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The map label for this gene is tpa [H]

Identifier: 220903499

GI number: 220903499

Start: 269497

End: 270855

Strand: Direct

Name: tpa [H]

Synonym: Ddes_0218

Alternate gene names: 220903499

Gene position: 269497-270855 (Clockwise)

Preceding gene: 220903498

Following gene: 220903501

Centisome position: 9.38

GC content: 54.6

Gene sequence:

>1359_bases
ATGTCAGCAAAGAACACAAATGAATATGTCAACGGGGATATAAAAAACGTATGGCACCATCTGATGCTGCATCAGGGCAA
TGCCCCCATGATTGCGGTAGAGGGCAAGGGCCTGTACCTCAAGGATCTTAACGGCAAGGAATATCTGGATGCCACCTCCG
GCGGCGTCTGGTGCGTCAATGTGGGTTACGGCCGTGACCGTATCGCCAATGCCGCCGCCGAGCAGATGAAAAAACTGCCT
TTTTATGCGGCCAGTTGCGGCTCCCAGCCTGCCATTGATTTTTCTGAAAAGCTGCTTTCGCACATGCCGGGGCTTTCCCG
CGTGTATATTTCCAGCAGTGGCTCCGAGGCCAACGAAAAGGCCTTCAAGATGGTGCGCCAGATTTCCCAGCTCAAGCACG
GCGGCAAAAAATATAAAATCATTTACCGTGACCGCGATTACCACGGCACCACCATCAGCACCCTGAGCGCTTGCGGCCAG
GAAGAGCGCCGTGAGCAGTATGGTCCCTTTACCCCCGGTTTTGTGGAGTTTCCCGCTTGTCTGGCCTATCGTTCCCCCTA
TCCTGAAGGCACGAAAAACCTGGGCGAAAAGTTTGCCCGCGAGCTGGAAGCCGTGGTTCTGAAGGAAGGTCCCGACACCG
TGGGCGCTGTTATTCTGGAGCCGATCACGGCTGGCGGCGGCATCATTGTGCCTCCGGAAGGCTACTATGAGACCATCTCC
GAGATATGCAAGAAATACGGCATCCTGATCATTATGGATGAAGTGGTCTGCGGTCTTGGCAGAACGGGCAAATGGTTCGG
CTACCAGCACTTCAACATCCAGCCCGACATTGTGACCATGGCCAAGGGTGTTGCCAGCGCCTACATGCCCATTTCCTGCA
CCGTGACCACCGAAGAAGTGTTTGCGGCCCTGCAGGATACCACCGACAAACTCTCGTATTTCCGCGATATCAGTACCTTC
GGTGGCTGCCTTGCCGCCCCGGCTGCGGCTCTTGAAAACATCAAGATCATTGAAGAAGAAAGCCTGCTGGACAATGTTGT
AGCCATGGGCGACTACCTGCAGCAGGGGCTTCAGGAGCTGCTTTCGCACAGCAATGTGGGCGATGTACGCGGCAAAGGTC
TTTTGCAGGGCATTGAATTTGTTGCTGACAAGGCTTCGAAAAAGCCCCTTGAAGAAGAAAAGGTCATCGCCGTCTGCGGA
GCCATGGCCAAGCGCGGCGTGCTTGTGGGCAGAACAAACCGCAGCTTTGTGGGCCGAAACAATATCGTCAATGTGGCTCC
GGCCTATATTGTGACCAAGGATCAGATTGATATCATTCTCAAGGCGCTGCGCGAGTCCATAACCGAAGTTCTGGGCTAG

Upstream 100 bases:

>100_bases
CGGCCCTTGCCGGATGCGCGGAATGTTTTGTTGAACTATGGGATTTTGATTTCAGAGCTGTTTATGGCCGCAGTCCAACA
TTTTTAAGGAGTGAACTTCC

Downstream 100 bases:

