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The map label for this gene is ciaH [H]

Identifier: 218901767

GI number: 218901767

Start: 593118

End: 594296

Strand: Direct

Name: ciaH [H]

Synonym: BCAH820_0628

Alternate gene names: 218901767

Gene position: 593118-594296 (Clockwise)

Preceding gene: 218901766

Following gene: 218901768

Centisome position: 11.19

GC content: 35.37

Gene sequence:

>1179_bases
TTGATAGGCGTATTAGGTAGTATCATTTATTCTTACACATATAAGCGTATTTATAGTGGAGTAAATGAATCGATAGAAAA
AGCCGTTCAACATAGAAAGAATGCAGATGATAAAAAACTACCTAAAAAAATTAGAGGATATCCTCCAATTGGGGATCCAA
GGATAATGGAGTTAACTTGGCTTGGAAACACGGTGGAGATAGATATTGAAAACGGCAAACGTCGTTTTATTTTTGAAGAC
AATTTGGAAAAGTTTTCTCCAAAGAAATTAGGAACTTTGCAAGATATAGAAGTACAAGGACGATATTTTAGAATATTTGC
ATTTCAGAAAGATGCAAAAATAGTTCAAATTGCAAGGGATATAACGGCTGAAAAAGAAATGTTACATACTTTATTTTTAA
TTCTTGTGATAGGGTGTAGCATAGGAAGTCTATGTGCAATAGGAATCGGATTTTTCTTAGCTGGCAGGGCACTCGTACCT
ATTCAAAATTCATGGGAAAAACAGCAACAATTTGTGTCGGACGCATCACATGAATTAAGGACACCGCTTGCGGTTATTCA
ATCCAAAACAGATATATTATTTCAGTCACCATCTGCGACAATAGAAGAAAAAGCGATGGATATTTCTACGATTTCAAAGG
AGTGTAGACGATTATCTAAGCTTGTAGCTAATTTATTATTGTTAGCACGTTCAGATTCTAATCAAATTGAGATGGATAAG
AAAATATTTGAACTCGATAAATTGTTAGAAGAAATAGTAGAGCCATATAAGGAAATTGCTTCCTACCAAGAAAAAGAGAT
GATATTGAAAGTAGAGCATGACATATCATTTATGGGTGATAGGGAGAGAATTCATCAAATGATGGTCATATTGTTAGATA
ATGCGATGAAGTATACAAATGAGGGAGGACATATACAAATCGATTGTACGCAAACGAACAGTTCGATTCGTATACGAGTG
AAAGATGATGGGATAGGAGTGAAAGGTGAGGACATTCCGAAACTATTTGATCGTTTTTATCAAGGAGATAAAGCGAGAAG
TGCGTCAGAGGGAGCGGGATTAGGCCTTTCAATCGCGAACTGGATTGTAGAAAAGCATTATGGGAAAATATCAGTAGAGA
GCCAATGGGGAGAGGGCACTTGCTTTGAAGTGATTCTTCCTAAAAATCAAAGAATATAA

Upstream 100 bases:

>100_bases
GTGGTATTGGATATATATTAAAAGAACAATGAAAAAGGGAAGTATGTTTCAGAAGACGCGTATTCGATTGACTATATTGA
ATTCATTAGTATTTATCATT

Downstream 100 bases:

>100_bases
GTGAGAAGACGACCTTGTTTTTACAAGGTCGTCTTTTTTTTTAAGGGAAAGTTAAGAAACTATTTATAACATGTATTATA
TACAGAAAGTTTGTCCCCTA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIMELTWLGNTVEIDIENGKRRFIFED
NLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILVIGCSIGSLCAIGIGFFLAGRALVP
IQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECRRLSKLVANLLLLARSDSNQIEMDK
KIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDISFMGDRERIHQMMVILLDNAMKYTNEGGHIQIDCTQTNSSIRIRV
KDDGIGVKGEDIPKLFDRFYQGDKARSASEGAGLGLSIANWIVEKHYGKISVESQWGEGTCFEVILPKNQRI

Sequences:

>Translated_392_residues
MIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIMELTWLGNTVEIDIENGKRRFIFED
NLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILVIGCSIGSLCAIGIGFFLAGRALVP
IQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECRRLSKLVANLLLLARSDSNQIEMDK
KIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDISFMGDRERIHQMMVILLDNAMKYTNEGGHIQIDCTQTNSSIRIRV
KDDGIGVKGEDIPKLFDRFYQGDKARSASEGAGLGLSIANWIVEKHYGKISVESQWGEGTCFEVILPKNQRI
>Mature_392_residues
MIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIMELTWLGNTVEIDIENGKRRFIFED
NLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARDITAEKEMLHTLFLILVIGCSIGSLCAIGIGFFLAGRALVP
IQNSWEKQQQFVSDASHELRTPLAVIQSKTDILFQSPSATIEEKAMDISTISKECRRLSKLVANLLLLARSDSNQIEMDK
KIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDISFMGDRERIHQMMVILLDNAMKYTNEGGHIQIDCTQTNSSIRIRV
KDDGIGVKGEDIPKLFDRFYQGDKARSASEGAGLGLSIANWIVEKHYGKISVESQWGEGTCFEVILPKNQRI

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=33.9055793991416, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.5964125560538, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=30.2631578947368, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=32, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=29.004329004329, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=27.5109170305677, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=31.3636363636364, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=284, Percent_Identity=24.2957746478873, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=28.3783783783784, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=27.1255060728745, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=27.7310924369748, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=27.0386266094421, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=238, Percent_Identity=26.890756302521, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787374, Length=223, Percent_Identity=28.2511210762332, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=25.6038647342995, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87081816, Length=221, Percent_Identity=25.7918552036199, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=24.2152466367713, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=219, Percent_Identity=28.310502283105, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789808, Length=220, Percent_Identity=26.3636363636364, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44598; Mature: 44598

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIMELTW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEEEE
LGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARD
CCCEEEEEECCCCEEEEEECCHHHCCCHHCCCCCCEEECCEEEEEEEEECCCHHHHHHHH
ITAEKEMLHTLFLILVIGCSIGSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHH
TPLAVIQSKTDILFQSPSATIEEKAMDISTISKECRRLSKLVANLLLLARSDSNQIEMDK
CHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDISFMGDRERIHQMMVILLDNAMKYTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHCC
EGGHIQIDCTQTNSSIRIRVKDDGIGVKGEDIPKLFDRFYQGDKARSASEGAGLGLSIAN
CCCEEEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
WIVEKHYGKISVESQWGEGTCFEVILPKNQRI
HHHHHCCCEEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MIGVLGSIIYSYTYKRIYSGVNESIEKAVQHRKNADDKKLPKKIRGYPPIGDPRIMELTW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEEEEE
LGNTVEIDIENGKRRFIFEDNLEKFSPKKLGTLQDIEVQGRYFRIFAFQKDAKIVQIARD
CCCEEEEEECCCCEEEEEECCHHHCCCHHCCCCCCEEECCEEEEEEEEECCCHHHHHHHH
ITAEKEMLHTLFLILVIGCSIGSLCAIGIGFFLAGRALVPIQNSWEKQQQFVSDASHELR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHH
TPLAVIQSKTDILFQSPSATIEEKAMDISTISKECRRLSKLVANLLLLARSDSNQIEMDK
CHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KIFELDKLLEEIVEPYKEIASYQEKEMILKVEHDISFMGDRERIHQMMVILLDNAMKYTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHCC
EGGHIQIDCTQTNSSIRIRVKDDGIGVKGEDIPKLFDRFYQGDKARSASEGAGLGLSIAN
CCCEEEEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
WIVEKHYGKISVESQWGEGTCFEVILPKNQRI
HHHHHCCCEEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]