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The map label for this gene is ahcY [H]

Identifier: 220903325

GI number: 220903325

Start: 49852

End: 51273

Strand: Reverse

Name: ahcY [H]

Synonym: Ddes_0039

Alternate gene names: 220903325

Gene position: 51273-49852 (Counterclockwise)

Preceding gene: 220903326

Following gene: 220903324

Centisome position: 1.78

GC content: 58.02

Gene sequence:

>1422_bases
ATGACCAAAGCTCTTGATCTGAGCCTGGCGCACAAAGTTGCGGATATGGCCCTGGCCGACTTCGGCAAAAAAGAAATGCA
GCTTTCCGAGCGGGAAGTGCCCGGTCTTATGGAGTGCATCAAAAAATACGGCTCCAGCCAGCCCCTCAAGGGGCTCAAGA
TTACCGGCTCGCTGCACATGACCATCCAGACGGCCATGCTTATTCAGACCCTGCACGCCCTGGGCGCGGATCTTCGCTGG
GCTTCATGCAATATCTTTTCCACTCAGGACCACGCCGCCGCCGCCATTGCCGACCTGGGCATGGCGAAGGTTTTTGCCTG
GAAAGGCGAAACCCTTGAAGATTACTGGTGGTGCACCGAAATGGCCCTTACCTGGCCCGACGGCTCCGGTCCCGACCTTA
TCGTGGACGACGGCGGCGATGCCACCCTGCTCATCCACAAGGGTGTGGAAGCTGAAAACAATCCCGCCATCCTTGACGAA
AAGACCGATAACAAGGAACTTCAGTGCATCCTTGACCGCCTCAAACTGCGCCTCAAGGAAGACCCGCAGCACTGGCACAA
GGTTGCCGCCGGCATGAAGGGCGTGTCGGAAGAAACCACCACTGGCGTACACCGCCTTTACCAGCTTGAGGCCGCGGGCA
AACTGCTTTTCCCGGCCATCAACGTCAACGATGCGGTGACCAAGTCCAAATTCGACAACCTGTACGGCTGCCGCGAATCG
CTGGCAGACGGCATCAAGCGTGCCACTGACGTCATGATCGCCGGCAAGGTGGTTGTGGTGATCGGCTACGGCGACGTGGG
CAAAGGCTGCGCCCAGTCCATGCGCGGCCTCGGCGCGCGCGTTCTGGTGACCGAGATCGACCCCATCTGCGCACTTCAGG
CCGCCATGGAAGGCTACGAAGTCACCACGGTTGAAGACGCCCTGCCCTACGGTGACATTTATGTGACCTGCACGGGCAAC
TATCATGTCATCAGCGGCAAACATATGGAAGGCATGAAAGACGAAGCCATCGTGTGCAATATCGGCCACTTCGATAACGA
AATCGAAATGACCTATCTGGAAAACACGCCCGGCATCACCTGCCTGAACATCAAGCCGCAGGTGGACAAGTGGACCCTCA
AGTCCGGCCGCAGCATCATTGTGCTGGCCGAAGGCCGCCTGGTAAACCTTGGCTGCGCCACAGGCCACGCCAGCTTTGTC
ATGTCCAACAGCTTTACCAACCAGACACTGGCCCAGATCAAGCTGGCCACTGAAAAGCTGGAAAACAAGGTCTACACCCT
GCCCAAGGAGCTGGACGAAGAAGTGGCCCGTCTGCATCTTGGCCGCCTCGGCGCAAAACTGACCAAACTTTCCAGGGAAC
AGGCCGACTATATCGGCGTTAACGTGGACGGTCCCTACAAGTCGGACCACTACCGCTACTAG

Upstream 100 bases:

>100_bases
GCCGCAAGGCCGCGGGGTTTTCCGGGCAGCAGAAGCATGCCCGGCGCGCATCCGGACACAATGCAAACAAACATACCATG
TCAAAGGATAGGAGAAACAC

Downstream 100 bases:

>100_bases
AACATACCCACTCTGAAATGCCTGCCTGACGGCGAGACACTTCTGCTGTCTGCGTCCGCACCCTGATGCACCGTAACGGC
GGGATCAGGTCCGTCTTGCA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTKALDLSLAHKVADMALADFGKKEMQLSEREVPGLMECIKKYGSSQPLKGLKITGSLHMTIQTAMLIQTLHALGADLRW
ASCNIFSTQDHAAAAIADLGMAKVFAWKGETLEDYWWCTEMALTWPDGSGPDLIVDDGGDATLLIHKGVEAENNPAILDE
KTDNKELQCILDRLKLRLKEDPQHWHKVAAGMKGVSEETTTGVHRLYQLEAAGKLLFPAINVNDAVTKSKFDNLYGCRES
LADGIKRATDVMIAGKVVVVIGYGDVGKGCAQSMRGLGARVLVTEIDPICALQAAMEGYEVTTVEDALPYGDIYVTCTGN
YHVISGKHMEGMKDEAIVCNIGHFDNEIEMTYLENTPGITCLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATGHASFV
MSNSFTNQTLAQIKLATEKLENKVYTLPKELDEEVARLHLGRLGAKLTKLSREQADYIGVNVDGPYKSDHYRY

Sequences:

