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The map label for this gene is msrA [H]

Identifier: 218906353

GI number: 218906353

Start: 4958819

End: 4960453

Strand: Direct

Name: msrA [H]

Synonym: BCAH820_5266

Alternate gene names: 218906353

Gene position: 4958819-4960453 (Clockwise)

Preceding gene: 218906352

Following gene: 218906362

Centisome position: 93.52

GC content: 37.25

Gene sequence:

>1635_bases
ATGACTATTTTATTCGCACGTAATATTGAGAAGGGCTTTGGTAATCGTACACTATTTACGTTACCATCACTGGAAATTCA
ATCACATGATCGCATAGGAATTGTCGGAGTCAACGGTGCTGGTAAATCTACGTTATTACAAATATTAAGTAAAGAAATAG
AAGCTGACAAAGGCATAGTAACTCATCATAGTTCTATCAGCATCATTCCTCAAATTAGCGAGGAATTACCCAAAGTCGCT
TCTTCTACAGCAAAAGGAAAATGGAATATTTCAAACATCTCAAATTCAATGAGCGGCGGGGAACGAATGCTTCTAAAGAT
TGCCCATGCTCTCGAACAAGATGCAGGCATTCTATTCGCTGATGAACCAACAAGCCACTTAGATATGTTCGGTACAGAGC
AATTAGAAAAGGCACTTTTATCTTATAAAGGTGCACTTGTTTTAATATCACATGATCGTGAATTTCTAGATAATATATGT
ACAAAAATCATTGAAATTGAAGACGGGATAATTCAAGAATATAAAGGAAACTATTCCAACTATCGAAAGCAAAAAGAACG
TGAACGAACACAAAAACAAGCAGAATACGAGCAGTATATAAACGAAAAAGAGCGTTTAGAGAAGTCCATTTTACAAAAAA
AGCAACGTGCTTCTAGCATGACAAAAATCCCAACACGGTTCAGTTCATCTGAATCTAAACTTTATAAATTAAGTGGGGCT
CATGGCCAAGAACAGGTTAGTAAAGCAGCAAAAGCATTAGAGACACGTCTTGAAAAACTAGAAAAGAAAGAAAAGCCAAA
GGAGCTTTCTCAAGCACAGTTTGATGTACAATACCATACACCCATTCATAGTAAAGTGGCAGTACAGTTCAATAAAGCAA
CAAAGAAAATAGGTGACCGCACACTATTTAAAAATATGAATGGAACGATTGCTCCTGGTGCAAAGCTTGCTATTTTAGGG
GCAAACGGAAGTGGAAAAACGACCCTGTTTAACATGCTTCTCGCAAATGAGCGTGGCATTCAGCTTTCAAAACGTTGTAA
GATTGGGTACTTTGAACAAACACTATCCATTTTAAAAACAGATAAAACCATTTTAGAAAATGTTCTAGAAGAAACAAACT
ATACAGAGTCGTTCGTTCGCACAATACTTGCACGGCTTCTATTCCGCCGTGAAGATGTTCATAAACCTGTGCACGTTCTA
AGCGGGGGTGAGCGAATGAAGGTTGCACTCGCAAAAGTATTTTTAGGAAACTATAATATGCTTCTGCTCGATGAACCGAC
AAACTATTTAGACTTAGCGACGCAAGAAGAATTAGAAAGCATGTTACAAGAATATCCTGGCACTATACTTTTCATTAGCC
ATGACCGTGCCTTCATTCGTTCTGTTGCAGACCATATTCTACAAGTAGATGAAAGTGAACCAAGAGTATTCCACGGTAAT
TACGAGCAATACACAAACAGAACAACCGATGCTTCTGTAAACGTTACTGCACAAGAATTATTACGATTACAAACAAAATT
AACAGAAATCATCGGCCGAATTTCCATACCAAATCATCACGATGACATCACATCTCTCGAACAAGAATACGAAACATTAT
TAGTTAAAATCCGGAAATGTAAAGAAGCACTCTAA

Upstream 100 bases:

>100_bases
TCTTTCGAAACGATCATGTAAAAAAATCGTTTATTTATGTACGATTTTTACATGCAAGGGCGACGTTTATCCTCTCTAGT
GAAACTAGGGAGGTTTTTTT

Downstream 100 bases:

