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The map label for this gene is xsc [H]

Identifier: 220903501

GI number: 220903501

Start: 273168

End: 274910

Strand: Direct

Name: xsc [H]

Synonym: Ddes_0220

Alternate gene names: 220903501

Gene position: 273168-274910 (Clockwise)

Preceding gene: 220903499

Following gene: 220903502

Centisome position: 9.51

GC content: 59.27

Gene sequence:

>1743_bases
ATGCCCAAGATGACGCCCAGTGAAGCCATGACAGAAGTTCTGGTGCAGGAAGGAGTAAACCATGTAAGCGGCATTCTCGG
TTCCGCATTCATGGATATGCTGGATTTGTTCCCCGCTGCGGGGATTGATTTTGTCTCGGTGCGCCATGAGCAGACCGCCG
GGCATATGGAAGACGCCTACAGCCGCCTTACCGGCAGGGCGGGCGTGGTTATCGGGCAGAACGGGCCTGGAATCACCAAC
TATGTGACGGCCGTGGCCACTGCCAATATGGCACATTCTCCCATGGTGGTCATCTCTCCCAGCGCAGGCAGCATCTCTGT
GGGCTGGGACGGCTTTCAGGAATGCGACACATGGAATCTGTTCAAACCCATCACCAAAGCCTCGCTGCGCGTGCCGCATC
CCAAGCGCGCCGCCGACATCCTGCGTACGGCCTTCCGTATTGCCTACGCCGAGCGCGGCCCCGTGCTCGTGGATATTCCC
CGCGACTATTTCTACGGTGAACTGGATGAAGATATCCTGCATCCCTCCCAGTACCGCGTAGCCCCCGGCGGCATCGGCAA
TCCCGAACACTTTGCCGCCGCCGTGGAAGTGCTGAAAAATGCCAAAAACCCGGTCATCATTTCGGGCCGCGGCGTGGTGG
ATTCCGGCTGCATGGAAACCCTCAAAGCCATGGCAGAATATCTGGGCGCACCCGTGGCCACCACCTACCTGCACAACGAT
GCCTTCCCCTGCGATCATCCGCTGTGGACCGGCCCCATCGGCTATATGGGTTCCAAGGCCGCCATGCGCATCCTGCAGAA
GGCCGACGTTATCCTGGCTGTGGGTACCAGGTTGTCCTATTTCGGCACACTGCCGCAGTATGACATCAACTACTTCCCCA
AGACCGCCAAGATCGTGCAGATTGACATCAACCCCCGTCATATCGCCAAGACGCACCCCGTTGCTGTGGGGCTGTGTGCC
GATGCCAAGGACGCCTCGGAAGAGCTGTTCGCGCGTCTGCGTGAAGCCGTGCCTGCCAAGAAGGACCTCACCCCGGTGCA
CAACCTGGTGAAGGACGAACTGGAAAACTGGTACAAGGAAATTGCGCTGATCGCCGACGAACCTGTGGAAGCCGGACGCA
TGCACCCGCGCAAGGCTCTGGAAGTGGTGGGCAAGTTCATTACGGATCACGATGCCATTGCCACTACCGACATCGGCAAT
ACGTCTTCCACTGCCAACAGCTACCTGCGTTTCAAGAAGACCAAGCGCCATGTGGCCACCCTGACCTTCGGCAACACGGG
CTTTGCCTATCAGGCCGCCCTGGGCGCGCAGCTGGCCTGCCCCGAAGACCTGACGGTGGCCATTGTGGGTGACGGCGCGT
GGGGCATGAGCCTTTTTGAAGTGCCTACCGCCTGCCAGTACAACCTGCCGGTTATTGCCACCGTGTACAACAACGGTGCC
TGGTGCGCTGAAAAGAAAAACCAGGTGGACTTTTACAATAACCGTTTTGTGGGCGCGGACATCTGGTCCAAATCCTACGC
CAAGATAGGCGAAGCCATGGGGGCTGACGGCTATACCGTCAATACGCAGAAGGATCTGGCCGAGGCTCTGGACACGGCCA
GAAAGAACCGGCGCCCCGCGGTTATCGAAATCATGACCGATGGTACGCGCCTTGCGCCTCCCTTCCGTAGGGACGCCCTG
GCCTTGCCGACCAGGTTCCTGCCCAAGTACGAGCATCTCGACAAGGCGCACTTCAACAAATAG

Upstream 100 bases:

>100_bases
GTTTTGCAATCCACGGGCCACAAGCCCGTAAAACATGACAAGACGCCGGATACGCGGGCAGCGGTAACGAAACCTATCAT
GCATTGTATCGGAGGATAAC

Downstream 100 bases:

>100_bases
TCAAAAAGGGCGCGTCCGGGTAACCCCCGGGCGCGCCCTTCCGCTTATTGAGGCAAATTTATTCATATTTCAGATACGGC
GATTTTTTTGCGCTCCACAA

Product: sulfoacetaldehyde acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MPKMTPSEAMTEVLVQEGVNHVSGILGSAFMDMLDLFPAAGIDFVSVRHEQTAGHMEDAYSRLTGRAGVVIGQNGPGITN
YVTAVATANMAHSPMVVISPSAGSISVGWDGFQECDTWNLFKPITKASLRVPHPKRAADILRTAFRIAYAERGPVLVDIP
RDYFYGELDEDILHPSQYRVAPGGIGNPEHFAAAVEVLKNAKNPVIISGRGVVDSGCMETLKAMAEYLGAPVATTYLHND
AFPCDHPLWTGPIGYMGSKAAMRILQKADVILAVGTRLSYFGTLPQYDINYFPKTAKIVQIDINPRHIAKTHPVAVGLCA
DAKDASEELFARLREAVPAKKDLTPVHNLVKDELENWYKEIALIADEPVEAGRMHPRKALEVVGKFITDHDAIATTDIGN
TSSTANSYLRFKKTKRHVATLTFGNTGFAYQAALGAQLACPEDLTVAIVGDGAWGMSLFEVPTACQYNLPVIATVYNNGA
WCAEKKNQVDFYNNRFVGADIWSKSYAKIGEAMGADGYTVNTQKDLAEALDTARKNRRPAVIEIMTDGTRLAPPFRRDAL
ALPTRFLPKYEHLDKAHFNK

Sequences:

>Translated_580_residues
MPKMTPSEAMTEVLVQEGVNHVSGILGSAFMDMLDLFPAAGIDFVSVRHEQTAGHMEDAYSRLTGRAGVVIGQNGPGITN
YVTAVATANMAHSPMVVISPSAGSISVGWDGFQECDTWNLFKPITKASLRVPHPKRAADILRTAFRIAYAERGPVLVDIP
RDYFYGELDEDILHPSQYRVAPGGIGNPEHFAAAVEVLKNAKNPVIISGRGVVDSGCMETLKAMAEYLGAPVATTYLHND
AFPCDHPLWTGPIGYMGSKAAMRILQKADVILAVGTRLSYFGTLPQYDINYFPKTAKIVQIDINPRHIAKTHPVAVGLCA
DAKDASEELFARLREAVPAKKDLTPVHNLVKDELENWYKEIALIADEPVEAGRMHPRKALEVVGKFITDHDAIATTDIGN
TSSTANSYLRFKKTKRHVATLTFGNTGFAYQAALGAQLACPEDLTVAIVGDGAWGMSLFEVPTACQYNLPVIATVYNNGA
WCAEKKNQVDFYNNRFVGADIWSKSYAKIGEAMGADGYTVNTQKDLAEALDTARKNRRPAVIEIMTDGTRLAPPFRRDAL
ALPTRFLPKYEHLDKAHFNK
>Mature_579_residues
PKMTPSEAMTEVLVQEGVNHVSGILGSAFMDMLDLFPAAGIDFVSVRHEQTAGHMEDAYSRLTGRAGVVIGQNGPGITNY
VTAVATANMAHSPMVVISPSAGSISVGWDGFQECDTWNLFKPITKASLRVPHPKRAADILRTAFRIAYAERGPVLVDIPR
DYFYGELDEDILHPSQYRVAPGGIGNPEHFAAAVEVLKNAKNPVIISGRGVVDSGCMETLKAMAEYLGAPVATTYLHNDA
FPCDHPLWTGPIGYMGSKAAMRILQKADVILAVGTRLSYFGTLPQYDINYFPKTAKIVQIDINPRHIAKTHPVAVGLCAD
AKDASEELFARLREAVPAKKDLTPVHNLVKDELENWYKEIALIADEPVEAGRMHPRKALEVVGKFITDHDAIATTDIGNT
SSTANSYLRFKKTKRHVATLTFGNTGFAYQAALGAQLACPEDLTVAIVGDGAWGMSLFEVPTACQYNLPVIATVYNNGAW
CAEKKNQVDFYNNRFVGADIWSKSYAKIGEAMGADGYTVNTQKDLAEALDTARKNRRPAVIEIMTDGTRLAPPFRRDALA
LPTRFLPKYEHLDKAHFNK

