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The map label for this gene is tyrA [H]

Identifier: 220903614

GI number: 220903614

Start: 406765

End: 407643

Strand: Reverse

Name: tyrA [H]

Synonym: Ddes_0334

Alternate gene names: 220903614

Gene position: 407643-406765 (Counterclockwise)

Preceding gene: 220903615

Following gene: 220903612

Centisome position: 14.19

GC content: 64.16

Gene sequence:

>879_bases
ATGACGGCGCACAAAGACCAAAGCCGCTGCCGTGCCACAACGGCAGACAGCCTGGATGCGGACACGGTGGACTCAACGGA
GGCCGGAAAAACGAAAGAACACGCGGGCAGAACAGTCATTGTCGGTTCCCGGGGGCGCATGGGGGCCATGCTTGTGGCCC
GCGCCGAGGCTGCCGGTCTTGGTATCGTCGGGGTGGACGTTCCCCTTGCGCCGGAAAAGCTCTCGGAATCCTGCTCAGGG
GCAGATATGGCCGTGCTGTGCGTTCCCGCTGCCGTATTCGGCGAGGTGGCGGCCGCAGTATGCCCGCACCTGCCCGCGCG
GGCGGTGTTGGCCGACATCACTTCGGTGAAGGAACAGCCCATGCGCCAGATGGAGCGCGTCTGGCCCGGTCCCGTGGTGG
GAACCCATCCTCTTTTCGGCCCCAGCCCGGAAGCGGAGGCAGACCTTCCCGTTGCCCTGACCCCCGGCCGCAATGCGGAG
CCGGAGCATGTGGCTCTGGTGGAAGCCTTTTTTACAAGAATCGGCTGCCGTACCTTCATGACCACGGCGGAAAAGCACGA
CAAGGCCATGGCGCGCATACAGAACATGAACTTTATCACGAGCCTGGCCTATTTCTCGCTGCTGGCCGGGCAGGATGACC
TGCTGCCCTTTCTGACGCCGTCTTTCCGCCGCCGCCACAATGCGGCCCGAAAAATGCTGACGGAAGATGCCCGCCTTTTT
GCCGGACTGTTTGAAGCCAACGCTCACAGCCATGAGGCCGTGCGCCAGTACCGGCAGATGCTCAACCTGGCTGCCGCCGG
GGACATCGACCTGCTCTGCCAGCGGGCAGCGTGGTGGTGGCCGGAAGAATGCGGGCAGGACGAGCTGGCAGAAGCCTGA

Upstream 100 bases:

>100_bases
ACCTTTGCCGCTCCGAAGCCGTGGTACGTTCGCGCCTGGACGATCCTTCGGTAGTCGGCAAATCCTTTCCGCAATTCTGG
AATATCTGGGAGAAACTGGC

Downstream 100 bases:

>100_bases
AATACGCGCTTTGCACATCCCCCTGGCCCCGCGCGGGGAGACGCGCGCCCGTTTCAGCCCTTGCCCGAAGGGGCAGGAAA
GGCCGTCCGGCTCTTTGGCT

Product: Prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTAHKDQSRCRATTADSLDADTVDSTEAGKTKEHAGRTVIVGSRGRMGAMLVARAEAAGLGIVGVDVPLAPEKLSESCSG
ADMAVLCVPAAVFGEVAAAVCPHLPARAVLADITSVKEQPMRQMERVWPGPVVGTHPLFGPSPEAEADLPVALTPGRNAE
PEHVALVEAFFTRIGCRTFMTTAEKHDKAMARIQNMNFITSLAYFSLLAGQDDLLPFLTPSFRRRHNAARKMLTEDARLF
AGLFEANAHSHEAVRQYRQMLNLAAAGDIDLLCQRAAWWWPEECGQDELAEA

Sequences:

>Translated_292_residues
MTAHKDQSRCRATTADSLDADTVDSTEAGKTKEHAGRTVIVGSRGRMGAMLVARAEAAGLGIVGVDVPLAPEKLSESCSG
ADMAVLCVPAAVFGEVAAAVCPHLPARAVLADITSVKEQPMRQMERVWPGPVVGTHPLFGPSPEAEADLPVALTPGRNAE
PEHVALVEAFFTRIGCRTFMTTAEKHDKAMARIQNMNFITSLAYFSLLAGQDDLLPFLTPSFRRRHNAARKMLTEDARLF
AGLFEANAHSHEAVRQYRQMLNLAAAGDIDLLCQRAAWWWPEECGQDELAEA
>Mature_291_residues
TAHKDQSRCRATTADSLDADTVDSTEAGKTKEHAGRTVIVGSRGRMGAMLVARAEAAGLGIVGVDVPLAPEKLSESCSGA
DMAVLCVPAAVFGEVAAAVCPHLPARAVLADITSVKEQPMRQMERVWPGPVVGTHPLFGPSPEAEADLPVALTPGRNAEP
EHVALVEAFFTRIGCRTFMTTAEKHDKAMARIQNMNFITSLAYFSLLAGQDDLLPFLTPSFRRRHNAARKMLTEDARLFA
GLFEANAHSHEAVRQYRQMLNLAAAGDIDLLCQRAAWWWPEECGQDELAEA

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=248, Percent_Identity=27.4193548387097, Blast_Score=81, Evalue=9e-17,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 31546; Mature: 31415

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHKDQSRCRATTADSLDADTVDSTEAGKTKEHAGRTVIVGSRGRMGAMLVARAEAAGL
CCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCEEEEECCCCCCHHHEEHHHHCCC
GIVGVDVPLAPEKLSESCSGADMAVLCVPAAVFGEVAAAVCPHLPARAVLADITSVKEQP
EEEECCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
MRQMERVWPGPVVGTHPLFGPSPEAEADLPVALTPGRNAEPEHVALVEAFFTRIGCRTFM
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
TTAEKHDKAMARIQNMNFITSLAYFSLLAGQDDLLPFLTPSFRRRHNAARKMLTEDARLF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHH
AGLFEANAHSHEAVRQYRQMLNLAAAGDIDLLCQRAAWWWPEECGQDELAEA
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHCCCHHHCCC
>Mature Secondary Structure 
TAHKDQSRCRATTADSLDADTVDSTEAGKTKEHAGRTVIVGSRGRMGAMLVARAEAAGL
CCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCEEEEECCCCCCHHHEEHHHHCCC
GIVGVDVPLAPEKLSESCSGADMAVLCVPAAVFGEVAAAVCPHLPARAVLADITSVKEQP
EEEECCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
MRQMERVWPGPVVGTHPLFGPSPEAEADLPVALTPGRNAEPEHVALVEAFFTRIGCRTFM
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
TTAEKHDKAMARIQNMNFITSLAYFSLLAGQDDLLPFLTPSFRRRHNAARKMLTEDARLF
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHH
AGLFEANAHSHEAVRQYRQMLNLAAAGDIDLLCQRAAWWWPEECGQDELAEA
HHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]