>100_bases
TGTCTTCCCTATATATCGACGGGACCTTCCGCATTTCCCAAGAAATATTGAATCTTCGACATAGCATACAAAAAGCCGTG
CAGTTCATCAGCACGGCCTT

Product: putative macrolide efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MTILFARNIEKGFGNRTLFTLPSLEIQSHDRIGIVGVNGAGKSTLLQILSKEIEADKGIVTHHSSISIIPQISEELPKVA
SSTAKGKWNISNISNSMSGGERMLLKIAHALEQDAGILFADEPTSHLDMFGTEQLEKALLSYKGALVLISHDREFLDNIC
TKIIEIEDGIIQEYKGNYSNYRKQKERERTQKQAEYEQYINEKERLEKSILQKKQRASSMTKIPTRFSSSESKLYKLSGA
HGQEQVSKAAKALETRLEKLEKKEKPKELSQAQFDVQYHTPIHSKVAVQFNKATKKIGDRTLFKNMNGTIAPGAKLAILG
ANGSGKTTLFNMLLANERGIQLSKRCKIGYFEQTLSILKTDKTILENVLEETNYTESFVRTILARLLFRREDVHKPVHVL
SGGERMKVALAKVFLGNYNMLLLDEPTNYLDLATQEELESMLQEYPGTILFISHDRAFIRSVADHILQVDESEPRVFHGN
YEQYTNRTTDASVNVTAQELLRLQTKLTEIIGRISIPNHHDDITSLEQEYETLLVKIRKCKEAL

Sequences:

>Translated_544_residues
MTILFARNIEKGFGNRTLFTLPSLEIQSHDRIGIVGVNGAGKSTLLQILSKEIEADKGIVTHHSSISIIPQISEELPKVA
SSTAKGKWNISNISNSMSGGERMLLKIAHALEQDAGILFADEPTSHLDMFGTEQLEKALLSYKGALVLISHDREFLDNIC
TKIIEIEDGIIQEYKGNYSNYRKQKERERTQKQAEYEQYINEKERLEKSILQKKQRASSMTKIPTRFSSSESKLYKLSGA
HGQEQVSKAAKALETRLEKLEKKEKPKELSQAQFDVQYHTPIHSKVAVQFNKATKKIGDRTLFKNMNGTIAPGAKLAILG
ANGSGKTTLFNMLLANERGIQLSKRCKIGYFEQTLSILKTDKTILENVLEETNYTESFVRTILARLLFRREDVHKPVHVL
SGGERMKVALAKVFLGNYNMLLLDEPTNYLDLATQEELESMLQEYPGTILFISHDRAFIRSVADHILQVDESEPRVFHGN
YEQYTNRTTDASVNVTAQELLRLQTKLTEIIGRISIPNHHDDITSLEQEYETLLVKIRKCKEAL
>Mature_543_residues
TILFARNIEKGFGNRTLFTLPSLEIQSHDRIGIVGVNGAGKSTLLQILSKEIEADKGIVTHHSSISIIPQISEELPKVAS
STAKGKWNISNISNSMSGGERMLLKIAHALEQDAGILFADEPTSHLDMFGTEQLEKALLSYKGALVLISHDREFLDNICT
KIIEIEDGIIQEYKGNYSNYRKQKERERTQKQAEYEQYINEKERLEKSILQKKQRASSMTKIPTRFSSSESKLYKLSGAH
GQEQVSKAAKALETRLEKLEKKEKPKELSQAQFDVQYHTPIHSKVAVQFNKATKKIGDRTLFKNMNGTIAPGAKLAILGA
NGSGKTTLFNMLLANERGIQLSKRCKIGYFEQTLSILKTDKTILENVLEETNYTESFVRTILARLLFRREDVHKPVHVLS
GGERMKVALAKVFLGNYNMLLLDEPTNYLDLATQEELESMLQEYPGTILFISHDRAFIRSVADHILQVDESEPRVFHGNY
EQYTNRTTDASVNVTAQELLRLQTKLTEIIGRISIPNHHDDITSLEQEYETLLVKIRKCKEAL

