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The map label for this gene is glmS [H]

Identifier: 218884769

GI number: 218884769

Start: 1350437

End: 1352251

Strand: Reverse

Name: glmS [H]

Synonym: DKAM_1458

Alternate gene names: 218884769

Gene position: 1352251-1350437 (Counterclockwise)

Preceding gene: 218884771

Following gene: 218884768

Centisome position: 99.05

GC content: 45.29

Gene sequence:

>1815_bases
ATGGGAGGCATATTCGGCGTAATATGTAGCACCACTATACCTAGAGGGCTCATAGTTACTGGGCTACGAAGGCTCCTTTA
TAGGGGATACAATGGCATCGGTGTTGTATTCCCCGTAGACAAGGGGCTTGAAATTAGGAAAGCCCCAGGACACTTGGACG
ATGTAGTTAAGCAAGTAGACCTGGAAAACATACCCTCCCGTATAGCGCTGGCCCATACCAGGTATGCAAGCCGTGGCTGG
CCGGTTTATGAAAATACTCATCCATTAACCGATTGCAACGGGGGGATAGCTGTTGTTGGAGATGGCATAATAGACAACTA
TGAGGCATATAGGACAGAGCTTGAAAAAGAGGGGCATATATTAAGATCTAGAACCGATACAGAGATCGCGGCACACCTCC
TCGAGAAATACTATACTATGGAGAGGGACCTACTAAGAGCTTTACTAAGGATAGGCAGTGAGTTGAAGGGTCTGTACTCA
TTAGCATTCCTCGTCTCCGGGGTGGATGGTATATTATTTATTCAGAATGGCCAACCCCTGGTCATAGGGATCGGTTCTCA
ATGCGTGTACCTCTCCAGTGATCTAACATCGCTTCACGGATTAGCGGACACAGCATACATCATTGAGGATGGAATGGCTG
GATTAATCAGCTTAGAGAAACAAGTATTATATAGGATCTCGACAGGAGAACACGTGGATTTAGCTAGTCTACAGAGTAAG
CGTGTTAAATATGGTATTGAATACGTGGAAAAAGCCGGCTTCCCACATTACATGCTGAAGGAGATATATGAGACCCCGGA
CGCTATCTATAGGACAACCATTGCAATAATGGATAAATACCTAAGGCTAGCCTCGATGATTATACATGGCGCTAGAGACG
TCTATATAGTTGCGAACGGTTCAAGCCTCCATGCAGGATTGGTTGCCTCATACTATTTCGCCGAGCTAGCCGGTATCTCC
ATTACACCTGTCTCAGCGGCTGAGTTCCCCTACTCCATACTAGAGTCCATAACCACGGGCTCCGTTCTTATAGCAGTGAG
CCAGAGCGGTGAGACGAGTGATGTAATAAATAGCGTTAAACTAGCTAAGCAACGGGGGGCCGTTATTATAGGGGTCACTA
ACAACGTTGGTTCACGCCTTGCGTTAGAATCAAACGTGTATCTACCAATAGGGGCAGGCCCCGAGATAGCTGTGCCGGCT
ACCAAGTCTTTCTCCTCAACAATAGCTGCATTATTACTACTGGCATCATACACTGGGATATTTAATGGAAGACAGAGCTT
CAATGATTATAATACAATAATTAACGAGATTAGGAACACTAGTAAAGAGCTCAAGGAATTAATTACAAGGTTTGACTCTA
GGATTACATCGATAGTGAATTCCCTCCCATTATTCTATAATGTATACGTTGCCGGAAGCGGTATCACATACCCTATAGCG
CTGGAGGGCGCATTAAAGCTTAAAGAGGCAGCCCTAATACATGCAGAAGGAGTGCAGCTAGGCGAGTTGAGACACGGCCC
TCTTACCCTGGTATCCCATGAATTCCCAGTAATACTAATCGAGCCCTTTGAAGAACCAGCGAAGCAACTCTATTTGAAAG
TTGTAAAAGAGGTCCTCAACCGTGACGCCATATTGTTCTCCATCAATATCAATGATGTCCCGTGTAAAAATATATGTGTA
GAAGTGCCGGGTAAAAAATACCTATACCCTGTTATAGCGACGATACCACTTCAATTGTTCTCATACAGGATCGGTGTGAA
GCTCGGAAGACCAATAGATCACCCACCAGGGCTGGCAAAGGCTATAACGACATAA

Upstream 100 bases:

>100_bases
TCTGAGTTTTATAATAGTGTATCGAGGCATGACGCGTTCTCCCGTACTCTAGCTAAATTAATATAAATAGAGAATCGAAT
TATTAAAACGGTGCTTTAGT

Downstream 100 bases:

