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The map label for this gene is moeA1 [H]

Identifier: 218903284

GI number: 218903284

Start: 2053991

End: 2055280

Strand: Direct

Name: moeA1 [H]

Synonym: BCAH820_2168

Alternate gene names: 218903284

Gene position: 2053991-2055280 (Clockwise)

Preceding gene: 218903283

Following gene: 218903285

Centisome position: 38.73

GC content: 38.99

Gene sequence:

>1290_bases
ATGTTAGCAAAACGTATACCGATTCCAGTGGCAGAAGCAGTTGCACGAGTAATGAAATATGCTCATCAAGGTGAAACAGA
GGAGGTTTCTCTTATAGAAAGTTACGGAAGAACGCTTGGAGAAGATGTTATTGCAGATCATGATGTCCCGCATTTTGATC
GCTCTCCGTACGACGGATTTGCGATTCGAGCGGAAGATACAAAAGAAGCAAGTAGCAGTAATCCCATTCAGTTTGAAGTG
ATTGGTGAAATTGGAGCAGGGGTTGTTTTTACAGAAGAAGTGAAAGCATTTCAAGCTGTCCGTATTATGACAGGAGCCGC
AATTCCGAGAGGGTGTAATGCGGTTGTTATGTTAGAACTAACGGAAGGATTTGAAAAAAACGAAAAGACTTATATGACAT
TAAAACGCTGTTTCGCAGCCGGTGATAACATTTCTTTTAAAGGTGAAGATGTAAAACAAAATACTATCCTTGTGAAAGAA
GGGACTGTTATTAACCCGGGAGTTGCAGCACTTCTTGCTACGTTTGGTTATAGTTCCGTACACGTTGTAAAACGGCCGAT
TATTGGCATTGTAACGACGGGTAGTGAACTACTTGAAGTACATGAACAATTAAAACCAGGAAAGATTCGAAATAGTAATT
CCTATATGATTGCTGCTCAAATTGAACGAGCGGGCGGAGTTGTACAGTATTATGGGAAATTCGCTGACGATTTTGAGACT
TGTTTTAACACTGTAAAAAAAGCAATAAAAGAAGTCGATATTTTAATTACAACTGGTGGTGTTTCGATAGGAGACTATGA
CTATTTACCTGCTATTTATGAGAGATTACAAGCAAATGTACTTTTCAATAAAATTGCGATGCGACCAGGAAGTGTGACAA
CTGTAGCTGAGATAGAGGGAAAACTATTATTTGGTCTATCTGGTAATCCTTCAGCTTGTTATGTCGGATGTGAGTTATAT
GTTCGACCAGTCATTGGAACATATTTGCATAGGAAAGATTCACATATTTATCGTGCAGAAGCAATTTTACAGAAAGACTT
TTCGAAAGCAAATCCGTTTACTCGTTTTGTAAGAGGGAGAGTGGAATTTGCAGATGGTCAATTACAAGTTACACCAGTTG
GTTTAGATAAATCTAGCGCAATTTCTTCACTTGCAGAAGCGAATGCATTTATTGTTTTGCCAGGGGGAACGAGAGGATTT
AAAGCTGGAATTACTGTTTCGGTACTGTTACTAGAATCAACCAGCGGAAGTGAATGGCCATGGAAAGAATCGCTTCGTTC
ATACAAATAA

Upstream 100 bases:

>100_bases
TTCATGGGACAAATGATGTGAAAATAGCAAAACGATTGTACGCAAAATATATAGGATGAACAGAGAGAATTTCCCCCTTA
TTAAAACGAGGTGAAAAAGA

Downstream 100 bases:

>100_bases
TAGAAAAATAGGTTGCTAATTTATACAAAGATAAGAGGTGCGAAATGACACATACGTATTATGAAGTAATTGATACACCT
ATATCAATTGAAGAAGTTAC

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLAKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGFAIRAEDTKEASSSNPIQFEV
IGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLELTEGFEKNEKTYMTLKRCFAAGDNISFKGEDVKQNTILVKE
GTVINPGVAALLATFGYSSVHVVKRPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVQYYGKFADDFET
CFNTVKKAIKEVDILITTGGVSIGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEIEGKLLFGLSGNPSACYVGCELY
VRPVIGTYLHRKDSHIYRAEAILQKDFSKANPFTRFVRGRVEFADGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGF
KAGITVSVLLLESTSGSEWPWKESLRSYK

Sequences:

>Translated_429_residues
MLAKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGFAIRAEDTKEASSSNPIQFEV
IGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLELTEGFEKNEKTYMTLKRCFAAGDNISFKGEDVKQNTILVKE
GTVINPGVAALLATFGYSSVHVVKRPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVQYYGKFADDFET
CFNTVKKAIKEVDILITTGGVSIGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEIEGKLLFGLSGNPSACYVGCELY
VRPVIGTYLHRKDSHIYRAEAILQKDFSKANPFTRFVRGRVEFADGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGF
KAGITVSVLLLESTSGSEWPWKESLRSYK
>Mature_429_residues
MLAKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGFAIRAEDTKEASSSNPIQFEV
IGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLELTEGFEKNEKTYMTLKRCFAAGDNISFKGEDVKQNTILVKE
GTVINPGVAALLATFGYSSVHVVKRPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVQYYGKFADDFET
CFNTVKKAIKEVDILITTGGVSIGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEIEGKLLFGLSGNPSACYVGCELY
VRPVIGTYLHRKDSHIYRAEAILQKDFSKANPFTRFVRGRVEFADGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGF
KAGITVSVLLLESTSGSEWPWKESLRSYK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=389, Percent_Identity=33.1619537275064, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI66932975, Length=389, Percent_Identity=33.1619537275064, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1787049, Length=390, Percent_Identity=30.2564102564103, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25147659, Length=302, Percent_Identity=30.4635761589404, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=365, Percent_Identity=24.9315068493151, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136978, Length=363, Percent_Identity=27.8236914600551, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24638841, Length=363, Percent_Identity=27.8236914600551, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46843; Mature: 46843

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00028 ZINC_FINGER_C2H2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGF
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEASSSNPIQFEVIGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TEGFEKNEKTYMTLKRCFAAGDNISFKGEDVKQNTILVKEGTVINPGVAALLATFGYSSV
CCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCEEEEECCCEECCHHHHHHHHHCCCCE
HVVKRPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVQYYGKFADDFET
EEECCCEEEEEECCHHHHHHHHHCCCCCEECCCCEEEEEEEHHCCCCHHHHHHHHHHHHH
CFNTVKKAIKEVDILITTGGVSIGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEIEG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
KLLFGLSGNPSACYVGCELYVRPVIGTYLHRKDSHIYRAEAILQKDFSKANPFTRFVRGR
EEEEEECCCCCEEEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCE
VEFADGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGFKAGITVSVLLLESTSGSEWP
EEECCCEEEEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WKESLRSYK
HHHHHHCCC
>Mature Secondary Structure
MLAKRIPIPVAEAVARVMKYAHQGETEEVSLIESYGRTLGEDVIADHDVPHFDRSPYDGF
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEASSSNPIQFEVIGEIGAGVVFTEEVKAFQAVRIMTGAAIPRGCNAVVMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TEGFEKNEKTYMTLKRCFAAGDNISFKGEDVKQNTILVKEGTVINPGVAALLATFGYSSV
CCCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCEEEEECCCEECCHHHHHHHHHCCCCE
HVVKRPIIGIVTTGSELLEVHEQLKPGKIRNSNSYMIAAQIERAGGVVQYYGKFADDFET
EEECCCEEEEEECCHHHHHHHHHCCCCCEECCCCEEEEEEEHHCCCCHHHHHHHHHHHHH
CFNTVKKAIKEVDILITTGGVSIGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEIEG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
KLLFGLSGNPSACYVGCELYVRPVIGTYLHRKDSHIYRAEAILQKDFSKANPFTRFVRGR
EEEEEECCCCCEEEEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCE
VEFADGQLQVTPVGLDKSSAISSLAEANAFIVLPGGTRGFKAGITVSVLLLESTSGSEWP
EEECCCEEEEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WKESLRSYK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]