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The map label for this gene is thlA [H]

Identifier: 218904157

GI number: 218904157

Start: 2880871

End: 2882049

Strand: Reverse

Name: thlA [H]

Synonym: BCAH820_3041

Alternate gene names: 218904157

Gene position: 2882049-2880871 (Counterclockwise)

Preceding gene: 218904158

Following gene: 218904156

Centisome position: 54.35

GC content: 41.56

Gene sequence:

>1179_bases
ATGAAAGAAATTGTTTTATTAGAGGGAGCAAGGACTCCGTTCGCTGCGATTTCTGGATCGTTTCGAGGATTAAATGCAAC
AGATTTAGGAGCTATTGCTGCTAAGGAAGCAATACGAAAAGCTGCTATTTCTGCAGAAGATATTGATCAAGTTGTATTTG
GTAATGTTCAGCAATCTAGCAAAGATGCACATTTATTAGCGAGACATGTTGGGTTAAAAGCCGGAGCACCTATTCAAGTC
CCAGCTTTGACGATCAATCGCCTTTGCGGAACAGGTGTTGAATCTATTTTAACAGCAGCTCGTTATATTCTTAGCGGAGA
AGCAGAAGTTGCACTTGCCGGAGGAACGGAGAACATGAGCCAAGTCCCGCATGTAATACCTGGCATGAGATGGGGAAGTC
CACTTGGCGGTCCGGTAATAGAAGATTGGTTGTGGGATGGTCTATATGATACGTATGGTAAATGTACGATGGGAGAAACG
GCTGAAAATTTAGCTGCAAAATATAACGTAACGAGAGAAGAAGTAGATCAGCATGCACTATCGAGTCATGAACGAGCTCT
TTTAGCAAGGGAAAAAGGGTATTTCAAAGAAGAGATTGTTCCAGTAACAGTGAAAGGGAGAAAAGGAGAACAAGTGATTG
AAGAGGATGAGCATATCCGTCATACGAGTCTAGAAAAACTTGCAAAGTTAAAACCTCGTTTTGTGGAAAATGGTGTCGTA
ACTCCTGGTAGTGCAAGCGGTATGGTGGATGGTGCAGCGGCAGTTGTTTTAGCATCGAGCGACTTTGCAAAAGATAGAGG
ATTACAACCAATTGCTAAGCTCATTTCTTGGGCTGTTGTAGGAGTAGAACCTAAGTATATGGGAATCGGTCCAGTCCCAG
CCATTCAAAGTGCATTAGAAAAAGTAAATTTAACTTTGGCAGATTTAGATTTGATTGAAATTAATGAAGCATTTTCTGCG
CAGTACTTAGCTTGTCAAAAAGAATTAGGATTCGATCTTAATAAAGCGAATGTAAATGGTGGGGCAATTGCGATAGGACA
TCCCCTTGCTGCGAGTGGAACGAGAATTTCTCTATCCTTAATTTATGAATTAAGGAGAAGAAACAAGAAATATGGAGTAT
CTGCTGTTTGTATTGGCGGAGGCCAAGGAATCGCAGCGATTTGGGAAGCATTGTACTAG

Upstream 100 bases:

>100_bases
TGGGAATGCTTTCGCAACAGAGGATCGTAAAGAAGGATTACAAGCATTCGTTGAAAAAAGAAAACCAGTTTATTTAGGGA
AATAATGAGGTGAAAAGGAT

Downstream 100 bases:

>100_bases
GGAGACAAACCAGGAAGAGTCCTTCCTGGTTTTACCTACATCGTTTCTTTAAGTAAAAATTCGGGCTAGTTGGTAAGACG
ATAGAAAGTGAGTGGGAAAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKEIVLLEGARTPFAAISGSFRGLNATDLGAIAAKEAIRKAAISAEDIDQVVFGNVQQSSKDAHLLARHVGLKAGAPIQV
PALTINRLCGTGVESILTAARYILSGEAEVALAGGTENMSQVPHVIPGMRWGSPLGGPVIEDWLWDGLYDTYGKCTMGET
AENLAAKYNVTREEVDQHALSSHERALLAREKGYFKEEIVPVTVKGRKGEQVIEEDEHIRHTSLEKLAKLKPRFVENGVV
TPGSASGMVDGAAAVVLASSDFAKDRGLQPIAKLISWAVVGVEPKYMGIGPVPAIQSALEKVNLTLADLDLIEINEAFSA
QYLACQKELGFDLNKANVNGGAIAIGHPLAASGTRISLSLIYELRRRNKKYGVSAVCIGGGQGIAAIWEALY

Sequences:

>Translated_392_residues
MKEIVLLEGARTPFAAISGSFRGLNATDLGAIAAKEAIRKAAISAEDIDQVVFGNVQQSSKDAHLLARHVGLKAGAPIQV
PALTINRLCGTGVESILTAARYILSGEAEVALAGGTENMSQVPHVIPGMRWGSPLGGPVIEDWLWDGLYDTYGKCTMGET
AENLAAKYNVTREEVDQHALSSHERALLAREKGYFKEEIVPVTVKGRKGEQVIEEDEHIRHTSLEKLAKLKPRFVENGVV
TPGSASGMVDGAAAVVLASSDFAKDRGLQPIAKLISWAVVGVEPKYMGIGPVPAIQSALEKVNLTLADLDLIEINEAFSA
QYLACQKELGFDLNKANVNGGAIAIGHPLAASGTRISLSLIYELRRRNKKYGVSAVCIGGGQGIAAIWEALY
>Mature_392_residues
MKEIVLLEGARTPFAAISGSFRGLNATDLGAIAAKEAIRKAAISAEDIDQVVFGNVQQSSKDAHLLARHVGLKAGAPIQV
PALTINRLCGTGVESILTAARYILSGEAEVALAGGTENMSQVPHVIPGMRWGSPLGGPVIEDWLWDGLYDTYGKCTMGET
AENLAAKYNVTREEVDQHALSSHERALLAREKGYFKEEIVPVTVKGRKGEQVIEEDEHIRHTSLEKLAKLKPRFVENGVV
TPGSASGMVDGAAAVVLASSDFAKDRGLQPIAKLISWAVVGVEPKYMGIGPVPAIQSALEKVNLTLADLDLIEINEAFSA
QYLACQKELGFDLNKANVNGGAIAIGHPLAASGTRISLSLIYELRRRNKKYGVSAVCIGGGQGIAAIWEALY

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=50, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI148539872, Length=386, Percent_Identity=43.7823834196891, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=40.7594936708861, Blast_Score=274, Evalue=8e-74,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=37.7215189873418, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=32.3943661971831, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=26.9922879177378, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=42.9667519181586, Blast_Score=305, Evalue=2e-84,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=42.0924574209246, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=45.6852791878173, Blast_Score=304, Evalue=7e-84,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=40.3990024937656, Blast_Score=267, Evalue=8e-73,
Organism=Escherichia coli, GI1788683, Length=415, Percent_Identity=33.4939759036145, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=51.413881748072, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=39.9491094147583, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI25147385, Length=381, Percent_Identity=33.8582677165354, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=33.411214953271, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17535917, Length=398, Percent_Identity=27.8894472361809, Blast_Score=148, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=36.0201511335013, Blast_Score=239, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6322031, Length=347, Percent_Identity=35.7348703170029, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=49.618320610687, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=43.5114503816794, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=37.5, Blast_Score=251, Evalue=4e-67,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=34.9056603773585, Blast_Score=208, Evalue=6e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41732; Mature: 41732

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIVLLEGARTPFAAISGSFRGLNATDLGAIAAKEAIRKAAISAEDIDQVVFGNVQQSS
CCCEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
KDAHLLARHVGLKAGAPIQVPALTINRLCGTGVESILTAARYILSGEAEVALAGGTENMS
CHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCHH
QVPHVIPGMRWGSPLGGPVIEDWLWDGLYDTYGKCTMGETAENLAAKYNVTREEVDQHAL
HCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
SSHERALLAREKGYFKEEIVPVTVKGRKGEQVIEEDEHIRHTSLEKLAKLKPRFVENGVV
HHHHHHHHHHHCCCHHHCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
TPGSASGMVDGAAAVVLASSDFAKDRGLQPIAKLISWAVVGVEPKYMGIGPVPAIQSALE
CCCCCCCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
KVNLTLADLDLIEINEAFSAQYLACQKELGFDLNKANVNGGAIAIGHPLAASGTRISLSL
HHCCEEECCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCEEHHHH
IYELRRRNKKYGVSAVCIGGGQGIAAIWEALY
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHC
>Mature Secondary Structure
MKEIVLLEGARTPFAAISGSFRGLNATDLGAIAAKEAIRKAAISAEDIDQVVFGNVQQSS
CCCEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
KDAHLLARHVGLKAGAPIQVPALTINRLCGTGVESILTAARYILSGEAEVALAGGTENMS
CHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCHH
QVPHVIPGMRWGSPLGGPVIEDWLWDGLYDTYGKCTMGETAENLAAKYNVTREEVDQHAL
HCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
SSHERALLAREKGYFKEEIVPVTVKGRKGEQVIEEDEHIRHTSLEKLAKLKPRFVENGVV
HHHHHHHHHHHCCCHHHCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
TPGSASGMVDGAAAVVLASSDFAKDRGLQPIAKLISWAVVGVEPKYMGIGPVPAIQSALE
CCCCCCCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
KVNLTLADLDLIEINEAFSAQYLACQKELGFDLNKANVNGGAIAIGHPLAASGTRISLSL
HHCCEEECCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCEEHHHH
IYELRRRNKKYGVSAVCIGGGQGIAAIWEALY
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA