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The map label for this gene is gabP [H]

Identifier: 218904850

GI number: 218904850

Start: 3565048

End: 3565977

Strand: Reverse

Name: gabP [H]

Synonym: BCAH820_3734

Alternate gene names: 218904850

Gene position: 3565977-3565048 (Counterclockwise)

Preceding gene: 218904853

Following gene: 218904849

Centisome position: 67.25

GC content: 39.46

Gene sequence:

>930_bases
ATGATCTCAATTGGCGGCGTAATAGGAGCTGGTTTGTTTGTTGGAAGTGGGGCAGTTGTGCATTCAGCAGGACCAGGTTC
TATCGTTTCATATGCATTAGCAGGACTTTTAGTCGTTTTCGTTATGAGAATGCTTGGGGAAATGGCAGCTATTAACCCGA
CAAGTGGATCATTTGCAACATATGCAAGAGAAGCAATTGGTCCGTGGGCCGGTTATACAATTGGGTGGCTATATTGGTTT
TTCTGGGTAATTGTTATTGCGATAGAAGCCACAGCGGGTGCTGGTATTATTCAGTACTGGATTCCAGAAATCCCGCTTTG
GTTATTAAGCTTAATATTAACGATTTTATTAACATTGACGAATGTTTTTTCAGTGAAATCATTTGGAGAGTTTGAATATT
GGTTTTCTTTTATTAAAGTAATAAGTATTGTTTTGTTCCTTTGTCTTGGACTAGCTGTTATTTTAGGATTTGTACCAGGA
ACGGAAGCACCTGGCACTTCGAACTTAGTGGGGCAAGGAGGATTTATGCCAAACGGTATAAGTTCGGTGCTACTTGGAAT
TACTGTCGTTATATTTTCATTTATGGGATCAGAGATTGTAGCGGTAGCAGCTGGTGAGTCTGCAGAACCTGTAAAAGCAG
TAAAAACAGCAACAAATAGTGTAATTTGGCGTATTCTCGTATTTTTCATTGGATCTATCGCTGTAGTTGTTACACTTCTT
CCGTGGAATTCAGCAAACATACTAAAAAGTCCGTTTGTAGCGGTGCTAGAACATATAGGGATACCAGCGGCAGCGCAAAT
TATGAATTTTATCGTTTTAACAGCTGTACTTTCTTGTTTAAATTCTGGTTTATATACGAACTCAAGAATGCTTTTTTCGA
TGGCGGAAAGAGGAGATGCTCCAAAGGCGTTCTTGAAATTTGAACAGTAG

Upstream 100 bases:

>100_bases
GCCCGTTAATGCGGGATAAATTTCAAAATTACGTTTGGAAGGGGATGTATAAGAGTTGGATAAAAATCTTAAGAAAGACC
TCAAAATACGCCACATTACA

Downstream 100 bases:

>100_bases
TGGTGTTCCAGTTCGGGCCGTTTTATTCGGAACGTTCTTCGCTTATATTGGAGTTGTTTTTAGTTACATATCTCCAGATA
AAGTCTTTTTATTTTTAGTG

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWF
FWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPG
TEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKAFLKFEQ

Sequences:

>Translated_309_residues
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWF
FWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPG
TEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKAFLKFEQ
>Mature_309_residues
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFATYAREAIGPWAGYTIGWLYWF
FWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPG
TEAPGTSNLVGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKAFLKFEQ

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=333, Percent_Identity=24.9249249249249, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI258614005, Length=333, Percent_Identity=24.9249249249249, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI258614003, Length=333, Percent_Identity=24.6246246246246, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4507047, Length=331, Percent_Identity=24.4712990936556, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789017, Length=311, Percent_Identity=54.0192926045016, Blast_Score=329, Evalue=1e-91,
Organism=Escherichia coli, GI1786302, Length=309, Percent_Identity=42.7184466019417, Blast_Score=264, Evalue=6e-72,
Organism=Escherichia coli, GI87081708, Length=313, Percent_Identity=40.5750798722045, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1788480, Length=320, Percent_Identity=40.9375, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI48994972, Length=310, Percent_Identity=42.258064516129, Blast_Score=247, Evalue=7e-67,
Organism=Escherichia coli, GI1790653, Length=311, Percent_Identity=40.1929260450161, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1786789, Length=302, Percent_Identity=39.7350993377483, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI87081915, Length=317, Percent_Identity=41.6403785488959, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1786602, Length=306, Percent_Identity=41.1764705882353, Blast_Score=227, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17532491, Length=328, Percent_Identity=22.8658536585366, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=325, Percent_Identity=36.3076923076923, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320772, Length=323, Percent_Identity=36.2229102167183, Blast_Score=188, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6322892, Length=319, Percent_Identity=34.7962382445141, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324553, Length=308, Percent_Identity=35.3896103896104, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6324059, Length=302, Percent_Identity=34.1059602649007, Blast_Score=155, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6320717, Length=318, Percent_Identity=31.1320754716981, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324924, Length=335, Percent_Identity=28.6567164179104, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324990, Length=330, Percent_Identity=32.7272727272727, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6319824, Length=326, Percent_Identity=29.1411042944785, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=313, Percent_Identity=30.9904153354633, Blast_Score=138, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6321629, Length=322, Percent_Identity=30.1242236024845, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=315, Percent_Identity=31.1111111111111, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319542, Length=321, Percent_Identity=28.6604361370716, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319543, Length=314, Percent_Identity=26.7515923566879, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6320251, Length=325, Percent_Identity=28.6153846153846, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319608, Length=333, Percent_Identity=25.8258258258258, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324981, Length=313, Percent_Identity=30.0319488817891, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221512776, Length=319, Percent_Identity=23.1974921630094, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24666159, Length=319, Percent_Identity=23.1974921630094, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 32815; Mature: 32815

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFAT
CCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
SSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
PKAFLKFEQ
CHHHHCCCC
>Mature Secondary Structure
MISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVVFVMRMLGEMAAINPTSGSFAT
CCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPEIPLWLLSLILTILLTLT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPGTSNLVGQGGFMPNGI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
SSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRILVFFIGSIAVVVTLL
HHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
PKAFLKFEQ
CHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]