>100_bases
CAGCCGGCTTGCCGGGCTGATTCACATCGGCAGCCTGTCTGCCCTCCGGCAATAGTGAGCCTTGCCGGTCGGTACTGGGC
AACCCGAAGAGGACGGCCGG

Product: class III aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSAKNTNEYVNGDIKNVWHHLMLHQGNAPMIAVEGKGLYLKDLNGKEYLDATSGGVWCVNVGYGRDRIANAAAEQMKKLP
FYAASCGSQPAIDFSEKLLSHMPGLSRVYISSSGSEANEKAFKMVRQISQLKHGGKKYKIIYRDRDYHGTTISTLSACGQ
EERREQYGPFTPGFVEFPACLAYRSPYPEGTKNLGEKFARELEAVVLKEGPDTVGAVILEPITAGGGIIVPPEGYYETIS
EICKKYGILIIMDEVVCGLGRTGKWFGYQHFNIQPDIVTMAKGVASAYMPISCTVTTEEVFAALQDTTDKLSYFRDISTF
GGCLAAPAAALENIKIIEEESLLDNVVAMGDYLQQGLQELLSHSNVGDVRGKGLLQGIEFVADKASKKPLEEEKVIAVCG
AMAKRGVLVGRTNRSFVGRNNIVNVAPAYIVTKDQIDIILKALRESITEVLG

Sequences:

>Translated_452_residues
MSAKNTNEYVNGDIKNVWHHLMLHQGNAPMIAVEGKGLYLKDLNGKEYLDATSGGVWCVNVGYGRDRIANAAAEQMKKLP
FYAASCGSQPAIDFSEKLLSHMPGLSRVYISSSGSEANEKAFKMVRQISQLKHGGKKYKIIYRDRDYHGTTISTLSACGQ
EERREQYGPFTPGFVEFPACLAYRSPYPEGTKNLGEKFARELEAVVLKEGPDTVGAVILEPITAGGGIIVPPEGYYETIS
EICKKYGILIIMDEVVCGLGRTGKWFGYQHFNIQPDIVTMAKGVASAYMPISCTVTTEEVFAALQDTTDKLSYFRDISTF
GGCLAAPAAALENIKIIEEESLLDNVVAMGDYLQQGLQELLSHSNVGDVRGKGLLQGIEFVADKASKKPLEEEKVIAVCG
AMAKRGVLVGRTNRSFVGRNNIVNVAPAYIVTKDQIDIILKALRESITEVLG
>Mature_451_residues
SAKNTNEYVNGDIKNVWHHLMLHQGNAPMIAVEGKGLYLKDLNGKEYLDATSGGVWCVNVGYGRDRIANAAAEQMKKLPF
YAASCGSQPAIDFSEKLLSHMPGLSRVYISSSGSEANEKAFKMVRQISQLKHGGKKYKIIYRDRDYHGTTISTLSACGQE
ERREQYGPFTPGFVEFPACLAYRSPYPEGTKNLGEKFARELEAVVLKEGPDTVGAVILEPITAGGGIIVPPEGYYETISE
ICKKYGILIIMDEVVCGLGRTGKWFGYQHFNIQPDIVTMAKGVASAYMPISCTVTTEEVFAALQDTTDKLSYFRDISTFG
GCLAAPAAALENIKIIEEESLLDNVVAMGDYLQQGLQELLSHSNVGDVRGKGLLQGIEFVADKASKKPLEEEKVIAVCGA
MAKRGVLVGRTNRSFVGRNNIVNVAPAYIVTKDQIDIILKALRESITEVLG

Specific function: Catalyzes the degradation of taurine into alanine and sulfoacetaldehyde. Can also transaminate hypotaurine (2- aminosulfinate), beta-alanine and with low activity cysteine and 3-aminopropanesulfonate. In addition to pyruvate, 2-ketobutyrate and oxaloaceta

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI24119277, Length=440, Percent_Identity=30.2272727272727, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI4557809, Length=421, Percent_Identity=27.5534441805226, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI37574042, Length=440, Percent_Identity=28.8636363636364, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI13994255, Length=446, Percent_Identity=29.372197309417, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI226442705, Length=440, Percent_Identity=29.0909090909091, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI226442709, Length=408, Percent_Identity=28.6764705882353, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI284507298, Length=338, Percent_Identity=27.810650887574, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI188536080, Length=399, Percent_Identity=25.5639097744361, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38679950, Length=399, Percent_Identity=25.5639097744361, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38679946, Length=399, Percent_Identity=25.5639097744361, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI145693181, Length=413, Percent_Identity=31.7191283292978, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789759, Length=428, Percent_Identity=28.9719626168224, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1788044, Length=411, Percent_Identity=27.9805352798054, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789016, Length=370, Percent_Identity=28.6486486486486, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1787560, Length=416, Percent_Identity=26.4423076923077, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1786991, Length=453, Percent_Identity=27.3730684326711, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=446, Percent_Identity=30.2690582959641, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25144271, Length=423, Percent_Identity=27.4231678486998, Blast_Score=158, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI71992977, Length=442, Percent_Identity=25.5656108597285, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=310, Percent_Identity=29.3548387096774, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=443, Percent_Identity=23.0248306997743, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=454, Percent_Identity=27.3127753303965, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324432, Length=350, Percent_Identity=28.2857142857143, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324386, Length=479, Percent_Identity=24.8434237995825, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=448, Percent_Identity=24.1071428571429, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28574759, Length=454, Percent_Identity=29.9559471365639, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=29.6875, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI21357415, Length=423, Percent_Identity=28.1323877068558, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21356575, Length=434, Percent_Identity=28.3410138248848, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI281366494, Length=449, Percent_Identity=24.9443207126949, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24667139, Length=449, Percent_Identity=24.9443207126949, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24667143, Length=449, Percent_Identity=24.9443207126949, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.77 [H]

Molecular weight: Translated: 49360; Mature: 49229

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKNTNEYVNGDIKNVWHHLMLHQGNAPMIAVEGKGLYLKDLNGKEYLDATSGGVWCVN
CCCCCCCHHCCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCHHEECCCCCEEEEE
VGYGRDRIANAAAEQMKKLPFYAASCGSQPAIDFSEKLLSHMPGLSRVYISSSGSEANEK
ECCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHH
AFKMVRQISQLKHGGKKYKIIYRDRDYHGTTISTLSACGQEERREQYGPFTPGFVEFPAC
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCHHHHHHHCCCCCCCHHHHHHH
LAYRSPYPEGTKNLGEKFARELEAVVLKEGPDTVGAVILEPITAGGGIIVPPEGYYETIS
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCEEECCCCHHHHHH
EICKKYGILIIMDEVVCGLGRTGKWFGYQHFNIQPDIVTMAKGVASAYMPISCTVTTEEV
HHHHHCCEEEEEHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEEHHHH
FAALQDTTDKLSYFRDISTFGGCLAAPAAALENIKIIEEESLLDNVVAMGDYLQQGLQEL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LSHSNVGDVRGKGLLQGIEFVADKASKKPLEEEKVIAVCGAMAKRGVLVGRTNRSFVGRN
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCC
NIVNVAPAYIVTKDQIDIILKALRESITEVLG
CCEEECCEEEEEHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SAKNTNEYVNGDIKNVWHHLMLHQGNAPMIAVEGKGLYLKDLNGKEYLDATSGGVWCVN
CCCCCCHHCCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCHHEECCCCCEEEEE
VGYGRDRIANAAAEQMKKLPFYAASCGSQPAIDFSEKLLSHMPGLSRVYISSSGSEANEK
ECCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHH
AFKMVRQISQLKHGGKKYKIIYRDRDYHGTTISTLSACGQEERREQYGPFTPGFVEFPAC
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCHHHHHHHCCCCCCCHHHHHHH
LAYRSPYPEGTKNLGEKFARELEAVVLKEGPDTVGAVILEPITAGGGIIVPPEGYYETIS
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEEECCCCCEEECCCCHHHHHH
EICKKYGILIIMDEVVCGLGRTGKWFGYQHFNIQPDIVTMAKGVASAYMPISCTVTTEEV
HHHHHCCEEEEEHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEEHHHH
FAALQDTTDKLSYFRDISTFGGCLAAPAAALENIKIIEEESLLDNVVAMGDYLQQGLQEL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHH
LSHSNVGDVRGKGLLQGIEFVADKASKKPLEEEKVIAVCGAMAKRGVLVGRTNRSFVGRN
HHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCC
NIVNVAPAYIVTKDQIDIILKALRESITEVLG
CCEEECCEEEEEHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11082195 [H]