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The map label for this gene is xasA [C]

Identifier: 220903332

GI number: 220903332

Start: 60864

End: 62351

Strand: Reverse

Name: xasA [C]

Synonym: Ddes_0046

Alternate gene names: 220903332

Gene position: 62351-60864 (Counterclockwise)

Preceding gene: 220903335

Following gene: 220903331

Centisome position: 2.17

GC content: 55.51

Gene sequence:

>1488_bases
ATGCCCGAACAACCCCCAAAAAACGTCGCCATTTCAACCCTCGCCCTGATGGCGCTGGGCACAGTTGTAAGTCTGAACGC
ACTGCCCATGATGGCCCTTGAGGGGCTTTCGCTGGTTTTCTATATTCTTTTTGCTACAGTTGTTTTTCTTCTGCCTGCCG
GCATGGTGTCTGCCGAACTGGGCAGCGCCTTTGCCGAACGCAAGGGCGGCGTCTACATATGGGTAAAAGAGGCTTTCGGC
CCACGCTGGGGCTTTGTAGCCATATGGTTGCAGTGGGTGCAGACCCTGGCCTGGTACCCCACCATTCTCGGCTTTTCCGC
AGCCTCTCTGGCTTATTGCCTGGGCGACCCGCACCTGTCGCAAAGCGGCGTGTACACCGGACTTGTCAGCATAGGCATTT
ATGCCTGCGCCACCGGCGTGGCGCTGAGCGGCACCGGCGCAGTCAACACGCTGACCAAGTACAGCGTCTTTATGGGAACT
CTTGTTCCAAGCCTGTTCATCATCATTCTCGGCCTGTTCTGGATTGACCAGGGCAATGCCGTGGCCTTTCTGACGCAAAA
CACGCAGATAGACGGGCATATGGTGCGCGAACATGTGCATCCGCGCTTTTTTCCGCATTTCACGGGCCTTGGCAGTGTGA
CCTTTCTTGCGGGCATTCTGCTTATGTTTTCAGGTATTGAAGTACAGGGGGTTCAGGCGGCAAGCATGAAAAATCCGCGC
CGGGATTTTCCCATTGCCATGCTGCTGGCTTCGGCTATTGCCTTTCTTATTTATCTTATGGGGTCGCTTGCCGTGGCAAC
CGTGCTTACACCCAAAGAAATAAGCCTCACGGCCGGGCTGATGGAGGCCTTTTCCCTGATGCTGCACAAGTTTGATCTGG
ATTTTCTTGTGCCGCTGATCGCCCTGCTTATCACCTTCGGCGGCGTGGGGAATGTGATGGCCTGGGTTTCCGGCCCAAGC
AAAGGTATGCTGCAGACTGCCCGCGACGGCGAAGCACCGCCGTTTTTCGGCAAGGTGAACAAGGCCGGTGCGCCCGTGGC
CCTGCTTGCCATACAGGGCGTTATCGTTCTTGCCCTGAGTTCCATCTACTTTCTGGTAAAAAATGTCAGTATCGCCTTTT
TCATTCTGACAACGCTTACGGCCAGCATCTATCTGGCCATGTATCTGCTCATGTTCGGCGCGGCCATACGCCTTCGCATC
ACCCGACCCGATCTTCCGCGAACATACAGCGTGCCCGGCGGTCTTGTGGGCATGTTTCTGATCGGCGGCACGGGTCTGCT
GGGCGTGGCCTTTGCCTTTACGGCGGGATTTTTCCCGCCGCACAACCTGCCTGTGGGCAATCCTGCCCTGTATGTAGCCC
TTGTGGCGGGCGGTCTGTCGATCTTTATTGCCATTCCGCTCATCATCCAGGCCTTCAAAAAGCCTCAATGGAAACGCACA
ACAAGTGCGGAAAACAATTTTTCAATTAACGGCAACAATGGAGATTAA

Upstream 100 bases:

>100_bases
TTGGCTTTTTACTAATCAAAACGATTCTTCATTTTACCTGAAGAACGGCGAGTCCCTGAATTCAGATTTCTTTTTTTCCT
CTTGCCATTCGAGGATACGG

Downstream 100 bases:

>100_bases
AGCATGACTGCGAAAAACACCTTGCGCAATACGGTACTTGATGACACCTATGCCGCGTCGGATATGGCAAATGCCATGCC
GCGCCATGAGATGCCCCAAC

Product: amino acid permease-associated protein

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MPEQPPKNVAISTLALMALGTVVSLNALPMMALEGLSLVFYILFATVVFLLPAGMVSAELGSAFAERKGGVYIWVKEAFG
PRWGFVAIWLQWVQTLAWYPTILGFSAASLAYCLGDPHLSQSGVYTGLVSIGIYACATGVALSGTGAVNTLTKYSVFMGT
LVPSLFIIILGLFWIDQGNAVAFLTQNTQIDGHMVREHVHPRFFPHFTGLGSVTFLAGILLMFSGIEVQGVQAASMKNPR
RDFPIAMLLASAIAFLIYLMGSLAVATVLTPKEISLTAGLMEAFSLMLHKFDLDFLVPLIALLITFGGVGNVMAWVSGPS
KGMLQTARDGEAPPFFGKVNKAGAPVALLAIQGVIVLALSSIYFLVKNVSIAFFILTTLTASIYLAMYLLMFGAAIRLRI
TRPDLPRTYSVPGGLVGMFLIGGTGLLGVAFAFTAGFFPPHNLPVGNPALYVALVAGGLSIFIAIPLIIQAFKKPQWKRT
TSAENNFSINGNNGD

Sequences:

>Translated_495_residues
MPEQPPKNVAISTLALMALGTVVSLNALPMMALEGLSLVFYILFATVVFLLPAGMVSAELGSAFAERKGGVYIWVKEAFG
PRWGFVAIWLQWVQTLAWYPTILGFSAASLAYCLGDPHLSQSGVYTGLVSIGIYACATGVALSGTGAVNTLTKYSVFMGT
LVPSLFIIILGLFWIDQGNAVAFLTQNTQIDGHMVREHVHPRFFPHFTGLGSVTFLAGILLMFSGIEVQGVQAASMKNPR
RDFPIAMLLASAIAFLIYLMGSLAVATVLTPKEISLTAGLMEAFSLMLHKFDLDFLVPLIALLITFGGVGNVMAWVSGPS
KGMLQTARDGEAPPFFGKVNKAGAPVALLAIQGVIVLALSSIYFLVKNVSIAFFILTTLTASIYLAMYLLMFGAAIRLRI
TRPDLPRTYSVPGGLVGMFLIGGTGLLGVAFAFTAGFFPPHNLPVGNPALYVALVAGGLSIFIAIPLIIQAFKKPQWKRT
TSAENNFSINGNNGD
>Mature_494_residues
PEQPPKNVAISTLALMALGTVVSLNALPMMALEGLSLVFYILFATVVFLLPAGMVSAELGSAFAERKGGVYIWVKEAFGP
RWGFVAIWLQWVQTLAWYPTILGFSAASLAYCLGDPHLSQSGVYTGLVSIGIYACATGVALSGTGAVNTLTKYSVFMGTL
VPSLFIIILGLFWIDQGNAVAFLTQNTQIDGHMVREHVHPRFFPHFTGLGSVTFLAGILLMFSGIEVQGVQAASMKNPRR
DFPIAMLLASAIAFLIYLMGSLAVATVLTPKEISLTAGLMEAFSLMLHKFDLDFLVPLIALLITFGGVGNVMAWVSGPSK
GMLQTARDGEAPPFFGKVNKAGAPVALLAIQGVIVLALSSIYFLVKNVSIAFFILTTLTASIYLAMYLLMFGAAIRLRIT
RPDLPRTYSVPGGLVGMFLIGGTGLLGVAFAFTAGFFPPHNLPVGNPALYVALVAGGLSIFIAIPLIIQAFKKPQWKRTT
SAENNFSINGNNGD

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787768, Length=475, Percent_Identity=30.3157894736842, Blast_Score=216, Evalue=4e-57,
Organism=Escherichia coli, GI48994921, Length=444, Percent_Identity=23.8738738738739, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081798, Length=349, Percent_Identity=22.3495702005731, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI2367353, Length=377, Percent_Identity=25.7294429708223, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=405, Percent_Identity=24.1975308641975, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357367, Length=428, Percent_Identity=24.0654205607477, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52775; Mature: 52644

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEQPPKNVAISTLALMALGTVVSLNALPMMALEGLSLVFYILFATVVFLLPAGMVSAEL
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GSAFAERKGGVYIWVKEAFGPRWGFVAIWLQWVQTLAWYPTILGFSAASLAYCLGDPHLS
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QSGVYTGLVSIGIYACATGVALSGTGAVNTLTKYSVFMGTLVPSLFIIILGLFWIDQGNA
CCCHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VAFLTQNTQIDGHMVREHVHPRFFPHFTGLGSVTFLAGILLMFSGIEVQGVQAASMKNPR
EEEEECCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCCHHHCCCCC
RDFPIAMLLASAIAFLIYLMGSLAVATVLTPKEISLTAGLMEAFSLMLHKFDLDFLVPLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ALLITFGGVGNVMAWVSGPSKGMLQTARDGEAPPFFGKVNKAGAPVALLAIQGVIVLALS
HHHHHHCCHHHHHEEECCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
SIYFLVKNVSIAFFILTTLTASIYLAMYLLMFGAAIRLRITRPDLPRTYSVPGGLVGMFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEECCCCHHHHHHH
IGGTGLLGVAFAFTAGFFPPHNLPVGNPALYVALVAGGLSIFIAIPLIIQAFKKPQWKRT
HCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TSAENNFSINGNNGD
CCCCCCEEECCCCCC
>Mature Secondary Structure 
PEQPPKNVAISTLALMALGTVVSLNALPMMALEGLSLVFYILFATVVFLLPAGMVSAEL
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH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CCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]