>100_bases
CTTTAATACTCCTTTCATTGCTCTCTCTTATTAATCGATGAAGGCAATGAGGTATCCTAGTCCAGGTTGAATAGTGATGA
GGAATCTCCGGGACCGAGCC

Product: glutamine-fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MGGIFGVICSTTIPRGLIVTGLRRLLYRGYNGIGVVFPVDKGLEIRKAPGHLDDVVKQVDLENIPSRIALAHTRYASRGW
PVYENTHPLTDCNGGIAVVGDGIIDNYEAYRTELEKEGHILRSRTDTEIAAHLLEKYYTMERDLLRALLRIGSELKGLYS
LAFLVSGVDGILFIQNGQPLVIGIGSQCVYLSSDLTSLHGLADTAYIIEDGMAGLISLEKQVLYRISTGEHVDLASLQSK
RVKYGIEYVEKAGFPHYMLKEIYETPDAIYRTTIAIMDKYLRLASMIIHGARDVYIVANGSSLHAGLVASYYFAELAGIS
ITPVSAAEFPYSILESITTGSVLIAVSQSGETSDVINSVKLAKQRGAVIIGVTNNVGSRLALESNVYLPIGAGPEIAVPA
TKSFSSTIAALLLLASYTGIFNGRQSFNDYNTIINEIRNTSKELKELITRFDSRITSIVNSLPLFYNVYVAGSGITYPIA
LEGALKLKEAALIHAEGVQLGELRHGPLTLVSHEFPVILIEPFEEPAKQLYLKVVKEVLNRDAILFSININDVPCKNICV
EVPGKKYLYPVIATIPLQLFSYRIGVKLGRPIDHPPGLAKAITT

Sequences:

>Translated_604_residues
MGGIFGVICSTTIPRGLIVTGLRRLLYRGYNGIGVVFPVDKGLEIRKAPGHLDDVVKQVDLENIPSRIALAHTRYASRGW
PVYENTHPLTDCNGGIAVVGDGIIDNYEAYRTELEKEGHILRSRTDTEIAAHLLEKYYTMERDLLRALLRIGSELKGLYS
LAFLVSGVDGILFIQNGQPLVIGIGSQCVYLSSDLTSLHGLADTAYIIEDGMAGLISLEKQVLYRISTGEHVDLASLQSK
RVKYGIEYVEKAGFPHYMLKEIYETPDAIYRTTIAIMDKYLRLASMIIHGARDVYIVANGSSLHAGLVASYYFAELAGIS
ITPVSAAEFPYSILESITTGSVLIAVSQSGETSDVINSVKLAKQRGAVIIGVTNNVGSRLALESNVYLPIGAGPEIAVPA
TKSFSSTIAALLLLASYTGIFNGRQSFNDYNTIINEIRNTSKELKELITRFDSRITSIVNSLPLFYNVYVAGSGITYPIA
LEGALKLKEAALIHAEGVQLGELRHGPLTLVSHEFPVILIEPFEEPAKQLYLKVVKEVLNRDAILFSININDVPCKNICV
EVPGKKYLYPVIATIPLQLFSYRIGVKLGRPIDHPPGLAKAITT
>Mature_603_residues
GGIFGVICSTTIPRGLIVTGLRRLLYRGYNGIGVVFPVDKGLEIRKAPGHLDDVVKQVDLENIPSRIALAHTRYASRGWP
VYENTHPLTDCNGGIAVVGDGIIDNYEAYRTELEKEGHILRSRTDTEIAAHLLEKYYTMERDLLRALLRIGSELKGLYSL
AFLVSGVDGILFIQNGQPLVIGIGSQCVYLSSDLTSLHGLADTAYIIEDGMAGLISLEKQVLYRISTGEHVDLASLQSKR
VKYGIEYVEKAGFPHYMLKEIYETPDAIYRTTIAIMDKYLRLASMIIHGARDVYIVANGSSLHAGLVASYYFAELAGISI
TPVSAAEFPYSILESITTGSVLIAVSQSGETSDVINSVKLAKQRGAVIIGVTNNVGSRLALESNVYLPIGAGPEIAVPAT
KSFSSTIAALLLLASYTGIFNGRQSFNDYNTIINEIRNTSKELKELITRFDSRITSIVNSLPLFYNVYVAGSGITYPIAL
EGALKLKEAALIHAEGVQLGELRHGPLTLVSHEFPVILIEPFEEPAKQLYLKVVKEVLNRDAILFSININDVPCKNICVE
VPGKKYLYPVIATIPLQLFSYRIGVKLGRPIDHPPGLAKAITT

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=27.3913043478261, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4826742, Length=694, Percent_Identity=28.2420749279539, Blast_Score=216, Evalue=5e-56,
Organism=Escherichia coli, GI1790167, Length=618, Percent_Identity=32.2006472491909, Blast_Score=276, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17539970, Length=701, Percent_Identity=28.6733238231098, Blast_Score=218, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17532897, Length=433, Percent_Identity=29.3302540415704, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17532899, Length=433, Percent_Identity=29.3302540415704, Blast_Score=167, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322745, Length=375, Percent_Identity=31.7333333333333, Blast_Score=150, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323731, Length=435, Percent_Identity=24.8275862068966, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=31.7307692307692, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357745, Length=703, Percent_Identity=28.4495021337127, Blast_Score=231, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65974; Mature: 65843

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGIFGVICSTTIPRGLIVTGLRRLLYRGYNGIGVVFPVDKGLEIRKAPGHLDDVVKQVD
CCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHC
LENIPSRIALAHTRYASRGWPVYENTHPLTDCNGGIAVVGDGIIDNYEAYRTELEKEGHI
HHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCE
LRSRTDTEIAAHLLEKYYTMERDLLRALLRIGSELKGLYSLAFLVSGVDGILFIQNGQPL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEE
VIGIGSQCVYLSSDLTSLHGLADTAYIIEDGMAGLISLEKQVLYRISTGEHVDLASLQSK
EEEECCCEEEEECCHHHHHCCHHHHHHHHCCCHHHHHHHHHHHEEECCCCCEEHHHHHHH
RVKYGIEYVEKAGFPHYMLKEIYETPDAIYRTTIAIMDKYLRLASMIIHGARDVYIVANG
HHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
SSLHAGLVASYYFAELAGISITPVSAAEFPYSILESITTGSVLIAVSQSGETSDVINSVK
CCCHHHHHHHHHHHHHCCCEECCCCHHHCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
LAKQRGAVIIGVTNNVGSRLALESNVYLPIGAGPEIAVPATKSFSSTIAALLLLASYTGI
HHHHCCCEEEEECCCCCCEEEEECCEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHH
FNGRQSFNDYNTIINEIRNTSKELKELITRFDSRITSIVNSLPLFYNVYVAGSGITYPIA
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEE
LEGALKLKEAALIHAEGVQLGELRHGPLTLVSHEFPVILIEPFEEPAKQLYLKVVKEVLN
ECCHHHHHHHHEEEECCCEECCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
RDAILFSININDVPCKNICVEVPGKKYLYPVIATIPLQLFSYRIGVKLGRPIDHPPGLAK
CCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCHH
AITT
HCCC
>Mature Secondary Structure 
GGIFGVICSTTIPRGLIVTGLRRLLYRGYNGIGVVFPVDKGLEIRKAPGHLDDVVKQVD
CCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHC
LENIPSRIALAHTRYASRGWPVYENTHPLTDCNGGIAVVGDGIIDNYEAYRTELEKEGHI
HHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCE
LRSRTDTEIAAHLLEKYYTMERDLLRALLRIGSELKGLYSLAFLVSGVDGILFIQNGQPL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEE
VIGIGSQCVYLSSDLTSLHGLADTAYIIEDGMAGLISLEKQVLYRISTGEHVDLASLQSK
EEEECCCEEEEECCHHHHHCCHHHHHHHHCCCHHHHHHHHHHHEEECCCCCEEHHHHHHH
RVKYGIEYVEKAGFPHYMLKEIYETPDAIYRTTIAIMDKYLRLASMIIHGARDVYIVANG
HHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
SSLHAGLVASYYFAELAGISITPVSAAEFPYSILESITTGSVLIAVSQSGETSDVINSVK
CCCHHHHHHHHHHHHHCCCEECCCCHHHCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
LAKQRGAVIIGVTNNVGSRLALESNVYLPIGAGPEIAVPATKSFSSTIAALLLLASYTGI
HHHHCCCEEEEECCCCCCEEEEECCEEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHH
FNGRQSFNDYNTIINEIRNTSKELKELITRFDSRITSIVNSLPLFYNVYVAGSGITYPIA
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEE
LEGALKLKEAALIHAEGVQLGELRHGPLTLVSHEFPVILIEPFEEPAKQLYLKVVKEVLN
ECCHHHHHHHHEEEECCCEECCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
RDAILFSININDVPCKNICVEVPGKKYLYPVIATIPLQLFSYRIGVKLGRPIDHPPGLAK
CCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCHH
AITT
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA