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The map label for this gene is trpS [H]

Identifier: 220903318

GI number: 220903318

Start: 42937

End: 43926

Strand: Reverse

Name: trpS [H]

Synonym: Ddes_0032

Alternate gene names: 220903318

Gene position: 43926-42937 (Counterclockwise)

Preceding gene: 220903319

Following gene: 220903317

Centisome position: 1.53

GC content: 58.48

Gene sequence:

>990_bases
ATGAGCAAAGAACTGCGCACTGTTTCCGGCATGCGGCCCACCGGCCCCCTGCACCTCGGCCATTACTTCGGCGTGCTGAA
AAACTGGGTTGAACTGCAACACACAGAAGAGGCATACTTTTTTGTGGCAGACTGGCATGCCCTCACCAGCGACTACGCCG
ACCCGTCCAAAGTCGGCCAGAATATCCGCGAAATGGTCAAGGACTGGGTGGGCGCGGGCCTCAACCCCGAAGACTGCGTG
ATCTTCCGCCAGTCTGCGGTGAAGGAACATGCCGAACTTTCGCTGCTGCTCTCCATGATCACGCCCGTATCCTGGCTTGA
GCGCAACCCCACCTACAAAGAACAGCAGCAGCAGATCAGCAACAAGGATCTCGGCAATGCGGGCTTTTTGTGCTATCCTG
TGCTCATGGCGGCGGATATTCTCATGTACCGCCCCCACGGCGTGCCTGTGGGCGAAGACCAGTTGCCCCATATGGAGCTG
ACCCGCGAAATAGCCCGGCGCTTCAACTATCTTTACGGCGGCGACCTGTTGCCCGAACCCAAGGCCATGCTCACCCCGGC
AGCCAAATGCCCCGGCCTTGACGGGCGCAAAATGTCGAAAAGCTACAACAACGGCATTTTCCTTTCCGACAACATGGCGG
ATATTCAGGAAAAAGTGCGCGGAATGTTTACCGACAAAGCCCGCCTGCGCAAGTCCGACCCCGGCAATCCCGATGTCTGT
AATCTCTTTCCCTACCACGTGCTCCTGAGCAGCGCCGAAGAGCAGGCAGAGATCCGCCAGGGCTGCACCGGCGCGACCCT
GGGCTGTGTGGACTGCAAAAAAATATTCCTTAGGAATCTTGAAGCATTCCTGACGCCTCTTCAGGAACGCCGCGCCGTGC
TTGATGCCAACCCCGCCCGGGTGGATGAAATTCTTGCCCACGGCAATGAGCGCGCCCGCGCCTTTGCCTGCCAGACCATG
AGCCTGGTACGCGAAAAAATGGGGGTGTAG

Upstream 100 bases:

>100_bases
ACCGGCCTGCTGGGCATGGTACTGGGTCCGCTGGTGAGCGGCAGCGCCCGTGGCCTGCTGTCTCTGCTGGGCATTTTATA
ATTTCAAAGGACTGTTTTTC

Downstream 100 bases:

>100_bases
TTGAAATTTGTAAGTGTGGATTACGGCCTGGCCCGCACGGGCCTGGCCGTGTCAGACCCTGACGGGCGAATGGCTTTCCC
CCTGGCGACCGTGCGCCTGC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSKELRTVSGMRPTGPLHLGHYFGVLKNWVELQHTEEAYFFVADWHALTSDYADPSKVGQNIREMVKDWVGAGLNPEDCV
IFRQSAVKEHAELSLLLSMITPVSWLERNPTYKEQQQQISNKDLGNAGFLCYPVLMAADILMYRPHGVPVGEDQLPHMEL
TREIARRFNYLYGGDLLPEPKAMLTPAAKCPGLDGRKMSKSYNNGIFLSDNMADIQEKVRGMFTDKARLRKSDPGNPDVC
NLFPYHVLLSSAEEQAEIRQGCTGATLGCVDCKKIFLRNLEAFLTPLQERRAVLDANPARVDEILAHGNERARAFACQTM
SLVREKMGV

Sequences:

>Translated_329_residues
MSKELRTVSGMRPTGPLHLGHYFGVLKNWVELQHTEEAYFFVADWHALTSDYADPSKVGQNIREMVKDWVGAGLNPEDCV
IFRQSAVKEHAELSLLLSMITPVSWLERNPTYKEQQQQISNKDLGNAGFLCYPVLMAADILMYRPHGVPVGEDQLPHMEL
TREIARRFNYLYGGDLLPEPKAMLTPAAKCPGLDGRKMSKSYNNGIFLSDNMADIQEKVRGMFTDKARLRKSDPGNPDVC
NLFPYHVLLSSAEEQAEIRQGCTGATLGCVDCKKIFLRNLEAFLTPLQERRAVLDANPARVDEILAHGNERARAFACQTM
SLVREKMGV
>Mature_328_residues
SKELRTVSGMRPTGPLHLGHYFGVLKNWVELQHTEEAYFFVADWHALTSDYADPSKVGQNIREMVKDWVGAGLNPEDCVI
FRQSAVKEHAELSLLLSMITPVSWLERNPTYKEQQQQISNKDLGNAGFLCYPVLMAADILMYRPHGVPVGEDQLPHMELT
REIARRFNYLYGGDLLPEPKAMLTPAAKCPGLDGRKMSKSYNNGIFLSDNMADIQEKVRGMFTDKARLRKSDPGNPDVCN
LFPYHVLLSSAEEQAEIRQGCTGATLGCVDCKKIFLRNLEAFLTPLQERRAVLDANPARVDEILAHGNERARAFACQTMS
LVREKMGV

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=334, Percent_Identity=32.9341317365269, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI41352700, Length=181, Percent_Identity=40.3314917127072, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1789786, Length=330, Percent_Identity=33.9393939393939, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982800, Length=332, Percent_Identity=29.8192771084337, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71982793, Length=332, Percent_Identity=29.8192771084337, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320474, Length=257, Percent_Identity=36.5758754863813, Blast_Score=147, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24666151, Length=336, Percent_Identity=30.952380952381, Blast_Score=148, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 36988; Mature: 36857

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKELRTVSGMRPTGPLHLGHYFGVLKNWVELQHTEEAYFFVADWHALTSDYADPSKVGQ
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCCCCHHHHHH
NIREMVKDWVGAGLNPEDCVIFRQSAVKEHAELSLLLSMITPVSWLERNPTYKEQQQQIS
HHHHHHHHHHCCCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NKDLGNAGFLCYPVLMAADILMYRPHGVPVGEDQLPHMELTREIARRFNYLYGGDLLPEP
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHCCCCCCCC
KAMLTPAAKCPGLDGRKMSKSYNNGIFLSDNMADIQEKVRGMFTDKARLRKSDPGNPDVC
HHHHCCHHHCCCCCCHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
NLFPYHVLLSSAEEQAEIRQGCTGATLGCVDCKKIFLRNLEAFLTPLQERRAVLDANPAR
HHHHHHHHHHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHH
VDEILAHGNERARAFACQTMSLVREKMGV
HHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKELRTVSGMRPTGPLHLGHYFGVLKNWVELQHTEEAYFFVADWHALTSDYADPSKVGQ
CCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCCCCHHHHHH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HHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]