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The map label for this gene is rnhA [H]

Identifier: 220903323

GI number: 220903323

Start: 46566

End: 47036

Strand: Reverse

Name: rnhA [H]

Synonym: Ddes_0037

Alternate gene names: 220903323

Gene position: 47036-46566 (Counterclockwise)

Preceding gene: 220903324

Following gene: 220903322

Centisome position: 1.64

GC content: 59.87

Gene sequence:

>471_bases
ATGCAAAACGTGACCATTCACACTGACGGCTCCTGTCTCGGCAATCCCGGCCCCGGCGGCTGGGCCGCCATCCTCAGGCT
GGACGAGGGCGACCACCGCAAGGAATTTTCCGGCGGGTACGCCCTGACCACCAATAACCGTATGGAAATGCTGGCCGTCA
TTGAGGCCCTGGCCCTGCTCAAAAGCCCCTGTACCGTGGACCTGTACACAGACTCACGCTACGTGTGCGACAGCGTGAGC
AAGGGCTGGCTGTGGGGATGGGTGAAAAAAAACTGGATCAAGTCCGACAAAAAACCTGTGCTCAATGTAGACCTGTGGCA
GCGCATGCTGCCCCTCCTGCGCCAGCACAAGGTAAATTTTCACTGGCTGAAAGGACACGCCGGGCATCCCGAAAACGAAC
GCTGTGACGTTCTGGCCCGCGCCCAGGCAAGCCGCCGTGACCTCCCCCCGGATACAGGCTATAAACCCTGA

Upstream 100 bases:

>100_bases
AAGCTGACACCTCCTGCTCCGCGCTACCCGCCTCACACTGTGGCGCATCCGTGCTGGGGCCGGAACGGCGTGTGCCAATT
CATGATTTTCAAGGAATACA

Downstream 100 bases:

>100_bases
CAGATAACCACCGTGTCCGGGTGCAGGCCTGCCGCCGCGCTCCGGGCATAAGCCGCAAAACCGCAATATCATGCCCGTAA
GTCCTTCCGCCGCAGAAAAC

Product: Ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MQNVTIHTDGSCLGNPGPGGWAAILRLDEGDHRKEFSGGYALTTNNRMEMLAVIEALALLKSPCTVDLYTDSRYVCDSVS
KGWLWGWVKKNWIKSDKKPVLNVDLWQRMLPLLRQHKVNFHWLKGHAGHPENERCDVLARAQASRRDLPPDTGYKP

Sequences:

>Translated_156_residues
MQNVTIHTDGSCLGNPGPGGWAAILRLDEGDHRKEFSGGYALTTNNRMEMLAVIEALALLKSPCTVDLYTDSRYVCDSVS
KGWLWGWVKKNWIKSDKKPVLNVDLWQRMLPLLRQHKVNFHWLKGHAGHPENERCDVLARAQASRRDLPPDTGYKP
>Mature_156_residues
MQNVTIHTDGSCLGNPGPGGWAAILRLDEGDHRKEFSGGYALTTNNRMEMLAVIEALALLKSPCTVDLYTDSRYVCDSVS
KGWLWGWVKKNWIKSDKKPVLNVDLWQRMLPLLRQHKVNFHWLKGHAGHPENERCDVLARAQASRRDLPPDTGYKP

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Escherichia coli, GI1786408, Length=155, Percent_Identity=56.7741935483871, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI115532542, Length=143, Percent_Identity=36.3636363636364, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 17678; Mature: 17678

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNVTIHTDGSCLGNPGPGGWAAILRLDEGDHRKEFSGGYALTTNNRMEMLAVIEALALL
CCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHCCCCEEEEECCCHHHHHHHHHHHHH
KSPCTVDLYTDSRYVCDSVSKGWLWGWVKKNWIKSDKKPVLNVDLWQRMLPLLRQHKVNF
CCCCEEEEEECCCHHHCCCCCCCEEHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCE
HWLKGHAGHPENERCDVLARAQASRRDLPPDTGYKP
EEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQNVTIHTDGSCLGNPGPGGWAAILRLDEGDHRKEFSGGYALTTNNRMEMLAVIEALALL
CCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHCCCCEEEEECCCHHHHHHHHHHHHH
KSPCTVDLYTDSRYVCDSVSKGWLWGWVKKNWIKSDKKPVLNVDLWQRMLPLLRQHKVNF
CCCCEEEEEECCCHHHCCCCCCCEEHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCE
HWLKGHAGHPENERCDVLARAQASRRDLPPDTGYKP
EEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA