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The map label for this gene is ciaR [H]

Identifier: 218901766

GI number: 218901766

Start: 592378

End: 593049

Strand: Direct

Name: ciaR [H]

Synonym: BCAH820_0627

Alternate gene names: 218901766

Gene position: 592378-593049 (Clockwise)

Preceding gene: 218901765

Following gene: 218901767

Centisome position: 11.17

GC content: 35.71

Gene sequence:

>672_bases
ATGCGCTTACTCGTAGTAGAAGATAATGCTTCTTTATTAGAGTCCATTGTCCAAATATTATGCGATGAATTTGAAGTAGA
TACGGCATTGAATGGAGAAGATGGATTGTTTTTAGCGCTTCAAAATATATATGATGCAATTTTGCTTGATGTGATGATGC
CAGAAATGGATGGATTTGAAGTGATTCAAAAAATACGTGATAAAAAGATTGAAACACCTGTCTTATTTTTGACAGCGAGA
GATTCTTTAGAAGATCGCGTGAAAGGGTTGGATTTTGGCGGGGATGACTATATCGTTAAGCCGTTTCAGGCCCCAGAATT
AAAAGCAAGAATTCGTGCTTTATTAAGGCGAAGTGGTAGTTTAACAACGAAGCAGACCATTCGCTATAAAGGGATTGAAC
TGTTCGGAAAAGATAAAGATGTTCAAGTAGATGGACAAAGTATGAAGCTAACATTAAAACAATATGAGCTTCTAGAGTAC
CTTGTTCAAAATAGCGGAAAGATTTTAATGAGGGAACAAATTTTTGATCGTGTCTGGGGATTCGATTCAGATACGACAGT
AGCGATTGTAGAAGTGTATGTACATCATTTACGTAAAAAATTAGAGCCATTCGGTTATCAGAAAGATATTCAAACCGTTC
GTGGTATTGGATATATATTAAAAGAACAATGA

Upstream 100 bases:

>100_bases
TAAGGAAGAGTTTTTATAATAAGTCTTTCAAATTTTATATCAAAAAAACGTTAAAATGTAATTATAAATAGAATTGAACA
ATATGGTGGAAGGTGAGAAT

Downstream 100 bases:

>100_bases
AAAAGGGAAGTATGTTTCAGAAGACGCGTATTCGATTGACTATATTGAATTCATTAGTATTTATCATTTTGATAGGCGTA
TTAGGTAGTATCATTTATTC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRLLVVEDNASLLESIVQILCDEFEVDTALNGEDGLFLALQNIYDAILLDVMMPEMDGFEVIQKIRDKKIETPVLFLTAR
DSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGSLTTKQTIRYKGIELFGKDKDVQVDGQSMKLTLKQYELLEY
LVQNSGKILMREQIFDRVWGFDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ

Sequences:

>Translated_223_residues
MRLLVVEDNASLLESIVQILCDEFEVDTALNGEDGLFLALQNIYDAILLDVMMPEMDGFEVIQKIRDKKIETPVLFLTAR
DSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGSLTTKQTIRYKGIELFGKDKDVQVDGQSMKLTLKQYELLEY
LVQNSGKILMREQIFDRVWGFDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ
>Mature_223_residues
MRLLVVEDNASLLESIVQILCDEFEVDTALNGEDGLFLALQNIYDAILLDVMMPEMDGFEVIQKIRDKKIETPVLFLTAR
DSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGSLTTKQTIRYKGIELFGKDKDVQVDGQSMKLTLKQYELLEY
LVQNSGKILMREQIFDRVWGFDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=41.3636363636364, Blast_Score=168, Evalue=2e-43,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=39.2857142857143, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=37.9464285714286, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=37.6106194690265, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=34.5454545454545, Blast_Score=136, Evalue=9e-34,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=32.8828828828829, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=35.5855855855856, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=32.2727272727273, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=29.0748898678414, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=34.1991341991342, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=30, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=26.9911504424779, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1787229, Length=190, Percent_Identity=32.1052631578947, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=37.6146788990826, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI145693140, Length=239, Percent_Identity=25.9414225941423, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1790437, Length=121, Percent_Identity=33.0578512396694, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25653; Mature: 25653

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVVEDNASLLESIVQILCDEFEVDTALNGEDGLFLALQNIYDAILLDVMMPEMDGFE
CEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
VIQKIRDKKIETPVLFLTARDSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGS
HHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCC
LTTKQTIRYKGIELFGKDKDVQVDGQSMKLTLKQYELLEYLVQNSGKILMREQIFDRVWG
CCHHHHHHCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHC
FDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLLVVEDNASLLESIVQILCDEFEVDTALNGEDGLFLALQNIYDAILLDVMMPEMDGFE
CEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
VIQKIRDKKIETPVLFLTARDSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGS
HHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCC
LTTKQTIRYKGIELFGKDKDVQVDGQSMKLTLKQYELLEYLVQNSGKILMREQIFDRVWG
CCHHHHHHCCCEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHC
FDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]