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The map label for this gene is ppiB [H]

Identifier: 220903351

GI number: 220903351

Start: 85516

End: 86025

Strand: Direct

Name: ppiB [H]

Synonym: Ddes_0065

Alternate gene names: 220903351

Gene position: 85516-86025 (Clockwise)

Preceding gene: 220903349

Following gene: 220903352

Centisome position: 2.98

GC content: 57.25

Gene sequence:

>510_bases
ATGGCTGATAATCCCACGGTTTTGCTGGAAACCACGTCCGGCGATATTTTGCTGGAACTTTTCCCCGACAAGGCCCCGAA
AACCGTTGCCAACTTTCTGCAGTATGTGGATGATGGTTTTTACAACAATACCATTTTCCACCGCGTTATCCCCGGCTTCA
TGATCCAGGGCGGCGGCCTCGGCGCGCGCATGGATGAAAAGGCCACCCGCGAGCCCGTTGCCAACGAGGCCGACAACGGC
GTGAAAAACGAGCGCGGCACCATCGCCATGGCCCGTACGCGCGACCCGCACAGCGCCACCGCCCAGTTCTTCATCAACCT
GGTGGACAATGATTTTCTCAACCACAGCGCACCCACCCTTGATGGTTGGGGCTACTGCGCTTTCGGCCGCGTGACCGAAG
GCATGGAAGTGGTGGAAAAGATCGCCAAGGTCAAAACCAAGAGCATGGGCATGCATGAAAACGTGCCTGTGGATATGGTG
CTCATTACCGGGGCCAGCCGCTTCGAGTAA

Upstream 100 bases:

>100_bases
GCGGGCATTGTCATCTGCCGGGGCATGGCCTATATTCCGGATCGGGCGCATTCCGGCCTTTGCCGGAGCGCGCCGCCACC
ACAAGTAGCAAGGAGCTGTC

Downstream 100 bases:

>100_bases
TATTTCGCCGCCGTAAGGCGCGCAGCCTGTCCTCAAGAGACGCGCCCCGGCCTTGTCGGCCGAGGGCGCGTCCTGTTTTT
TTGCCTGTATCCGCCGGGCG

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MADNPTVLLETTSGDILLELFPDKAPKTVANFLQYVDDGFYNNTIFHRVIPGFMIQGGGLGARMDEKATREPVANEADNG
VKNERGTIAMARTRDPHSATAQFFINLVDNDFLNHSAPTLDGWGYCAFGRVTEGMEVVEKIAKVKTKSMGMHENVPVDMV
LITGASRFE

Sequences:

>Translated_169_residues
MADNPTVLLETTSGDILLELFPDKAPKTVANFLQYVDDGFYNNTIFHRVIPGFMIQGGGLGARMDEKATREPVANEADNG
VKNERGTIAMARTRDPHSATAQFFINLVDNDFLNHSAPTLDGWGYCAFGRVTEGMEVVEKIAKVKTKSMGMHENVPVDMV
LITGASRFE
>Mature_168_residues
ADNPTVLLETTSGDILLELFPDKAPKTVANFLQYVDDGFYNNTIFHRVIPGFMIQGGGLGARMDEKATREPVANEADNGV
KNERGTIAMARTRDPHSATAQFFINLVDNDFLNHSAPTLDGWGYCAFGRVTEGMEVVEKIAKVKTKSMGMHENVPVDMVL
ITGASRFE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI64276486, Length=133, Percent_Identity=40.6015037593985, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI24308049, Length=146, Percent_Identity=36.3013698630137, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=36.3636363636364, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI19557636, Length=143, Percent_Identity=35.6643356643357, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI22547212, Length=161, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI7657473, Length=161, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1786736, Length=156, Percent_Identity=63.4615384615385, Blast_Score=213, Evalue=6e-57,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=55.5555555555556, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17539496, Length=147, Percent_Identity=39.4557823129252, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=35.6643356643357, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=143, Percent_Identity=35.6643356643357, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=169, Percent_Identity=33.1360946745562, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=149, Percent_Identity=35.5704697986577, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=167, Percent_Identity=35.3293413173653, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=165, Percent_Identity=35.7575757575758, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565860, Length=171, Percent_Identity=34.5029239766082, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=163, Percent_Identity=36.8098159509202, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=37.8048780487805, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19922912, Length=142, Percent_Identity=36.6197183098592, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=28.4848484848485, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357249, Length=104, Percent_Identity=36.5384615384615, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18569; Mature: 18438

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNPTVLLETTSGDILLELFPDKAPKTVANFLQYVDDGFYNNTIFHRVIPGFMIQGGGL
CCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCC
GARMDEKATREPVANEADNGVKNERGTIAMARTRDPHSATAQFFINLVDNDFLNHSAPTL
CCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCHHCCCCCCCC
DGWGYCAFGRVTEGMEVVEKIAKVKTKSMGMHENVPVDMVLITGASRFE
CCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
ADNPTVLLETTSGDILLELFPDKAPKTVANFLQYVDDGFYNNTIFHRVIPGFMIQGGGL
CCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEECCCC
GARMDEKATREPVANEADNGVKNERGTIAMARTRDPHSATAQFFINLVDNDFLNHSAPTL
CCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCHHCCCCCCCC
DGWGYCAFGRVTEGMEVVEKIAKVKTKSMGMHENVPVDMVLITGASRFE
CCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]