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The map label for this gene is ykoH [H]

Identifier: 218904352

GI number: 218904352

Start: 3075372

End: 3076682

Strand: Direct

Name: ykoH [H]

Synonym: BCAH820_3236

Alternate gene names: 218904352

Gene position: 3075372-3076682 (Clockwise)

Preceding gene: 218904351

Following gene: 218904356

Centisome position: 58.0

GC content: 35.24

Gene sequence:

>1311_bases
ATGGCACTCGTGTTAGCTTTTATTTTAACTTCTTCAGATAAAGTTTTGCTTTTTAATATGAAAAATCAATTGAAGAGCAC
AGTAAAAGAAAGCGTTGAAGATATCGAGTATAAGCATGGGCAATTAAAGATGGACGATGATTTTGAAACCTTTGAAGATG
GAGTAAATATCATCATTTATAATAAACAAAGTGAGCTGCTGGCAGGTAATAGTCCAACAAGCTTTAATAAAAAGATATCG
CTTAAATCCGATGAAATACAAATTATTAAAGACGGTAATAAAGAATGGATCGTATATGATTTTCTCCATAATGCAGACGG
CGGTGAGCAAGTCTGGGTGCGCGGAATAATGACGATGAGCCAATTATCATCAACGATGAATACACTTATCGTATTAACAC
TGATCTCATTTCCATTACTTATTCTCATTGCGGCAGTGGGAGGATATTTTATTACGCAAAGAGCGTTTCGACCTGTGCAG
CAAATGAGTGATTCAGCCAGTAAAATTGGTGATGGTAAAGACCTTTCGAAGAGAATTAATTTAAAAGGTTCACCGAAAGA
CGAAATGTATCATTTAGCACAAACTTTTGACAAAATGTTTGAGCGATTGGAGACATCATTTGAAAGTGAAAAACAATTTA
CATCTGACGCATCTCATGAATTAAGAACACCAACATCTGTTATTATTTCGCAATGCGAATACGCTTTATCGCAGAGAAAT
AATCCGAAAGAAATGGAAGAATCGTTAGAAGTAATTTTAAAGCAATCACGTAAAATGTCCGCGCTAATCTCACAACTCTT
ATTATTAGCAAGAGCTGACCAAGGAAACGATAATACTTTCCAATTTGAATGTATCAATATGAGTGAATTAACAGAAATCG
TTGTAGAAGAACTTTCATTAATGGTTCAAGAAGCTTCGATTGATATAACAACTCATATAGAGGAAGACCTGTTTATAAAA
GCAGATCAAACATTGATGATGCGTTTATTAATGAATTTATTAACGAATGCGATTGCTTATAGCAAAGCGAACGGAACTGT
TCATATGCAACTGTTCCGTGACGAAACCAACATAATAGGTAAAGTCTCCGATAATGGCATAGGCATCAGTGAGCAACATA
TTACGAAAATTTGGGACCGCTTCTATCGAGTTGACGCAGCACGAACATCTTCAAACATTGGAAATACAGGTTTAGGATTG
TCAATGGTAAAATGGATTGTCGAACTGCACGGAGGAGAAATTACAGTTGAAAGTGAATTAGGAGAAGGCAGTACTTTTAC
CTTTAAACTACCAATTGAAAAACAAGCATAA

Upstream 100 bases:

>100_bases
CAGTAAGAGGAACTGGTTACGTATTGCGAGTAGAATCATGAAAAGACTATCAATAAAAATGAGAGTAACCCTGTGGTATA
CGGGGCTAATTGTAATTATT

Downstream 100 bases:

>100_bases
TTGATGAGCAACTGTAGATTTAGAATAAAGACCTCTCTTCCCCCTTATTATATAAAAATAATTGACGTATTTTAAACATC
ATTAATGAACAGGGTAAAAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKHGQLKMDDDFETFEDGVNIIIYNKQSELLAGNSPTSFNKKIS
LKSDEIQIIKDGNKEWIVYDFLHNADGGEQVWVRGIMTMSQLSSTMNTLIVLTLISFPLLILIAAVGGYFITQRAFRPVQ
QMSDSASKIGDGKDLSKRINLKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASHELRTPTSVIISQCEYALSQRN
NPKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNTFQFECINMSELTEIVVEELSLMVQEASIDITTHIEEDLFIK
ADQTLMMRLLMNLLTNAIAYSKANGTVHMQLFRDETNIIGKVSDNGIGISEQHITKIWDRFYRVDAARTSSNIGNTGLGL
SMVKWIVELHGGEITVESELGEGSTFTFKLPIEKQA

Sequences:

>Translated_436_residues
MALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKHGQLKMDDDFETFEDGVNIIIYNKQSELLAGNSPTSFNKKIS
LKSDEIQIIKDGNKEWIVYDFLHNADGGEQVWVRGIMTMSQLSSTMNTLIVLTLISFPLLILIAAVGGYFITQRAFRPVQ
QMSDSASKIGDGKDLSKRINLKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASHELRTPTSVIISQCEYALSQRN
NPKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNTFQFECINMSELTEIVVEELSLMVQEASIDITTHIEEDLFIK
ADQTLMMRLLMNLLTNAIAYSKANGTVHMQLFRDETNIIGKVSDNGIGISEQHITKIWDRFYRVDAARTSSNIGNTGLGL
SMVKWIVELHGGEITVESELGEGSTFTFKLPIEKQA
>Mature_435_residues
ALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKHGQLKMDDDFETFEDGVNIIIYNKQSELLAGNSPTSFNKKISL
KSDEIQIIKDGNKEWIVYDFLHNADGGEQVWVRGIMTMSQLSSTMNTLIVLTLISFPLLILIAAVGGYFITQRAFRPVQQ
MSDSASKIGDGKDLSKRINLKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASHELRTPTSVIISQCEYALSQRNN
PKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNTFQFECINMSELTEIVVEELSLMVQEASIDITTHIEEDLFIKA
DQTLMMRLLMNLLTNAIAYSKANGTVHMQLFRDETNIIGKVSDNGIGISEQHITKIWDRFYRVDAARTSSNIGNTGLGLS
MVKWIVELHGGEITVESELGEGSTFTFKLPIEKQA

Specific function: Probable member of the two-component regulatory system ykoH/ykoG. Potentially phosphorylates ykoG [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=306, Percent_Identity=29.0849673202614, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788279, Length=320, Percent_Identity=28.125, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=25.6317689530686, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.1479820627803, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789403, Length=283, Percent_Identity=29.6819787985866, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790346, Length=282, Percent_Identity=27.6595744680851, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=31.2757201646091, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787894, Length=306, Percent_Identity=27.7777777777778, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790861, Length=309, Percent_Identity=26.537216828479, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=25.5144032921811, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=24.496644295302, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=30.9090909090909, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790551, Length=308, Percent_Identity=28.2467532467532, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790436, Length=320, Percent_Identity=24.0625, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=26.9387755102041, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=25.8474576271186, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=24.3589743589744, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789808, Length=306, Percent_Identity=24.5098039215686, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49162; Mature: 49031

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKHGQLKMDDDFETFEDGVNIIIY
CCEEEEEHHCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCEEEEE
NKQSELLAGNSPTSFNKKISLKSDEIQIIKDGNKEWIVYDFLHNADGGEQVWVRGIMTMS
CCCCCEECCCCCCCCCCEEEECCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHH
QLSSTMNTLIVLTLISFPLLILIAAVGGYFITQRAFRPVQQMSDSASKIGDGKDLSKRIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
LKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASHELRTPTSVIISQCEYALSQRN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCC
NPKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNTFQFECINMSELTEIVVEELSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHH
MVQEASIDITTHIEEDLFIKADQTLMMRLLMNLLTNAIAYSKANGTVHMQLFRDETNIIG
HHHHHCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEE
KVSDNGIGISEQHITKIWDRFYRVDAARTSSNIGNTGLGLSMVKWIVELHGGEITVESEL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
GEGSTFTFKLPIEKQA
CCCCEEEEEECCCCCC
>Mature Secondary Structure 
ALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKHGQLKMDDDFETFEDGVNIIIY
CEEEEEHHCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCEEEEE
NKQSELLAGNSPTSFNKKISLKSDEIQIIKDGNKEWIVYDFLHNADGGEQVWVRGIMTMS
CCCCCEECCCCCCCCCCEEEECCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHH
QLSSTMNTLIVLTLISFPLLILIAAVGGYFITQRAFRPVQQMSDSASKIGDGKDLSKRIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
LKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASHELRTPTSVIISQCEYALSQRN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCC
NPKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNTFQFECINMSELTEIVVEELSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHH
MVQEASIDITTHIEEDLFIKADQTLMMRLLMNLLTNAIAYSKANGTVHMQLFRDETNIIG
HHHHHCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEE
KVSDNGIGISEQHITKIWDRFYRVDAARTSSNIGNTGLGLSMVKWIVELHGGEITVESEL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCC
GEGSTFTFKLPIEKQA
CCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]