Specific function: Confers resistance to 14-membered ring macrolides (like erythromycin) and to B streptogramins, by acting as an ATP- dependent efflux pump [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=455, Percent_Identity=28.1318681318681, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI10947137, Length=524, Percent_Identity=27.0992366412214, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI27881506, Length=524, Percent_Identity=27.0992366412214, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI10947135, Length=404, Percent_Identity=27.4752475247525, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI69354671, Length=404, Percent_Identity=27.4752475247525, Blast_Score=132, Evalue=9e-31,
Organism=Escherichia coli, GI1789751, Length=618, Percent_Identity=29.6116504854369, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1787041, Length=550, Percent_Identity=28.9090909090909, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI2367384, Length=432, Percent_Identity=33.1018518518519, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1787182, Length=378, Percent_Identity=29.3650793650794, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1788165, Length=197, Percent_Identity=26.9035532994924, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788225, Length=220, Percent_Identity=24.5454545454545, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789672, Length=217, Percent_Identity=27.6497695852535, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787164, Length=198, Percent_Identity=26.7676767676768, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17555318, Length=525, Percent_Identity=26.8571428571429, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17559834, Length=413, Percent_Identity=25.90799031477, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17553372, Length=404, Percent_Identity=28.4653465346535, Blast_Score=143, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320874, Length=402, Percent_Identity=27.363184079602, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321121, Length=421, Percent_Identity=28.0285035629454, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6323278, Length=178, Percent_Identity=31.4606741573034, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324314, Length=180, Percent_Identity=30, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6325030, Length=203, Percent_Identity=31.0344827586207, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24642252, Length=531, Percent_Identity=26.5536723163842, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI18859989, Length=531, Percent_Identity=26.5536723163842, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24641342, Length=416, Percent_Identity=27.8846153846154, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24666836, Length=412, Percent_Identity=26.9417475728155, Blast_Score=145, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 61554; Mature: 61423

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILFARNIEKGFGNRTLFTLPSLEIQSHDRIGIVGVNGAGKSTLLQILSKEIEADKGIV
CEEEEECCHHHCCCCCEEEEECCCEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEE
THHSSISIIPQISEELPKVASSTAKGKWNISNISNSMSGGERMLLKIAHALEQDAGILFA
EECCCEEECHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEE
DEPTSHLDMFGTEQLEKALLSYKGALVLISHDREFLDNICTKIIEIEDGIIQEYKGNYSN
CCCCHHHHHCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
YRKQKERERTQKQAEYEQYINEKERLEKSILQKKQRASSMTKIPTRFSSSESKLYKLSGA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCC
HGQEQVSKAAKALETRLEKLEKKEKPKELSQAQFDVQYHTPIHSKVAVQFNKATKKIGDR
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEECCCCCCCEEEEEHHHHHHHCCH
TLFKNMNGTIAPGAKLAILGANGSGKTTLFNMLLANERGIQLSKRCKIGYFEQTLSILKT
HHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHC
DKTILENVLEETNYTESFVRTILARLLFRREDVHKPVHVLSGGERMKVALAKVFLGNYNM
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCE
LLLDEPTNYLDLATQEELESMLQEYPGTILFISHDRAFIRSVADHILQVDESEPRVFHGN
EEEECCCCHHHCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEECC
YEQYTNRTTDASVNVTAQELLRLQTKLTEIIGRISIPNHHDDITSLEQEYETLLVKIRKC
HHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
KEAL
HHCC
>Mature Secondary Structure 
TILFARNIEKGFGNRTLFTLPSLEIQSHDRIGIVGVNGAGKSTLLQILSKEIEADKGIV
EEEEECCHHHCCCCCEEEEECCCEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEE
THHSSISIIPQISEELPKVASSTAKGKWNISNISNSMSGGERMLLKIAHALEQDAGILFA
EECCCEEECHHHHHHHHHHHHCCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEE
DEPTSHLDMFGTEQLEKALLSYKGALVLISHDREFLDNICTKIIEIEDGIIQEYKGNYSN
CCCCHHHHHCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
YRKQKERERTQKQAEYEQYINEKERLEKSILQKKQRASSMTKIPTRFSSSESKLYKLSGA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCC
HGQEQVSKAAKALETRLEKLEKKEKPKELSQAQFDVQYHTPIHSKVAVQFNKATKKIGDR
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEEECCCCCCCEEEEEHHHHHHHCCH
TLFKNMNGTIAPGAKLAILGANGSGKTTLFNMLLANERGIQLSKRCKIGYFEQTLSILKT
HHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHC
DKTILENVLEETNYTESFVRTILARLLFRREDVHKPVHVLSGGERMKVALAKVFLGNYNM
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCE
LLLDEPTNYLDLATQEELESMLQEYPGTILFISHDRAFIRSVADHILQVDESEPRVFHGN
EEEECCCCHHHCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEECC
YEQYTNRTTDASVNVTAQELLRLQTKLTEIIGRISIPNHHDDITSLEQEYETLLVKIRKC
HHHHCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
KEAL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2233255 [H]