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The map label for this gene is rmlC [H]

Identifier: 220903819

GI number: 220903819

Start: 653505

End: 654044

Strand: Direct

Name: rmlC [H]

Synonym: Ddes_0542

Alternate gene names: 220903819

Gene position: 653505-654044 (Clockwise)

Preceding gene: 220903818

Following gene: 220903821

Centisome position: 22.74

GC content: 60.0

Gene sequence:

>540_bases
ATGGAAGTAGCGGCAACGCCTCTGGCCGGAGTCATGCTTATAAAGCCCAGGGTATGGGGTGACAGGCGGGGCTATTTTGT
CGAGACCTGGCAGCATGAACGGTACGCGGCTGCGGGCATTGACGCGGCTTTTGTGCAGGATAACCATTCCATGTCGACGT
ATGGCATATTGCGCGGCCTACATTTCCAGAAAACCCGTCCCCAGGGCAAGCTTGTGAGCGTTTCCCTGGGCAGGGTATTT
GATGTGGCCGTGGATATCCGGCCCGGGTCGCCCACCTTCGGCCAGTGGTATGGCGTGGAGCTGACGCAGGACAATCAGTG
GCAGCTCTGGGTTCCGCCGGGCATGGCGCACGGCTTTGCCGTGACCAGCCAGGTGGCGCACTTTCATTACAAGTGCACAG
ACTATTACTGCCCCGAAGACGAAGGGGGCATACGCTGGAACGATCCGGACCTTGCTGTGGCCTGGCCCGTGGCGCAGCCT
CTTTTGTCGGACAAGGACCGGCACACGCCTTCGTGGCGGGAATTTCTGGCAGGACTGTAA

Upstream 100 bases:

>100_bases
GCTATATTTCATCCGATGAGGTGCGCGCCCTGGCACGGCCCATGGGCAAGACCGGCTACGGCCAGTATTTGCTTGACCTT
GTGGATACGGGGATAGGCCA

Downstream 100 bases:

>100_bases
GAATATCAGGGGGATGTATATGCTTCAGCAGCGATAAGGCTTGGGCAAAAAATTGTAAGAGCTGGATGTTTTTGCAATGA
GTTGAAGACCGCTTACGCGC

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MEVAATPLAGVMLIKPRVWGDRRGYFVETWQHERYAAAGIDAAFVQDNHSMSTYGILRGLHFQKTRPQGKLVSVSLGRVF
DVAVDIRPGSPTFGQWYGVELTQDNQWQLWVPPGMAHGFAVTSQVAHFHYKCTDYYCPEDEGGIRWNDPDLAVAWPVAQP
LLSDKDRHTPSWREFLAGL

Sequences:

>Translated_179_residues
MEVAATPLAGVMLIKPRVWGDRRGYFVETWQHERYAAAGIDAAFVQDNHSMSTYGILRGLHFQKTRPQGKLVSVSLGRVF
DVAVDIRPGSPTFGQWYGVELTQDNQWQLWVPPGMAHGFAVTSQVAHFHYKCTDYYCPEDEGGIRWNDPDLAVAWPVAQP
LLSDKDRHTPSWREFLAGL
>Mature_179_residues
MEVAATPLAGVMLIKPRVWGDRRGYFVETWQHERYAAAGIDAAFVQDNHSMSTYGILRGLHFQKTRPQGKLVSVSLGRVF
DVAVDIRPGSPTFGQWYGVELTQDNQWQLWVPPGMAHGFAVTSQVAHFHYKCTDYYCPEDEGGIRWNDPDLAVAWPVAQP
LLSDKDRHTPSWREFLAGL

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=179, Percent_Identity=48.6033519553073, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17550412, Length=174, Percent_Identity=43.6781609195402, Blast_Score=141, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 20231; Mature: 20231

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVAATPLAGVMLIKPRVWGDRRGYFVETWQHERYAAAGIDAAFVQDNHSMSTYGILRGL
CCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCEEECCCCCEEEEECCCCCCHHHHHHCC
HFQKTRPQGKLVSVSLGRVFDVAVDIRPGSPTFGQWYGVELTQDNQWQLWVPPGMAHGFA
CCCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCCHH
VTSQVAHFHYKCTDYYCPEDEGGIRWNDPDLAVAWPVAQPLLSDKDRHTPSWREFLAGL
HHHHHEEEEEEECCEECCCCCCCEEECCCCEEEECCCHHHHHCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MEVAATPLAGVMLIKPRVWGDRRGYFVETWQHERYAAAGIDAAFVQDNHSMSTYGILRGL
CCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCEEECCCCCEEEEECCCCCCHHHHHHCC
HFQKTRPQGKLVSVSLGRVFDVAVDIRPGSPTFGQWYGVELTQDNQWQLWVPPGMAHGFA
CCCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCCCHH
VTSQVAHFHYKCTDYYCPEDEGGIRWNDPDLAVAWPVAQPLLSDKDRHTPSWREFLAGL
HHHHHEEEEEEECCEECCCCCCCEEECCCCEEEECCCHHHHHCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]