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=585, Percent_Identity=25.2991452991453, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI21361361, Length=589, Percent_Identity=25.9762308998302, Blast_Score=143, Evalue=4e-34,
Organism=Escherichia coli, GI87081685, Length=581, Percent_Identity=31.6695352839931, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1790104, Length=551, Percent_Identity=29.038112522686, Blast_Score=196, Evalue=5e-51,
Organism=Escherichia coli, GI1788716, Length=561, Percent_Identity=27.6292335115865, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1786717, Length=569, Percent_Identity=26.713532513181, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI1787096, Length=564, Percent_Identity=26.063829787234, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17542570, Length=593, Percent_Identity=26.1382799325464, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17531299, Length=583, Percent_Identity=25.9005145797599, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17531301, Length=583, Percent_Identity=25.9005145797599, Blast_Score=136, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323755, Length=565, Percent_Identity=26.9026548672566, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320816, Length=564, Percent_Identity=23.5815602836879, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI19922626, Length=579, Percent_Identity=26.7702936096718, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017820
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.3.3.15 [H]

Molecular weight: Translated: 63339; Mature: 63208

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKMTPSEAMTEVLVQEGVNHVSGILGSAFMDMLDLFPAAGIDFVSVRHEQTAGHMEDAY
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCHHHHHH
SRLTGRAGVVIGQNGPGITNYVTAVATANMAHSPMVVISPSAGSISVGWDGFQECDTWNL
HHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCHHHCCCCHH
FKPITKASLRVPHPKRAADILRTAFRIAYAERGPVLVDIPRDYFYGELDEDILHPSQYRV
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCHHHCCCCCEEE
APGGIGNPEHFAAAVEVLKNAKNPVIISGRGVVDSGCMETLKAMAEYLGAPVATTYLHND
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECC
AFPCDHPLWTGPIGYMGSKAAMRILQKADVILAVGTRLSYFGTLPQYDINYFPKTAKIVQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCHHHHHCCCCCCCCCCCCCCEEEEE
IDINPRHIAKTHPVAVGLCADAKDASEELFARLREAVPAKKDLTPVHNLVKDELENWYKE
EECCCHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
IALIADEPVEAGRMHPRKALEVVGKFITDHDAIATTDIGNTSSTANSYLRFKKTKRHVAT
HHHHCCCCCHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCEEEE
LTFGNTGFAYQAALGAQLACPEDLTVAIVGDGAWGMSLFEVPTACQYNLPVIATVYNNGA
EEECCCCCEEHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCCCCEEEEEECCCE
WCAEKKNQVDFYNNRFVGADIWSKSYAKIGEAMGADGYTVNTQKDLAEALDTARKNRRPA
EECCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCE
VIEIMTDGTRLAPPFRRDALALPTRFLPKYEHLDKAHFNK
EEEEEECCCCCCCCHHCCHHHCCHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
PKMTPSEAMTEVLVQEGVNHVSGILGSAFMDMLDLFPAAGIDFVSVRHEQTAGHMEDAY
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCHHHHHH
SRLTGRAGVVIGQNGPGITNYVTAVATANMAHSPMVVISPSAGSISVGWDGFQECDTWNL
HHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCHHHCCCCHH
FKPITKASLRVPHPKRAADILRTAFRIAYAERGPVLVDIPRDYFYGELDEDILHPSQYRV
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCHHHCCCCCEEE
APGGIGNPEHFAAAVEVLKNAKNPVIISGRGVVDSGCMETLKAMAEYLGAPVATTYLHND
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECC
AFPCDHPLWTGPIGYMGSKAAMRILQKADVILAVGTRLSYFGTLPQYDINYFPKTAKIVQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCHHHHHCCCCCCCCCCCCCCEEEEE
IDINPRHIAKTHPVAVGLCADAKDASEELFARLREAVPAKKDLTPVHNLVKDELENWYKE
EECCCHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
IALIADEPVEAGRMHPRKALEVVGKFITDHDAIATTDIGNTSSTANSYLRFKKTKRHVAT
HHHHCCCCCHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCEEEE
LTFGNTGFAYQAALGAQLACPEDLTVAIVGDGAWGMSLFEVPTACQYNLPVIATVYNNGA
EEECCCCCEEHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCCCCEEEEEECCCE
WCAEKKNQVDFYNNRFVGADIWSKSYAKIGEAMGADGYTVNTQKDLAEALDTARKNRRPA
EECCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCE
VIEIMTDGTRLAPPFRRDALALPTRFLPKYEHLDKAHFNK
EEEEEECCCCCCCCHHCCHHHCCHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11439112; 12358600 [H]