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The map label for this gene is aroA [H]

Identifier: 220903615

GI number: 220903615

Start: 407640

End: 409094

Strand: Reverse

Name: aroA [H]

Synonym: Ddes_0335

Alternate gene names: 220903615

Gene position: 409094-407640 (Counterclockwise)

Preceding gene: 220903616

Following gene: 220903614

Centisome position: 14.24

GC content: 66.25

Gene sequence:

>1455_bases
ATGAGCCAGACCAAGGGCGCCGCAGCCGCCAACCATGCTGTGGAAGCCGCCGGAATTACGGAAACGGTGACCGTTACGGC
TCCCGCCTCCAAATCGGTATCGCACCGCTATCTTATGGGCGCGGCCCTGGCCGGGGGGACCTCCATTGTGCGCCATACCC
TTGAAAGCCGCGACCTGGAGCGCACCCGCGCCATCCTTTGCGCAGCCGGGGCAACAATGGCAGAACTGCCCGAGAGCACC
CCCGCCTCGGGAGCCTGGCAGGTCACGGGCATGAACGGCGCCCCCCGCGGCGGTACAGCCGCAGCGCCCCTGTCCTGCGA
TGTGGAAGAGTCGGGAACCACCTGCCGCCTGCTTACGGCCGTGCTGGCCGCCGGGCAGGGGGTGTTCCGTATCCACGGAG
CAGCCCGCATGCACGAACGGCCCATTGCGGAACTGACCGATGCCCTGGCCGCCCTGGGTACGCAGACAAGCTTTGAGGAA
AAACCGGACTGCCCCCCCTGTGTCCTCACCGCTCACGGCCTTGACCCGGCCCGCTGCGGCGGCATTGTGGAACTGGGCAT
GGATATTTCAAGCCAGTATTTTTCCGGCCTGCTGCTGGCCGCCCCCATGGGACCAGCGCCCCTGACCCTGGCCCTGGGCG
GCCGCAAGGCCGTGTCCTGGCCCTATGTGGGCCTGACCCTGCAATGCCTTACGGACTACGGCATCAGATTTGAAGTGCAG
ACCCGCCGCGACATCGGAGCCCCCTGGCAGCCCATGGGCGACGGTGCGTGGCGCAGGCTGGACGAGGCCCTGCCCGGCTG
CCTGCGCATCACCGTTTACCCCGGCCCTTACCGTGCCGGAGAATATACCGTTGAGGGGGACTGGTCCGGCGCGTCCTACC
TGCTTGCCGCGGGAGCCATCGGCCGCCGCCCGGTACGTGTGGAAGGCCTGCGGGCCGACTCCCTTCAGGGTGATCGCGCC
ATGCTGAACATCCTGCAAAGAATGGGGGCACGGGTGGATGTGCAGCCCCTGGCCGTGACGGTCTATCCCTCGCGCCTGCA
CGGCGTGGATCTGGATATGGGGCACTGCCCGGACCTTGTACCCACAGTGGCGACGGTGGCGGCCTTTGCCCAGGGGTCTA
CGCGCATCCGTAACGTGGCCCACCTGCGCCACAAAGAGTCTGACCGCATCAAGGCTCCGGCCACGGAACTGGGCAAAGCC
GGCGTGGTCGTGGACGAACTTTCGGACGGCATGCTGGTCAACGGCCTGGGCGGCCGCAACAACGGCAAACCCGATCACCC
CATTCTGCCCGACGGCCAGACCCTTTCGGCCCATAACGATCACCGCATCGCCATGTCGCTGGCCCTGCTTGACCTTTGCC
GCTCCGAAGCCGTGGTACGTTCGCGCCTGGACGATCCTTCGGTAGTCGGCAAATCCTTTCCGCAATTCTGGAATATCTGG
GAGAAACTGGCATGA

Upstream 100 bases:

>100_bases
GCCACGCCTGTACGGGCTTTCGCATTCTGGGCAGCTACCCCACGGGACCGCAGCTGGACCGCCTTGACCTTCATACGGAC
GAACCGGAGCAGAAAGAATC

Downstream 100 bases:

>100_bases
CGGCGCACAAAGACCAAAGCCGCTGCCGTGCCACAACGGCAGACAGCCTGGATGCGGACACGGTGGACTCAACGGAGGCC
GGAAAAACGAAAGAACACGC

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSQTKGAAAANHAVEAAGITETVTVTAPASKSVSHRYLMGAALAGGTSIVRHTLESRDLERTRAILCAAGATMAELPEST
PASGAWQVTGMNGAPRGGTAAAPLSCDVEESGTTCRLLTAVLAAGQGVFRIHGAARMHERPIAELTDALAALGTQTSFEE
KPDCPPCVLTAHGLDPARCGGIVELGMDISSQYFSGLLLAAPMGPAPLTLALGGRKAVSWPYVGLTLQCLTDYGIRFEVQ
TRRDIGAPWQPMGDGAWRRLDEALPGCLRITVYPGPYRAGEYTVEGDWSGASYLLAAGAIGRRPVRVEGLRADSLQGDRA
MLNILQRMGARVDVQPLAVTVYPSRLHGVDLDMGHCPDLVPTVATVAAFAQGSTRIRNVAHLRHKESDRIKAPATELGKA
GVVVDELSDGMLVNGLGGRNNGKPDHPILPDGQTLSAHNDHRIAMSLALLDLCRSEAVVRSRLDDPSVVGKSFPQFWNIW
EKLA

Sequences:

>Translated_484_residues
MSQTKGAAAANHAVEAAGITETVTVTAPASKSVSHRYLMGAALAGGTSIVRHTLESRDLERTRAILCAAGATMAELPEST
PASGAWQVTGMNGAPRGGTAAAPLSCDVEESGTTCRLLTAVLAAGQGVFRIHGAARMHERPIAELTDALAALGTQTSFEE
KPDCPPCVLTAHGLDPARCGGIVELGMDISSQYFSGLLLAAPMGPAPLTLALGGRKAVSWPYVGLTLQCLTDYGIRFEVQ
TRRDIGAPWQPMGDGAWRRLDEALPGCLRITVYPGPYRAGEYTVEGDWSGASYLLAAGAIGRRPVRVEGLRADSLQGDRA
MLNILQRMGARVDVQPLAVTVYPSRLHGVDLDMGHCPDLVPTVATVAAFAQGSTRIRNVAHLRHKESDRIKAPATELGKA
GVVVDELSDGMLVNGLGGRNNGKPDHPILPDGQTLSAHNDHRIAMSLALLDLCRSEAVVRSRLDDPSVVGKSFPQFWNIW
EKLA
>Mature_483_residues
SQTKGAAAANHAVEAAGITETVTVTAPASKSVSHRYLMGAALAGGTSIVRHTLESRDLERTRAILCAAGATMAELPESTP
ASGAWQVTGMNGAPRGGTAAAPLSCDVEESGTTCRLLTAVLAAGQGVFRIHGAARMHERPIAELTDALAALGTQTSFEEK
PDCPPCVLTAHGLDPARCGGIVELGMDISSQYFSGLLLAAPMGPAPLTLALGGRKAVSWPYVGLTLQCLTDYGIRFEVQT
RRDIGAPWQPMGDGAWRRLDEALPGCLRITVYPGPYRAGEYTVEGDWSGASYLLAAGAIGRRPVRVEGLRADSLQGDRAM
LNILQRMGARVDVQPLAVTVYPSRLHGVDLDMGHCPDLVPTVATVAAFAQGSTRIRNVAHLRHKESDRIKAPATELGKAG
VVVDELSDGMLVNGLGGRNNGKPDHPILPDGQTLSAHNDHRIAMSLALLDLCRSEAVVRSRLDDPSVVGKSFPQFWNIWE
KLA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=461, Percent_Identity=32.5379609544469, Blast_Score=194, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6320332, Length=483, Percent_Identity=32.0910973084886, Blast_Score=169, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 51137; Mature: 51006

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTKGAAAANHAVEAAGITETVTVTAPASKSVSHRYLMGAALAGGTSIVRHTLESRDLE
CCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
RTRAILCAAGATMAELPESTPASGAWQVTGMNGAPRGGTAAAPLSCDVEESGTTCRLLTA
HHHHHHHCCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VLAAGQGVFRIHGAARMHERPIAELTDALAALGTQTSFEEKPDCPPCVLTAHGLDPARCG
HHHCCCCEEEECCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHCC
GIVELGMDISSQYFSGLLLAAPMGPAPLTLALGGRKAVSWPYVGLTLQCLTDYGIRFEVQ
CEEEECCCHHHHHHCCEEEECCCCCCCEEEEECCCCCCCCCCCCEEHEEECCCCEEEEEE
TRRDIGAPWQPMGDGAWRRLDEALPGCLRITVYPGPYRAGEYTVEGDWSGASYLLAAGAI
ECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCHHHEECCCC
GRRPVRVEGLRADSLQGDRAMLNILQRMGARVDVQPLAVTVYPSRLHGVDLDMGHCPDLV
CCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEECEEEEEEECCHHCCCCCCCCCCCCHH
PTVATVAAFAQGSTRIRNVAHLRHKESDRIKAPATELGKAGVVVDELSDGMLVNGLGGRN
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCEEEECCCCCC
NGKPDHPILPDGQTLSAHNDHRIAMSLALLDLCRSEAVVRSRLDDPSVVGKSFPQFWNIW
CCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
EKLA
HHCC
>Mature Secondary Structure 
SQTKGAAAANHAVEAAGITETVTVTAPASKSVSHRYLMGAALAGGTSIVRHTLESRDLE
CCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
RTRAILCAAGATMAELPESTPASGAWQVTGMNGAPRGGTAAAPLSCDVEESGTTCRLLTA
HHHHHHHCCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
VLAAGQGVFRIHGAARMHERPIAELTDALAALGTQTSFEEKPDCPPCVLTAHGLDPARCG
HHHCCCCEEEECCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCHHHCC
GIVELGMDISSQYFSGLLLAAPMGPAPLTLALGGRKAVSWPYVGLTLQCLTDYGIRFEVQ
CEEEECCCHHHHHHCCEEEECCCCCCCEEEEECCCCCCCCCCCCEEHEEECCCCEEEEEE
TRRDIGAPWQPMGDGAWRRLDEALPGCLRITVYPGPYRAGEYTVEGDWSGASYLLAAGAI
ECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCHHHEECCCC
GRRPVRVEGLRADSLQGDRAMLNILQRMGARVDVQPLAVTVYPSRLHGVDLDMGHCPDLV
CCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCEECEEEEEEECCHHCCCCCCCCCCCCHH
PTVATVAAFAQGSTRIRNVAHLRHKESDRIKAPATELGKAGVVVDELSDGMLVNGLGGRN
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCEEEECCCCCC
NGKPDHPILPDGQTLSAHNDHRIAMSLALLDLCRSEAVVRSRLDDPSVVGKSFPQFWNIW
CCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHH
EKLA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA