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The map label for this gene is pcoR [H]

Identifier: 218904351

GI number: 218904351

Start: 3074638

End: 3075312

Strand: Direct

Name: pcoR [H]

Synonym: BCAH820_3235

Alternate gene names: 218904351

Gene position: 3074638-3075312 (Clockwise)

Preceding gene: 218904347

Following gene: 218904352

Centisome position: 57.98

GC content: 35.7

Gene sequence:

>675_bases
ATGCGAGTTCTTATTGTCGAAGATGAACAAGACTTACAAAATATATTAGTAAAGCGATTAAATGCAGAACATTATAGTGT
CGATGCATGCGGGAATGGAGAAGATGCCTTAGATTATATAAACTTGGCTACCTACGATTTGATCGTGCTTGACATTATGA
TTCCCGGAATAAATGGTTTACAAGTATTACAAAAATTACGCGCGGACAATCATACAACTCCTGTCTTGCTTCTTACAGCT
AAAGATACAATTGATGATCGCGTAAAAGGACTCGACTTAGGTGCGGATGATTATTTAGTAAAGCCGTTCGCTTTTGACGA
ACTGCTAGCAAGAATTCGAGTGTTAATGCGAAGAAAAACAGGAAATACATCTAATGTGTTTGAAATTGCTGACCTAGTGG
TGGATTGTAATATGCATAAAGTAACAAGAGGAGACCAAGTTATTACTCTTTCCAGTAAAGAATTTGCTATTTTAGAATAT
ATGATTCGTAATAAAGAAGTTGTGTTGACACGAGATAAAATTGAGCAACATGTGTGGAATTACGACTATGAAGGTGGCTC
AAATATTATTGATGTTTACGTCCGCTATCTTCGAAAAAAAATTGATAGCCAGTTTGAAACGAAGTTAATTCATACAGTAA
GAGGAACTGGTTACGTATTGCGAGTAGAATCATGA

Upstream 100 bases:

>100_bases
GTACAAAAAATAAAATGATATAATTAAATCGTTTCTAATCTCTCTTTAATGTTTTGGAATTATAGTGATACATATAAATA
AGGAAAAAAGGAGAATGTTA

Downstream 100 bases:

>100_bases
AAAGACTATCAATAAAAATGAGAGTAACCCTGTGGTATACGGGGCTAATTGTAATTATTATGGCACTCGTGTTAGCTTTT
ATTTTAACTTCTTCAGATAA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINLATYDLIVLDIMIPGINGLQVLQKLRADNHTTPVLLLTA
KDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKTGNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEY
MIRNKEVVLTRDKIEQHVWNYDYEGGSNIIDVYVRYLRKKIDSQFETKLIHTVRGTGYVLRVES

Sequences:

>Translated_224_residues
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINLATYDLIVLDIMIPGINGLQVLQKLRADNHTTPVLLLTA
KDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKTGNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEY
MIRNKEVVLTRDKIEQHVWNYDYEGGSNIIDVYVRYLRKKIDSQFETKLIHTVRGTGYVLRVES
>Mature_224_residues
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINLATYDLIVLDIMIPGINGLQVLQKLRADNHTTPVLLLTA
KDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKTGNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEY
MIRNKEVVLTRDKIEQHVWNYDYEGGSNIIDVYVRYLRKKIDSQFETKLIHTVRGTGYVLRVES

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May be involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box) [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=50.2242152466368, Blast_Score=212, Evalue=2e-56,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=43.8356164383562, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=39.5454545454545, Blast_Score=168, Evalue=3e-43,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=34.5454545454545, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=36.3636363636364, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=34.6846846846847, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.15859030837, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=32.4324324324324, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=31.6742081447964, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1786911, Length=217, Percent_Identity=32.258064516129, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=29.2035398230088, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.9559471365639, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=36.6336633663366, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=31.4814814814815, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788713, Length=117, Percent_Identity=31.6239316239316, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25660; Mature: 25660

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINLATYDLIVLDIMIPGINGL
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHEEEHHCCCCCHH
QVLQKLRADNHTTPVLLLTAKDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKT
HHHHHHHCCCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHCC
GNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEYMIRNKEVVLTRDKIEQHVWN
CCCCHHHHHHHHHHCCCCCEECCCCEEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHCC
YDYEGGSNIIDVYVRYLRKKIDSQFETKLIHTVRGTGYVLRVES
CCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINLATYDLIVLDIMIPGINGL
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHEEEHHCCCCCHH
QVLQKLRADNHTTPVLLLTAKDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKT
HHHHHHHCCCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHCC
GNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEYMIRNKEVVLTRDKIEQHVWN
CCCCHHHHHHHHHHCCCCCEECCCCEEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHCC
YDYEGGSNIIDVYVRYLRKKIDSQFETKLIHTVRGTGYVLRVES
CCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8594334; 9141682 [H]