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The map label for this gene is uppS [H]

Identifier: 220903795

GI number: 220903795

Start: 628722

End: 629564

Strand: Reverse

Name: uppS [H]

Synonym: Ddes_0518

Alternate gene names: 220903795

Gene position: 629564-628722 (Counterclockwise)

Preceding gene: 220903796

Following gene: 220903794

Centisome position: 21.91

GC content: 63.11

Gene sequence:

>843_bases
ATGACCCCACACGACACTCTCCTGCCGGGGCAGAAGCCCTGCACACAGGCGGACGCCACAGCCGCCGGAGCAACCGCCGC
ACAACCCGCAGCTGACGATGGCCGGGAAAGCGGCCGCGCCGGTGACCTGCCGGTCACGCAGCTGCCTGTTCATCTGGCGA
TCATTATGGACGGTAACGGCCGCTGGGCACAGGCCCGAAACCTGCCGCGCGAGGCAGGGCACAAGGCAGGGGCCGAGGCC
GTGCGCGCCGTGGTTACAGAGTGCCGCAGGCTGGGCATACGCCACCTGACGCTCTATACGTTCTCCAGTGAAAACTGGAA
CCGCCCCAAGGCGGAAATAAGCGCCCTGTTCTCACTATTGCTGGAATTTCTGCGCCGGGAACTGCCGCGCCTTGAAGAAC
AGGGCATCGCCCTCAGGGTGCTGGGTGATCTGGACGGCCTGCCGCTGGCACAGCGCACTGCCCTGCGCCACGCCATAAAA
CGCACGGCCGACGGCCCGCATATGGTTTTGAACCTGGCACTCAATTATGGTTCGCGGGCAGAACTGGTGCGCGCCATGCG
CTCTTTTCTGCATGACGGTGCACGGCCCGAAGATATTACTGAAGAAAGCCTGGCACAGCGCCTTTATACCGCGGGACAGC
CCGATCCGGACCTGCTCATCCGTACCAGCGGCGAGCAGCGCCTGAGCAACTACCTGCTGTACCAGTGCGCTTACAGTGAG
TTGTACTTTACCCAGGTGGCCTGGCCAGATTTTGACGCCGCGCAACTGCGTCTGGCCCTGGAAGCTTACGCCGCGCGGTC
GCGCCGCTTTGGCAAAACACAGGAGCAAATAGATGCCCATTGA

Upstream 100 bases:

>100_bases
CTACAGCGGGGCGGGGGCGGCGCGTTCTGGCAGCGGTGTGTTTTTTGCCTGAGAATCCGCGCCGCTGGCCCGGGCAGCAT
TTTTATACAGGCTGAGCAGT

Downstream 100 bases:

>100_bases
ACCCACCGCCAATCCCATCGACATCCGCCGCATCATAACCGGCGTATTGCTGGCCGCAGTGCTGTTGCTGGTGCTCTGGC
TGCGGGGCTGGCCCCTGCTG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTPHDTLLPGQKPCTQADATAAGATAAQPAADDGRESGRAGDLPVTQLPVHLAIIMDGNGRWAQARNLPREAGHKAGAEA
VRAVVTECRRLGIRHLTLYTFSSENWNRPKAEISALFSLLLEFLRRELPRLEEQGIALRVLGDLDGLPLAQRTALRHAIK
RTADGPHMVLNLALNYGSRAELVRAMRSFLHDGARPEDITEESLAQRLYTAGQPDPDLLIRTSGEQRLSNYLLYQCAYSE
LYFTQVAWPDFDAAQLRLALEAYAARSRRFGKTQEQIDAH

Sequences:

>Translated_280_residues
MTPHDTLLPGQKPCTQADATAAGATAAQPAADDGRESGRAGDLPVTQLPVHLAIIMDGNGRWAQARNLPREAGHKAGAEA
VRAVVTECRRLGIRHLTLYTFSSENWNRPKAEISALFSLLLEFLRRELPRLEEQGIALRVLGDLDGLPLAQRTALRHAIK
RTADGPHMVLNLALNYGSRAELVRAMRSFLHDGARPEDITEESLAQRLYTAGQPDPDLLIRTSGEQRLSNYLLYQCAYSE
LYFTQVAWPDFDAAQLRLALEAYAARSRRFGKTQEQIDAH
>Mature_279_residues
TPHDTLLPGQKPCTQADATAAGATAAQPAADDGRESGRAGDLPVTQLPVHLAIIMDGNGRWAQARNLPREAGHKAGAEAV
RAVVTECRRLGIRHLTLYTFSSENWNRPKAEISALFSLLLEFLRRELPRLEEQGIALRVLGDLDGLPLAQRTALRHAIKR
TADGPHMVLNLALNYGSRAELVRAMRSFLHDGARPEDITEESLAQRLYTAGQPDPDLLIRTSGEQRLSNYLLYQCAYSEL
YFTQVAWPDFDAAQLRLALEAYAARSRRFGKTQEQIDAH

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=211, Percent_Identity=39.3364928909953, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI45580738, Length=211, Percent_Identity=39.3364928909953, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=45.1754385964912, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=33.7777777777778, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=234, Percent_Identity=31.6239316239316, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=222, Percent_Identity=31.0810810810811, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18857969, Length=222, Percent_Identity=36.4864864864865, Blast_Score=151, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 31001; Mature: 30870

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPHDTLLPGQKPCTQADATAAGATAAQPAADDGRESGRAGDLPVTQLPVHLAIIMDGNG
CCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHCCCCCCCCCEECCEEEEEEECCCC
RWAQARNLPREAGHKAGAEAVRAVVTECRRLGIRHLTLYTFSSENWNRPKAEISALFSLL
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
LEFLRRELPRLEEQGIALRVLGDLDGLPLAQRTALRHAIKRTADGPHMVLNLALNYGSRA
HHHHHHHCCCHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHH
ELVRAMRSFLHDGARPEDITEESLAQRLYTAGQPDPDLLIRTSGEQRLSNYLLYQCAYSE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
LYFTQVAWPDFDAAQLRLALEAYAARSRRFGKTQEQIDAH
HHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure 
TPHDTLLPGQKPCTQADATAAGATAAQPAADDGRESGRAGDLPVTQLPVHLAIIMDGNG
CCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCHHCCCCCCCCCEECCEEEEEEECCCC
RWAQARNLPREAGHKAGAEAVRAVVTECRRLGIRHLTLYTFSSENWNRPKAEISALFSLL
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
LEFLRRELPRLEEQGIALRVLGDLDGLPLAQRTALRHAIKRTADGPHMVLNLALNYGSRA
HHHHHHHCCCHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHH
ELVRAMRSFLHDGARPEDITEESLAQRLYTAGQPDPDLLIRTSGEQRLSNYLLYQCAYSE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
LYFTQVAWPDFDAAQLRLALEAYAARSRRFGKTQEQIDAH
HHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]