>Translated_473_residues
MTKALDLSLAHKVADMALADFGKKEMQLSEREVPGLMECIKKYGSSQPLKGLKITGSLHMTIQTAMLIQTLHALGADLRW
ASCNIFSTQDHAAAAIADLGMAKVFAWKGETLEDYWWCTEMALTWPDGSGPDLIVDDGGDATLLIHKGVEAENNPAILDE
KTDNKELQCILDRLKLRLKEDPQHWHKVAAGMKGVSEETTTGVHRLYQLEAAGKLLFPAINVNDAVTKSKFDNLYGCRES
LADGIKRATDVMIAGKVVVVIGYGDVGKGCAQSMRGLGARVLVTEIDPICALQAAMEGYEVTTVEDALPYGDIYVTCTGN
YHVISGKHMEGMKDEAIVCNIGHFDNEIEMTYLENTPGITCLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATGHASFV
MSNSFTNQTLAQIKLATEKLENKVYTLPKELDEEVARLHLGRLGAKLTKLSREQADYIGVNVDGPYKSDHYRY
>Mature_472_residues
TKALDLSLAHKVADMALADFGKKEMQLSEREVPGLMECIKKYGSSQPLKGLKITGSLHMTIQTAMLIQTLHALGADLRWA
SCNIFSTQDHAAAAIADLGMAKVFAWKGETLEDYWWCTEMALTWPDGSGPDLIVDDGGDATLLIHKGVEAENNPAILDEK
TDNKELQCILDRLKLRLKEDPQHWHKVAAGMKGVSEETTTGVHRLYQLEAAGKLLFPAINVNDAVTKSKFDNLYGCRESL
ADGIKRATDVMIAGKVVVVIGYGDVGKGCAQSMRGLGARVLVTEIDPICALQAAMEGYEVTTVEDALPYGDIYVTCTGNY
HVISGKHMEGMKDEAIVCNIGHFDNEIEMTYLENTPGITCLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATGHASFVM
SNSFTNQTLAQIKLATEKLENKVYTLPKELDEEVARLHLGRLGAKLTKLSREQADYIGVNVDGPYKSDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=467, Percent_Identity=58.6723768736617, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI239937451, Length=443, Percent_Identity=59.3679458239278, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI24308043, Length=464, Percent_Identity=46.3362068965517, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI298286489, Length=464, Percent_Identity=46.3362068965517, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI195539337, Length=464, Percent_Identity=46.3362068965517, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI195539349, Length=464, Percent_Identity=46.3362068965517, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI21361647, Length=464, Percent_Identity=45.2586206896552, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17506425, Length=469, Percent_Identity=60.1279317697228, Blast_Score=544, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6320882, Length=480, Percent_Identity=57.2916666666667, Blast_Score=518, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=58.7982832618026, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24656245, Length=456, Percent_Identity=47.3684210526316, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=46.2203023758099, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=46.1038961038961, Blast_Score=394, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51867; Mature: 51736

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKALDLSLAHKVADMALADFGKKEMQLSEREVPGLMECIKKYGSSQPLKGLKITGSLHM
CCCEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEECEEEE
TIQTAMLIQTLHALGADLRWASCNIFSTQDHAAAAIADLGMAKVFAWKGETLEDYWWCTE
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCHHEEEEECCCCHHHHEEEEE
MALTWPDGSGPDLIVDDGGDATLLIHKGVEAENNPAILDEKTDNKELQCILDRLKLRLKE
EEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCC
DPQHWHKVAAGMKGVSEETTTGVHRLYQLEAAGKLLFPAINVNDAVTKSKFDNLYGCRES
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
LADGIKRATDVMIAGKVVVVIGYGDVGKGCAQSMRGLGARVLVTEIDPICALQAAMEGYE
HHHHHHHHHHEEEECEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCE
VTTVEDALPYGDIYVTCTGNYHVISGKHMEGMKDEAIVCNIGHFDNEIEMTYLENTPGIT
EEEHHHCCCCCCEEEEEECCEEEEECCCCCCCCCCEEEEECCCCCCEEEEEEEECCCCEE
CLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATGHASFVMSNSFTNQTLAQIKLATEKL
EEECCCCCCCEECCCCCEEEEEECCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHH
ENKVYTLPKELDEEVARLHLGRLGAKLTKLSREQADYIGVNVDGPYKSDHYRY
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TKALDLSLAHKVADMALADFGKKEMQLSEREVPGLMECIKKYGSSQPLKGLKITGSLHM
CCEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEECEEEE
TIQTAMLIQTLHALGADLRWASCNIFSTQDHAAAAIADLGMAKVFAWKGETLEDYWWCTE
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCHHEEEEECCCCHHHHEEEEE
MALTWPDGSGPDLIVDDGGDATLLIHKGVEAENNPAILDEKTDNKELQCILDRLKLRLKE
EEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCC
DPQHWHKVAAGMKGVSEETTTGVHRLYQLEAAGKLLFPAINVNDAVTKSKFDNLYGCRES
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
LADGIKRATDVMIAGKVVVVIGYGDVGKGCAQSMRGLGARVLVTEIDPICALQAAMEGYE
HHHHHHHHHHEEEECEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCE
VTTVEDALPYGDIYVTCTGNYHVISGKHMEGMKDEAIVCNIGHFDNEIEMTYLENTPGIT
EEEHHHCCCCCCEEEEEECCEEEEECCCCCCCCCCEEEEECCCCCCEEEEEEEECCCCEE
CLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATGHASFVMSNSFTNQTLAQIKLATEKL
EEECCCCCCCEECCCCCEEEEEECCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHH
ENKVYTLPKELDEEVARLHLGRLGAKLTKLSREQADYIGVNVDGPYKSDHYRY
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA