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The map label for this gene is glyA [H]

Identifier: 218906493

GI number: 218906493

Start: 5106065

End: 5107306

Strand: Reverse

Name: glyA [H]

Synonym: BCAH820_5407

Alternate gene names: 218906493

Gene position: 5107306-5106065 (Counterclockwise)

Preceding gene: 218906494

Following gene: 218906492

Centisome position: 96.32

GC content: 40.18

Gene sequence:

>1242_bases
GTGGATCATTTAAAACGTCAAGATGAAAAGGTATTTGCTGCAATTGAGGCAGAACTAGGAAGACAGCGTTCGAAGATTGA
GTTAATTGCTTCGGAAAACTTCGTAAGTGAAGCGGTAATGGAGGCGCAAGGTTCTGTTTTAACGAATAAGTATGCTGAAG
GATATCCTGGGAAACGTTACTATGGTGGTTGTGAACACGTAGACGTAGTAGAAGATATCGCACGTGATCGCGTAAAAGAA
ATTTTCGGCGCAGAGCACGTAAATGTTCAACCGCATTCTGGTGCACAAGCGAACATGGCAGTATACTTCACGATTTTAGA
GCAAGGCGATACAGTACTTGGTATGAATTTATCTCATGGTGGTCACTTAACACACGGAAGCCCTGTTAACTTCAGTGGAG
TACAATATAATTTCGTAGAATATGGCGTGGATGCTGAATCTCACCGTATTAATTACGATGATGTATTAGCAAAAGCGAAA
GAACATAAACCAAAATTAATCGTTGCAGGTGCAAGTGCATACCCTCGTGTTATCGATTTCAAACGATTCCGTGAGATTGC
AGATGAAGTGGGCGCATACTTAATGGTTGATATGGCACATATCGCTGGTTTAGTAGCTGCTGGTTTACATCCAAACCCAG
TACCACATGCACATTTCGTTACAACGACAACACATAAAACGTTACGTGGCCCACGTGGTGGTATGATTTTATGTGAAGAA
CAATTTGCAAAACAAATTGATAAATCCATCTTCCCTGGTATTCAAGGTGGTCCACTTATGCACGTAATCGCTGCAAAAGC
TGTTGCGTTTGGTGAGGCACTTCAAGATGATTTCAAAACATATGCACAAAATATCATTAACAATGCGAACCGCTTAGCTG
AAGGTCTTCAAAAAGAAGGACTTACACTTGTTTCTGGTGGAACAGACAATCACTTAATCTTAATTGATGTTCGTAACTTA
GAAATCACAGGTAAAGTAGCAGAGCACGTATTAGACGAAGTTGGTATTACTGTGAACAAAAATACAATTCCATTTGAAAC
AGCAAGCCCATTTGTAACAAGTGGTGTACGTATCGGTACAGCAGCTGTAACATCTCGCGGTTTCGGTTTAGAAGACATGG
ATGAAATTGCTTCACTTATTGCTTACACATTAAAAAATCATGAAAATGAAGCTGCATTAGAAGAAGCACGTAAGCGTGTA
GAAGCGTTAACGAGCAAATTCCCAATGTACACAGATCTATAA

Upstream 100 bases:

>100_bases
AAGGTTCGAAAGAATTACAACCTGAATTTTCGTTTTTTCTGAATAAATAAGAAAAAACTGTTGGGAATCGATGTAATTCG
TTCAGAAAAGGGGGATTTTG

Downstream 100 bases:

>100_bases
TAGATTGAAGTAGACTGCTGAAACGTAATTGTTTTGGCAGTCTTTTTTGTGGACATATATTGTTCTTGAAGTATGTATAC
AAATGATGAATAAATTTTGG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRVKE
IFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDAESHRINYDDVLAKAK
EHKPKLIVAGASAYPRVIDFKRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
QFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIINNANRLAEGLQKEGLTLVSGGTDNHLILIDVRNL
EITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGTAAVTSRGFGLEDMDEIASLIAYTLKNHENEAALEEARKRV
EALTSKFPMYTDL

Sequences:

>Translated_413_residues
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRVKE
IFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDAESHRINYDDVLAKAK
EHKPKLIVAGASAYPRVIDFKRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
QFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIINNANRLAEGLQKEGLTLVSGGTDNHLILIDVRNL
EITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGTAAVTSRGFGLEDMDEIASLIAYTLKNHENEAALEEARKRV
EALTSKFPMYTDL
>Mature_413_residues
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRVKE
IFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDAESHRINYDDVLAKAK
EHKPKLIVAGASAYPRVIDFKRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
QFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIINNANRLAEGLQKEGLTLVSGGTDNHLILIDVRNL
EITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGTAAVTSRGFGLEDMDEIASLIAYTLKNHENEAALEEARKRV
EALTSKFPMYTDL

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=453, Percent_Identity=41.0596026490066, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI261862352, Length=453, Percent_Identity=41.0596026490066, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI261862350, Length=453, Percent_Identity=41.0596026490066, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI261862348, Length=453, Percent_Identity=41.0596026490066, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI261862346, Length=448, Percent_Identity=41.0714285714286, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI22547186, Length=453, Percent_Identity=42.1633554083885, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI22547189, Length=438, Percent_Identity=41.324200913242, Blast_Score=295, Evalue=5e-80,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=57.7937649880096, Blast_Score=477, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI25144732, Length=452, Percent_Identity=42.4778761061947, Blast_Score=354, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=452, Percent_Identity=42.4778761061947, Blast_Score=353, Evalue=7e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=415, Percent_Identity=46.0240963855422, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=402, Percent_Identity=44.0298507462687, Blast_Score=320, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24640005, Length=452, Percent_Identity=42.0353982300885, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=452, Percent_Identity=42.0353982300885, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45165; Mature: 45165

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRY
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
YGGCEHVDVVEDIARDRVKEIFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGSPVNFSGVQYNFVEYGVDAESHRINYDDVLAKAKEHKPKLIVAGASAYPRVIDF
CCCCCCCCCCCCCEEEEHEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHH
KRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCCCCEEEEHH
QFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIINNANRLAEGLQKEG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTLVSGGTDNHLILIDVRNLEITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGT
CEEEECCCCCEEEEEEECCEEECHHHHHHHHHHCCCEECCCCCCCCCCCCHHHCCEEECH
AAVTSRGFGLEDMDEIASLIAYTLKNHENEAALEEARKRVEALTSKFPMYTDL
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRY
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
YGGCEHVDVVEDIARDRVKEIFGAEHVNVQPHSGAQANMAVYFTILEQGDTVLGMNLSHG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGSPVNFSGVQYNFVEYGVDAESHRINYDDVLAKAKEHKPKLIVAGASAYPRVIDF
CCCCCCCCCCCCCEEEEHEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHH
KRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCCCCEEEEHH
QFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIINNANRLAEGLQKEG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTLVSGGTDNHLILIDVRNLEITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGT
CEEEECCCCCEEEEEEECCEEECHHHHHHHHHHCCCEECCCCCCCCCCCCHHHCCEEECH
AAVTSRGFGLEDMDEIASLIAYTLKNHENEAALEEARKRVEALTSKFPMYTDL
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA