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The map label for this gene is hisG [H]

Identifier: 220903640

GI number: 220903640

Start: 438295

End: 439188

Strand: Reverse

Name: hisG [H]

Synonym: Ddes_0360

Alternate gene names: 220903640

Gene position: 439188-438295 (Counterclockwise)

Preceding gene: 220903641

Following gene: 220903638

Centisome position: 15.28

GC content: 59.96

Gene sequence:

>894_bases
ATGAGCGCGGACATAAAACCCATCATCAAGCTCGGCGTGCCCAAAGGCTCGCTGGAAGAAGCCACCATCAATCTTTTCGA
ACGTGCGGGCTGGAAAATCCGCAAGCATACGCGCAACTACTTTCCCGACATCAACGATCCTGAAATCACGGCCTCGCTGT
GCCGCGTGCAGGAAATCGGCGGCTATATCGAAGCCGGGGTACTGGATGTGGGCATAACCGGCCTTGACTGGCTCACCGAA
CGCAACCACGAAGACAAGGTGGTGCGCGTTTCCGACCTGGTGTATTCCAAAACTTCCAACCGCCCCTGCCGCTGGGTGCT
GGCCGTGGCGGGCGATGCCCCCTACCAGTGTGCCGCCGACCTGGCGGGAAAACGCATCGCCACCGAGCTTGAAGGCCTTA
CCCGCCGCTATTTCGAACAGGCCGGCGTCCCCGTAAATGTCTTCTACTCCTGGGGGGCCACAGAGGCCAAAGTTGTGGAA
GGCCTTGCCGACGGCATTGTGGAAGTGACCGAAACAGGCACCACCATCCGCGCCCACGGCCTGCGTATCATTGATGACGT
CATGCTGTCCTACCCTGTGCTCATCGCCAACAGGGACGCCTGGGCCGACCCGGCCAAGCGCGCCAAGATCGAGCAGCTCG
ACCTGCTGCTTCAGGGCGCCTTGCGGGCAGAGAATCTGGTCGCCCTCAAAATGAACGCCCCGGCGGGCAATCTGGCGTTC
ATCCTTGAAATGCTGCCGTCGCTCAATTCGCCCACAGTTTCTCCCCTGCGGGACGAAAAATGGCTTTCAGTAGAGTCTGT
CGTGCAGGTTGATGTGGTGCGCGACCTTATACCGCGCCTGCGCGAAGCCGGGGCGGAAGGCATCATCGAATACGCCCTGA
ACAAAGTTATCTAG

Upstream 100 bases:

>100_bases
GCACCTGCTTTTACCGGGAATGGAAGGATGGCGCCGTCAGCGAGTGCGCCCCGATGGTCTTTGATCCCCAAAAAGTTTAC
GGCGTATAAAGGAAAGAATC

Downstream 100 bases:

>100_bases
GAGCGTTTCACCCCTGAAATGCCGCAGGCAAAGGCGGGCCGAAAGTGCCGCGCAACAGGCGCAGGCAGACGTACCCGTTG
CAAATCACGGCTTCAGGCGG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSADIKPIIKLGVPKGSLEEATINLFERAGWKIRKHTRNYFPDINDPEITASLCRVQEIGGYIEAGVLDVGITGLDWLTE
RNHEDKVVRVSDLVYSKTSNRPCRWVLAVAGDAPYQCAADLAGKRIATELEGLTRRYFEQAGVPVNVFYSWGATEAKVVE
GLADGIVEVTETGTTIRAHGLRIIDDVMLSYPVLIANRDAWADPAKRAKIEQLDLLLQGALRAENLVALKMNAPAGNLAF
ILEMLPSLNSPTVSPLRDEKWLSVESVVQVDVVRDLIPRLREAGAEGIIEYALNKVI

Sequences:

>Translated_297_residues
MSADIKPIIKLGVPKGSLEEATINLFERAGWKIRKHTRNYFPDINDPEITASLCRVQEIGGYIEAGVLDVGITGLDWLTE
RNHEDKVVRVSDLVYSKTSNRPCRWVLAVAGDAPYQCAADLAGKRIATELEGLTRRYFEQAGVPVNVFYSWGATEAKVVE
GLADGIVEVTETGTTIRAHGLRIIDDVMLSYPVLIANRDAWADPAKRAKIEQLDLLLQGALRAENLVALKMNAPAGNLAF
ILEMLPSLNSPTVSPLRDEKWLSVESVVQVDVVRDLIPRLREAGAEGIIEYALNKVI
>Mature_296_residues
SADIKPIIKLGVPKGSLEEATINLFERAGWKIRKHTRNYFPDINDPEITASLCRVQEIGGYIEAGVLDVGITGLDWLTER
NHEDKVVRVSDLVYSKTSNRPCRWVLAVAGDAPYQCAADLAGKRIATELEGLTRRYFEQAGVPVNVFYSWGATEAKVVEG
LADGIVEVTETGTTIRAHGLRIIDDVMLSYPVLIANRDAWADPAKRAKIEQLDLLLQGALRAENLVALKMNAPAGNLAFI
LEMLPSLNSPTVSPLRDEKWLSVESVVQVDVVRDLIPRLREAGAEGIIEYALNKVI

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=285, Percent_Identity=28.4210526315789, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320896, Length=243, Percent_Identity=27.9835390946502, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32715; Mature: 32584

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADIKPIIKLGVPKGSLEEATINLFERAGWKIRKHTRNYFPDINDPEITASLCRVQEIG
CCCCCCCHHEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GYIEAGVLDVGITGLDWLTERNHEDKVVRVSDLVYSKTSNRPCRWVLAVAGDAPYQCAAD
CHHHCCCEEECCCCHHHHHCCCCCCCEEEEHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
LAGKRIATELEGLTRRYFEQAGVPVNVFYSWGATEAKVVEGLADGIVEVTETGTTIRAHG
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHEEECCCCCEEECCC
LRIIDDVMLSYPVLIANRDAWADPAKRAKIEQLDLLLQGALRAENLVALKMNAPAGNLAF
HHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
ILEMLPSLNSPTVSPLRDEKWLSVESVVQVDVVRDLIPRLREAGAEGIIEYALNKVI
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SADIKPIIKLGVPKGSLEEATINLFERAGWKIRKHTRNYFPDINDPEITASLCRVQEIG
CCCCCCHHEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
GYIEAGVLDVGITGLDWLTERNHEDKVVRVSDLVYSKTSNRPCRWVLAVAGDAPYQCAAD
CHHHCCCEEECCCCHHHHHCCCCCCCEEEEHHHHHHCCCCCCEEEEEEECCCCCHHHHHH
LAGKRIATELEGLTRRYFEQAGVPVNVFYSWGATEAKVVEGLADGIVEVTETGTTIRAHG
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHEEECCCCCEEECCC
LRIIDDVMLSYPVLIANRDAWADPAKRAKIEQLDLLLQGALRAENLVALKMNAPAGNLAF
HHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
ILEMLPSLNSPTVSPLRDEKWLSVESVVQVDVVRDLIPRLREAGAEGIIEYALNKVI
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA