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The map label for this gene is icd [H]

Identifier: 220903387

GI number: 220903387

Start: 130685

End: 131827

Strand: Reverse

Name: icd [H]

Synonym: Ddes_0101

Alternate gene names: 220903387

Gene position: 131827-130685 (Counterclockwise)

Preceding gene: 220903388

Following gene: 220903386

Centisome position: 4.59

GC content: 64.13

Gene sequence:

>1143_bases
ATGCGCAAGACTGTGTACTGGATCGAAGGCGATGGCATTGGCCCGGAAATCTGGCAGGCCGCCCGCCCGGTCATTGAAGG
GGCCATTCGCGCCGCCGGGGCTGACCTTACCCTTGACTGGGTAGAACTACTGGCTGGCGACAAGGCCGTGAAAGAAAACG
GTCATCCCCTGCCCGAAGCCACGCTTGAAGCCCTGCGCCATGCCGAACTCGCCATGAAGGGTCCCCTGGGTACGCCCGTG
GGCACGGGCATCCGCAGTCTTAACGTGGCCCTGCGCCAGACCCTGGACCTTTACGCCTGCATCCGCCCCGTGCGCCACTT
TGAAGGGCTGGAAACCCCGGTCAAGCATCCCGAGCGCGTCAACATGGTCATCTTTCGTGAAAATACCGAAGACGTGTACG
CGGGTGTGGAATTTGCCGCCAACACCCCCGAGGCGCGCAAACTTGTGGCCTTTCTGCGCGATGAGCTGGGCGTGACCAAG
GTCGGCGACGACGCTGCCGTGGGCATCAAACCCATGACGGAAGCAGGCTCCAAGCGCCTTGTGCGCCGCGCCCTGCGCTT
TGCCCTGGACCAGAAGCAGGAAAGCCTCACCCTTGTGCACAAGGGCAACATCATGAAATTCACCGAAGGCGCTTTTCGCC
AGTGGGGCTATGACGTGGCCGCCCAGGAATTCGGCGACTGCACCTGCACCGAAAAAGAACCCGTGGCCGGGCGCCTTGTG
GTCAAAGACCGCATAGCCGACGCCATGTTCCAGGAGGCGCTGTTGCGCCCCGAGCAGTATCAGGTGCTGGCAACGCCCAA
CCTCAACGGCGACTATATCTCCGATGCGCTGGCGGCCCAGGTGGGCGGCCTCGGCCTTGCACCGGGCGTGAACATGTCCG
ACACGCTGGCCTTCTACGAAGCCACCCACGGCACTGCCCCCACCATCGCGGGCAAGGACAGGGCCAATCCCGGCAGCGTT
ATCCTGTGCGGCGCGCTCATGCTTGAGCACCTGGGCCAGCACGATGCCGCCGGGCGCATCCGCAGGGCCGTGGCCAAGGC
CATTGCGGGCAAGGCCGTTACCGAAGACCTGGCCGCCCAGGTTACCGGATCCCGCGTGGTGGGCTGCAAGGAGTTTGGCG
ACATCATCGGGACCAACCTGTAG

Upstream 100 bases:

>100_bases
TGACGGGGACTAGACCGCTTTTCAGCATCAGACCGGGGCCGGGCTTGGGATGGCCCGGCCCTGCTTCATATTCAACGCTA
TTACAAAAGGACGGGGGAAC

Downstream 100 bases:

>100_bases
CAGCCGTGCTGGCGAAACAGGCCCGCGCAGTGCCGGCATGGCACGCCTACCGCAGAATGCCGTGCGGCGCACGGGCCAAA
AAGCCAAAACGCTATTTGCC

Product: isocitrate/isopropylmalate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MRKTVYWIEGDGIGPEIWQAARPVIEGAIRAAGADLTLDWVELLAGDKAVKENGHPLPEATLEALRHAELAMKGPLGTPV
GTGIRSLNVALRQTLDLYACIRPVRHFEGLETPVKHPERVNMVIFRENTEDVYAGVEFAANTPEARKLVAFLRDELGVTK
VGDDAAVGIKPMTEAGSKRLVRRALRFALDQKQESLTLVHKGNIMKFTEGAFRQWGYDVAAQEFGDCTCTEKEPVAGRLV
VKDRIADAMFQEALLRPEQYQVLATPNLNGDYISDALAAQVGGLGLAPGVNMSDTLAFYEATHGTAPTIAGKDRANPGSV
ILCGALMLEHLGQHDAAGRIRRAVAKAIAGKAVTEDLAAQVTGSRVVGCKEFGDIIGTNL

Sequences:

>Translated_380_residues
MRKTVYWIEGDGIGPEIWQAARPVIEGAIRAAGADLTLDWVELLAGDKAVKENGHPLPEATLEALRHAELAMKGPLGTPV
GTGIRSLNVALRQTLDLYACIRPVRHFEGLETPVKHPERVNMVIFRENTEDVYAGVEFAANTPEARKLVAFLRDELGVTK
VGDDAAVGIKPMTEAGSKRLVRRALRFALDQKQESLTLVHKGNIMKFTEGAFRQWGYDVAAQEFGDCTCTEKEPVAGRLV
VKDRIADAMFQEALLRPEQYQVLATPNLNGDYISDALAAQVGGLGLAPGVNMSDTLAFYEATHGTAPTIAGKDRANPGSV
ILCGALMLEHLGQHDAAGRIRRAVAKAIAGKAVTEDLAAQVTGSRVVGCKEFGDIIGTNL
>Mature_380_residues
MRKTVYWIEGDGIGPEIWQAARPVIEGAIRAAGADLTLDWVELLAGDKAVKENGHPLPEATLEALRHAELAMKGPLGTPV
GTGIRSLNVALRQTLDLYACIRPVRHFEGLETPVKHPERVNMVIFRENTEDVYAGVEFAANTPEARKLVAFLRDELGVTK
VGDDAAVGIKPMTEAGSKRLVRRALRFALDQKQESLTLVHKGNIMKFTEGAFRQWGYDVAAQEFGDCTCTEKEPVAGRLV
VKDRIADAMFQEALLRPEQYQVLATPNLNGDYISDALAAQVGGLGLAPGVNMSDTLAFYEATHGTAPTIAGKDRANPGSV
ILCGALMLEHLGQHDAAGRIRRAVAKAIAGKAVTEDLAAQVTGSRVVGCKEFGDIIGTNL

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=366, Percent_Identity=34.9726775956284, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI4758582, Length=370, Percent_Identity=30.2702702702703, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI28178838, Length=355, Percent_Identity=30.7042253521127, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI28178816, Length=333, Percent_Identity=28.2282282282282, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI28178821, Length=332, Percent_Identity=28.3132530120482, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI28178819, Length=207, Percent_Identity=29.4685990338164, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787381, Length=386, Percent_Identity=51.0362694300518, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788101, Length=379, Percent_Identity=26.9129287598945, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI87081683, Length=386, Percent_Identity=27.4611398963731, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71986051, Length=363, Percent_Identity=34.1597796143251, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI25144293, Length=371, Percent_Identity=30.7277628032345, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17505779, Length=371, Percent_Identity=29.9191374663073, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17550882, Length=365, Percent_Identity=27.1232876712329, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324709, Length=369, Percent_Identity=31.7073170731707, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322097, Length=372, Percent_Identity=33.0645161290323, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6324291, Length=361, Percent_Identity=32.409972299169, Blast_Score=159, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24643270, Length=379, Percent_Identity=35.3562005277045, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24643268, Length=379, Percent_Identity=35.3562005277045, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24661184, Length=380, Percent_Identity=34.2105263157895, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161078635, Length=369, Percent_Identity=27.9132791327913, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI161078633, Length=369, Percent_Identity=27.9132791327913, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24650122, Length=369, Percent_Identity=27.9132791327913, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI161078637, Length=369, Percent_Identity=27.9132791327913, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI161078639, Length=361, Percent_Identity=27.9778393351801, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI281362242, Length=371, Percent_Identity=27.4932614555256, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24648872, Length=371, Percent_Identity=27.4932614555256, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI20130355, Length=364, Percent_Identity=24.4505494505494, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 40899; Mature: 40899

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTVYWIEGDGIGPEIWQAARPVIEGAIRAAGADLTLDWVELLAGDKAVKENGHPLPEA
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCCCCCCHH
TLEALRHAELAMKGPLGTPVGTGIRSLNVALRQTLDLYACIRPVRHFEGLETPVKHPERV
HHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
NMVIFRENTEDVYAGVEFAANTPEARKLVAFLRDELGVTKVGDDAAVGIKPMTEAGSKRL
EEEEEECCCCHHHHCCHHCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHH
VRRALRFALDQKQESLTLVHKGNIMKFTEGAFRQWGYDVAAQEFGDCTCTEKEPVAGRLV
HHHHHHHHHHCCHHCEEEEECCCEEEEHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEH
VKDRIADAMFQEALLRPEQYQVLATPNLNGDYISDALAAQVGGLGLAPGVNMSDTLAFYE
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHEE
ATHGTAPTIAGKDRANPGSVILCGALMLEHLGQHDAAGRIRRAVAKAIAGKAVTEDLAAQ
CCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VTGSRVVGCKEFGDIIGTNL
HCCCEEECHHHHHHHHCCCC
>Mature Secondary Structure
MRKTVYWIEGDGIGPEIWQAARPVIEGAIRAAGADLTLDWVELLAGDKAVKENGHPLPEA
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCCCCCCCHH
TLEALRHAELAMKGPLGTPVGTGIRSLNVALRQTLDLYACIRPVRHFEGLETPVKHPERV
HHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
NMVIFRENTEDVYAGVEFAANTPEARKLVAFLRDELGVTKVGDDAAVGIKPMTEAGSKRL
EEEEEECCCCHHHHCCHHCCCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHH
VRRALRFALDQKQESLTLVHKGNIMKFTEGAFRQWGYDVAAQEFGDCTCTEKEPVAGRLV
HHHHHHHHHHCCHHCEEEEECCCEEEEHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCEEH
VKDRIADAMFQEALLRPEQYQVLATPNLNGDYISDALAAQVGGLGLAPGVNMSDTLAFYE
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHEE
ATHGTAPTIAGKDRANPGSVILCGALMLEHLGQHDAAGRIRRAVAKAIAGKAVTEDLAAQ
CCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VTGSRVVGCKEFGDIIGTNL
HCCCEEECHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]