Click here to switch to the map view.

The map label for this gene is trpS [H]

Identifier: 218884768

GI number: 218884768

Start: 1349207

End: 1350322

Strand: Reverse

Name: trpS [H]

Synonym: DKAM_1457

Alternate gene names: 218884768

Gene position: 1350322-1349207 (Counterclockwise)

Preceding gene: 218884769

Following gene: 218884766

Centisome position: 98.91

GC content: 43.91

Gene sequence:

>1116_bases
GTGGTTGAAATGGGTGCCAAGCTAGATCCATGGGGTCACTACGCTATAGAGGATTACAGGAAACTACTGGAGGAATTCGG
TATTAGCCCGATCGATAAGATCCTGGGGCTACTGCCCCATAAACACAAGTACTTTGAGAGACTAGTCATATTCGGACACA
GGGATTTCGACGTATGGCTTGAAGCACTTAAACGCGGTGAAAAAGTAGCTGTGCTCACCGGGTTCATGCCTAGTGGAAGA
CCCCACCTTGGGACAGCGATGGTTTATGAGGAATTAAAGTTCCTTCAATCCCTTGGAGCACATATAAAAATAGCTATAGC
GGATGCCGAAGCATATATTGTGAGAAGAGAGGATAGGAGCGAGGTAATAAGAAGAGGAGTTGAATTTGTAGCTCACTCTA
TTGCATGGGGGATAAACCCGGATAACGCTGAATTCTACTATCAGACAGCTATGGATAATGAATACTATAGACTCATACAA
TTATTCTCCAGAAAGATCACTGCGGCTGAAATGGAGGCTATATACGGCGATATAAATCCTGGTAAAATTATGGCAGCGCT
AACACAATCGGCAGATATACTGCATCTCCAATTAGATAAATATGGAGGTTACAAGTACATAGTGGTACCCGTTGGAGCCG
ATCAAGACCCACACCTGCGATTGACGAGGGATATAGCTGATAGATTTGAGCAGGAGTTTGGGTTGAAGAGGCCTAGCTCC
ATCTATCATAAGCTATTAAGGGGGTTGGATGGAAACAAAATGAGTAAAAGCCGTCCTGAGTACGCTATACACCTCGACGA
TGATCCAGAGATGGCGGAAAAGAAGCTTGCGAACGCGTTAACCGGTGGAAGGGCTACAGCAGAGGAACAGAGAAGACTTG
GAGGGGAGCCATGGAAGTGTAGCATATTCGAGCTCTACGTATATCATTTAATAGATGATGAAAAAGAATTGAAGGAGAGA
TATGATGAGTGTGTGAACGGTAAAATACTCTGCGGGCAATGCAAGAGAATAGCGGCTGAGAAGCTTAGAAAGCTACTTAT
AGAGCATCAGAAGAGATTCAAGGAAGTAATCACCAGTGGGATAGTGGAAAAAATATTGAAGAAGCCATCTTTTTAA

Upstream 100 bases:

>100_bases
TCATTGCTCTCTCTTATTAATCGATGAAGGCAATGAGGTATCCTAGTCCAGGTTGAATAGTGATGAGGAATCTCCGGGAC
CGAGCCAGAATTTGAATAGG

Downstream 100 bases:

>100_bases
CCTACCTATAACTCCACCGCCTCATGTTATTATGAAAGCTTACCGAGTATTTCATCCACTACTTCAAGGGGATTAGATGC
CTTTGTTATAGCACCCCCCA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MVEMGAKLDPWGHYAIEDYRKLLEEFGISPIDKILGLLPHKHKYFERLVIFGHRDFDVWLEALKRGEKVAVLTGFMPSGR
PHLGTAMVYEELKFLQSLGAHIKIAIADAEAYIVRREDRSEVIRRGVEFVAHSIAWGINPDNAEFYYQTAMDNEYYRLIQ
LFSRKITAAEMEAIYGDINPGKIMAALTQSADILHLQLDKYGGYKYIVVPVGADQDPHLRLTRDIADRFEQEFGLKRPSS
IYHKLLRGLDGNKMSKSRPEYAIHLDDDPEMAEKKLANALTGGRATAEEQRRLGGEPWKCSIFELYVYHLIDDEKELKER
YDECVNGKILCGQCKRIAAEKLRKLLIEHQKRFKEVITSGIVEKILKKPSF

Sequences:

>Translated_371_residues
MVEMGAKLDPWGHYAIEDYRKLLEEFGISPIDKILGLLPHKHKYFERLVIFGHRDFDVWLEALKRGEKVAVLTGFMPSGR
PHLGTAMVYEELKFLQSLGAHIKIAIADAEAYIVRREDRSEVIRRGVEFVAHSIAWGINPDNAEFYYQTAMDNEYYRLIQ
LFSRKITAAEMEAIYGDINPGKIMAALTQSADILHLQLDKYGGYKYIVVPVGADQDPHLRLTRDIADRFEQEFGLKRPSS
IYHKLLRGLDGNKMSKSRPEYAIHLDDDPEMAEKKLANALTGGRATAEEQRRLGGEPWKCSIFELYVYHLIDDEKELKER
YDECVNGKILCGQCKRIAAEKLRKLLIEHQKRFKEVITSGIVEKILKKPSF
>Mature_371_residues
MVEMGAKLDPWGHYAIEDYRKLLEEFGISPIDKILGLLPHKHKYFERLVIFGHRDFDVWLEALKRGEKVAVLTGFMPSGR
PHLGTAMVYEELKFLQSLGAHIKIAIADAEAYIVRREDRSEVIRRGVEFVAHSIAWGINPDNAEFYYQTAMDNEYYRLIQ
LFSRKITAAEMEAIYGDINPGKIMAALTQSADILHLQLDKYGGYKYIVVPVGADQDPHLRLTRDIADRFEQEFGLKRPSS
IYHKLLRGLDGNKMSKSRPEYAIHLDDDPEMAEKKLANALTGGRATAEEQRRLGGEPWKCSIFELYVYHLIDDEKELKER
YDECVNGKILCGQCKRIAAEKLRKLLIEHQKRFKEVITSGIVEKILKKPSF

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI47419920, Length=386, Percent_Identity=27.979274611399, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI47419918, Length=386, Percent_Identity=27.979274611399, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI47419916, Length=386, Percent_Identity=28.2383419689119, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI47419914, Length=386, Percent_Identity=28.2383419689119, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI72001474, Length=389, Percent_Identity=26.4781491002571, Blast_Score=111, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324475, Length=370, Percent_Identity=27.2972972972973, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320474, Length=262, Percent_Identity=28.6259541984733, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17864462, Length=386, Percent_Identity=29.0155440414508, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24645295, Length=386, Percent_Identity=29.0155440414508, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- InterPro:   IPR020653 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 42674; Mature: 42674

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEMGAKLDPWGHYAIEDYRKLLEEFGISPIDKILGLLPHKHKYFERLVIFGHRDFDVWL
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHH
EALKRGEKVAVLTGFMPSGRPHLGTAMVYEELKFLQSLGAHIKIAIADAEAYIVRREDRS
HHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCHH
EVIRRGVEFVAHSIAWGINPDNAEFYYQTAMDNEYYRLIQLFSRKITAAEMEAIYGDINP
HHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GKIMAALTQSADILHLQLDKYGGYKYIVVPVGADQDPHLRLTRDIADRFEQEFGLKRPSS
HHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHH
IYHKLLRGLDGNKMSKSRPEYAIHLDDDPEMAEKKLANALTGGRATAEEQRRLGGEPWKC
HHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEE
SIFELYVYHLIDDEKELKERYDECVNGKILCGQCKRIAAEKLRKLLIEHQKRFKEVITSG
HHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVEKILKKPSF
HHHHHHHCCCC
>Mature Secondary Structure
MVEMGAKLDPWGHYAIEDYRKLLEEFGISPIDKILGLLPHKHKYFERLVIFGHRDFDVWL
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHH
EALKRGEKVAVLTGFMPSGRPHLGTAMVYEELKFLQSLGAHIKIAIADAEAYIVRREDRS
HHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCHH
EVIRRGVEFVAHSIAWGINPDNAEFYYQTAMDNEYYRLIQLFSRKITAAEMEAIYGDINP
HHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GKIMAALTQSADILHLQLDKYGGYKYIVVPVGADQDPHLRLTRDIADRFEQEFGLKRPSS
HHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHH
IYHKLLRGLDGNKMSKSRPEYAIHLDDDPEMAEKKLANALTGGRATAEEQRRLGGEPWKC
HHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEE
SIFELYVYHLIDDEKELKERYDECVNGKILCGQCKRIAAEKLRKLLIEHQKRFKEVITSG
HHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVEKILKKPSF
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]