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The map label for this gene is sdaC [H]

Identifier: 218904402

GI number: 218904402

Start: 3129933

End: 3131252

Strand: Reverse

Name: sdaC [H]

Synonym: BCAH820_3286

Alternate gene names: 218904402

Gene position: 3131252-3129933 (Counterclockwise)

Preceding gene: 218904403

Following gene: 218904400

Centisome position: 59.05

GC content: 36.29

Gene sequence:

>1320_bases
ATGAATGGGAATACTGCAAAAAACATAGAATTTCAAGCTGATAATACGGCAGTAAAAAATGAAAAATACCTAGACCCTAA
AAAATGGCATAAACAGGATACTACCTGGGCATTGAGCCTTTTTGGAACAGCAATTGGAGCAGGGGTACTCTTTTTACCGA
TTAATGCAGGTTCAGGTGGTTTATTATCATTGCTGTTAATTACCATACTTGCATATCCAGTTATGTACTACTCACATAGG
GCGCTTGCTAAAATGATTTACGCTTCGAATTCTGCCGATGAGGGGATTACAGGTACAATAAGAGAATATTTCGGAAATAA
AGCAAGTATCATTTTTAACATCGTATATTTCGTCTCCATTTATACGATCGTGCTGATGTACTCGGTCGCACTTACAAATA
CGGCAAGTAGTTTTATTGTACACCAATTGCACATGCCGGAGCCTCCAAGGGCTATTTTATCACTTGTATTAGTACTCGGT
CTTATCACTATACTAAATTTTGGTCAGGATATTACTGTAAAGATAATGAGCATGCTAGTATATCCTTTCATTGCTTCTCT
ACTTTTTATTGCAATATCTTTAATTCCACAATGGAATACTTCAATGCTAAGTTTTTCAAGTGTTTCTACTGCTTCAACTG
GAACGGGCTATTTTGGAATGATTTGGATGATTCTACCAATCATCGTATTCTCGTTTAATCATTCTCCTATGATTTCGTCA
TTTGTTATGAAACAGAGAGCTACGTATGGAATAGATGCTACTGATGCCAAGTGTGCTCAAATACAAAAAGTTTGTTATAT
CATGACATTCGCTGTTGTTATGTTCTTTGTGTGGAGCAGTACTTTAAGTTTGACTCCAGATGATCTTAAGGTGGCAAAAG
AACAGAACTTGTCAATTCTATCATATCTTGCTAATGAGCTTAATTCGCCTGTAATCACGATTGCAGCTCCTATCATTGCG
TTTGTGGCTATTACAAAGTCTTTCCTTGGTCATTATATAGGAGCGTATGAGGTAATGCGTGACATGATTATCAAGTCCGG
TAAAAAACGTGGGAAAGATATAGGAGAAAAAACAGTTAAGACAATGATTCTTACTTTTGTTGTGCTAACATGCTGGTATG
TTGCTTATACAAATCCAAGTATTCTTGGAATCATTGATGCCCTTAGCGGTCCGTTAGTCGCTGCTATCTTATGTCTATTA
CCGATGTATGCGATTCGTAAAGTACCAGTACTAGCAAAATACAGAGGGAAAATGAGCAATGTATTTGTAATTATTATAGG
GATACTTACTGTTCTAGCAAGTATTAAGTCATTATTCTAA

Upstream 100 bases:

>100_bases
AGGATATACGATGTGGCGCACTTTATAAACAAAAAGAACGGTCTATATTCCTATACCTTAAATAAAGACGTAAGAATAGG
AAACAAGGAGGAATTAATAT

Downstream 100 bases:

>100_bases
TTTACTGTAGTTAGTTCTGATGCGAAAATAATAGGATATGAAATAAGAATGAAAGATTCCTAGCGGAACTAAATTATATA
GTGTTAAACCAAAGAGATTC

Product: serine/threonine transporter family protein

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNGNTAKNIEFQADNTAVKNEKYLDPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLSLLLITILAYPVMYYSHR
ALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFVSIYTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLG
LITILNFGQDITVKIMSMLVYPFIASLLFIAISLIPQWNTSMLSFSSVSTASTGTGYFGMIWMILPIIVFSFNHSPMISS
FVMKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSTLSLTPDDLKVAKEQNLSILSYLANELNSPVITIAAPIIA
FVAITKSFLGHYIGAYEVMRDMIIKSGKKRGKDIGEKTVKTMILTFVVLTCWYVAYTNPSILGIIDALSGPLVAAILCLL
PMYAIRKVPVLAKYRGKMSNVFVIIIGILTVLASIKSLF

Sequences:

>Translated_439_residues
MNGNTAKNIEFQADNTAVKNEKYLDPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLSLLLITILAYPVMYYSHR
ALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFVSIYTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLG
LITILNFGQDITVKIMSMLVYPFIASLLFIAISLIPQWNTSMLSFSSVSTASTGTGYFGMIWMILPIIVFSFNHSPMISS
FVMKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSTLSLTPDDLKVAKEQNLSILSYLANELNSPVITIAAPIIA
FVAITKSFLGHYIGAYEVMRDMIIKSGKKRGKDIGEKTVKTMILTFVVLTCWYVAYTNPSILGIIDALSGPLVAAILCLL
PMYAIRKVPVLAKYRGKMSNVFVIIIGILTVLASIKSLF
>Mature_439_residues
MNGNTAKNIEFQADNTAVKNEKYLDPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLSLLLITILAYPVMYYSHR
ALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFVSIYTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLG
LITILNFGQDITVKIMSMLVYPFIASLLFIAISLIPQWNTSMLSFSSVSTASTGTGYFGMIWMILPIIVFSFNHSPMISS
FVMKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSTLSLTPDDLKVAKEQNLSILSYLANELNSPVITIAAPIIA
FVAITKSFLGHYIGAYEVMRDMIIKSGKKRGKDIGEKTVKTMILTFVVLTCWYVAYTNPSILGIIDALSGPLVAAILCLL
PMYAIRKVPVLAKYRGKMSNVFVIIIGILTVLASIKSLF

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=429, Percent_Identity=50.8158508158508, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1789504, Length=428, Percent_Identity=44.392523364486, Blast_Score=353, Evalue=9e-99,
Organism=Escherichia coli, GI1789211, Length=409, Percent_Identity=36.1858190709046, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI145693183, Length=429, Percent_Identity=25.6410256410256, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789961, Length=408, Percent_Identity=24.7549019607843, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1790145, Length=422, Percent_Identity=25.1184834123223, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 48311; Mature: 48311

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGNTAKNIEFQADNTAVKNEKYLDPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGG
CCCCCCCCEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCH
LLSLLLITILAYPVMYYSHRALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFVSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
YTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLGLITILNFGQDITVKIMSMLV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YPFIASLLFIAISLIPQWNTSMLSFSSVSTASTGTGYFGMIWMILPIIVFSFNHSPMISS
HHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
FVMKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSTLSLTPDDLKVAKEQNLSIL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHH
SYLANELNSPVITIAAPIIAFVAITKSFLGHYIGAYEVMRDMIIKSGKKRGKDIGEKTVK
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHHHHHH
TMILTFVVLTCWYVAYTNPSILGIIDALSGPLVAAILCLLPMYAIRKVPVLAKYRGKMSN
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHH
VFVIIIGILTVLASIKSLF
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGNTAKNIEFQADNTAVKNEKYLDPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGG
CCCCCCCCEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCH
LLSLLLITILAYPVMYYSHRALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFVSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
YTIVLMYSVALTNTASSFIVHQLHMPEPPRAILSLVLVLGLITILNFGQDITVKIMSMLV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YPFIASLLFIAISLIPQWNTSMLSFSSVSTASTGTGYFGMIWMILPIIVFSFNHSPMISS
HHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
FVMKQRATYGIDATDAKCAQIQKVCYIMTFAVVMFFVWSSTLSLTPDDLKVAKEQNLSIL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHH
SYLANELNSPVITIAAPIIAFVAITKSFLGHYIGAYEVMRDMIIKSGKKRGKDIGEKTVK
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCHHHHHHHHH
TMILTFVVLTCWYVAYTNPSILGIIDALSGPLVAAILCLLPMYAIRKVPVLAKYRGKMSN
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHCCHHH
VFVIIIGILTVLASIKSLF
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]