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The map label for this gene is rmlA1 [H]

Identifier: 220903818

GI number: 220903818

Start: 652621

End: 653514

Strand: Direct

Name: rmlA1 [H]

Synonym: Ddes_0541

Alternate gene names: 220903818

Gene position: 652621-653514 (Clockwise)

Preceding gene: 220903817

Following gene: 220903819

Centisome position: 22.71

GC content: 59.06

Gene sequence:

>894_bases
ATGAGCGCATGGAAAGGCATTGTTCTTGCCGGGGGATCAGGTTCGCGCCTTTATCCCCTGACCCTGAGCGTGAGCAAGCA
GCTCATGCCCATCTACGACAAGCCCATGATTTACTATCCGCTGGCCACCCTGCTGATGGCCGGCATCCGCGAAATATGCC
TTATTTCGACGCCCGACCACCTTCCACTGTACCAGGCCCTGCTGCAGGACGGTTCCCAGTGGGGCTGCTCCATCTCTTAT
GTTGCGCAGCCGCGCCCCGAGGGGCTGGCGCAGGCCTTTTTGCTGGCGGAAGAGCATATTGCCGGGCATAACACCTGTCT
TGTGCTTGGCGACAACGTTTTTTTTGGCCACGGCATGCCCGATCTTACCCGTGAGGCCATGACGCGCAGCCGGGGAGCGA
CCGTTTTTGGCTATCATGTGCGCGATCCGCAGCGCTATGGCGTGGTGGAGTTTGACAGCGAGCGCCGCGTGGTGAGCATT
GAGGAAAAGCCCCGGGAGCCAAAATCAAATTTCGCCGTTACGGGTTTGTATTTTTATGACGCCGATGTGGTGAACATCGC
CCGTTCTGTGCGGCCTTCGGCACGCGGCGAGCTTGAAATAACCGACGTCAACAATGCCTATCTGGCGCGCGGCGACCTGC
ATGTGGAGCTTATGGGCCGGGGTATCGCATGGCTGGACACGGGTACCCACGATTCTCTCATGGATGCCGGGGCCTTTGTG
CAGGCCGTGGAAAAACGCCAGGGCCTCAAGGTGGCCTGCCTTGAAGAAATTGCCTGGCGCAACGGCTATATTTCATCCGA
TGAGGTGCGCGCCCTGGCACGGCCCATGGGCAAGACCGGCTACGGCCAGTATTTGCTTGACCTTGTGGATACGGGGATAG
GCCAATGGAAGTAG

Upstream 100 bases:

>100_bases
ACAGCGCCTGGGTAGATCTTGTGCGCAGCGGGGCCTATCTTGAGTGGATGGATATCAACTACGGGCGGCGTACCATTGCA
GGCGGCGGGGGGGAAAGCCT

Downstream 100 bases:

>100_bases
CGGCAACGCCTCTGGCCGGAGTCATGCTTATAAAGCCCAGGGTATGGGGTGACAGGCGGGGCTATTTTGTCGAGACCTGG
CAGCATGAACGGTACGCGGC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSAWKGIVLAGGSGSRLYPLTLSVSKQLMPIYDKPMIYYPLATLLMAGIREICLISTPDHLPLYQALLQDGSQWGCSISY
VAQPRPEGLAQAFLLAEEHIAGHNTCLVLGDNVFFGHGMPDLTREAMTRSRGATVFGYHVRDPQRYGVVEFDSERRVVSI
EEKPREPKSNFAVTGLYFYDADVVNIARSVRPSARGELEITDVNNAYLARGDLHVELMGRGIAWLDTGTHDSLMDAGAFV
QAVEKRQGLKVACLEEIAWRNGYISSDEVRALARPMGKTGYGQYLLDLVDTGIGQWK

Sequences:

>Translated_297_residues
MSAWKGIVLAGGSGSRLYPLTLSVSKQLMPIYDKPMIYYPLATLLMAGIREICLISTPDHLPLYQALLQDGSQWGCSISY
VAQPRPEGLAQAFLLAEEHIAGHNTCLVLGDNVFFGHGMPDLTREAMTRSRGATVFGYHVRDPQRYGVVEFDSERRVVSI
EEKPREPKSNFAVTGLYFYDADVVNIARSVRPSARGELEITDVNNAYLARGDLHVELMGRGIAWLDTGTHDSLMDAGAFV
QAVEKRQGLKVACLEEIAWRNGYISSDEVRALARPMGKTGYGQYLLDLVDTGIGQWK
>Mature_296_residues
SAWKGIVLAGGSGSRLYPLTLSVSKQLMPIYDKPMIYYPLATLLMAGIREICLISTPDHLPLYQALLQDGSQWGCSISYV
AQPRPEGLAQAFLLAEEHIAGHNTCLVLGDNVFFGHGMPDLTREAMTRSRGATVFGYHVRDPQRYGVVEFDSERRVVSIE
EKPREPKSNFAVTGLYFYDADVVNIARSVRPSARGELEITDVNNAYLARGDLHVELMGRGIAWLDTGTHDSLMDAGAFVQ
AVEKRQGLKVACLEEIAWRNGYISSDEVRALARPMGKTGYGQYLLDLVDTGIGQWK

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=251, Percent_Identity=25.0996015936255, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI11761621, Length=251, Percent_Identity=25.0996015936255, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788351, Length=289, Percent_Identity=61.9377162629758, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=62.1052631578947, Blast_Score=386, Evalue=1e-109,
Organism=Escherichia coli, GI1787488, Length=243, Percent_Identity=26.3374485596708, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=182, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=27.6679841897233, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=24.7011952191235, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=24.7011952191235, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32845; Mature: 32714

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAWKGIVLAGGSGSRLYPLTLSVSKQLMPIYDKPMIYYPLATLLMAGIREICLISTPDH
CCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCC
LPLYQALLQDGSQWGCSISYVAQPRPEGLAQAFLLAEEHIAGHNTCLVLGDNVFFGHGMP
CHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCC
DLTREAMTRSRGATVFGYHVRDPQRYGVVEFDSERRVVSIEEKPREPKSNFAVTGLYFYD
HHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
ADVVNIARSVRPSARGELEITDVNNAYLARGDLHVELMGRGIAWLDTGTHDSLMDAGAFV
CHHHHHHHHCCCCCCCCEEEEECCCEEEEECCEEEEEECCCEEEEECCCCHHHHHHHHHH
QAVEKRQGLKVACLEEIAWRNGYISSDEVRALARPMGKTGYGQYLLDLVDTGIGQWK
HHHHHHCCCEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAWKGIVLAGGSGSRLYPLTLSVSKQLMPIYDKPMIYYPLATLLMAGIREICLISTPDH
CCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCC
LPLYQALLQDGSQWGCSISYVAQPRPEGLAQAFLLAEEHIAGHNTCLVLGDNVFFGHGMP
CHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCEEEECCCC
DLTREAMTRSRGATVFGYHVRDPQRYGVVEFDSERRVVSIEEKPREPKSNFAVTGLYFYD
HHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
ADVVNIARSVRPSARGELEITDVNNAYLARGDLHVELMGRGIAWLDTGTHDSLMDAGAFV
CHHHHHHHHCCCCCCCCEEEEECCCEEEEECCEEEEEECCCEEEEECCCCHHHHHHHHHH
QAVEKRQGLKVACLEEIAWRNGYISSDEVRALARPMGKTGYGQYLLDLVDTGIGQWK
HHHHHHCCCEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]