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The map label for this gene is frr [H]

Identifier: 220903796

GI number: 220903796

Start: 629710

End: 630270

Strand: Reverse

Name: frr [H]

Synonym: Ddes_0519

Alternate gene names: 220903796

Gene position: 630270-629710 (Counterclockwise)

Preceding gene: 220903797

Following gene: 220903795

Centisome position: 21.93

GC content: 55.44

Gene sequence:

>561_bases
ATGGATATCGACAGCATCCTTCTTGATGCCGAAGACCGCATGGAAAAAGCCCTTGCCGCTCTTGACCGCGACTTTGCCAA
ACTGCGCACCGGCCGCGCCACCACCGCCCTTGTGGACGGCATAAAGGCCGACTATTACGGCACCCCCACCCCCATCAGCC
AGATGGCCTCCATCGCTGTGCCCGACAGCCGCACCCTGACCATCCAGCCTTGGGACAAGGGCGGTATTGCCCTGATAGAA
AAAGCTATTCTCAAGTCTGACCTCGGCCTTACGCCTGTCAATGACGGCAAGCTGATCCGCATTGTCATGCCCCCCCTCAC
TGAAGAACGCCGCAAAGAACTGAGCAAGGTCGCGCGTAAATACAGTGAAGAAGGCAAGGTAGCCGTGCGCAACGTGCGCC
GCGACGCCAACGACAGCTTGAAAAAGCTGGAAAAAGAAAAGACCATTACCGAAGACGAACAAAAGCGCGCCACTGACGAT
GTGCAGAAGCTTACCGACAAATATGTGGCCGAAGTGGACAAGCGTTGCGCTGCCAAGGAAAAGGAAATTATGGAAATATA
G

Upstream 100 bases:

>100_bases
TTTTTCAGCGTCAGACCGTTCCGGATTTTTTCGCAAAGGGAGGCGCAGCGCCATCCCCAAAGGAACAGGCCGCAGGCCGC
AGCCCCAAGGAGAATAATTT

Downstream 100 bases:

>100_bases
CCGTGGCGGCTCATCCGCCACGTGCCGCCGCCCGCCGCGTTCCTGCTACAGCGGGGCGGGGGCGGCGCGTTCTGGCAGCG
GTGTGTTTTTTGCCTGAGAA

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MDIDSILLDAEDRMEKALAALDRDFAKLRTGRATTALVDGIKADYYGTPTPISQMASIAVPDSRTLTIQPWDKGGIALIE
KAILKSDLGLTPVNDGKLIRIVMPPLTEERRKELSKVARKYSEEGKVAVRNVRRDANDSLKKLEKEKTITEDEQKRATDD
VQKLTDKYVAEVDKRCAAKEKEIMEI

Sequences:

>Translated_186_residues
MDIDSILLDAEDRMEKALAALDRDFAKLRTGRATTALVDGIKADYYGTPTPISQMASIAVPDSRTLTIQPWDKGGIALIE
KAILKSDLGLTPVNDGKLIRIVMPPLTEERRKELSKVARKYSEEGKVAVRNVRRDANDSLKKLEKEKTITEDEQKRATDD
VQKLTDKYVAEVDKRCAAKEKEIMEI
>Mature_186_residues
MDIDSILLDAEDRMEKALAALDRDFAKLRTGRATTALVDGIKADYYGTPTPISQMASIAVPDSRTLTIQPWDKGGIALIE
KAILKSDLGLTPVNDGKLIRIVMPPLTEERRKELSKVARKYSEEGKVAVRNVRRDANDSLKKLEKEKTITEDEQKRATDD
VQKLTDKYVAEVDKRCAAKEKEIMEI

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another [H]

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family [H]

Homologues:

Organism=Homo sapiens, GI20270317, Length=181, Percent_Identity=28.7292817679558, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1786368, Length=184, Percent_Identity=52.1739130434783, Blast_Score=190, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24661488, Length=173, Percent_Identity=28.3236994219653, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002661
- InterPro:   IPR015998 [H]

Pfam domain/function: PF01765 RRF [H]

EC number: NA

Molecular weight: Translated: 20845; Mature: 20845

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDSILLDAEDRMEKALAALDRDFAKLRTGRATTALVDGIKADYYGTPTPISQMASIAV
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCC
PDSRTLTIQPWDKGGIALIEKAILKSDLGLTPVNDGKLIRIVMPPLTEERRKELSKVARK
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
YSEEGKVAVRNVRRDANDSLKKLEKEKTITEDEQKRATDDVQKLTDKYVAEVDKRCAAKE
HHHCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIMEI
HHHHCC
>Mature Secondary Structure
MDIDSILLDAEDRMEKALAALDRDFAKLRTGRATTALVDGIKADYYGTPTPISQMASIAV
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCC
PDSRTLTIQPWDKGGIALIEKAILKSDLGLTPVNDGKLIRIVMPPLTEERRKELSKVARK
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
YSEEGKVAVRNVRRDANDSLKKLEKEKTITEDEQKRATDDVQKLTDKYVAEVDKRCAAKE
HHHCCCHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEIMEI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA