECCCHHHHCCCCCHHHHHHHH
LGNLARDKAQLENARKDLSRYAKLVQGSFIAAQQYETQRALVRQYEGTVEADQAAVDSAR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LQLEYSRITAPISGRLGLRNVDEGNMIKSSDSGGLVRITEISPCDVIFTLPESQVPLVVQ
EEEEEHHEECCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCEEEECCCCCCCHHHH
ALRRAEAQPAPHRLAVQAWDREQKYLLGTGRLISLDNQIDSATGTVRLKAVFPNKDEALY
HHHHHCCCCCCCEEEEEECCCCCEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCCCC
PNQFVNARLLVRVLHDAVTVPAAAVQLGRRGAYVYVVRQGEKGGDEAELRLVTPGISAGG
CCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCC
LTVIEKGLEPGEKVVVDGLDRLREGIAVRVAATTETPRAESADTAPENGPDAVSAFAPGT
HHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCCC
PPSAGASSPAGPAPGTGGAP
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVIQHRPVSGLLSGRRKAVVLILALLALAAGWKLLGRGAGRPDMSMDAPPVRVAAALAQ
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCHHHHHHHHHH
NVPHFLNGLGTVLPSGDVLVTSRVDGQLLRLHFAEGQRVKAGDLLAEIDPRPFQASLDQA
CCHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCEEECCCHHHHCCCCCHHHHHHHH
LGNLARDKAQLENARKDLSRYAKLVQGSFIAAQQYETQRALVRQYEGTVEADQAAVDSAR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LQLEYSRITAPISGRLGLRNVDEGNMIKSSDSGGLVRITEISPCDVIFTLPESQVPLVVQ
EEEEEHHEECCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCEEEECCCCCCCHHHH
ALRRAEAQPAPHRLAVQAWDREQKYLLGTGRLISLDNQIDSATGTVRLKAVFPNKDEALY
HHHHHCCCCCCCEEEEEECCCCCEEEEECCCEEEECCCCCCCCCEEEEEEECCCCCCCCC
PNQFVNARLLVRVLHDAVTVPAAAVQLGRRGAYVYVVRQGEKGGDEAELRLVTPGISAGG
CCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCC
LTVIEKGLEPGEKVVVDGLDRLREGIAVRVAATTETPRAESADTAPENGPDAVSAFAPGT
HHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCCC
PPSAGASSPAGPAPGTGGAP
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA